Annotation

PREDICTED:_cytoplasmic_tRNA_2-thiolation_protein_1_[Papilio_machaon]

Description

Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.      

Annotation

PREDICTED:_mitochondrial_ubiquitin_ligase_activator_of_nfkb_1-A_[Papilio_xuthus]

Description

Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fission. Negatively regulates the mitochondrial fusion protein marf by promoting its ubiquitination, acting in a pathway that is parallel to the park/pink1 regulatory pathway.      

Annotation

PREDICTED:_ATP-dependent_RNA_helicase_DHX8_[Papilio_xuthus]

Description

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:18981222, PubMed:24244416). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (By similarity). Before and after egg-chamber formation, required for nurse-cell chromatin dispersal (NCCD) probably by playing a role in spliceosome localization to chromatin/interchromatin spaces (PubMed:24244416).      

Annotation

PREDICTED:_mediator_of_RNA_polymerase_II_transcription_subunit_9_[Amyelois_transitella]

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.       + More
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).      

Annotation

GTP-binding_protein_1_[Papilio_xuthus]

Description

GTP-binding_protein_1_[Papilio_xuthus]

Annotation

PREDICTED:_GTP-binding_protein_1_[Amyelois_transitella]

Description

PREDICTED:_GTP-binding_protein_1_[Amyelois_transitella]

Annotation

fibroin-modulator-binding_protein-1_[Bombyx_mori]

Description

fibroin-modulator-binding_protein-1_[Bombyx_mori]

Annotation

PREDICTED:_E3_ubiquitin-protein_ligase_MGRN1_[Bombyx_mori]

Description

PREDICTED:_E3_ubiquitin-protein_ligase_MGRN1_[Bombyx_mori]

Annotation

ribosomal_protein_L10_[Bombyx_mori]

Description

ribosomal_protein_L10_[Bombyx_mori]

Annotation

PREDICTED:_DNA_polymerase_eta_isoform_X2_[Bombyx_mori]

Description

DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586).      

Annotation

PREDICTED:_fidgetin-like_protein_1_[Papilio_polytes]

Description

PREDICTED:_fidgetin-like_protein_1_[Papilio_polytes]

Annotation

PREDICTED:_josephin-2_[Amyelois_transitella]

Description

Involved in autophagic vesicle formation.      

Annotation

gag-pol_polyprotein?_partial_[Lasius_niger]

Description

gag-pol_polyprotein?_partial_[Lasius_niger]

Annotation

PREDICTED:_probable_cytosolic_Fe-S_cluster_assembly_factor_GL21135_[Amyelois_transitella]

Description

Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins (By similarity).      

Annotation

PREDICTED:_dynein_light_chain_4?_axonemal_[Plutella_xylostella]

Description

PREDICTED:_dynein_light_chain_4?_axonemal_[Plutella_xylostella]