Gene
KWMTBOMO05971
Pre Gene Modal
BGIBMGA002808
Annotation
PREDICTED:_cytoplasmic_tRNA_2-thiolation_protein_1_[Papilio_machaon]
Full name
Cytoplasmic tRNA 2-thiolation protein 1
Alternative Name
Cytoplasmic tRNA adenylyltransferase 1
Location in the cell
Nuclear Reliability : 3.369
Sequence
CDS
ATGTACGCACATTACAAGAAATTAGTATATTTCTCTACAGAGTGTGTCTTCGCACCGAATGCTTACAGAGGACATGCACGCGCCTTGCTCAAGGATATGGAAAAGATAAGGCCGTCATGCATAATGGATATTATTTATTCAGGCGAGACAATGTCTATAAAAGAAGAAGTGTCACTCCCGACCCAGAGGTTATGCATAAGATGCAACTTTGTGTCGTCACAGGAAGTGTGCAAAGCATGTGTTTTGCTTGAAGGCTTAAATAAAGGGTTACCGAAACTTGGAATCGGTAAAAGTTCTAAAGTGAAGAAATTACTTGACGAATACAACACCAGGCAGAATAATTTAGAAACAGCAGTCAAAGATTTAGAAGACTGTAATATTACTGATAAGAAAACAAGTAAAACTTGTAAAAACATATCAAATGGTTTCAAACAAAAAGAATGTAATGCTACAAATTGCTGTACTAATAAAACAGAACGTAATGTTGAGAAGAATAATGAAAAACTTCAAACAGTACTAGATAAGTATTCGTTAGAGAATAACTCGCAAGTTAAACTTGACGAAGAAGACTCTGATGACTCAGAAATCAAACATCAAGATGAAGACGACACTTGCTCCAGTAGTTGCGGGAGACTGGGTGTTGGGTTTTGA
Protein
MYAHYKKLVYFSTECVFAPNAYRGHARALLKDMEKIRPSCIMDIIYSGETMSIKEEVSLPTQRLCIRCNFVSSQEVCKACVLLEGLNKGLPKLGIGKSSKVKKLLDEYNTRQNNLETAVKDLEDCNITDKKTSKTCKNISNGFKQKECNATNCCTNKTERNVEKNNEKLQTVLDKYSLENNSQVKLDEEDSDDSEIKHQDEDDTCSSSCGRLGVGF
Summary
Description
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Similarity
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
Uniprot
EC Number
2.7.7.-
EMBL
Proteomes
Interpro
Gene 3D
ProteinModelPortal
Ontologies
PANTHER
Topology
Subcellular location
Cytoplasm
Length:
216
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.02277
Exp number, first 60 AAs:
0.0226
Total prob of N-in:
0.19631
outside
1 - 216
Population Genetic Test Statistics
Pi
14.902656
Theta
15.442129
Tajima's D
0.007008
CLR
3.754443
CSRT
0.377031148442578
Interpretation
Uncertain
