Annotation

PREDICTED:_protein_Wnt-6_[Bombyx_mori]

Description

Ligand for members of the frizzled family of seven transmembrane receptors.      

Annotation

PREDICTED:_protein_Wnt-10-like?_partial_[Bombyx_mori]

Description

Ligand for members of the frizzled family of seven transmembrane receptors.       + More
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for normal tooth development (PubMed:29178643). Regulates the expression of genes involved in tooth development (PubMed:29178643).      

Annotation

PREDICTED:_neither_inactivation_nor_afterpotential_protein_C_[Amyelois_transitella]

Description

Ligand for members of the frizzled family of seven transmembrane receptors.       + More
Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities (PubMed:2449973). Essential for the expression and stability of the rtp protein in the photoreceptors (PubMed:20107052). The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina (PubMed:20739554).      

Annotation

PREDICTED:_zinc_finger_protein_131-like_isoform_X1_[Amyelois_transitella]

Description

PREDICTED:_zinc_finger_protein_131-like_isoform_X1_[Amyelois_transitella]

Annotation

PREDICTED:_lipase_3-like_[Amyelois_transitella]

Description

PREDICTED:_lipase_3-like_[Amyelois_transitella]

Annotation

PREDICTED:_protein_Hook_homolog_1-like?_partial_[Bombyx_mori]

Description

PREDICTED:_protein_Hook_homolog_1-like?_partial_[Bombyx_mori]

Annotation

integrin_beta2_[Bombyx_mori]

Description

integrin_beta2_[Bombyx_mori]

Annotation

integrin_beta3_[Bombyx_mori]

Description

Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions (PubMed:19023419, PubMed:17326220, PubMed:23283987). During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration (PubMed:19023419). Component of an integrin containing attachment complex, which is required for muscle development and maintenance (PubMed:22253611). Involved in the assembly of dense bodies and M lines during body wall muscle embryonic development by recruiting one of their components, cpna-1, to integrin-mediated attachment sites (PubMed:23283987). May play a similar role in the assembly of dense bodies in gonadal myoepithelial sheath cells (PubMed:17326220). Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672). Required for ovulation (PubMed:17326220). Dephosphorylated, probably within the alpha pat-2/beta pat-3 integrin receptor complex, by the phosphatase dep-1, which leads to down-stream effects including the negative regulation of let-23 signaling and vulval induction (PubMed:28135265). When unphosphosphorylated, recruits the cytoplasmic adapter protein tln-1 to the plasma membrane of secondary vulval precursor cells (PubMed:28135265). This promotes the linking of focal adhesion sites to the F-actin cytoskeleton, and it also acts to restrict the mobility of the let-23 receptor on the plasma membrane of vulval cells which thereby attenuates let-23 signaling (PubMed:28135265).      

Annotation

PREDICTED:_integrin_beta-PS-like_[Bombyx_mori]

Description

PREDICTED:_integrin_beta-PS-like_[Bombyx_mori]

Annotation

reverse_transcriptase_[Bombyx_mori]

Description

reverse_transcriptase_[Bombyx_mori]

Annotation

endonuclease-reverse_transcriptase_[Bombyx_mori]

Description

endonuclease-reverse_transcriptase_[Bombyx_mori]

Annotation

hypothetical_protein_KGM_01509_[Danaus_plexippus]

Description

hypothetical_protein_KGM_01509_[Danaus_plexippus]

Annotation

integrin_beta4_[Bombyx_mori]

Description

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surfaces. Fibrinogen binding enhances SELP expression in activated platelets (PubMed:19332769). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (By similarity). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (By similarity). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity).       + More
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881). It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881). Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447).      
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.      
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260).      

Annotation

PREDICTED:_serine/threonine-protein_kinase_26_[Bombyx_mori]

Description

PREDICTED:_serine/threonine-protein_kinase_26_[Bombyx_mori]

Annotation

PREDICTED:_tubulin_glycylase_3A-like_isoform_X2_[Bombyx_mori]

Description

Polylycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved both in the side-chain initiation and elongation steps of the polyglycylation reaction by adding a single glycine chain to generate monoglycine side chains and by elongating monoglycine side chains to polyglycine side chains.