Gene

KWMTBOMO01773

Annotation

PREDICTED:_protein_Wnt-10-like?_partial_[Bombyx_mori]

Location

Bomo_Chr4(+):4391139-4405848      View in EpiBrowser

Full name

Protein Wnt       + More
Protein Wnt-10a      

Location in the cell

Extracellular   Reliability : 2.207 PlasmaMembrane   Reliability : 1.662

CDS

ATGGAGGTGCGGTGCAAATGTCATGGTTTGTCCGGAAGCTGTCAACTGCGGACATGTTGGAGGACCACGCCTGATTTCAGAGTGGTCGCTTCAACTATCAAAAGACAGTATCGGAAGGCATTAGTTGCAGCGCAAGAGGGACAGATTAATAACGGCATGTCAGTATTGAAGGGTAGACCGAGGGGTAGGAGGAAGAGCAAACCACGACCGGCGCCAAAGACAAGTCTGTTGTTTTTTGAACGGTCACCTAATTTCTGTGAAGTGGACCCCAGGACGGACTCGGCCGGCACAAGTGGGAGAGTGTGTCGTGTGGGACGACCCTCGAGGTCTGGCGCTTGCGAGCTCCTGTGCTGCGGTCGGGGTCACTCTCTCGTCAGGAAATCCAGCATTAAGCCCTGCAACTGTACCTTTCACTGGTGCTGCACTGTCGACTGTCAACGGTGCAGAGACGATAGATGGATCGCTGAAATTGAACAACTCAAAAAGGTGCTGTAA

Protein

MEVRCKCHGLSGSCQLRTCWRTTPDFRVVASTIKRQYRKALVAAQEGQINNGMSVLKGRPRGRRKSKPRPAPKTSLLFFERSPNFCEVDPRTDSAGTSGRVCRVGRPSRSGACELLCCGRGHSLVRKSSIKPCNCTFHWCCTVDCQRCRDDRWIAEIEQLKKVL

Description

Ligand for members of the frizzled family of seven transmembrane receptors.
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for normal tooth development (PubMed:29178643). Regulates the expression of genes involved in tooth development (PubMed:29178643).

Miscellaneous

Wnt10a overexpression in embryos results in loss of anterior neural identity, causing a phenotype with small or no eyes.

Similarity

Belongs to the Wnt family.

Keywords

Complete proteome   Developmental protein   Disulfide bond   Extracellular matrix   Glycoprotein   Lipoprotein   Reference proteome   Secreted   Signal   Wnt signaling pathway  

Feature

chain  Protein Wnt

Uniprot

A0A2H1WNJ4   A0A2A4J4F7   A0A194PL05   A0A194R258   A0A212FB54   A0A077DH97   + More
A0A2R7WJD0   H3BB92   P79856   Q9PVT4   A0A1S3NWD7   A0A060VS93   A0A1V4K7P4   G1KMN3   T1HKG5   A0A3P8YFJ0   A0A3B3SK21   A0A3P8WW94   W5MDP0   A0A091I7F7   F6SDS7   A0A3B3Y5W7   W5MDL7   Q3L249   A0A1A6G307   A0A3P9PMZ5   A0A3B5M4Z1   G1NFT1   A0A3P9PN69   H2S5F3   A0A3B4FB28   A0A091FKL6   H3DI33   A0A091VYP1   A0A091E6A1   A0A087QTS5   A0A093G2U2   A0A2J7RGB2   A0A091N7G1   A0A1S3PLK3   A0A093R9J2   A0A099Z7K4   A0A091PPU6   U3JNI5   A0A2I0LIK5   A0A346FPZ3   A0A0Q3PT81   A0A1V4K642   A0A3B4EGQ0   A0A1L2A1N5   A0A2I0UKI2   A0A226NNY1   A0A3L8SN20   A0A3M0L0V5   A0A226PBI7   A0A2P4T077   Q60GF6   A0A3N0Z251   A0A3B5BNJ7   A0A3P8P6E3   A0A3P9AYH6   G1NFT5   A0A3B4YE50   A0A0P7URS5   A4ZGN7   H3C786   A0A1U7Q659   B7ZQU5   A0A218VAZ4   A0A0S7IX60   H3BIB0   I3J9F4   A0A1W5ASP3   B0V1G8   A0A3B3R208   A0A3B4YL29   H3DC73   Q4RW24   A0A3B4UB81   A0A3P9PMY1   A0A3B3UX37   G3T9L8   A0A0F8CJL4   A0A1W4ZDN4   A0A3B5QKE5   A0A2Y9DKT0   A0A3P8SPC5   A0A3B1JZM6   A0A3P9KLN9   A0A3P9IZU5   H2TUW6   A0A3B3X597   A0A096M425   A0A3B4D0Z2   P43446   Q9CUV1   A0A087XFF5   A0A0P7X879   H2MVK9  

Pubmed

26354079    22118469    25196151    9215903    9022051    24755649    + More
25069045    29240929    24487278    20431018    16258938    20838655    21551351    15496914    23371554    29567137    30282656    24621616    15592404    15789446    25186727    17436276    27762356    23594743    25835551    23542700    25329095    17554307    8330668    29178643    10349636    11042159    11076861    11217851    12466851    16141073   

EMBL

ODYU01009908    SOQ54641.1    NWSH01003424    PCG66330.1    KQ459601    KPI94012.1    + More
KQ460855    KPJ11873.1    AGBW02009374    OWR50975.1    KJ906609    AIL33838.1    KK854927    PTY19736.1    AFYH01036103    AFYH01036104    AFYH01036105    AFYH01036106    AFYH01036107    AFYH01036108    AFYH01036109    AFYH01036110    AFYH01036111    U65428    AAB38531.1    AB026729    BAA85879.1    FR904292    CDQ57828.1    LSYS01004331    OPJ79917.1    ACPB03023451    AHAT01028894    AHAT01028895    KL218243    KFP03315.1    AAMC01028450    AAMC01028451    AY753295    AAW81997.1    LZPO01107543    OBS60581.1    KL447081    KFO69694.1    KL410197    KFQ94713.1    KK717809    KFO52766.1    KL225902    KFM04629.1    KL215153    KFV63403.1    NEVH01004401    PNF39863.1    KK842622    KFP84789.1    KL225119    KFW67659.1    KL890375    KGL77746.1    KK677284    KFQ09942.1    AGTO01001151    AKCR02000392    PKK17203.1    MF416116    AXN72354.1    LMAW01001113    KQK84443.1    OPJ79916.1    KU169900    ALO81631.1    KZ505705    PKU46552.1    MCFN01000003    OXB69201.1    QUSF01000012    RLW04917.1    QRBI01000096    RMC18641.1    AWGT02000105    OXB77114.1    PPHD01014126    POI29761.1    AADN05000350    AB177400    BAD61009.1    RJVU01016332    ROL52352.1    JARO02002572    KPP72365.1    DQ658155    ABG49498.1    BC169932    BC169934    CM004482    AAI69932.1    OCT63407.1    MUZQ01000015    OWK63215.1    GBYX01423809    JAO57422.1    AFYH01001812    AFYH01001813    AERX01009451    CR847976    CAAE01014991    CAG07408.1    KQ041905    KKF21274.1    AYCK01009421    U02544    AK013836    BAB29012.1    JARO02003374    KPP70623.1   

Proteomes

UP000218220    UP000053268    UP000053240    UP000007151    UP000008672    UP000087266    + More
UP000193380    UP000190648    UP000001646    UP000015103    UP000265140    UP000261540    UP000265120    UP000018468    UP000054308    UP000008143    UP000261480    UP000092124    UP000242638    UP000261380    UP000001645    UP000005226    UP000261460    UP000053760    UP000007303    UP000053283    UP000052976    UP000053286    UP000053875    UP000235965    UP000054081    UP000053641    UP000016665    UP000053872    UP000051836    UP000261440    UP000198323    UP000276834    UP000269221    UP000198419    UP000000539    UP000261400    UP000265100    UP000265160    UP000261360    UP000034805    UP000189706    UP000186698    UP000197619    UP000005207    UP000192224    UP000000437    UP000261420    UP000261500    UP000007646    UP000002852    UP000248480    UP000265080    UP000018467    UP000265180    UP000265200    UP000028760    UP000001038   

PRIDE

P43446   

Pfam

PF00110   wnt

Interpro

IPR018161   Wnt_CS        + More
IPR005817   Wnt       
IPR013302   Wnt10       

ProteinModelPortal

A0A2H1WNJ4   A0A2A4J4F7   A0A194PL05   A0A194R258   A0A212FB54   A0A077DH97   + More
A0A2R7WJD0   H3BB92   P79856   Q9PVT4   A0A1S3NWD7   A0A060VS93   A0A1V4K7P4   G1KMN3   T1HKG5   A0A3P8YFJ0   A0A3B3SK21   A0A3P8WW94   W5MDP0   A0A091I7F7   F6SDS7   A0A3B3Y5W7   W5MDL7   Q3L249   A0A1A6G307   A0A3P9PMZ5   A0A3B5M4Z1   G1NFT1   A0A3P9PN69   H2S5F3   A0A3B4FB28   A0A091FKL6   H3DI33   A0A091VYP1   A0A091E6A1   A0A087QTS5   A0A093G2U2   A0A2J7RGB2   A0A091N7G1   A0A1S3PLK3   A0A093R9J2   A0A099Z7K4   A0A091PPU6   U3JNI5   A0A2I0LIK5   A0A346FPZ3   A0A0Q3PT81   A0A1V4K642   A0A3B4EGQ0   A0A1L2A1N5   A0A2I0UKI2   A0A226NNY1   A0A3L8SN20   A0A3M0L0V5   A0A226PBI7   A0A2P4T077   Q60GF6   A0A3N0Z251   A0A3B5BNJ7   A0A3P8P6E3   A0A3P9AYH6   G1NFT5   A0A3B4YE50   A0A0P7URS5   A4ZGN7   H3C786   A0A1U7Q659   B7ZQU5   A0A218VAZ4   A0A0S7IX60   H3BIB0   I3J9F4   A0A1W5ASP3   B0V1G8   A0A3B3R208   A0A3B4YL29   H3DC73   Q4RW24   A0A3B4UB81   A0A3P9PMY1   A0A3B3UX37   G3T9L8   A0A0F8CJL4   A0A1W4ZDN4   A0A3B5QKE5   A0A2Y9DKT0   A0A3P8SPC5   A0A3B1JZM6   A0A3P9KLN9   A0A3P9IZU5   H2TUW6   A0A3B3X597   A0A096M425   A0A3B4D0Z2   P43446   Q9CUV1   A0A087XFF5   A0A0P7X879   H2MVK9  

PDB

6AHY     E-value=2.85036e-25,     Score=281

KEGG

101741036    K01357 wingless-type MMTV integration site family, member 10 | (RefSeq) protein Wnt-10-like

PATHWAY

04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005102   GO:0005576   GO:0016055   GO:0007275   GO:0048730   GO:0005109   GO:0071560   GO:0048018   GO:0005615   GO:0045165   GO:0042476   GO:0030182   GO:0043586   GO:0048733   GO:0060070   GO:0042487   GO:0010628   GO:0014033   GO:0031069   GO:0016021   GO:0016020   GO:0005215   GO:0006810   GO:0006397   GO:0004651   GO:0005634  

PANTHER

PTHR12027  

Subcellular location

  
Secreted  
Extracellular space  
Extracellular matrix  

Length:

164

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00016

Exp number, first 60 AAs:

0.00016

Total prob of N-in:

0.22278

outside

1  -  164

 

 

Pi

258.713451

Theta

181.027063

Tajima's D

1.640808

CLR

0.09124

CSRT

0.818209089545523

Interpretation

Uncertain