Gene

KWMTBOMO01784

Pre Gene Modal

BGIBMGA006151

Annotation

integrin_beta4_[Bombyx_mori]

Location

Bomo_Chr4(+):4522289-4549688      View in EpiBrowser

Full name

Integrin beta       + More
Integrin beta-3      
Integrin beta-6      

Alternative Name

Platelet membrane glycoprotein IIIa

Location in the cell

PlasmaMembrane   Reliability : 4.938

CDS

ATGATTACTCAACACTGCTGGCCTGAATTCTCGGATGCCTGTGCGAAAAACTTCGAGGAACTACCGTCCGCGATGTTAAGAAGCAATAACGGGACGAAGTTACTGAGCATTAACTACATTGAACAATCCGTGCGGCCGTCTTCGCAATATGAACTGACCATAGAATACAACGCGGCGACTCAATCTCAGATAAAAATAGAAATCGTAAACTCGACGCAGACTAGGAATCTTAAATTTTCTGACACAACGAAATGCGAAAATTCTGAATGCACTGCAAAGATTGCGGTCAGGCCATTGGAAACGTTCTGCACGTCTTCCGGTAGTCCTTACGAATACGTATACGCGAACATTTTCTTTGTGGACCTGAACGAATCGACATTAGTGAAGTATTTGATTTCGTGCGCGTGTCCTTGTTCCGCCCAACCCGAACCAAACTCGGAGACGTGCCACAAGAACGGACAATTAATTTGTGGTATTTGCGAATGCTACGACGGATGGTCTGGAAGTTTCTGCAACGAAGCAGCTCAGACTCCAATAACGCCTGTTGTACCTACAATTGTTGAGAAGAAATCACCGAAATGTGAATATCACGGCCATTGGCTGTCAAGCGGAATTTGCGATTGCTTTAAAGGATGGACGGGAAAGAACTGCAACGTACTGAACTGCGGACGCAGACGTGGAGATATCGGCTGCAGTCGAACCAGTGAACTTGGGGAATGCTCAGGGAACGGTGAGTGCGACGCTTGCGGCGACGCCTGCGTCTGCAAAACCGACATCGAAGGGGCCCAGTACTTAGAAGCGGACAACAACTGCGTGGACCTGTGCATGACTGTTGAACAGTGCAAGGATTGTTTATCTAGCAACGGGCCGATGCAGTGTTCGAACTGCAACATTGTGAAGGACGCGTACAACCGTACCGTCTCGGAAGAGCTAGACTATTTAAACAGGAGAGTGTGGATGCATTGCAGCTACATCAACGTCACGACTGAGTGCAAAGTCTTGTATTTGGCGATGAGAGAAAACGAAGTTGTGCATATAATGATTGAGGACTATTGCGAGGTGTCAACGCCGGCCGGTCTGTTCGCGTCGCCGGTGACGTCGGTACTATTTGGACTACTAGCCGTGATATGCGCGGCGTCGCTAGTCGCTGTGGCCGTGTGGAAGTACTTCAATCGCATCCCAGCACAGGACTTGATAAAGCCAGGCTACATGAGCGTGGAGGCGGCCACAAGCACCGTACAGAACCCGGCCTACGTGACGCCGATCTCTTCGTTCATCAACCCTACGTACCAAAAATGCTGA

Protein

MITQHCWPEFSDACAKNFEELPSAMLRSNNGTKLLSINYIEQSVRPSSQYELTIEYNAATQSQIKIEIVNSTQTRNLKFSDTTKCENSECTAKIAVRPLETFCTSSGSPYEYVYANIFFVDLNESTLVKYLISCACPCSAQPEPNSETCHKNGQLICGICECYDGWSGSFCNEAAQTPITPVVPTIVEKKSPKCEYHGHWLSSGICDCFKGWTGKNCNVLNCGRRRGDIGCSRTSELGECSGNGECDACGDACVCKTDIEGAQYLEADNNCVDLCMTVEQCKDCLSSNGPMQCSNCNIVKDAYNRTVSEELDYLNRRVWMHCSYINVTTECKVLYLAMRENEVVHIMIEDYCEVSTPAGLFASPVTSVLFGLLAVICAASLVAVAVWKYFNRIPAQDLIKPGYMSVEAATSTVQNPAYVTPISSFINPTYQKC

Description

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surfaces. Fibrinogen binding enhances SELP expression in activated platelets (PubMed:19332769). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (By similarity). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (By similarity). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity).
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881). It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881). Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447).
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260).

Subunit

Heterodimer of an alpha and a beta subunit (By similarity). Beta-3 (ITGB3) associates with either alpha-IIB (ITGA2B) or alpha-V (ITGAV). Interacts with FLNB and COMP (By similarity). Interacts with PDIA6 following platelet stimulation (By similarity). Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion (By similarity). Interacts with MYO10 (By similarity). Interacts with DAB2 (PubMed:12606711). Interacts with FERMT2 (PubMed:18483218). Integrin ITGAV:ITGB3 interacts with FBLN5 (via N-terminus) (PubMed:11805835). Interacts with EMP2; regulates the levels of the heterodimer ITGA5:ITGB3 integrin expression on the plasma membrane (By similarity). ITGAV:ITGB3 interacts with CCN3 (By similarity). ITGAV:ITGB3 interacts with AGRA2 (By similarity). ITGAV:ITGB3 is found in a ternary complex with CX3CR1 and CX3CL1. ITGAV:ITGB3 is found in a ternary complex with NRG1 and ERBB3. ITGAV:ITGB3 is found in a ternary complex with FGF1 and FGFR1. ITGAV:ITGB3 interacts with FGF2; it is likely that FGF2 can simultaneously bind ITGAV:ITGB3 and FGF receptors (By similarity). ITGAV:ITGB3 binds to IL1B (By similarity). ITGAV:ITGB3 is found in a ternary complex with IGF1 and IGF1R (By similarity). ITGAV:ITGB3 interacts with IGF2 (By similarity). ITGAV:ITGB3 interacts with FBN1 (By similarity). ITGAV:ITGB3 interacts with CD9, CD81 and CD151 (via second extracellular domain) (By similarity). Interacts (via the allosteric site (site 2)) with CXCL12 in a CXCR4-independent manner (By similarity). Interacts with MXRA8/DICAM; the interaction inhibits ITGAV:ITGB3 heterodimer formation (PubMed:22492581). ITGAV:ITGB3 interacts with PTN. Forms a complex with PTPRZ1 and PTN that stimulates endothelial cell migration through ITGB3 Tyr-772 phosphorylation (By similarity).
Heterodimer of an alpha and a beta subunit (PubMed:11807098, PubMed:17545607, PubMed:17158881). Interacts with FLNB (PubMed:11807098). Interacts with HAX1 (PubMed:17545607). ITGAV:ITGB6 interacts with FBN1 (PubMed:17158881). ITGAV:ITGB6 interacts with TGFB1 (PubMed:22278742, PubMed:28117447).
(Microbial infection) Integrin ITGAV:ITGB6 interacts with coxsackievirus A9, coxsackievirus B1 capsid proteins (PubMed:9426447, PubMed:15194773).
(Microbial infection) Integrin ITGAV:ITGB6 interacts with herpes simplex virus-1/HHV-1 gH:gL proteins.

Similarity

Belongs to the integrin beta chain family.

Keywords

3D-structure   Cell adhesion   Cell junction   Cell membrane   Cell projection   Complete proteome   Disulfide bond   Glycoprotein   Integrin   Membrane   Phosphoprotein   Receptor   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix   Alternative splicing   Amelogenesis imperfecta   Disease mutation   Host cell receptor for virus entry   Host-virus interaction   Polymorphism  

Feature

chain  Integrin beta
splice variant  In isoform 2.
sequence variant  In AI1H; dbSNP:rs140015315.

Uniprot

A0A076JU43   H9J9F8   A0A1S6PU27   A0A2H1V7R3   A0A2A4KAT3   A0A212F7G3   + More
A0A212FB72   A0A194R7N4   A0A194PSA2   D6X0D6   A0A336KRK3   F6SRR1   A0A336MVT2   A0A1S3GJ18   A0A2K5LTD5   A0A2K5J5N2   A0A2K6KCB9   A0A2K5LTE2   A0A2K6BAY6   A0A2K5J5H3   A0A2K6KC64   A0A2K6Q2S9   A0A096P692   A0A2K5LTC9   A0A2K6BAZ5   A0A2K5YHH7   A0A2I3MIT0   A0A2K5LTD1   G7NJ66   G7PV32   A0A2K5J5M1   A0A0D9QUZ5   F7FG54   A0A2K5WY82   A0A2I3NH66   B7ZQZ8   Q6GP06   Q07012   A0A2Y9ED82   H0XE40   A0A340X9R2   A0A340X5H4   A0A2Y9H9C9   A0A2Y9H988   G1M853   A0A3P8YQD8   B5APS2   A0A3P8YNF4   A0A2U3VC82   A0A1L8DL40   A0A383ZL92   A0A1L8DMT3   A0A1L8DMF7   G1LCS5   A0A1L8DMR9   D2H505   W8AY85   A0A1L8DMS5   A0A1L8DMI8   A0A1L8DMJ4   A0A0B5H7U8   S4RSM3   A0A087WXP3   O54890   B4E2B8   G1TSS7   F7FW35   J9P3C1   P18564   A0A3B3XFV2   A0A2I3TGA0   K7DU23   Q9TUN3   K7DN27   A0A2M4ACS8   A0A3Q0CI27   E9PEE8   A0A2M4ACZ9   H2QDA1   A0A2Y9KBB9   A8K2N5   G1T7R4   A0A2I3RVJ2   A0A3P9Q7K9   G3HGD1  

Pubmed

25064490    19121390    28232041    22118469    26354079    18362917    + More
19820115    20431018    25362486    22002653    17431167    27762356    7693527    20010809    25069045    19443046    24495485    15815621    16141072    19468303    15489334    11805835    12606711    18483218    19332769    21183079    22492581    21993624    17495919    16341006    2365683    14702039    1382574    9426447    11807098    15184403    15194773    17545607    17158881    22278742    24367260    24319098    24305999    28117447    16136131    26319212    21804562   

EMBL

KJ511857    AII79416.1    BABH01004757    BABH01004758    BABH01004759    BABH01004760    + More
KY346540    AQV03248.1    ODYU01001118    SOQ36885.1    NWSH01000013    PCG80850.1    AGBW02009882    OWR49658.1    AGBW02009374    OWR50968.1    KQ460855    KPJ11881.1    KQ459601    KPI94005.1    KQ971372    EFA10689.2    UFQS01000673    UFQT01000673    SSX06025.1    SSX26382.1    AAMC01124678    AAMC01124679    UFQS01003187    UFQT01003187    SSX15340.1    SSX34714.1    AHZZ02010501    CM001268    EHH25088.1    AQIA01028217    CM001291    EHH58231.1    AQIB01117870    JSUE03016688    BC169987    BC169991    CM004482    AAI69987.1    OCT62291.1    BC073343    AAH73343.1    L13591    AAA17427.1    AAQR03042280    AAQR03042281    ACTA01040108    EU867790    ACF93732.1    GFDF01006905    JAV07179.1    GFDF01006410    JAV07674.1    GFDF01006529    JAV07555.1    ACTA01050688    ACTA01058688    ACTA01066688    ACTA01074688    GFDF01006409    JAV07675.1    GL192494    EFB14276.1    GAMC01020742    GAMC01020741    GAMC01020740    GAMC01020739    GAMC01020738    JAB85816.1    GFDF01006407    JAV07677.1    GFDF01006408    JAV07676.1    GFDF01006406    JAV07678.1    KJ535130    AJF38203.1    AC080166    AC092153    AF026509    AK157958    AL603709    BX000996    CH466558    BC125518    BC125520    AK304203    BAG65080.1    AAGW02039896    AAEX03017055    M35198    AK313944    CH471058    BC121178    S49380    AACZ04071172    AC185328    GABE01000473    GABE01000472    GABE01000471    GABE01000469    JAA44267.1    AF170529    AAD51955.1    GABE01000470    JAA44269.1    GGFK01005275    MBW38596.1    GGFK01005281    MBW38602.1    AK290300    BAF82989.1    AAGW02013727    AAGW02013728    JH000347    EGV96758.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000007266    + More
UP000008143    UP000081671    UP000233060    UP000233080    UP000233180    UP000233120    UP000233200    UP000028761    UP000233140    UP000009130    UP000233100    UP000029965    UP000006718    UP000186698    UP000248484    UP000005225    UP000265300    UP000248481    UP000008912    UP000265140    UP000245340    UP000261681    UP000245300    UP000005640    UP000000589    UP000001811    UP000002280    UP000002254    UP000261480    UP000002277    UP000189706    UP000248482    UP000242638    UP000001075   

PRIDE

H9J9F8    A0A087WXP3    O54890    B4E2B8    J9P3C1    P18564    + More
E9PEE8    A8K2N5    G3HGD1   

Pfam

PF18372   I-EGF_1        + More
PF08725   Integrin_b_cyt
PF07965   Integrin_B_tail
PF07974   EGF_2
PF00362   Integrin_beta
PF17205   PSI_integrin

Interpro

IPR040622   I-EGF_1        + More
IPR015812   Integrin_bsu       
IPR014836   Integrin_bsu_cyt_dom       
IPR036465   vWFA_dom_sf       
IPR032695   Integrin_dom_sf       
IPR013111   EGF_extracell       
IPR033760   Integrin_beta_N       
IPR002369   Integrin_bsu_VWA       
IPR012896   Integrin_bsu_tail       
IPR036349   Integrin_bsu_tail_dom_sf       
IPR027068   Integrin_beta-3       
IPR016201   PSI       
IPR027067   Integrin_beta-5       
IPR002035   VWF_A       
IPR015436   Integrin_bsu-6       
IPR011992   EF-hand-dom_pair       
IPR002048   EF_hand_dom       

SUPFAM

SSF69687   SSF69687        + More
SSF53300   SSF53300       
SSF69179   SSF69179       
SSF47473   SSF47473       

Gene 3D

3.40.50.410    

CDD

cd00051  EFh

ProteinModelPortal

A0A076JU43   H9J9F8   A0A1S6PU27   A0A2H1V7R3   A0A2A4KAT3   A0A212F7G3   + More
A0A212FB72   A0A194R7N4   A0A194PSA2   D6X0D6   A0A336KRK3   F6SRR1   A0A336MVT2   A0A1S3GJ18   A0A2K5LTD5   A0A2K5J5N2   A0A2K6KCB9   A0A2K5LTE2   A0A2K6BAY6   A0A2K5J5H3   A0A2K6KC64   A0A2K6Q2S9   A0A096P692   A0A2K5LTC9   A0A2K6BAZ5   A0A2K5YHH7   A0A2I3MIT0   A0A2K5LTD1   G7NJ66   G7PV32   A0A2K5J5M1   A0A0D9QUZ5   F7FG54   A0A2K5WY82   A0A2I3NH66   B7ZQZ8   Q6GP06   Q07012   A0A2Y9ED82   H0XE40   A0A340X9R2   A0A340X5H4   A0A2Y9H9C9   A0A2Y9H988   G1M853   A0A3P8YQD8   B5APS2   A0A3P8YNF4   A0A2U3VC82   A0A1L8DL40   A0A383ZL92   A0A1L8DMT3   A0A1L8DMF7   G1LCS5   A0A1L8DMR9   D2H505   W8AY85   A0A1L8DMS5   A0A1L8DMI8   A0A1L8DMJ4   A0A0B5H7U8   S4RSM3   A0A087WXP3   O54890   B4E2B8   G1TSS7   F7FW35   J9P3C1   P18564   A0A3B3XFV2   A0A2I3TGA0   K7DU23   Q9TUN3   K7DN27   A0A2M4ACS8   A0A3Q0CI27   E9PEE8   A0A2M4ACZ9   H2QDA1   A0A2Y9KBB9   A8K2N5   G1T7R4   A0A2I3RVJ2   A0A3P9Q7K9   G3HGD1  

PDB

6BXJ     E-value=1.55108e-11,     Score=168

KEGG

101739184    no KO assigned | (RefSeq) teneurin-2-like

GO

GO:0016021   GO:0007229   GO:0009986   GO:0033627   GO:0007160   GO:0005925   GO:0005178   GO:0008305   GO:0016477   GO:0007155   GO:0001968   GO:0070527   GO:0035866   GO:0001954   GO:0010763   GO:0007044   GO:0043277   GO:0048008   GO:0036120   GO:2000406   GO:1900026   GO:0098978   GO:0099699   GO:1903053   GO:0061097   GO:0032956   GO:0005080   GO:0048146   GO:0010628   GO:0009897   GO:0071133   GO:0033690   GO:0016324   GO:0038023   GO:0034684   GO:0043149   GO:0035987   GO:0090136   GO:0007179   GO:0005654   GO:0030054   GO:0005813   GO:0032587   GO:0042470   GO:0099149   GO:0031528   GO:0035868   GO:0042802   GO:0032147   GO:0050839   GO:0010888   GO:0050731   GO:0050840   GO:0048858   GO:0034446   GO:0005886   GO:0048661   GO:0050748   GO:0045766   GO:0030168   GO:0010745   GO:0034679   GO:0070374   GO:0072126   GO:0007566   GO:0010595   GO:0038027   GO:0014911   GO:0031527   GO:0070051   GO:0032369   GO:0034683   GO:0043235   GO:0016020   GO:0033630   GO:0045672   GO:1990314   GO:0035867   GO:0003756   GO:0001938   GO:0031589   GO:0045715   GO:0014823   GO:0046718   GO:0014909   GO:0071260   GO:0030335   GO:0019899   GO:0009314   GO:1900731   GO:0034113   GO:0008277   GO:0051279   GO:0030334   GO:0043184   GO:0002020   GO:0005634   GO:0002687   GO:0060548   GO:0045780   GO:0050919   GO:0031258   GO:0035690   GO:0034685   GO:0006954   GO:0038044   GO:1901388   GO:0001618   GO:0030198   GO:0005509  

PANTHER

PTHR10082   PTHR10082:SF25   PTHR10082:SF26   PTHR10082:SF11  

Subcellular location

Membrane  
Cell membrane  
Cell projection  
Lamellipodium membrane  
Cell junction  
Focal adhesion  

Length:

433

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.55924

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00534

outside

1  -  364

TMhelix

365  -  387

inside

388  -  433

 

 

Pi

237.163594

Theta

195.07975

Tajima's D

0.498285

CLR

0.471868

CSRT

0.508324583770811

Interpretation

Uncertain