SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO01774
Pre Gene Modal
BGIBMGA014526
Annotation
PREDICTED:_neither_inactivation_nor_afterpotential_protein_C_[Amyelois_transitella]
Full name
Protein Wnt       + More
Neither inactivation nor afterpotential protein C      
Location in the cell
Nuclear   Reliability : 3.372
 

Sequence

CDS
ATGAGATTAGGCTCGTTCCTAATTTACGAAGCCCCTGCACTTATGCGAGTTCGGAACGTGGTTGCCCACTTGTTCTTGTGGAAGGAGTTCAGGCTAGACGTGTTAGTCTGCTGTGGTCTGCTGCAACCAGATATTCTGCAAAGGTATCTTCATGCGCCATCCAAAATGAAAGACGGTCTCAACTTATCGTCCTTGCAAAATCCTTTGGAACGTTACAAACTAGACACTAAACTAGGTTCTGGCATATTTGGGGTAGTTTACAAGGCTACCGATACACAGGCGGCTGGAAAATCCGTTGCTGTTAAAATACAAAAATATACCGATAAAAATGAGGCACACATTCAAAAGGAATACAAAATACTTCGAGATTTCACTACTCATCTTAATCTTATCGACTTTTACGGAGTGTTCTGCGAGAGAGTCGATAATATAAACAAAATATGGTTTGTTCTTGAACTGTGCGAAAACGGATCGGTCATCGATATTGTCAGAAAGCTGAATACGGCAGAAAGAAAAATGTCCGAAGAACACATAGCTTACATCTTAAAATATACAATAAAGGCCCTCGTTTATCTGCACGAGAACAAAGTGATGCATCGGAACATAAGGTGTAGCAATATTTTAATCACAAAAGACGGTGAAGTTAAACTGTCTGATTTTGGACTGTCGTGTAAATTAAGCGGAACACTTGATAAGAGTAAAACGAATGTTGGTTCTCCGAGTTGGATGGCGCCCGAAGTGGTGACTGGCGGAGACGACGGTTACGGCAACAGGGTCGACGTTTGGGCCTTGGGCATAACTACTATAGAGATGGCAGACGGAAAAGCCCCTTACCAGGACATGCATCCGACACGCGCATTGTTTCAAATAGTAAGATGCCCTCCGCCGACCATTTCGAAGCCTTCAATGTGGTCGAACGATATCAACGATTTCATTTCTGAGTGTCTCGAAAAAAATCCGGAACATCGACCTTTCATAATGGAACTGGAAGAGCATCCGTTTATTCTGTCCGTTCCTGAGAACGATTATCACCTCTCAACAGAATTGAAGATACTCGCGAAAGAACTAAGTGGCAAGGTATCGCCAGATAAAACACCAGAACGGATAATAAGAGATGGCTTATTGACAACTGAAGGGAACCCTGAAGCCGAAACGATGCAAGTTGAGGATCTTGCCGCTCTAGAAATATTGACTGAGGAAAACTTACTCAATGAGTTGCAAATAAAATTGATGAAAGGTTCATTTATGTCTTTCGTCGGTGACATTCTACTTATTCTCAACCCCAACACCGATGATGATATTTATAACGAAAACCATCACAAGAAGTATGAGTGCAAATCAAGATCAGATAATGAGCCGCACATATTCGCGGTAGCCGATGGCGCTTACCAAGACGCACTTCATCATAACGAACCACAGCACATCGTGTTCTCTGGAGAAAGCAAATCCGGCAAAACTACGAACATGTTACACGCTCTGTCACATTTGACTCATTTAGGAGCGATGAAGAATAACACAGCAGATAGAATTCGTAAAGCAACTAGTATTATCCAAGCAGCTATTTCTGCCGCTACACCCATAAATGCACATTGCACCAGGGGTATTTTTCAAGTTCAAGTGACATACGGAAGCTCGGGAAAACTGAGCGGCGCTATCTTTTGGTTGTATCAATTAGAAAAGTGGCGAATCTCATCAACAGACATGACCCACGCTAACTTCGACTTAATTTATTATTTCTACGATGCGATGGAAGCGGGAAATCGATTAGATGAACTCTGTTTAGACAAAAACAGAAAACATAGATACTTACGGATATCAGATGAACCTGAAAAAGAATTAAAAGGCGTTAGAGAAAGTGTCGAAAATAACGTTCAAAATTATAAAAATATCATTGAGAACCTCACCGCAGTCGATTGGGAAGAAGAGGACATAGGATTTTTTGAAACAGTTTTAGCGTCGATTTTAGTTCTCGGTAATGTCAGATTCAAAGAAGGAAGGAATGGTTCAACCGAAATTGAAAATCCGGAGGAGGCTAAGAGGGTAGCGAAGCTATTGTCACTGGATGAAACAAAATTCCTTTGGGCTTTATTAAATTACTGTCTTATCGAAAGCGGGACTGCAGTAAAAAGAAAACATACTACAGATGAAGCGAGAGATGCTAGGGACACATTAGCAGGCACTTTATATAAAAGACTCATTGACTGGATGATAAATTTAATTAATTCGAAACTCTCCTTTATGAGATCTGTCTTTGGTGATAAATATTCAGTCAGCTTATTGGATATGTTCGGTTTTGAATGCTATCACAGAAATCGACTAGAGCAATTGATAGTAAATACAACAAATGAACAAATACAGTTCCTTTATAACCAAAGAATTTTCGCTTGGGAAATGCAAGAAGCCACAGAAGAAGGTATCGCAATGCCAGAACTAAGATTTTATGACAACAAAAATTCTGTGGATCAACTCATGGGCAGACCTTTAGGCTTGTTTTATGTATTGGACGAAGCGAGTAGAACTAGTAGTGGACAGGAATTCATCATGAGTACAATAAGGACAACGTGTAAAGGACCGTACATCAAATTATCCGGCAGTCATGAATTCAGTGTAGCTCACTATACAGGCAAAGTGAGCTACGATGCAAGAGAAATGGCAGAAAAGAACAAAGACTTCCTTCCTCCTGAAATGATAGAAACAATGAGGGCATCAGTCAATATAACAGTGCAACAGTTATTTAGAAATAAATTAACGAAAACAGGCAATCTTACGGTTTCGCCAAGTCAGCCTAAAGTCACAGTTGCTAAATCAAAATCAGAAAAGGAATTGGAAAACCTAAAAACTAGGAAATTCAACACGGTCTCCAAAGGGCAATTTTCTCAAGTTCATAGAATGAGAACAGCGGCTGCAACATACAGAGCAACCAGTTTAGAATTATTGAAACAGCTCGCCGTTGGGCCCGGCAGTGGCGGAACGCATTACGTCAGATGCATCAGACCAGATTTGAATGACAATCCCCGAGGTTTCCAAAAAGAGGTCGTGAGACAACAATTAAGAGCCTTGGCTGTTTTAGACACGGCCAAAGCCAGGCAGAGTGGCTTCTCCAGTCGCATACCTTTTGCTGAATTCATAAGGAGGTACCGCTTCTTAGCCTTCGATTTCGACGAAAACGTGGAAATGACAAAAGACAACTGTAGACTACTTATGATAAGGTTAAAAATGGAAGGTTGGGAGTTGGGAAAAACGAAAGTTTTCCTGAAATACTATAATGAAGAATTCTTGGCAAGATTGTACGAAACAAAAGTGAAAAAAATTATAAAAGTGCAATGTATGATGAGAGCTTTCTTGGCCAGAAGAAGGGCGATCAAGAGTAAATCAAAATTATTGCATATCAAAGAACTGAAGAAACAACAATCTCTGAACGTAACTGAGGATGAAGCGGCACTGTTGATTCAAAAAGCATACAGAGGTTATATCGTTCGTAAAGCATACGGACCGCTCATAAACAAATCTACGGGGCAAATTGACGAGGAAACAGCTTCGTTCCTAAAAAGATTCGCAATGAAATGGAAGAGCCGCTCCATATTCCAAGTTCTGCTGCAGTACAGAGCGGTTCGCTATCAGGACTTAGTGCACTTCTCGCAACAAGTGCATATTTACAATCAAGCCGTTTTAGAAGCACTGATGACAACTAGCACATCCGTTTTGCTAGACCGCGTGGACCCGCAAGCTAAAGAAGCCAATTTCCTTGGAACTAGCCCTCCGACCGTCTGGAAGCTACCGTTCAGAATTGATCAACTACAATTCTATGATACGATGCACATGTGCGATCCATCTGCAAAAAGCACCGACACTTTTGCTGGTCAGTACGATTCCGATCAAGAGCAATGGGACGAACCTCTGAAACGACGTTTTAGCGCCACACAGATAGACAGCATCGTAACGGCCACAACTCAAACGCTCATCACCGTGCCGTTCTGCCGAGATCCCACCCAGCCTGTCCCTAATCTGCCTCCAGAAGAAACTATCCAACAGCCACCATCCTCTCCTCGTATCGAGGATGGGTCCCGCAACCGTCCGACGGTCTACAAAAAGAAACACGGTAATGCACCACAAAGTTACTACCAGCCCCCGGAGCCGTGGAACGGTGCCCGCGACGACGACGACGTTCTAGAAAACAGCGCACCCAAATTTAAAAAGACGCACAGCCGAAGTCTTTATTGTATCGACGCTCCAGACATGCAGAATCCGATAAAAGAACTCCAAGCCATGGCGAGATCTACGAATGATTTGACCGAGGACGACGCACCATTCAACTTTCAAGCTATGTTGAAGAGGACGCCAAAAAATAGAGCGTCGATGAAACGACTGGGCGAGATCGACAACGGAACATTGGAGAAGCCGCAGTCTACGCCGAAACGTGCGCCGACACCAAAAGCAAAAGCTCCTCCCCCTCCCGTTCAAGTAACACCATCGAAAGCGCCAAACAAGGTCTTACCACCAACTCCACCACCCAGCGAAGTCACGCCCTCGCCGACACCAAATTCAATGCATAAAGAATTCACCAGGCATGATTCCAAAGATCTCATAATACAAGAATTACAGAAACGAGAATCTAGGCCAGAGTTCATTTACCCGAGCAACAAAGTTGAAAGCGAAAAAATCGAATTAGCCCCCGGTATCACGATTCAGGGGACCGTTACAGATTTATAA
Protein
MRLGSFLIYEAPALMRVRNVVAHLFLWKEFRLDVLVCCGLLQPDILQRYLHAPSKMKDGLNLSSLQNPLERYKLDTKLGSGIFGVVYKATDTQAAGKSVAVKIQKYTDKNEAHIQKEYKILRDFTTHLNLIDFYGVFCERVDNINKIWFVLELCENGSVIDIVRKLNTAERKMSEEHIAYILKYTIKALVYLHENKVMHRNIRCSNILITKDGEVKLSDFGLSCKLSGTLDKSKTNVGSPSWMAPEVVTGGDDGYGNRVDVWALGITTIEMADGKAPYQDMHPTRALFQIVRCPPPTISKPSMWSNDINDFISECLEKNPEHRPFIMELEEHPFILSVPENDYHLSTELKILAKELSGKVSPDKTPERIIRDGLLTTEGNPEAETMQVEDLAALEILTEENLLNELQIKLMKGSFMSFVGDILLILNPNTDDDIYNENHHKKYECKSRSDNEPHIFAVADGAYQDALHHNEPQHIVFSGESKSGKTTNMLHALSHLTHLGAMKNNTADRIRKATSIIQAAISAATPINAHCTRGIFQVQVTYGSSGKLSGAIFWLYQLEKWRISSTDMTHANFDLIYYFYDAMEAGNRLDELCLDKNRKHRYLRISDEPEKELKGVRESVENNVQNYKNIIENLTAVDWEEEDIGFFETVLASILVLGNVRFKEGRNGSTEIENPEEAKRVAKLLSLDETKFLWALLNYCLIESGTAVKRKHTTDEARDARDTLAGTLYKRLIDWMINLINSKLSFMRSVFGDKYSVSLLDMFGFECYHRNRLEQLIVNTTNEQIQFLYNQRIFAWEMQEATEEGIAMPELRFYDNKNSVDQLMGRPLGLFYVLDEASRTSSGQEFIMSTIRTTCKGPYIKLSGSHEFSVAHYTGKVSYDAREMAEKNKDFLPPEMIETMRASVNITVQQLFRNKLTKTGNLTVSPSQPKVTVAKSKSEKELENLKTRKFNTVSKGQFSQVHRMRTAAATYRATSLELLKQLAVGPGSGGTHYVRCIRPDLNDNPRGFQKEVVRQQLRALAVLDTAKARQSGFSSRIPFAEFIRRYRFLAFDFDENVEMTKDNCRLLMIRLKMEGWELGKTKVFLKYYNEEFLARLYETKVKKIIKVQCMMRAFLARRRAIKSKSKLLHIKELKKQQSLNVTEDEAALLIQKAYRGYIVRKAYGPLINKSTGQIDEETASFLKRFAMKWKSRSIFQVLLQYRAVRYQDLVHFSQQVHIYNQAVLEALMTTSTSVLLDRVDPQAKEANFLGTSPPTVWKLPFRIDQLQFYDTMHMCDPSAKSTDTFAGQYDSDQEQWDEPLKRRFSATQIDSIVTATTQTLITVPFCRDPTQPVPNLPPEETIQQPPSSPRIEDGSRNRPTVYKKKHGNAPQSYYQPPEPWNGARDDDDVLENSAPKFKKTHSRSLYCIDAPDMQNPIKELQAMARSTNDLTEDDAPFNFQAMLKRTPKNRASMKRLGEIDNGTLEKPQSTPKRAPTPKAKAPPPPVQVTPSKAPNKVLPPTPPPSEVTPSPTPNSMHKEFTRHDSKDLIIQELQKRESRPEFIYPSNKVESEKIELAPGITIQGTVTDL

Summary

Description
Ligand for members of the frizzled family of seven transmembrane receptors.
Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities (PubMed:2449973). Essential for the expression and stability of the rtp protein in the photoreceptors (PubMed:20107052). The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina (PubMed:20739554).
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Subunit
Interacts with rtp.
Similarity
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Belongs to the Wnt family.
In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
In the N-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Keywords
Actin-binding   Alternative splicing   ATP-binding   Complete proteome   Cytoplasm   Cytoskeleton   Kinase   Membrane   Motor protein   Myosin   Nucleotide-binding   Nucleus   Phosphoprotein   Reference proteome   Repeat   Sensory transduction   Transferase   Vision  
Feature
chain  Neither inactivation nor afterpotential protein C
splice variant  In isoform A.
EC Number
2.7.11.1
EMBL
BABH01042828    BABH01042829    BABH01042830    JTDY01000778    KOB75911.1    KQ459601    + More
KPI94011.1    AGBW02009374    OWR50974.1    NWSH01003424    PCG66328.1    ODYU01007965    SOQ51183.1    KK107578    EZA48669.1    QOIP01000002    RLU25647.1    KQ981082    KYN09731.1    AAZX01001625    GL888465    EGI60548.1    ADMH02000623    ETN65570.1    DS231927    EDS27056.1    CH477197    EAT48353.1    GL767051    EFZ14256.1    GFDL01004601    JAV30444.1    KQ982254    KYQ58801.1    JXUM01052119    KQ561720    KXJ77723.1    KQ414617    KOC68107.1    KQ977600    KYN01503.1    GFDL01004602    JAV30443.1    ADTU01012732    ADTU01012733    ADTU01012734    ADTU01012735    ADTU01012736    APCN01001777    AAAB01008980    EAA14178.4    ATLV01027002    KE525421    KFB53752.1    AXCN02000684    KQ976424    KYM88329.1    KQ981906    KYN33316.1    KQ435793    KOX74259.1    GL445900    EFN88873.1    GFDL01004618    JAV30427.1    GEBQ01021466    JAT18511.1    KQ434899    KZC10930.1    GEBQ01014480    JAT25497.1    CVRI01000037    CRK93540.1    KZ288367    PBC26822.1    KK852595    KDR20620.1    GBHO01005985    GBHO01005984    GBHO01005981    JAG37619.1    JAG37620.1    JAG37623.1    GEDC01020389    JAS16909.1    ACPB03023451    GL435626    EFN72913.1    GEDC01029452    JAS07846.1    CH933807    EDW12656.1    CH963920    EDW77896.1    CH940649    EDW64726.1    CH379060    EAL33457.1    CH954177    EDV59206.1    KQS70689.1    CH480818    EDW51982.1    J03131    M20230    M20231    AE014134    AY119496    CM002910    KMY88751.1    JRES01001454    KNC22848.1    CM000157    EDW87765.1    KRJ97381.1    CH916372    EDV99215.1    GAMC01008643    JAB97912.1    OUUW01000006    SPP82020.1    KQ971342    EFA03943.2    ABLF02030790    ABLF02030792    UFQS01000004    UFQT01000004    SSW96792.1    SSX17179.1    GDHF01022338    JAI29976.1    JXJN01019182    JXJN01019183    JXJN01019184    JXJN01019185    JXJN01019186    JXJN01019187    PYGN01000087    PSN54627.1    GFXV01002068    MBW13873.1    AXCM01001833    GDHF01010677    JAI41637.1    GBXI01000884    JAD13408.1    GAMC01008641    JAB97914.1    KA647489    AFP62118.1   
Pfam
PF00063   Myosin_head        + More
PF00069   Pkinase
PF00612   IQ
PF07714   Pkinase_Tyr
PF00110   wnt
PF11105   CCAP
Interpro
IPR000719   Prot_kinase_dom        + More
IPR000048   IQ_motif_EF-hand-BS       
IPR011009   Kinase-like_dom_sf       
IPR027417   P-loop_NTPase       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR001609   Myosin_head_motor_dom       
IPR017441   Protein_kinase_ATP_BS       
IPR036961   Kinesin_motor_dom_sf       
IPR008266   Tyr_kinase_AS       
IPR020635   Tyr_kinase_cat_dom       
IPR005817   Wnt       
IPR018161   Wnt_CS       
IPR008271   Ser/Thr_kinase_AS       
IPR024276   CCAP       
SUPFAM
SSF52540   SSF52540        + More
SSF56112   SSF56112       
Gene 3D

Ontologies

Topology

Subcellular location
  
Cytoplasm   Localizes in the cytoplasm or punctate structures within the nuclei in the absence of rtp. Co-localizes with rtp in the rhabdomere membrane.   With evidence from 10 publications.
Cytoskeleton   Localizes in the cytoplasm or punctate structures within the nuclei in the absence of rtp. Co-localizes with rtp in the rhabdomere membrane.   With evidence from 10 publications.
Nucleus   Localizes in the cytoplasm or punctate structures within the nuclei in the absence of rtp. Co-localizes with rtp in the rhabdomere membrane.   With evidence from 10 publications.
Membrane   Localizes in the cytoplasm or punctate structures within the nuclei in the absence of rtp. Co-localizes with rtp in the rhabdomere membrane.   With evidence from 10 publications.
Length:
1569
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.02595
Exp number, first 60 AAs:
0.02547
Total prob of N-in:
0.00118
outside
1  -  1569
 
 

Population Genetic Test Statistics

Pi
240.845887
Theta
203.325204
Tajima's D
-1.465269
CLR
1.870102
CSRT
0.0624968751562422
Interpretation
Uncertain
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