SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO01779
Pre Gene Modal
BGIBMGA006150
Annotation
integrin_beta3_[Bombyx_mori]
Full name
Integrin beta       + More
Integrin beta pat-3      
Alternative Name
Paralyzed arrest at two-fold protein 3
Location in the cell
Nuclear   Reliability : 4.127
 

Sequence

CDS
ATGAAACTTCGTATAGGTGAACCACAAAAGTTCAATTTCACCTACGATTTCAAGGACAATCCCGTTGATGTGTATTTCTTGTTGGATGCCTCCGCTATGATGGGAACGAAAATAAAGAATATTGCAAGCAAAGCCGACGGCCTTTACAAAACCCTGGAGACTCTGACGAACGACTTCACTTTAGGAGTGGGTACATTTATAGATAAAAACACGTGGAAGGAGAATGGTAAAGAAAGCTACTCATTCGCTCATGAATTGAGTTTGACAAAAGACCATCAGAAATTCGTTACTGCTTTAGAATCCACACCCACGGGCTACAATCGTGATCCGCCAACTGGATGCTTGGACGCTATAGCCCAGGCTATTGTCTGCGATAAGCTAATTGGATGGCGTGAAAAATCTAGAAAGATCATAGTCGTTCTAACCAACAACAATTACCATGACGCCGGCGACGGAAGACTATCCGGTATATTTGAGCCATATGACGGACAGTGTTACACGGATTTAAAGAACAAAAGATATAAGAGAGAATTGACAATGGATTACCCTAGCGTTGGCATGATTAATAAACTTGTCGATCATTACAAAGTGACAGTACTGTTTCTAGTTGAATCAACTGTGAAATCAGCTTACCAGAGTTTGTCAGATGTGATATCTGGTTCGTACATAGACGACTGGGTCAATGAACCGATTAATCCATACGACACTACAGGTCAAACTTTAAAGAAAATATACAAGCAAATCATTGGAAACGTCACGCTGAACGTGGATTTTAAAGCGAAAAATATTGAAAACGTGAAGATACACTTAAGTCCTAACTGCACTAAAGGAAACTACGATAAGAACTGCCTGGTCAAAACAGATCAATCTATAAAATTTGAAGGGTCAGTCGAGATTCTTAACTACGACAGTGCGGACAATGTTTCGGTCGAATTTTCGGTACAAGGACTGGCTGAGAAATTATCAATCGATATTGATGTTATAAGTGATTGTCGGTGCGAAGGAAATGAAAAATCCTCGGGATATTGCAACGGCAGACCTCTTGAGTGCGGACAGTGCTTATGTGACGACGGAAAGTACGTACCTGTTTACTGTAACTAG
Protein
MKLRIGEPQKFNFTYDFKDNPVDVYFLLDASAMMGTKIKNIASKADGLYKTLETLTNDFTLGVGTFIDKNTWKENGKESYSFAHELSLTKDHQKFVTALESTPTGYNRDPPTGCLDAIAQAIVCDKLIGWREKSRKIIVVLTNNNYHDAGDGRLSGIFEPYDGQCYTDLKNKRYKRELTMDYPSVGMINKLVDHYKVTVLFLVESTVKSAYQSLSDVISGSYIDDWVNEPINPYDTTGQTLKKIYKQIIGNVTLNVDFKAKNIENVKIHLSPNCTKGNYDKNCLVKTDQSIKFEGSVEILNYDSADNVSVEFSVQGLAEKLSIDIDVISDCRCEGNEKSSGYCNGRPLECGQCLCDDGKYVPVYCN

Summary

Description
Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions (PubMed:19023419, PubMed:17326220, PubMed:23283987). During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration (PubMed:19023419). Component of an integrin containing attachment complex, which is required for muscle development and maintenance (PubMed:22253611). Involved in the assembly of dense bodies and M lines during body wall muscle embryonic development by recruiting one of their components, cpna-1, to integrin-mediated attachment sites (PubMed:23283987). May play a similar role in the assembly of dense bodies in gonadal myoepithelial sheath cells (PubMed:17326220). Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672). Required for ovulation (PubMed:17326220). Dephosphorylated, probably within the alpha pat-2/beta pat-3 integrin receptor complex, by the phosphatase dep-1, which leads to down-stream effects including the negative regulation of let-23 signaling and vulval induction (PubMed:28135265). When unphosphosphorylated, recruits the cytoplasmic adapter protein tln-1 to the plasma membrane of secondary vulval precursor cells (PubMed:28135265). This promotes the linking of focal adhesion sites to the F-actin cytoskeleton, and it also acts to restrict the mobility of the let-23 receptor on the plasma membrane of vulval cells which thereby attenuates let-23 signaling (PubMed:28135265).
Subunit
Heterodimer of an alpha and a beta subunit (Probable). Interacts with alpha subunit ina-1 (PubMed:9247263). Interacts with alpha subunit pat-2 (Probable). Component of an integrin containing attachment complex, composed of at least pat-2, pat-3, pat-4, pat-6, unc-52, unc-97 and unc-112 (PubMed:22253611).
Similarity
Belongs to the integrin beta chain family.
Keywords
Cell adhesion   Cell junction   Cell membrane   Complete proteome   Cytoplasm   Glycoprotein   Integrin   Membrane   Phosphoprotein   Receptor   Reference proteome   Signal   Transmembrane   Transmembrane helix  
Feature
chain  Integrin beta
EMBL
BABH01004744    BABH01004745    BABH01004746    BABH01004747    KJ511856    AII79415.1    + More
JTDY01005041    KOB67435.1    NWSH01005801    PCG63940.1    ODYU01001118    SOQ36886.1    AGBW02009374    OWR50969.1    KQ459601    KPI94006.1    KQ460855    KPJ11880.1    AMQN01000124    KPI94009.1    JH432223    CAEY01001590    KPJ11876.1    UFQS01003187    UFQT01003187    SSX15340.1    SSX34714.1    GDIQ01164713    JAK87012.1    HAEI01004022    SBR86974.1    UFQS01000673    UFQT01000673    SSX06025.1    SSX26382.1    GDIP01111036    JAL92678.1    GDIP01164831    JAJ58571.1    MF140473    ATU31738.1    GDIP01182525    JAJ40877.1    U19744    BX284603    CAAE01014125    CAF95982.1    PDUG01000003    PIC39542.1    HE601339    CAP24466.2    AY630342    AAU11316.1    GDIP01114843    JAL88871.1    NNAY01001290    OXU24469.1    LFJK02001324    POM32568.1    GDIP01202671    JAJ20731.1    LIAE01007179    PAV81421.1    GL379789    EGT45620.1    MTYJ01000102    OQV14598.1    PAV81420.1    GDIP01126147    JAL77567.1    GDIQ01050308    JAN44429.1    NMWX01000217    OZF81893.1    DS268428    EFO94485.1    DQ289584    ABB92837.1    PAV81419.1    GDIQ01090133    JAN04604.1    HAEA01015386    SBQ43866.1    GDIP01215034    JAJ08368.1    HADY01005129    SBP43614.1    HAEJ01014815    SBS55272.1    GDIQ01026900    JAN67837.1    HAEF01010624    SBR50741.1    HAEH01008195    SBR83832.1    HAEE01003726    SBR23746.1    GDIP01140132    JAL63582.1    HADZ01002439    SBP66380.1    LIAE01006693    PAV86222.1    UYYA01004379    VDM61526.1    GDIP01171530    JAJ51872.1    GDIQ01098191    JAL53535.1    GDIP01078290    LRGB01002793    JAM25425.1    KZS06306.1    GDIP01163022    JAJ60380.1    GDIP01178880    JAJ44522.1    GDIQ01034304    JAN60433.1    GDIQ01170201    JAK81524.1    GDIP01015915    JAM87800.1    OWR50970.1    KP795392    AKJ26284.1    GDIP01192724    JAJ30678.1    KQ971342    EFA03618.2    DS235100    EEB11964.1    HAED01015348    SBR01793.1    GDIP01200122    JAJ23280.1    GDIP01201364    JAJ22038.1    GDIP01038202    JAM65513.1    HAEB01006064    SBQ52591.1    HAEC01014784    SBQ83001.1    UYSL01000037    VDL62417.1    PCG63939.1    LJIG01002322    KRT84618.1    MNPL01000976    OQR79540.1    GFWZ01000163    MBW20153.1    LJIG01022803    KRT78632.1    NEDP02004918    OWF44108.1    GCES01043159    JAR43164.1    GDIQ01169362    JAK82363.1    JRES01001480    KNC22570.1    AMQM01008990    KB095901    ESO10276.1    LN609528    CEF64818.1    GALX01002761    JAB65705.1    ABKE03000023    PDM80454.1   
Pfam
PF00362   Integrin_beta        + More
PF07974   EGF_2
PF08725   Integrin_b_cyt
PF18372   I-EGF_1
PF07965   Integrin_B_tail
PF17205   PSI_integrin
Interpro
IPR015812   Integrin_bsu        + More
IPR036465   vWFA_dom_sf       
IPR002035   VWF_A       
IPR002369   Integrin_bsu_VWA       
IPR013111   EGF_extracell       
IPR014836   Integrin_bsu_cyt_dom       
IPR040622   I-EGF_1       
IPR012896   Integrin_bsu_tail       
IPR036349   Integrin_bsu_tail_dom_sf       
IPR032695   Integrin_dom_sf       
IPR033760   Integrin_beta_N       
IPR016201   PSI       
IPR015439   Integrin_bsu-2       
IPR037076   Integrin_bsu_cyt_dom_sf       
IPR013032   EGF-like_CS       
IPR000742   EGF-like_dom       
SUPFAM
SSF53300   SSF53300        + More
SSF69687   SSF69687       
SSF69179   SSF69179       
Gene 3D
PDB
3V4V     E-value=5.71915e-39,     Score=404

Ontologies

Topology

Subcellular location
Membrane  
Cell membrane   In body wall muscle cells localizes to the base of thick filament M-lines, dense bodies (Z-disks) and in adhesion plaques which form between adjacent cells (PubMed:22479198, PubMed:20385102). In body wall muscles, colocalizes with cpna-1 at integrin adhesion structures (M line and dense bodies) (PubMed:23283987). Deacreased localization to dense bodies during the L2/L3 molt (PubMed:20385102). In myoepithelial sheath cells, colocalizes in dense bodies-like structures with actin thin filaments, deb-1/vinculin and unc-52 (PubMed:17326220).   With evidence from 4 publications.
Lateral cell membrane   In body wall muscle cells localizes to the base of thick filament M-lines, dense bodies (Z-disks) and in adhesion plaques which form between adjacent cells (PubMed:22479198, PubMed:20385102). In body wall muscles, colocalizes with cpna-1 at integrin adhesion structures (M line and dense bodies) (PubMed:23283987). Deacreased localization to dense bodies during the L2/L3 molt (PubMed:20385102). In myoepithelial sheath cells, colocalizes in dense bodies-like structures with actin thin filaments, deb-1/vinculin and unc-52 (PubMed:17326220).   With evidence from 4 publications.
Basal cell membrane   In body wall muscle cells localizes to the base of thick filament M-lines, dense bodies (Z-disks) and in adhesion plaques which form between adjacent cells (PubMed:22479198, PubMed:20385102). In body wall muscles, colocalizes with cpna-1 at integrin adhesion structures (M line and dense bodies) (PubMed:23283987). Deacreased localization to dense bodies during the L2/L3 molt (PubMed:20385102). In myoepithelial sheath cells, colocalizes in dense bodies-like structures with actin thin filaments, deb-1/vinculin and unc-52 (PubMed:17326220).   With evidence from 4 publications.
Cytoplasm   In body wall muscle cells localizes to the base of thick filament M-lines, dense bodies (Z-disks) and in adhesion plaques which form between adjacent cells (PubMed:22479198, PubMed:20385102). In body wall muscles, colocalizes with cpna-1 at integrin adhesion structures (M line and dense bodies) (PubMed:23283987). Deacreased localization to dense bodies during the L2/L3 molt (PubMed:20385102). In myoepithelial sheath cells, colocalizes in dense bodies-like structures with actin thin filaments, deb-1/vinculin and unc-52 (PubMed:17326220).   With evidence from 4 publications.
Myofibril   In body wall muscle cells localizes to the base of thick filament M-lines, dense bodies (Z-disks) and in adhesion plaques which form between adjacent cells (PubMed:22479198, PubMed:20385102). In body wall muscles, colocalizes with cpna-1 at integrin adhesion structures (M line and dense bodies) (PubMed:23283987). Deacreased localization to dense bodies during the L2/L3 molt (PubMed:20385102). In myoepithelial sheath cells, colocalizes in dense bodies-like structures with actin thin filaments, deb-1/vinculin and unc-52 (PubMed:17326220).   With evidence from 4 publications.
Sarcomere   In body wall muscle cells localizes to the base of thick filament M-lines, dense bodies (Z-disks) and in adhesion plaques which form between adjacent cells (PubMed:22479198, PubMed:20385102). In body wall muscles, colocalizes with cpna-1 at integrin adhesion structures (M line and dense bodies) (PubMed:23283987). Deacreased localization to dense bodies during the L2/L3 molt (PubMed:20385102). In myoepithelial sheath cells, colocalizes in dense bodies-like structures with actin thin filaments, deb-1/vinculin and unc-52 (PubMed:17326220).   With evidence from 4 publications.
M line   In body wall muscle cells localizes to the base of thick filament M-lines, dense bodies (Z-disks) and in adhesion plaques which form between adjacent cells (PubMed:22479198, PubMed:20385102). In body wall muscles, colocalizes with cpna-1 at integrin adhesion structures (M line and dense bodies) (PubMed:23283987). Deacreased localization to dense bodies during the L2/L3 molt (PubMed:20385102). In myoepithelial sheath cells, colocalizes in dense bodies-like structures with actin thin filaments, deb-1/vinculin and unc-52 (PubMed:17326220).   With evidence from 4 publications.
Cell junction   In body wall muscle cells localizes to the base of thick filament M-lines, dense bodies (Z-disks) and in adhesion plaques which form between adjacent cells (PubMed:22479198, PubMed:20385102). In body wall muscles, colocalizes with cpna-1 at integrin adhesion structures (M line and dense bodies) (PubMed:23283987). Deacreased localization to dense bodies during the L2/L3 molt (PubMed:20385102). In myoepithelial sheath cells, colocalizes in dense bodies-like structures with actin thin filaments, deb-1/vinculin and unc-52 (PubMed:17326220).   With evidence from 4 publications.
Focal adhesion   In body wall muscle cells localizes to the base of thick filament M-lines, dense bodies (Z-disks) and in adhesion plaques which form between adjacent cells (PubMed:22479198, PubMed:20385102). In body wall muscles, colocalizes with cpna-1 at integrin adhesion structures (M line and dense bodies) (PubMed:23283987). Deacreased localization to dense bodies during the L2/L3 molt (PubMed:20385102). In myoepithelial sheath cells, colocalizes in dense bodies-like structures with actin thin filaments, deb-1/vinculin and unc-52 (PubMed:17326220).   With evidence from 4 publications.
Length:
366
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00552
Exp number, first 60 AAs:
0.00486
Total prob of N-in:
0.01523
outside
1  -  366
 
 

Population Genetic Test Statistics

Pi
166.835578
Theta
153.839579
Tajima's D
0.35943
CLR
18.745802
CSRT
0.475176241187941
Interpretation
Uncertain
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