SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO16721
Pre Gene Modal
BGIBMGA004584
Annotation
PREDICTED:_zinc_finger_protein_891-like_[Papilio_polytes]
Full name
Zinc finger protein GLIS1      
Alternative Name
GLI-similar 1
Gli homologous protein 1
Transcription factor
Location in the cell
Nuclear   Reliability : 3.935
 

Sequence

CDS
ATGGGAACAGTGCTACGAGAGATATTCAAAATCAAAAACACACTAGTTGAACACATCGAGAGATCTCACGTCAACACTTATAAAGGAGACGAGTTTAGTTGCTTATGGCGCGAGTGTGCCCGGTCCAGGCGGCCCTTCAACGCCCGCTACAAGCTCCTCATTCACATGCGCGTTCACTCTGGACACAAGCCGAACAGATGTCATCACCCGGGCTGCGGGAAGGCCTTCTCCCGTCTGGAGAACCTGAAGATCCACGTGCGGTCCCACACGGGCGAGCGGCCCTACGCCTGCCCGGCGCCGCACTGCAGGAAGGCCTTCTCTAACTCCTCGGATCGAGCGAAACATCAGCGGACCCATTTTAACGCTCGACCTTACGCCTGCGGCGCGGCTGGGTGCGGTAAACGCTACACCGATCCGTCATCGTTGAGGAAGCACATCAAATCTCATCCTCACATCACCAACGTGCCGAGGACCTGCATTCCGGCATCGCGTCCCATCAGGAGACACGACCGGGAGCAGCTGGTTCCGAGCTCCCCGGCGAAGCTGACGACGCTCAGATGTATCAGGGATAAGTTGACCGTACCCAGGTTGCAGCGACTGTAG
Protein
MGTVLREIFKIKNTLVEHIERSHVNTYKGDEFSCLWRECARSRRPFNARYKLLIHMRVHSGHKPNRCHHPGCGKAFSRLENLKIHVRSHTGERPYACPAPHCRKAFSNSSDRAKHQRTHFNARPYACGAAGCGKRYTDPSSLRKHIKSHPHITNVPRTCIPASRPIRRHDREQLVPSSPAKLTTLRCIRDKLTVPRLQRL

Summary

Description
Acts as both a repressor and activator of transcription (PubMed:12042312, PubMed:12385751, PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (PubMed:12042312). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807, PubMed:30544251). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (PubMed:30544251).
Subunit
Interacts with KLF4. Interacts with POU5F1 and/or POU5F1B. Interacts with SOX2.
Similarity
Belongs to the GLI C2H2-type zinc-finger protein family.
Keywords
Activator   Alternative splicing   Complete proteome   Differentiation   DNA-binding   Metal-binding   Nucleus   Reference proteome   Repeat   Repressor   Transcription   Transcription regulation   Zinc   Zinc-finger  
Feature
chain  Zinc finger protein GLIS1
splice variant  In isoform 2.
EMBL
BABH01025710    KQ459890    KPJ19581.1    KQ458842    KPJ04901.1    ODYU01005403    + More
SOQ46201.1    RSAL01000078    RVE48730.1    NWSH01004650    PCG64818.1    AGBW02012867    OWR44311.1    KB203019    ESO86629.1    AMQN01000151    GL732885    EFX64073.1    CU468737    BC129173    AAI29174.1    KQ971346    EFA05809.2    KK852750    KDR17210.1    DS235763    EEB16665.1    NEVH01020934    PNF20641.1    CH477373    EAT42385.1    CR847832    CT025742    GDIP01077081    JAM26634.1    GBYX01436205    JAO45130.1    NCKV01004135    RWS25036.1    DS231865    EDS40376.1    DQ438880    ABE66437.1    AJVK01008627    JH431578    DS469538    EDO45177.1    CVRI01000009    CRK88699.1    CH964232    EDW80589.2    LRGB01000243    KZS20198.1    GDIQ01071596    JAN23141.1    KQ418176    KOF88499.1    LJIJ01001942    ODM90482.1    CH902617    EDV43025.1    CAAE01014575    CAF99221.1    KL443527    KFW94817.1    KK937871    KFQ48322.1    BFAA01002470    GCB61277.1    DQ438879    ABE66436.1    KL342558    KFZ53806.1    IACF01004679    LAB70268.1    NEDP02000216    OWF56312.1    CH940656    EDW58324.1    GDIQ01016615    JAN78122.1    CH933806    EDW16852.2    QCYY01002516    ROT69823.1    NCKU01000514    RWS15228.1    KK702719    KFQ28356.1    HAEB01020287    SBQ66814.1    JXUM01050355    KQ561645    KXJ77912.1    CM000364    EDX14007.1    GDIP01019223    JAM84492.1    AJ311850    CAC51080.1    KZ506319    PKU40196.1    KK677043    KFQ09786.1    CH479198    EDW28186.1    BX569796    KK743521    KFP39494.1    CH480815    EDW43274.1    AAPN01349185    AAPN01349186    AAPN01349187    AAPN01349188    AAPN01349189    AAPN01349190    AAPN01349191    AAPN01349192    AAPN01349193    AAPN01349194    CH954182    EDV54068.1    AY032609    AY121651    AE014297    AAK39641.1    AAM51978.1    AAN13923.1    AJWK01025000    AJWK01025001    AJWK01025002    CM012453    RVE60966.1    RQTK01000518    RUS78317.1    DQ438878    ABE66435.1    CM000160    EDW98082.2    GL192442    EFB29153.1    ACTA01058125    ACTA01066125    ACTA01074125    ACTA01082125    ACTA01090125    ACTA01098125    ACTA01106125    UFQT01000504    SSX24839.1    AL626784    AL627259    AAKN02049431    AAKN02049432    AAKN02049433    AABR07049535    AABR07049536    AF486579    AF220434    BC066157    AAH66157.1    AAM12150.1    AAM93156.1    ABQF01030906    ABQF01030907    OUUW01000007    SPP83025.1    AAQR03099840    AAQR03099841    AAQR03099842    AAQR03099843    AAQR03099844    AAQR03099845    AAQR03099846    AAQR03099847    AAQR03099848    AAQR03099849    AEYP01084165    AEYP01084166    AEYP01084167    AKHW03006358    KYO20836.1    GL442767    EFN63064.1    GEBF01006134    JAN97498.1   
Pfam
PF00096   zf-C2H2        + More
PF01347   Vitellogenin_N
PF09172   DUF1943
PF00094   VWD
Interpro
IPR036236   Znf_C2H2_sf        + More
IPR013087   Znf_C2H2_type       
IPR001747   Lipid_transpt_N       
IPR015255   Vitellinogen_open_b-sht       
IPR015816   Vitellinogen_b-sht_N       
IPR015819   Lipid_transp_b-sht_shell       
IPR011030   Lipovitellin_superhlx_dom       
IPR001846   VWF_type-D       
IPR030430   GLIS1       
IPR030405   GLIS3       
SUPFAM
SSF57667   SSF57667        + More
SSF56968   SSF56968       
SSF48431   SSF48431       
Gene 3D
PDB
2GLI     E-value=6.96341e-36,     Score=374

Ontologies

Topology

Subcellular location
Nucleus  
Length:
200
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0
Exp number, first 60 AAs:
0
Total prob of N-in:
0.07102
outside
1  -  200
 
 

Population Genetic Test Statistics

Pi
0
Theta
0
Tajima's D
0
CLR
0
CSRT
0
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
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