Gene

KWMTBOMO16721

Pre Gene Modal

BGIBMGA004584

Annotation

PREDICTED:_zinc_finger_protein_891-like_[Papilio_polytes]

Location

Bomo_Scaf128(+):21426-24170      View in EpiBrowser

Full name

Zinc finger protein GLIS1      

Alternative Name

GLI-similar 1
Gli homologous protein 1

Transcription factor

zf-C2H2

Location in the cell

Nuclear   Reliability : 3.935

CDS

ATGGGAACAGTGCTACGAGAGATATTCAAAATCAAAAACACACTAGTTGAACACATCGAGAGATCTCACGTCAACACTTATAAAGGAGACGAGTTTAGTTGCTTATGGCGCGAGTGTGCCCGGTCCAGGCGGCCCTTCAACGCCCGCTACAAGCTCCTCATTCACATGCGCGTTCACTCTGGACACAAGCCGAACAGATGTCATCACCCGGGCTGCGGGAAGGCCTTCTCCCGTCTGGAGAACCTGAAGATCCACGTGCGGTCCCACACGGGCGAGCGGCCCTACGCCTGCCCGGCGCCGCACTGCAGGAAGGCCTTCTCTAACTCCTCGGATCGAGCGAAACATCAGCGGACCCATTTTAACGCTCGACCTTACGCCTGCGGCGCGGCTGGGTGCGGTAAACGCTACACCGATCCGTCATCGTTGAGGAAGCACATCAAATCTCATCCTCACATCACCAACGTGCCGAGGACCTGCATTCCGGCATCGCGTCCCATCAGGAGACACGACCGGGAGCAGCTGGTTCCGAGCTCCCCGGCGAAGCTGACGACGCTCAGATGTATCAGGGATAAGTTGACCGTACCCAGGTTGCAGCGACTGTAG

Protein

MGTVLREIFKIKNTLVEHIERSHVNTYKGDEFSCLWRECARSRRPFNARYKLLIHMRVHSGHKPNRCHHPGCGKAFSRLENLKIHVRSHTGERPYACPAPHCRKAFSNSSDRAKHQRTHFNARPYACGAAGCGKRYTDPSSLRKHIKSHPHITNVPRTCIPASRPIRRHDREQLVPSSPAKLTTLRCIRDKLTVPRLQRL

Description

Acts as both a repressor and activator of transcription (PubMed:12042312, PubMed:12385751, PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (PubMed:12042312). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807, PubMed:30544251). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (PubMed:30544251).

Subunit

Interacts with KLF4. Interacts with POU5F1 and/or POU5F1B. Interacts with SOX2.

Similarity

Belongs to the GLI C2H2-type zinc-finger protein family.

Keywords

Activator   Alternative splicing   Complete proteome   Differentiation   DNA-binding   Metal-binding   Nucleus   Reference proteome   Repeat   Repressor   Transcription   Transcription regulation   Zinc   Zinc-finger  

Feature

chain  Zinc finger protein GLIS1
splice variant  In isoform 2.

Uniprot

H9J4Z4   A0A0N1PIA1   A0A0N1PGI9   A0A2H1VZE5   A0A3S2NE44   A0A2A4IZG8   + More
A0A212ES86   V4BDH9   X1YV67   A0A182FQ97   E9HVZ7   H3CUH6   A0A0R4IU95   A1L1Q6   D2A690   F1QB13   A0A067R2R3   E0VTF9   A0A1W4XT26   A0A2J7PWE6   Q177N3   F1QLU9   A0A0P5X6X2   A0A0S7I0U6   A0A443SBV3   B0W9Q7   Q1PHK2   A0A1B0GQS1   A0A3B4A7F0   T1IV86   A7RU02   A0A1J1HL90   B4N9F6   A0A162R3H3   A0A0N8E1A9   A0A0L8HH94   A0A1D2MC39   B3LZ98   Q4SJG1   A0A182LAF3   A0A093RFM2   A0A091RZC8   A0A401NKA2   A0A1S4FCC0   Q1PHK3   A0A094K6C9   A0A2P2I8C9   A0A210R5M1   B4MB53   A0A0P6JK72   A0A3B3CSB0   B4KBC4   A0A423T0A8   A0A443RJ01   A0A091QP27   A0A1A8G8W6   A0A182G9T4   B4R1C1   A0A0N8DMH8   Q7K9G4   A0A2I0U2A1   A0A091PR35   B4GYR7   F8W413   A0A091KFZ2   B4HF96   F6XVW8   B3P8H3   Q962I0   A0A1B0CRN1   A0A3P8NW70   A0A1W4V4S4   A0A3S2NWH4   A0A3Q2VDE2   A0A3B3DZ47   A0A433T9P3   Q1PHK4   B4PN27   D2H2F5   G1LSS7   A0A336M7J0   B1ASP5   A0A286XHC9   M0R4C0   A0A3Q2EHI9   A0A384CT15   A0A3B5KZB2   Q8K1M4-2   F7I5B0   H0ZG73   A0A3B0JLC0   H0XL54   M3Y4H1   A0A151M8J4   E2AU21   A0A0P6J2I6  

Pubmed

19121390    26354079    22118469    23254933    21292972    15496914    + More
23594743    18362917    19820115    24845553    20566863    17510324    16715098    25463417    17615350    17994087    27289101    20966253    30297745    28812685    29451363    26483478    11782407    18464734    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    20010809    19468303    21993624    15057822    12042312    12385751    15489334    21654807    30544251    20360741    22293439    20798317   

EMBL

BABH01025710    KQ459890    KPJ19581.1    KQ458842    KPJ04901.1    ODYU01005403    + More
SOQ46201.1    RSAL01000078    RVE48730.1    NWSH01004650    PCG64818.1    AGBW02012867    OWR44311.1    KB203019    ESO86629.1    AMQN01000151    GL732885    EFX64073.1    CU468737    BC129173    AAI29174.1    KQ971346    EFA05809.2    KK852750    KDR17210.1    DS235763    EEB16665.1    NEVH01020934    PNF20641.1    CH477373    EAT42385.1    CR847832    CT025742    GDIP01077081    JAM26634.1    GBYX01436205    JAO45130.1    NCKV01004135    RWS25036.1    DS231865    EDS40376.1    DQ438880    ABE66437.1    AJVK01008627    JH431578    DS469538    EDO45177.1    CVRI01000009    CRK88699.1    CH964232    EDW80589.2    LRGB01000243    KZS20198.1    GDIQ01071596    JAN23141.1    KQ418176    KOF88499.1    LJIJ01001942    ODM90482.1    CH902617    EDV43025.1    CAAE01014575    CAF99221.1    KL443527    KFW94817.1    KK937871    KFQ48322.1    BFAA01002470    GCB61277.1    DQ438879    ABE66436.1    KL342558    KFZ53806.1    IACF01004679    LAB70268.1    NEDP02000216    OWF56312.1    CH940656    EDW58324.1    GDIQ01016615    JAN78122.1    CH933806    EDW16852.2    QCYY01002516    ROT69823.1    NCKU01000514    RWS15228.1    KK702719    KFQ28356.1    HAEB01020287    SBQ66814.1    JXUM01050355    KQ561645    KXJ77912.1    CM000364    EDX14007.1    GDIP01019223    JAM84492.1    AJ311850    CAC51080.1    KZ506319    PKU40196.1    KK677043    KFQ09786.1    CH479198    EDW28186.1    BX569796    KK743521    KFP39494.1    CH480815    EDW43274.1    AAPN01349185    AAPN01349186    AAPN01349187    AAPN01349188    AAPN01349189    AAPN01349190    AAPN01349191    AAPN01349192    AAPN01349193    AAPN01349194    CH954182    EDV54068.1    AY032609    AY121651    AE014297    AAK39641.1    AAM51978.1    AAN13923.1    AJWK01025000    AJWK01025001    AJWK01025002    CM012453    RVE60966.1    RQTK01000518    RUS78317.1    DQ438878    ABE66435.1    CM000160    EDW98082.2    GL192442    EFB29153.1    ACTA01058125    ACTA01066125    ACTA01074125    ACTA01082125    ACTA01090125    ACTA01098125    ACTA01106125    UFQT01000504    SSX24839.1    AL626784    AL627259    AAKN02049431    AAKN02049432    AAKN02049433    AABR07049535    AABR07049536    AF486579    AF220434    BC066157    AAH66157.1    AAM12150.1    AAM93156.1    ABQF01030906    ABQF01030907    OUUW01000007    SPP83025.1    AAQR03099840    AAQR03099841    AAQR03099842    AAQR03099843    AAQR03099844    AAQR03099845    AAQR03099846    AAQR03099847    AAQR03099848    AAQR03099849    AEYP01084165    AEYP01084166    AEYP01084167    AKHW03006358    KYO20836.1    GL442767    EFN63064.1    GEBF01006134    JAN97498.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000283053    UP000218220    UP000007151    + More
UP000030746    UP000069272    UP000000305    UP000007303    UP000000437    UP000007266    UP000027135    UP000009046    UP000192223    UP000235965    UP000008820    UP000288716    UP000002320    UP000092462    UP000261520    UP000001593    UP000183832    UP000007798    UP000076858    UP000053454    UP000094527    UP000007801    UP000075882    UP000288216    UP000242188    UP000008792    UP000261560    UP000009192    UP000283509    UP000285301    UP000069940    UP000249989    UP000000304    UP000008744    UP000001292    UP000002279    UP000008711    UP000000803    UP000092461    UP000265100    UP000192221    UP000264840    UP000271974    UP000002282    UP000008912    UP000000589    UP000005447    UP000002494    UP000265020    UP000261680    UP000261380    UP000008225    UP000007754    UP000268350    UP000005225    UP000000715    UP000050525    UP000000311   

PRIDE

H9J4Z4    Q1PHK2    Q1PHK3    Q7K9G4    Q962I0    Q1PHK4    + More
B1ASP5    M0R4C0    Q8K1M4   

Pfam

PF00096   zf-C2H2        + More
PF01347   Vitellogenin_N
PF09172   DUF1943
PF00094   VWD

Interpro

IPR036236   Znf_C2H2_sf        + More
IPR013087   Znf_C2H2_type       
IPR001747   Lipid_transpt_N       
IPR015255   Vitellinogen_open_b-sht       
IPR015816   Vitellinogen_b-sht_N       
IPR015819   Lipid_transp_b-sht_shell       
IPR011030   Lipovitellin_superhlx_dom       
IPR001846   VWF_type-D       
IPR030430   GLIS1       
IPR030405   GLIS3       

SUPFAM

SSF57667   SSF57667        + More
SSF56968   SSF56968       
SSF48431   SSF48431       

Gene 3D

1.25.10.20     2.30.230.10    

ProteinModelPortal

H9J4Z4   A0A0N1PIA1   A0A0N1PGI9   A0A2H1VZE5   A0A3S2NE44   A0A2A4IZG8   + More
A0A212ES86   V4BDH9   X1YV67   A0A182FQ97   E9HVZ7   H3CUH6   A0A0R4IU95   A1L1Q6   D2A690   F1QB13   A0A067R2R3   E0VTF9   A0A1W4XT26   A0A2J7PWE6   Q177N3   F1QLU9   A0A0P5X6X2   A0A0S7I0U6   A0A443SBV3   B0W9Q7   Q1PHK2   A0A1B0GQS1   A0A3B4A7F0   T1IV86   A7RU02   A0A1J1HL90   B4N9F6   A0A162R3H3   A0A0N8E1A9   A0A0L8HH94   A0A1D2MC39   B3LZ98   Q4SJG1   A0A182LAF3   A0A093RFM2   A0A091RZC8   A0A401NKA2   A0A1S4FCC0   Q1PHK3   A0A094K6C9   A0A2P2I8C9   A0A210R5M1   B4MB53   A0A0P6JK72   A0A3B3CSB0   B4KBC4   A0A423T0A8   A0A443RJ01   A0A091QP27   A0A1A8G8W6   A0A182G9T4   B4R1C1   A0A0N8DMH8   Q7K9G4   A0A2I0U2A1   A0A091PR35   B4GYR7   F8W413   A0A091KFZ2   B4HF96   F6XVW8   B3P8H3   Q962I0   A0A1B0CRN1   A0A3P8NW70   A0A1W4V4S4   A0A3S2NWH4   A0A3Q2VDE2   A0A3B3DZ47   A0A433T9P3   Q1PHK4   B4PN27   D2H2F5   G1LSS7   A0A336M7J0   B1ASP5   A0A286XHC9   M0R4C0   A0A3Q2EHI9   A0A384CT15   A0A3B5KZB2   Q8K1M4-2   F7I5B0   H0ZG73   A0A3B0JLC0   H0XL54   M3Y4H1   A0A151M8J4   E2AU21   A0A0P6J2I6  

PDB

2GLI     E-value=6.96341e-36,     Score=374

KEGG

101742924    K09232 zinc finger protein GLIS1/3 | (RefSeq) zinc finger protein GLI2-like

GO

GO:0003676   GO:0006357   GO:0005634   GO:0005319   GO:0000981   GO:0007417   GO:0000977   GO:0003323   GO:1990798   GO:0042593   GO:0045944   GO:0007525   GO:0005737   GO:0007520   GO:0010817   GO:0007519   GO:0003700   GO:0007517   GO:0006355   GO:0001227   GO:0010454   GO:0001649   GO:0045444   GO:0001228   GO:0046872   GO:0003677   GO:0045893   GO:0000122   GO:0046677   GO:0006508   GO:0005975   GO:0046835   GO:0016773   GO:0006096   GO:0006281   GO:0006259  

PANTHER

PTHR45718:SF3   PTHR45718:SF1  

Subcellular location

Nucleus  

Length:

200

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.07102

outside

1  -  200

 

 

Pi

0

Theta

0

Tajima's D

0

CLR

0

CSRT

0

Interpretation

Uncertain