Silkworm Genome Informatics Database

Gene

KWMTBOMO16044 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004558

Annotation

PREDICTED:_lysine-specific_demethylase_lid_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr27(+):7417184-7455214 View in EpiBrowser

Full name

Lysine-specific demethylase lid + More
Lysine-specific demethylase 5A

Alternative Name

Histone demethylase lid
Jumonji/ARID domain-containing protein lid
Protein little imaginal disks
Retinoblastoma-binding protein 2 homolog
Histone demethylase JARID1A
Jumonji/ARID domain-containing protein 1A
Retinoblastoma-binding protein 2

Transcription factor

PLU-1

Location in the cell

Nuclear Reliability : 3.348

CDS

ATGGGAAAATGTGACGAAGCTAATGTCGAAGTTAGCATGGGGGACTCAGCGTCCCCCATGAAACCTGATAACTTTACGTTTACTCCACCTCCAGAGGCTCCTGTCTTTGAGCCTACACCAGAAGAGTTTTTGGACCCTTTAGCGTACATCAGTAAAATACGTCCTATCGCCGAGAAATCGGGCATTTGCAAGATAAAACCACCAGCGCACTGGCAACCCCCATTCGCAGTTGATGTGGACCGACTACGGTTTACACCGCGAATACAACGGTTAAATGAGCTCGAGGCAATAACGAGGGTGAAGCTTAACTTCTTAGACCAGATTATAAAGTTTTGGGAACTGCAAGGGTCAACGTTCAAGATTCCGACTGTCGAAAGGAAACCGCTCGATCTCTATTCGTTGCATAAGATTGTGAAAGAAGCCGGTGGCTTCGAAATATGTTCAGCAGAGAGGAAATGGTCGAAGATAGCCCGCCGCATGGGCTACCCGCAAGGCAAAGGCGTCGGTTCAATATTGAAGAATCACTACGAACGCATCCTGTATCCTTATGACGTGTTCAAGAACAATGGAGCAGTCGGAGACAATAAGGAGACAAAAATCGAAGTCAAATCAGAACAGACCCCCGAGAAGGCAACGGCGACACGCAGTCGTTCAACGACCAAATGTCCCCCCGGGGCCGCGGCCACCCCGCCTCCCGCCCGTCGGTACAAGTCCGAGCCCGAGCCGGCAGCTGAAGGTAGTCACACCGAAGGCGCCCTCGTCGGATCTGAAGATTCGATTATGAAAACTCCCATTAAAGAGGAGAACCCCGAAATAAGACGGACAAGTCCTCGTGAGAACAAATGGATGTCGGCGGGAGCCAGTTGCGGTTCGCGAGCGCGCGTGACCCGCTCCACCCGTCTCCGCGAGCATCGCGTCAACAACATGACGGTCTCCGTGACGCCTGCCCCGCCCGCACCCAACACGCATCCCGATGATCCGTTGGCGAAGTATATGTGTCACGTGTGCGGCCGGGGCGACGTCGAGGAGCAGATGCTGCTGTGCGACGGCTGCGACGACTCGTACCACACGTTCTGTCTCGTGCCGCCGCTCGCGGACGTGCCCAAGGGCGACTGGAGGTGTCCAGTGTGCTTAGCCGAAGAGGTATCGAAGCCGACTGAAGCTTTTGGTTTCGAGCAGGCCACCCGCGAGTACACGCTGCAACAGTTCGGCGAGATGGCGGATCAGTTTAAATCAGATTACTTCAACATGCCCGTGCACATGGTTCCAACGTCGACTGTGGAAAAGGAATTTTGGCGCATCGTATCGTCGATAGACGAAGACGTCACGGTCGAGTACGGAGCGGACCTTCACTCGATGGACCACGGCTCGGGGTTCCCGACCAAGTCCAGCGCTCACCTGTACCCTGGGGAGCAGCAGTACGCAGACTCCAGCTGGAACTTGAACAATCTACCGGTTCTGGAGGGTTCCGTGCTGGGACATATCAACGCTGATATATCAGGAATGAAGATACCTTGGCTGTACGTGGGCATGTGCTTCGCAACGTTCTGTTGGCACAACGAGGACCACTGGAGCTACTCCATCAATTATTTACATTGGGGAGAACCTAAGACATGGTACGGAGTGCCAAGTTCAAAGGCCGAGCAATTTGAAGCCGCAATGAAGGCGGAAGCTCCAGAGCTGTTCCAGCTGCAACCGGACCTGCTGCACCAGCTTGTCACGATCATGAACCCTAATGTGCTGATGAAAGCTGGTGTTCCCGTTTACAGAATGGATCAGCACGCTGGAGAATTCGTGATTACGTTTCCTCGCGCTTATCATGCCGGCTTCAACCAAGGCTATAATTTTGCCGAAGCGGTCAACTTTACACCAGCTGATTGGTTGAAAGTGGGCCGCGAATGCATCGCGCACTACTCCACGTTGCGGCGCTACTGCGTGTTCTCGCACGACGAGCTGGTCTGCAAGATGGCGCTGGAGGCCGACTCGCTCAGCCTCAGCGTCGCGCTGGCCGCCTACCGGGACATGCGCACCATGCTGCACGACGAACGGAAACTCCGGAAGGGACTGCTGGATTGGGGTGTAACGGAAGCGGAACGCGAGGCCTTCGAGCTGCTACCAGACGATGAGCGGCAATGTCACATGTGCAAGACGACGTGCTTTCTGTCGTGCGTGACGTGTCGCTGCACGCCCGCCGTCGCCTGCCTGCGACACTACGTCGAGCTGTGCAACTGCAGCCCGCAGGCGCACAGGCTCAGATACCGTTACACCTTAGATGAATTGCCAGCGATGCTGGAGAAACTAAAGAAGAAATCGGAACAGTTCAGGGAGTGGGCTGAAGCTGTGCAGAATGCTCTAGATCCAGATACGCCTAAGACTTGTGATTTAGACGGACTGAGGGCGCATTTGAAGAAAGCTCACGAACTTAAGATTCACAAGACCGAGCTAGTTCGTGCTTTAGAAACGGCTATAGAAGACGCCGAAAAGTGTGCTTCGGTAATACAGCAACTGGACTTGAACAAGATGCGGACTCGAACCCGACACCACGACCCCAAATACAGGCTGACCATACACGAGCTCACTTTGTTCGCGGCAGAAATTGACGGCCTCGCTTGTGTTTTGCCCGAAGGCTCGGCTGTCAAAGAAGTCTTACGTCAAACGTCAGAGTTTGAGTCGAAAGCATCGGAATTGATCAACAAAGACCTGGACAAGATTGAACCTGGCTACGTTAGGGAATTAGAAGAGGTTGTAGATTTAGGATCTCGGCTCTGTATAGTGCTGCCGCAGCTGGCGCCCCTGCAGGCGCGGCTCCAGCAAGTGAAGTTTGTCGATGAAGTGCAGCAATACAGGGACGAGTGCTCCACCCTCACTCCGGAGGTCATCGACCGGCTGTTGCAAGATGCCGAAAAACTTGTACCTCATCGCAGGGTTGAACTGGAGAGGGCTGGACTATACAAGTTGAAAGCCCTAGTAGAAGAATGGGAGGAACGCGCCCGAGCTGTCCTCATAGATACAACAAAGTCGAAAGATTCGTCGGAAGCGGACGAGCCGCAGTACACGACCCTGGCCGAGCTGAGTCTGCTGCTCGCCGACGGTGATGAGATCGAGGCGGCCCTGCCCTCGTACCACGCGCTGCAGACCGCCGTGGCTCACGCAAAGGACTGGCTGGCCAAGGTTGAAGAGATGCAATCCAAAGATCTGTACCCGTACATGCACAGCGTGGAGTCTGTTGTGCGCCGCGGGCAACAGATCCCGCTGGCGCTGTACGAGAAAGATCAGTTGGCGGCCGCCCTACAGTCTGCCAAGGAATGGAAACGTGGTGCGGCCGAAATGTTTCTAAAAAAGAATTGGCCATATTCGTTACTGGAAGCCCTGTCGCCAAGGACTGAAGGAGCCGAGAGCTTATCAACAGCGCGGCGCCGGGCGCGAGCCGCCGTCGGAACCGAACCGCCTCCCTCGACGTTAGAGGCCGGCCTATTCCTGAGGAACTTCAGCGAAGACTCCACCCCCACAGAAATCGTAGCGGCGTTCAAACAAGCGGAGATTACTGAACTCAATTCAATAAAAACTTTAAGAGCCCGTAACATGAGGAAGGAAGTCCGGGCCCCACCCGCGGCAGGCGTCACGTTTTGCGTCTGCCAGAAACGGCAATATGGTGTCATGACCCAGTGTGAGCTGTGCAAGGATTGGTTCCATGCTTCATGCATATCATCGATGAAGGACGAGCGGGAGGAGTCGCCGGACCGCGGGGAGGGCGCTCCGTTTTCGGGAGCCGAAAGTAAATTTCTGTGCCCGGACTGTATGAGGACCAAACGGCCCAGGCTGGACCGGATCTTGGGGCTACTGGTGTGGCTGCAGAAGCTGCCGGTCCGGCTGGCGGAGGGCGAGGCGCTGCAGTGCGTGACGGAGCGCGCCATGTCGTGGCAGGACAGCGCGCGGGCGCTGCTGGCCGCCCTGCCGCACCGCGCTGACATGACGAACAGAGAAAAGGCAGATAAACTGAATGCTGAGTTAAAGAAGGCAACAGGAAGAGCTCATGATCTCCATAATGCGCATAATCCAAGGTCGTCGGCCAGCGTGGAGCACGCGTACAGCGCCACGCCGCGGTCGCCCAGCGCGAGGATGGCGCCCGGCATGCTGCACAAGCTGGAGGAACTCATGCTCGAAGGCGACCTCTTGGAGGTGCGGCTAGAGGAGCAGGCGCAGGTGTGGTCGGCGGTGTGGTGCGCGCGCGCCGCCGACGGACGCAAGGCCACGCGCGTGCTCGACGCCGGCCGGCGGAAGCGGCAGCGGCAGCAGCGACACCACCACCAGCTCAAGAGGACCAGGACCAGGCATCACCACGGACCTACAACAACGAAAACATCAATCAAACGCGGCTCGGCCACGACGACTAATTATCTCAACAGAAAGCAGGGCGTGTCGTCGGGCTCGAGTCTGATGATGAGGAAACATTACATGGCGCGGCAGGAAAGACGTAAACGCGGCCTCGCCGCTGCCCGGGGGAAGCATTCGTCAAGGGGAGATGGCGCGTCCCACAGTACCGGAAGCCGGGCAATCGCGGCGAGTCGACGGAGCAGCTCATCCTCGATGTCCTCCGCCGATGATGACGAAGATTGCGCCGCTTCTAATTGTCTAAGGCCTACTGGTAAAGTGGATTGGGTGCAGTGCGACGGTGGGTGCGACCAGTGGTTCCACATGCACTGCGTCGGGCTCAGCCGCGGCGCGCTGCGCGACGACGACGACTACGTGTGCGGCACGTGCGCCGACGCGCGCTAG

Protein

MGKCDEANVEVSMGDSASPMKPDNFTFTPPPEAPVFEPTPEEFLDPLAYISKIRPIAEKSGICKIKPPAHWQPPFAVDVDRLRFTPRIQRLNELEAITRVKLNFLDQIIKFWELQGSTFKIPTVERKPLDLYSLHKIVKEAGGFEICSAERKWSKIARRMGYPQGKGVGSILKNHYERILYPYDVFKNNGAVGDNKETKIEVKSEQTPEKATATRSRSTTKCPPGAAATPPPARRYKSEPEPAAEGSHTEGALVGSEDSIMKTPIKEENPEIRRTSPRENKWMSAGASCGSRARVTRSTRLREHRVNNMTVSVTPAPPAPNTHPDDPLAKYMCHVCGRGDVEEQMLLCDGCDDSYHTFCLVPPLADVPKGDWRCPVCLAEEVSKPTEAFGFEQATREYTLQQFGEMADQFKSDYFNMPVHMVPTSTVEKEFWRIVSSIDEDVTVEYGADLHSMDHGSGFPTKSSAHLYPGEQQYADSSWNLNNLPVLEGSVLGHINADISGMKIPWLYVGMCFATFCWHNEDHWSYSINYLHWGEPKTWYGVPSSKAEQFEAAMKAEAPELFQLQPDLLHQLVTIMNPNVLMKAGVPVYRMDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFTPADWLKVGRECIAHYSTLRRYCVFSHDELVCKMALEADSLSLSVALAAYRDMRTMLHDERKLRKGLLDWGVTEAEREAFELLPDDERQCHMCKTTCFLSCVTCRCTPAVACLRHYVELCNCSPQAHRLRYRYTLDELPAMLEKLKKKSEQFREWAEAVQNALDPDTPKTCDLDGLRAHLKKAHELKIHKTELVRALETAIEDAEKCASVIQQLDLNKMRTRTRHHDPKYRLTIHELTLFAAEIDGLACVLPEGSAVKEVLRQTSEFESKASELINKDLDKIEPGYVRELEEVVDLGSRLCIVLPQLAPLQARLQQVKFVDEVQQYRDECSTLTPEVIDRLLQDAEKLVPHRRVELERAGLYKLKALVEEWEERARAVLIDTTKSKDSSEADEPQYTTLAELSLLLADGDEIEAALPSYHALQTAVAHAKDWLAKVEEMQSKDLYPYMHSVESVVRRGQQIPLALYEKDQLAAALQSAKEWKRGAAEMFLKKNWPYSLLEALSPRTEGAESLSTARRRARAAVGTEPPPSTLEAGLFLRNFSEDSTPTEIVAAFKQAEITELNSIKTLRARNMRKEVRAPPAAGVTFCVCQKRQYGVMTQCELCKDWFHASCISSMKDEREESPDRGEGAPFSGAESKFLCPDCMRTKRPRLDRILGLLVWLQKLPVRLAEGEALQCVTERAMSWQDSARALLAALPHRADMTNREKADKLNAELKKATGRAHDLHNAHNPRSSASVEHAYSATPRSPSARMAPGMLHKLEELMLEGDLLEVRLEEQAQVWSAVWCARAADGRKATRVLDAGRRKRQRQQRHHHQLKRTRTRHHHGPTTTKTSIKRGSATTTNYLNRKQGVSSGSSLMMRKHYMARQERRKRGLAAARGKHSSRGDGASHSTGSRAIAASRRSSSSSMSSADDDEDCAASNCLRPTGKVDWVQCDGGCDQWFHMHCVGLSRGALRDDDDYVCGTCADAR

Description

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. Regulates the expression of clock-controlled genes including tim, per and cry.
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228).

Cofactor

Fe(2+)

Biophysicochemical Properties

9 uM for 2-oxoglutarate
2.9 uM for histone H3K4me3

Subunit

Interacts with Myc. Part of a complex containing Lid, Myc and Ash2.
Interacts with SUZ12; the interaction is direct (By similarity). Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2. Interacts with HDAC1 (By similarity). Interacts with ARNTL/BMAL1 and CLOCK. Interacts (via PHD-type 1 zinc finger) with histone H3 unmodified at 'Lys-4' and (via PHD-type 3 zinc finger) with histone H3 di- and trimethylated at 'Lys-4' (PubMed:19430464).

Similarity

Belongs to the JARID1 histone demethylase family.

Keywords

3D-structure Biological rhythms Chromatin regulator Coiled coil Complete proteome Developmental protein Dioxygenase Iron Metal-binding Nucleus Oxidoreductase Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger Activator Alternative splicing Isopeptide bond Polymorphism Ubl conjugation

Feature

chain  Lysine-specific demethylase lid
splice variant  In isoform 2.
sequence variant  In dbSNP:rs11062385.

Uniprot

H9J4W8 A0A2H1W9J5 A0A194QJ18 A0A2A4JTF1 A0A2A4JRQ2 A0A212FCD9 + More
A0A0C9RHY9 A0A151X4K7 A0A2J7QD49 A0A088ALH5 A0A0L7QMR0 A0A0N0U5B4 N6TYB2 A0A067QX67 D6W7J7 K7J5L7 A0A154NXH3 A0A1Y1L5C8 A0A336LV36 W4VRT7 A0A1Y1L5N2 A0A1B0AWY0 A0A1A9UYA0 A0A1A9Y510 A0A1A9Z9E2 A0A1A9VZR6 A0A1B0FHN1 A0A034WDM5 A0A0K8UBE1 A0A0A1XN00 W8BTK0 A0A1I8PMS0 T1PL56 T1IT35 A0A0P4WL73 A0A1B6CKQ7 A0A1B6DAW0 A0A0M4EET9 A0A131YLU9 A0A1S3JWC7 A0A224YPN1 A0A1S3JXA8 B4LR76 A0A1S3JX97 A0A224YUY4 B3MMQ4 A0A3B0KK02 B3N5A4 A0A1W4UBV9 B5DH42 A0A224YPN0 B4KGG5 M9NEV0 Q9VMJ7 B4NZS6 A0A3B0JVG3 B4I1N7 A0A0J9TGR5 B4G6L2 A0A0T6BEF4 B4MUZ4 A0A2K6RHF1 A0A2K5HA15 A0A2I3M1E7 A0A2K6RHA8 A0A2K5P8B8 A0A1D5QJK5 V9GWB8 A0A2K6AYP7 A0A2K6AYQ6 A0A2K5TWG7 A0A0D9RHZ2 F7FU78 F1NN75 G7PJJ3 F7GI90 A0A2K5P8B9 A0A2K6AYQ9 A0A2K6KUY5 A0A2K5TWE4 A0A096N8H4 G7N5C3 A0A226PK38 A0A1B0CWY8 A0A2K6KUT1 G1P6E2 G1QNE9 K7DQK2 A0A151NIG8 A0A096MJZ8 A0A2J8S3S4 H2NG24 H2NG23 P29375-2 A0A2J8S3R7

EC Number

1.14.11.-

Pubmed

19121390 26354079 22118469 23537049 24845553 18362917 + More
19820115 20075255 28004739 25348373 25830018 24495485 25315136 26830274 28797301 17994087 18057021 15632085 23185243 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 26109357 26109356 12537569 11014813 17311883 17372656 17351631 17351630 18327897 21960634 17550304 22936249 25362486 17431167 15592404 22002653 25319552 24621616 21993624 22293439 15057822 22673903 8414517 16541075 15489334 1857421 7935440 9129143 11358960 15949438 17081983 17320163 17320161 17320160 18669648 19690332 20068231 23186163 24275569 28112733 18270511 19430464 27499454 27427228 26645689 27214401

EMBL

BABH01025736 ODYU01007122 SOQ49616.1 KQ458671 KPJ05553.1 NWSH01000704 + More
PCG74680.1 PCG74681.1 AGBW02009205 OWR51383.1 GBYB01012792 JAG82559.1 KQ982543 KYQ55365.1 NEVH01015827 PNF26510.1 KQ414889 KOC59831.1 KQ435794 KOX73732.1 APGK01047273 KB741077 ENN74310.1 KK852908 KDR13965.1 KQ971307 EFA11272.1 KQ434778 KZC04317.1 GEZM01063974 JAV68883.1 UFQT01000213 SSX21795.1 GANO01000303 JAB59568.1 GEZM01063973 JAV68884.1 JXJN01004961 CCAG010020379 GAKP01006510 JAC52442.1 GDHF01028322 GDHF01026578 GDHF01020500 GDHF01019764 GDHF01011066 GDHF01009763 JAI23992.1 JAI25736.1 JAI31814.1 JAI32550.1 JAI41248.1 JAI42551.1 GBXI01001916 JAD12376.1 GAMC01006258 GAMC01006257 JAC00299.1 KA648850 AFP63479.1 AFFK01019071 GDRN01040654 JAI67145.1 GEDC01023261 JAS14037.1 GEDC01014538 JAS22760.1 CP012523 ALC38767.1 GEDV01008313 JAP80244.1 GFPF01008411 MAA19557.1 CH940649 EDW63540.2 GFPF01008413 MAA19559.1 CH902620 EDV31945.1 OUUW01000010 SPP86086.1 CH954177 EDV57934.1 KQS70204.1 CH379058 EDY69617.1 KRT03332.1 GFPF01008412 MAA19558.1 CH933807 EDW12161.1 KRG03111.1 AE014134 AFH03582.1 AFH03583.1 AFH03584.1 AHN54164.1 AY095051 CM000157 EDW88860.1 KRJ98060.1 KRJ98061.1 SPP86085.1 CH480820 EDW54444.1 CM002910 KMY88429.1 KMY88430.1 KMY88431.1 CH479180 EDW28237.1 LJIG01001222 KRT85718.1 CH963857 EDW76339.1 AHZZ02001506 AHZZ02001507 JSUE03005893 JSUE03005894 JSUE03005895 GAQG01000004 JAB84503.1 AQIA01009614 AQIA01009615 AQIA01009616 AQIA01009617 AQIA01009618 AC239182 AQIB01143904 AQIB01143905 AQIB01143906 AADN05000523 CM001286 EHH65978.1 JU476643 CM001263 AFH33447.1 EHH20373.1 AWGT02000049 OXB80445.1 AJWK01032971 AAPE02024379 AAPE02024380 AAPE02024381 ADFV01077957 ADFV01077958 ADFV01077959 ADFV01077960 GABE01000739 JAA44000.1 AKHW03002956 KYO36588.1 AABR07061907 AABR07061908 AABR07061909 AABR07061910 NDHI03003614 PNJ15429.1 ABGA01223271 ABGA01223272 ABGA01223273 ABGA01223274 ABGA01244473 ABGA01244474 ABGA01244475 ABGA01244476 ABGA01244477 ABGA01244478 S66431 AB209999 AC005844 AC007406 BC048307 BC053893 BC110916 PNJ15433.1

Proteomes

UP000005204 UP000053268 UP000218220 UP000007151 UP000075809 UP000235965 + More
UP000005203 UP000053825 UP000053105 UP000019118 UP000027135 UP000007266 UP000002358 UP000076502 UP000092460 UP000078200 UP000092443 UP000092445 UP000091820 UP000092444 UP000095300 UP000095301 UP000092553 UP000085678 UP000008792 UP000007801 UP000268350 UP000008711 UP000192221 UP000001819 UP000009192 UP000000803 UP000002282 UP000001292 UP000008744 UP000007798 UP000233200 UP000233080 UP000028761 UP000233060 UP000006718 UP000233120 UP000233100 UP000029965 UP000000539 UP000009130 UP000233180 UP000198419 UP000092461 UP000001074 UP000001073 UP000050525 UP000002494 UP000001595 UP000005640

PRIDE

H9J4W8 Q9VMJ7 P29375

Pfam

PF08429   PLU-1        + More
PF00628   PHD
PF01388   ARID
PF02375   JmjN
PF02373   JmjC
PF02928   zf-C5HC2
PF04387   PTPLA
PF04969   CS

Interpro

IPR003349   JmjN        + More
IPR019786   Zinc_finger_PHD-type_CS
IPR013637   Lys_sp_deMease-like_dom
IPR001606   ARID_dom
IPR019787   Znf_PHD-finger
IPR013083   Znf_RING/FYVE/PHD
IPR001965   Znf_PHD
IPR036431   ARID_dom_sf
IPR011011   Znf_FYVE_PHD
IPR003347   JmjC_dom
IPR004198   Znf_C5HC2
IPR018247   EF_Hand_1_Ca_BS
IPR007052   CS_dom
IPR008978   HSP20-like_chaperone
IPR007482   Tyr_Pase-like_PTPLA

SUPFAM

SSF57903   SSF57903        + More
SSF46774   SSF46774
SSF49764   SSF49764

Gene 3D

1.10.150.60 3.30.40.10 2.60.40.790

ProteinModelPortal

H9J4W8 A0A2H1W9J5 A0A194QJ18 A0A2A4JTF1 A0A2A4JRQ2 A0A212FCD9 + More
A0A0C9RHY9 A0A151X4K7 A0A2J7QD49 A0A088ALH5 A0A0L7QMR0 A0A0N0U5B4 N6TYB2 A0A067QX67 D6W7J7 K7J5L7 A0A154NXH3 A0A1Y1L5C8 A0A336LV36 W4VRT7 A0A1Y1L5N2 A0A1B0AWY0 A0A1A9UYA0 A0A1A9Y510 A0A1A9Z9E2 A0A1A9VZR6 A0A1B0FHN1 A0A034WDM5 A0A0K8UBE1 A0A0A1XN00 W8BTK0 A0A1I8PMS0 T1PL56 T1IT35 A0A0P4WL73 A0A1B6CKQ7 A0A1B6DAW0 A0A0M4EET9 A0A131YLU9 A0A1S3JWC7 A0A224YPN1 A0A1S3JXA8 B4LR76 A0A1S3JX97 A0A224YUY4 B3MMQ4 A0A3B0KK02 B3N5A4 A0A1W4UBV9 B5DH42 A0A224YPN0 B4KGG5 M9NEV0 Q9VMJ7 B4NZS6 A0A3B0JVG3 B4I1N7 A0A0J9TGR5 B4G6L2 A0A0T6BEF4 B4MUZ4 A0A2K6RHF1 A0A2K5HA15 A0A2I3M1E7 A0A2K6RHA8 A0A2K5P8B8 A0A1D5QJK5 V9GWB8 A0A2K6AYP7 A0A2K6AYQ6 A0A2K5TWG7 A0A0D9RHZ2 F7FU78 F1NN75 G7PJJ3 F7GI90 A0A2K5P8B9 A0A2K6AYQ9 A0A2K6KUY5 A0A2K5TWE4 A0A096N8H4 G7N5C3 A0A226PK38 A0A1B0CWY8 A0A2K6KUT1 G1P6E2 G1QNE9 K7DQK2 A0A151NIG8 A0A096MJZ8 A0A2J8S3S4 H2NG24 H2NG23 P29375-2 A0A2J8S3R7

PDB

5V9T E-value=0, Score=2308

KEGG

101746976 K11446 histone demethylase JARID1 [EC:1.14.11.-] | (RefSeq) lysine-specific demethylase lid

GO

GO:0005634 GO:0046872 GO:0003677 GO:0008168 GO:0034647 GO:0006338 GO:0035097 GO:0032452 GO:0016021 GO:0033749 GO:0007526 GO:2000737 GO:0045893 GO:0036098 GO:0045475 GO:0032922 GO:0070822 GO:0030717 GO:0043992 GO:0070193 GO:0016491 GO:0004402 GO:0032453 GO:0034720 GO:0016577 GO:0043970 GO:0034721 GO:0006325 GO:0051213 GO:0008270 GO:0035064 GO:0003700 GO:0034648 GO:0044212 GO:0051090 GO:0032993 GO:0003713 GO:0031490 GO:0000122 GO:1901726 GO:0008584 GO:0007283 GO:0000981 GO:0005730 GO:0033169 GO:0042393 GO:0005654 GO:0005515 GO:0016706 GO:0006096 GO:0001678 GO:0005536 GO:0046835 GO:0006281 GO:0006259

Subcellular location

Nucleus
Nucleolus Occupies promoters of genes involved in RNA metabolism and mitochondrial function. With evidence from 18 publications.

Length:

1591

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00016

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00001

outside

1 - 1591

Pi

303.555168

Theta

189.656856

Tajima's D

2.120642

CLR

0.238918

CSRT

0.897455127243638

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics

Multiple alignment of Orthologues

Gene Tree