Gene

KWMTBOMO15162

Pre Gene Modal

BGIBMGA004983

Annotation

Lipopolysaccharide-induced_tumor_necrosis_factor-alpha_factor-like_protein_[Operophtera_brumata]

Location

Bomo_Chr25(-):5965493-5966963      View in EpiBrowser

Full name

Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog      

Alternative Name

Small integral membrane protein of lysosome/late endosome
Estrogen-enhanced transcript protein 1

Transcription factor

zf-LITAF-like

Location in the cell

Extracellular   Reliability : 2.662

CDS

ATGTCTACCCATCAAGGACCTAGTGCGCCACTAGACGATCTTCCACCGCCGTACTCATCGGTTGTAGGAACTACGCATTATGGCTTTGTGGCTCCGGCACTAAGTAATCCTATCCCGGATTCTGTAGGAGCATATCCACCTGCTAAACCATTTACTCCTCCAGGAGTTTACCCCCATCCCGAAGGTGTAACAAATGCAACTGTAAATATGCAGCCTTCTAGAATACCACCTCCACCACCAGGCTTACCAGTCGGTATTGTTCTTCCAAACGCTATGGGTACAGAACCAACCACTTTAACATGTTTCAACTGTAATAAAATAGTTACTACAAGAGTTACATACACAACAGCTTGGCACACACATTTAATTGCTGGGTCGATTTGCTTGATCACTATAGTTTGTTCACTATGCTGCCTGGGTTTGATCCCGTACTGCTTTGATACATTCAAGGAGGCTGAGCACTACTGCCCTAATTGCAACACATTCATCGGCAAAAGCAACAAGTGTTAA

Protein

MSTHQGPSAPLDDLPPPYSSVVGTTHYGFVAPALSNPIPDSVGAYPPAKPFTPPGVYPHPEGVTNATVNMQPSRIPPPPPGLPVGIVLPNAMGTEPTTLTCFNCNKIVTTRVTYTTAWHTHLIAGSICLITIVCSLCCLGLIPYCFDTFKEAEHYCPNCNTFIGKSNKC

Description

Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines.
Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines. May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10.

Subunit

Monomer. Interacts with NEDD4. Interacts (via PSAP motif) with TSG101, a component of the ESCRT-I complex (endosomal sorting complex required for transport I). Interacts with WWOX. Interacts with STAM, a component of the ESCRT-0 complex; the interaction is direct. Identified in a complex with STAM and HGS; within this complex, interacts directly with STAM, but not with HGS. Interacts with STAT6.

Similarity

Belongs to the CDIP1/LITAF family.

Keywords

Cell membrane   Complete proteome   Cytoplasm   DNA-binding   Endosome   Golgi apparatus   Lysosome   Membrane   Metal-binding   Nucleus   Reference proteome   Transcription   Transcription regulation   Zinc  

Feature

chain  Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog

Uniprot

H9J642   A0A0L7LPB8   A0A2H1WQ02   A0A194RKY7   A0A194PME3   S4PR50   + More
A0A212EZ24   G5B4G8   A0A336MCY4   G3WH57   A0A0N8ET20   L5KQM0   S7PRL7   A0A340XRQ9   A0A2P4TB50   A0A3Q2LLF6   A0A093K5J9   F6PP17   A0A3Q2LDN3   H0V8A5   A0A091U0I7   A0A3Q2H8I3   A0A093DXW7   F1NNL3   A0A2Y9SRV5   A0A2Y9QL88   A0A091CRW7   A0A341BE27   A0A2Y9LLU0   G3STV5   Q8QGW7   A0A2Y9QXY7   A0A2Y9LGY8   A0A091H2N9   S9XMI4   B2RYP2   P0C0T0   A0A091FZU0   A0A2Y9HPR8   A0A2U3Z2R2   A0A1A6GSL7   A0A2U3W0C3   A0A1U7QZX7   G3GWL3   K9IYC9  

Pubmed

19121390    26227816    26354079    23622113    22118469    21993625    + More
21709235    23258410    19892987    21993624    15592404    23149746    15489334    15632090    9275072    21804562    29704459   

EMBL

BABH01029946    JTDY01000430    KOB77214.1    ODYU01010192    SOQ55151.1    KQ460045    + More
KPJ18207.1    KQ459604    KPI92285.1    GAIX01001120    JAA91440.1    AGBW02011379    OWR46749.1    JH168449    EHB04179.1    UFQT01000784    SSX27211.1    AEFK01077910    GEBF01005603    JAN98029.1    KB030624    ELK13525.1    KE163197    EPQ11147.1    PPHD01003233    POI33592.1    KL206788    KFV85729.1    AAKN02007517    KK408314    KFQ83365.1    KL232961    KFV07011.1    AADN05000376    KN124499    KFO20992.1    AB058634    AB061737    AY765397    KL518851    KFO88930.1    KB017616    EPY76391.1    BC166851    CH474017    AAI66851.1    EDL96205.1    U53184    KL447645    KFO75750.1    LZPO01075857    OBS68899.1    JH000052    RAZU01000241    EGV96323.1    RLQ63293.1    GABZ01008306    JAA45219.1   

Proteomes

UP000005204    UP000037510    UP000053240    UP000053268    UP000007151    UP000006813    + More
UP000007648    UP000010552    UP000265300    UP000002281    UP000053584    UP000005447    UP000000539    UP000248484    UP000248480    UP000028990    UP000252040    UP000248483    UP000007646    UP000002494    UP000053760    UP000248481    UP000245341    UP000092124    UP000245340    UP000189706    UP000001075    UP000273346   

PRIDE

H9J642   

Pfam

PF10601   zf-LITAF-like

Interpro

IPR037519   LITAF_fam        + More
IPR006629   LITAF       

ProteinModelPortal

H9J642   A0A0L7LPB8   A0A2H1WQ02   A0A194RKY7   A0A194PME3   S4PR50   + More
A0A212EZ24   G5B4G8   A0A336MCY4   G3WH57   A0A0N8ET20   L5KQM0   S7PRL7   A0A340XRQ9   A0A2P4TB50   A0A3Q2LLF6   A0A093K5J9   F6PP17   A0A3Q2LDN3   H0V8A5   A0A091U0I7   A0A3Q2H8I3   A0A093DXW7   F1NNL3   A0A2Y9SRV5   A0A2Y9QL88   A0A091CRW7   A0A341BE27   A0A2Y9LLU0   G3STV5   Q8QGW7   A0A2Y9QXY7   A0A2Y9LGY8   A0A091H2N9   S9XMI4   B2RYP2   P0C0T0   A0A091FZU0   A0A2Y9HPR8   A0A2U3Z2R2   A0A1A6GSL7   A0A2U3W0C3   A0A1U7QZX7   G3GWL3   K9IYC9  

KEGG

101735961    K19363 lipopolysaccharide-induced tumor necrosis factor-alpha factor | (RefSeq) lipopolysaccharide-i

PATHWAY

04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0005794   GO:0098559   GO:0000978   GO:0009898   GO:0045944   GO:0005654   GO:0005829   GO:0008270   GO:0098560   GO:0098574   GO:0050699   GO:0001817   GO:1901223   GO:0071222   GO:0001816   GO:0005634   GO:0005125   GO:0000139   GO:0003677   GO:0019953   GO:0005765   GO:0005576   GO:0007568   GO:0043123  

PANTHER

PTHR23292  

Subcellular location

Cytoplasm   Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).   With evidence from 1 publications.
Nucleus   Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).   With evidence from 1 publications.
Lysosome membrane   Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).   With evidence from 1 publications.
Early endosome membrane   Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).   With evidence from 1 publications.
Late endosome membrane   Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).   With evidence from 1 publications.
Endosome membrane   Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).   With evidence from 1 publications.
Cell membrane   Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).   With evidence from 1 publications.
Golgi apparatus membrane   Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).   With evidence from 1 publications.

Length:

169

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.28057

Exp number, first 60 AAs:

0.16665

Total prob of N-in:

0.56753

inside

1  -  121

TMhelix

122  -  144

outside

145  -  169

 

 

Pi

244.061991

Theta

191.361356

Tajima's D

0.817437

CLR

0.124303

CSRT

0.612569371531423

Interpretation

Uncertain