Gene

KWMTBOMO14273

Annotation

PREDICTED:_gastrula_zinc_finger_protein_XlCGF46.1-like?_partial_[Bombyx_mori]

Location

Bomo_Chr24(+):518663-520777      View in EpiBrowser

Full name

Telomere zinc finger-associated protein      

Alternative Name

Krueppel-related zinc finger protein 3 homolog
Zinc finger and BTB domain-containing protein 48
Krueppel-related zinc finger protein 3
Zinc finger protein 855

Transcription factor

zf-C2H2

Location in the cell

Nuclear   Reliability : 3.12

CDS

ATGTTTTTAGGGGAAGAGATTTGTCAAGATATCCCTGGTATAGATGTTGTATGCGTGAACTGTGCTGATAAAACACTGGCAACAATAAGTTTTATTAAAAATTGTGAAAAATCCACACAACTATTGCATAAAGTATTTGATGATCTTAATAGAACATTGAATATTGACATAGAATCATCTGAAACAGGCGAGAGGCTTTACATTGTTGTAGGCAAAGAAGATTCAAAACTTGTTTTTGCAAAAAAAGATAAAATAGATAATGTTAAATCTATTAAAGTTAAATGTAGGGAGTGCGATGAAATATTCTGTAACATACAACAACTTAAAGAACATAATGAAACTACTCATGACAAATACACTTGCACCAAATGTTTAGAAGTATTTTTAACTGAAAATGATTTAATTGAACACGCTGACAGCACTGAAAACTTTACATGTCCTGAATGTCACCAGTACAGATGTACTAAAAAGAGTCTTAAAAAACATCAAGATGAACAACATACCAATTACATATGCAAGGGATGTGGTAAGACATTTAGAGGTCTACATAAATTACAGAGCCATGAGTTGAGACACAAAGTCAAGAGTACATGCCCAAAATGTGGCAAACATTATATTACCAAAGAATTTTACCTGCGTCATATAAAGCTATGCCTAGAAAACCAGTTGGACCCTCATCCAATGAGAAGTAAATTGGTGAAGACACACTTTTGTGATAAATGTGGGAAAGGATATAGTACTCCTGGGGGTTTGAGAGTTCATGAAAGATTTGTTCATGGTAATGCCAAACCACACATTTGTAAATATTGTAACAAGGGTTTCACAGCTCCGAGCTACTTAAAAATACATTTGGTTACACATACCGGTGAGAAAAAATTCCCATGTGAAATTTGTCAACGAAAATTTGTTTCCAAAGAAGCTCTGTTATATCATACAAGACGTCACACAGGGGAAAAGCCCTACAGTTGTCAATTATGCGATGAGCGATTTGTTAATGCCTCCACTAGGGCTGAACACATAAAATTTAAGCACATTGGCCCAACATTGTTATGTGAAATTTGTTCTCAAAAATTTGTGACACCATCATTTTTAAGACAGCACATGAAAAAGCATCACGATCCAACTAATAAATTGTATACAGAATGGACTTCAATACCTTCCAGTATTACAGAACAAAACGTCAGTATATCTTAG

Protein

MFLGEEICQDIPGIDVVCVNCADKTLATISFIKNCEKSTQLLHKVFDDLNRTLNIDIESSETGERLYIVVGKEDSKLVFAKKDKIDNVKSIKVKCRECDEIFCNIQQLKEHNETTHDKYTCTKCLEVFLTENDLIEHADSTENFTCPECHQYRCTKKSLKKHQDEQHTNYICKGCGKTFRGLHKLQSHELRHKVKSTCPKCGKHYITKEFYLRHIKLCLENQLDPHPMRSKLVKTHFCDKCGKGYSTPGGLRVHERFVHGNAKPHICKYCNKGFTAPSYLKIHLVTHTGEKKFPCEICQRKFVSKEALLYHTRRHTGEKPYSCQLCDERFVNASTRAEHIKFKHIGPTLLCEICSQKFVTPSFLRQHMKKHHDPTNKLYTEWTSIPSSITEQNVSIS

Description

Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A.
Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891).

Subunit

Interacts with EP300.
Interacts with EP300 (PubMed:24382891).

Similarity

Belongs to the krueppel C2H2-type zinc-finger protein family.

Keywords

Activator   Chromosome   Complete proteome   DNA-binding   Isopeptide bond   Metal-binding   Nucleus   Phosphoprotein   Reference proteome   Repeat   Telomere   Transcription   Transcription regulation   Ubl conjugation   Zinc   Zinc-finger   3D-structure   Polymorphism  

Feature

chain  Telomere zinc finger-associated protein
sequence variant  In dbSNP:rs2229330.

Uniprot

A0A2W1B5B3   A0A2A4J1T4   A0A2H1WYD7   S4PDZ1   A0A212ENN1   A0A0N1PH02   + More
A0A194Q6R1   A0A2A4K2W0   A0A2H1VT92   A0A2H1WYP6   A0A1E1W5A4   A0A194QCR4   A0A3S2PHW9   A0A2A4J049   A0A0N1IPL4   A0A194QMY8   A0A194RJK0   A0A1E1WM96   A0A212ERF6   A0A212ENM2   A0A1E1W228   A0A0N0PA51   A0A0N1IBY4   A0A1E1WS62   A0A2A4KBE3   A0A2H1VIT1   A0A2H1WDU9   A0A0L7LNQ4   A0A212EJS4   H9JRM3   A8WFT7   F1RBR7   D6WK38   A0A1S3KQP7   A0A2R8QHF4   A0A1L8FMI8   H9IWP9   A0A1S3QIB5   A0A3P8ZL65   Q6LCP1   A0A093HV52   A0A1L8FGI0   A0AUT5   A0A091UHB8   A0A0T6AUE3   V5MZQ1   Q5R633   A0A2K5TVP3   G7MGK2   A0A2K5MP43   A0A0D9S8S1   A0A2J8US06   A0A2K5TVP5   B2R702   A0A2K6F2R5   P10074   A0A2K6R0D5   A0A2K6DKL3   A0A096NQF9   A0A1D5RI52   G7NTB7   G3QVB5   A8K291   A0A2K5ZJB1   L5KGX1   G1RB88   A0A2R9BI40   H2PXX2   H0WIS4   V5MZH9   F6RE13   H3C680   A0A1S3L4R4   A0A1S3L3Z1   D2K7E4   A0A1S3ACC9   L9L5K3   A0A1S3WNF6   F1MS92   A0A087VDR8   A0A091JLW9   D2E441   A0A3Q7Y995   F7DLM8   A0A146RRK6   A0A2Y9KGB6   L5LPT0   V5N078   M7BBF6   A0A151LYI9   A0A1U7RXH5   A0A286X9T5   G3V777   K7F9Y6   A0A3P4RNP2   E1BPM6   D2K7E2   K7F9Z2  

Pubmed

28756777    23622113    22118469    26354079    26227816    19121390    + More
23594743    18362917    19820115    27762356    25069045    8661141    24454780    22002653    25319552    7969177    9516840    16710414    15489334    2850480    23186163    24382891    24275569    28500257    28112733    28082411    25362486    17431167    22398555    23258410    22722832    16136131    19892987    15496914    20044538    23385571    19393038    19997497    18464734    23624526    22293439    21993624    15057822    15632090    17381049   

EMBL

KZ150322    PZC71409.1    NWSH01004191    PCG65372.1    ODYU01012014    SOQ58085.1    + More
GAIX01003431    JAA89129.1    AGBW02013627    OWR43089.1    KQ460423    KPJ14824.1    KQ459386    KPJ01232.1    NWSH01000255    PCG77982.1    ODYU01004306    SOQ44029.1    SOQ58086.1    GDQN01008891    JAT82163.1    KPJ01231.1    RSAL01000028    RVE51894.1    PCG65371.1    KPJ14825.1    KQ458859    KPJ04846.1    KQ460124    KPJ17614.1    GDQN01002942    JAT88112.1    AGBW02013061    OWR44034.1    OWR43090.1    GDQN01010006    JAT81048.1    KQ458863    KPJ04728.1    KQ459988    KPJ18801.1    GDQN01001240    JAT89814.1    NWSH01000005    PCG80992.1    ODYU01002539    SOQ40164.1    ODYU01007672    SOQ50664.1    JTDY01000510    KOB76846.1    AGBW02014393    OWR41762.1    BABH01031739    BX855614    BC154452    AAI54453.1    KQ971342    EFA03619.2    CR392331    CM004478    OCT72812.1    BABH01021045    AH003660    AAB08974.1    KL206553    KFV83365.1    CM004479    OCT70685.1    BC124901    AAI24902.1    KK434677    KFQ89926.1    LJIG01022774    KRT78787.1    KF462501    AHA80597.1    CR860664    AQIA01006106    JU334257    CM001253    AFE78012.1    EHH14277.1    AQIB01136237    ABGA01121180    ABGA01121181    ABGA01121182    ABGA01121183    NDHI03003447    PNJ48054.1    PNJ48057.1    AK312786    BAG35649.1    L16896    U45325    U45324    AL591866    BC013573    M20677    AHZZ02015169    JSUE03000164    CM001276    EHH49497.1    CABD030000494    AK290156    BAF82845.1    KB030727    ELK10572.1    ADFV01080154    ADFV01080155    ADFV01080156    AJFE02076819    AJFE02076820    AACZ04044233    GABC01002775    GABF01007722    GABD01009775    GABE01009692    NBAG03000330    JAA08563.1    JAA14423.1    JAA23325.1    JAA35047.1    PNI39905.1    AAQR03101277    KF462428    AHA80524.1    GU183913    ADA81890.1    KB320563    ELW68697.1    KL489473    KFO10760.1    KK502278    KFP21949.1    FJ899854    ADA68114.1    GCES01115297    JAQ71025.1    KB109639    ELK28047.1    KF462470    AHA80566.1    KB528912    EMP35276.1    AKHW03007022    KYO17329.1    AAKN02046364    AABR07050549    AABR07050550    CH473968    EDL81212.1    AGCU01087339    CYRY02042692    VCX36553.1    GU183911    ADA81888.1   

Proteomes

UP000218220    UP000007151    UP000053240    UP000053268    UP000283053    UP000037510    + More
UP000005204    UP000000437    UP000007266    UP000087266    UP000186698    UP000265140    UP000053584    UP000001595    UP000233100    UP000233060    UP000029965    UP000233160    UP000005640    UP000233200    UP000233120    UP000028761    UP000006718    UP000009130    UP000001519    UP000233140    UP000010552    UP000001073    UP000240080    UP000002277    UP000005225    UP000002281    UP000007303    UP000079721    UP000011518    UP000009136    UP000053119    UP000286642    UP000002279    UP000248482    UP000031443    UP000050525    UP000189705    UP000005447    UP000002494    UP000007267   

PRIDE

H9JRM3    H9IWP9    Q6LCP1    Q5R633    B2R702    P10074    + More
A8K291   

Pfam

PF00096   zf-C2H2        + More
PF07776   zf-AD
PF00651   BTB
PF01352   KRAB

Interpro

IPR013087   Znf_C2H2_type        + More
IPR036236   Znf_C2H2_sf       
IPR012934   Znf_AD       
IPR036249   Thioredoxin-like_sf       
IPR011333   SKP1/BTB/POZ_sf       
IPR000210   BTB/POZ_dom       
IPR017114   YY-1-like       
IPR001909   KRAB       
IPR036051   KRAB_dom_sf       

SUPFAM

SSF57667   SSF57667        + More
SSF52833   SSF52833       
SSF54695   SSF54695       
SSF109640   SSF109640       

CDD

cd07765  KRAB_A-box

ProteinModelPortal

A0A2W1B5B3   A0A2A4J1T4   A0A2H1WYD7   S4PDZ1   A0A212ENN1   A0A0N1PH02   + More
A0A194Q6R1   A0A2A4K2W0   A0A2H1VT92   A0A2H1WYP6   A0A1E1W5A4   A0A194QCR4   A0A3S2PHW9   A0A2A4J049   A0A0N1IPL4   A0A194QMY8   A0A194RJK0   A0A1E1WM96   A0A212ERF6   A0A212ENM2   A0A1E1W228   A0A0N0PA51   A0A0N1IBY4   A0A1E1WS62   A0A2A4KBE3   A0A2H1VIT1   A0A2H1WDU9   A0A0L7LNQ4   A0A212EJS4   H9JRM3   A8WFT7   F1RBR7   D6WK38   A0A1S3KQP7   A0A2R8QHF4   A0A1L8FMI8   H9IWP9   A0A1S3QIB5   A0A3P8ZL65   Q6LCP1   A0A093HV52   A0A1L8FGI0   A0AUT5   A0A091UHB8   A0A0T6AUE3   V5MZQ1   Q5R633   A0A2K5TVP3   G7MGK2   A0A2K5MP43   A0A0D9S8S1   A0A2J8US06   A0A2K5TVP5   B2R702   A0A2K6F2R5   P10074   A0A2K6R0D5   A0A2K6DKL3   A0A096NQF9   A0A1D5RI52   G7NTB7   G3QVB5   A8K291   A0A2K5ZJB1   L5KGX1   G1RB88   A0A2R9BI40   H2PXX2   H0WIS4   V5MZH9   F6RE13   H3C680   A0A1S3L4R4   A0A1S3L3Z1   D2K7E4   A0A1S3ACC9   L9L5K3   A0A1S3WNF6   F1MS92   A0A087VDR8   A0A091JLW9   D2E441   A0A3Q7Y995   F7DLM8   A0A146RRK6   A0A2Y9KGB6   L5LPT0   V5N078   M7BBF6   A0A151LYI9   A0A1U7RXH5   A0A286X9T5   G3V777   K7F9Y6   A0A3P4RNP2   E1BPM6   D2K7E2   K7F9Z2  

PDB

5WJQ     E-value=7.42318e-23,     Score=265

KEGG

101743210    no KO assigned | (RefSeq) gastrula zinc finger protein XlCGF46.1-like

GO

GO:0005634   GO:0003676   GO:0008270   GO:0045893   GO:0000781   GO:0044212   GO:0003691   GO:0010833   GO:0046872   GO:0042802   GO:0005654   GO:0005829   GO:0000981   GO:0003700   GO:0006355   GO:0031461   GO:0016791   GO:0005488   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

Subcellular location

Nucleus   Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2. According to another report, binds telomeres regardless of their length.   With evidence from 1 publications.
Chromosome   Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2. According to another report, binds telomeres regardless of their length.   With evidence from 1 publications.
Telomere   Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2. According to another report, binds telomeres regardless of their length.   With evidence from 1 publications.

Length:

397

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.000810000000000001

Exp number, first 60 AAs:

0.00041

Total prob of N-in:

0.00255

outside

1  -  397

 

 

Pi

265.294826

Theta

189.799794

Tajima's D

1.245514

CLR

0

CSRT

0.727613619319034

Interpretation

Uncertain