Gene

KWMTBOMO12710

Pre Gene Modal

BGIBMGA001602

Annotation

PREDICTED:_histone_H4_transcription_factor-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr21(+):12667502-12674656      View in EpiBrowser

Full name

Histone H4 transcription factor      

Alternative Name

Histone nuclear factor P
MBD2-interacting zinc finger protein
Methyl-CpG-binding protein 2-interacting zinc finger protein

Transcription factor

zf-C2H2

Location in the cell

Nuclear   Reliability : 3.978

CDS

ATGTCAGTTAAAAAAAATGTGGAAATTCAACACAAAATTAAATTAAACCCTAAACTCGCAAGTTCTTTGCGGTGTATGCAATGGTTAAAGCATCAGAACAGTCCATCAAACAAGAAGGTTTTACAGTCAAAGAATGATGTCCTATTCGTTCAGACGAATAAATTTGAAAAACCCGAATTTTCAAATCTGGACACAGAAGATACCATTCCAGACGGTGTTAACGAATCTGTCATTAAACCAAAGACTGTGACTACAAAATTTTTACGAATTTCCAAACTGAGCTTGGCTTGTGAGTGGCAGGGATGCAAATTATTAACCAATAATTATGAATCATATCAGAAACACGTCATCGCTCATTTCTCTGATGTGATTCAAATAATAGATAAGGAAGAAACTGTAATGTATTCTTGTCTTTGGGATGTTTGTGGTCACAAAACAAAGGATTATAATGAGATGTTTCGGCATTTAAATTACCATGCTTATCATGGGAAGTTGCTGGCGATCGGCCTCAATGGTAGAGCTACATTAAAACTGGAAAGATGCAAGAAGAACTCCACTAAAAGAAATCAGTTACCTAATTTACCTAATGAACATATTTGCATGTGGACTGACTGCAATAGAAAGTTTAACTCAATACAGATCTTATTTGATCATGCAAAACTACATGTGAACTACTCTGAGAAGTTTCTATGTTCGTGGGCCGGTTGCGGTGCTTGGTTCACAACAAAGGCACTGCTCGGTGCTCATGTTCGCTCGCACACCGGTGAGAGGCTGATCGCTTGTTATCATTGCGGTCAGCACTTTGCTAATAATAGGAAACTGCGTGATCATTTGAGGAGGCAGAACGTGGATCCAGAGTCACCGTTCAAGTGCACGATGTGCGGCATACCGTGCGCGACCGAGTACCTGCTGAACGAGCATGCCCGCCAGCACGTGTCGGCGCACGTGTGCGCGCTCTGCGACATGACGGCCACCTCGCCCGCCGCGCTCGCGCAGCACGTGCGCTACCGGCACCTGCCGCGCGCGCCGCACCACGCCTGCACGCGCTGCGCCTACAGGGCCGTCACAAAGAACGATCTCCAGAAGCATTTGATGATACACGACAAGAAACGCAACAAGAAGAAGTCTGACCGCGAAAGCGACAGGGACTCGGATCTGAGCGACAATTCCATCATAACCACGAAGAAGAAGAAGAAGAAGATTCCCAGGAAATACGCCTGCCACATGTGCCCAGAGGATAAGATGAAGGTGTTCGCCAGAGGAAACACCCTCACGTCACACCTGGTGAAGGTGCACGGCGTGCAGTGGCCCTACGGACACAGCCGGTTCAGGTATCAGAAGAGCGAGGACGGCGTGTACCGTCTGACCACGACCCGTTACGAGGTTCTGGAAGTTTCCAACAAGATCTTCGCCCGGGACAGCGGCCCGAAACAATCCCTGAACGAAAACTTAGATTTCAAACTGAAACAGGTCGCGGAACCGACTTTCGACACGCCGAGGCGCTTCGAAATAATGCTGCTTGGGGGCGAGGGTGAGGGGGGGCATGGGGGGGTCGAGGAGTCCAGAGACAGCGGCCTGGTGGAGATCACGATGTGCGATGTGGACGATAAAGGGAACGTTATTAAATCAGAGCTTATCGAATCACAAGTCATTTGA

Protein

MSVKKNVEIQHKIKLNPKLASSLRCMQWLKHQNSPSNKKVLQSKNDVLFVQTNKFEKPEFSNLDTEDTIPDGVNESVIKPKTVTTKFLRISKLSLACEWQGCKLLTNNYESYQKHVIAHFSDVIQIIDKEETVMYSCLWDVCGHKTKDYNEMFRHLNYHAYHGKLLAIGLNGRATLKLERCKKNSTKRNQLPNLPNEHICMWTDCNRKFNSIQILFDHAKLHVNYSEKFLCSWAGCGAWFTTKALLGAHVRSHTGERLIACYHCGQHFANNRKLRDHLRRQNVDPESPFKCTMCGIPCATEYLLNEHARQHVSAHVCALCDMTATSPAALAQHVRYRHLPRAPHHACTRCAYRAVTKNDLQKHLMIHDKKRNKKKSDRESDRDSDLSDNSIITTKKKKKKIPRKYACHMCPEDKMKVFARGNTLTSHLVKVHGVQWPYGHSRFRYQKSEDGVYRLTTTRYEVLEVSNKIFARDSGPKQSLNENLDFKLKQVAEPTFDTPRRFEIMLLGGEGEGGHGGVEESRDSGLVEITMCDVDDKGNVIKSELIESQVI

Description

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter (By similarity).
Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.

Subunit

Binds MBD2 and a histone deacetylase complex. Interacts with NPAT (By similarity).
Binds MBD2 and a histone deacetylase complex. Interacts with NPAT.

Keywords

Activator   Complete proteome   DNA-binding   Metal-binding   Nucleus   Reference proteome   Repeat   Repressor   Transcription   Transcription regulation   Ubl conjugation   Zinc   Zinc-finger   Alternative splicing   Polymorphism  

Feature

chain  Histone H4 transcription factor
splice variant  In isoform 2.
sequence variant  In dbSNP:rs17850972.

Uniprot

H9IWH0   A0A3S2LVC0   A0A2H1W295   A0A2A4JTY3   A0A212ERI1   A0A194QC86   + More
A0A0N0PEM2   S4PXN5   A0A0L7L7V9   A0A067QM51   F4W8R0   A0A195B0K5   A0A158NKF6   A0A195FBI9   A0A336M5I8   A0A151WT41   A0A2P8XTN2   A0A195EHD6   E2AR50   A0A026X2X6   K7IX52   A0A1B6DVB0   A0A0J7KPS0   A0A2A3ERQ5   A0A151IJW6   A0A232EQA6   A0A088ATT2   A0A0P4W0P0   A0A0P4VW84   A0A310SRW5   A0A401RYB6   A0A401NWQ2   A0A0L7RHA3   A0A0B6ZZF7   A0A226F5Q3   A0A2D0QEP7   A0A1B6MJB9   F7D9I7   A0A154PJ93   V9KRB2   Q2TBP2   A0A3B4C617   A0A1U7U8P4   A0A0M9A3Y8   A0A340X466   G3TWB7   A0A212DHQ3   A0A452FPB2   A0A023F0C8   G1T008   L8IIN5   F1MZ17   W5K7M7   H0WW19   A0A2R9CEG2   A0A2I4BJE6   G3SDE8   H2Q4X8   A0A024R3F5   Q9BQA5   A0A401T0H3   A0A2Y9M4Q7   A0A384BAK3   G3TJ02   A0A2J8X0P5   A0A1B6ILH3   M3Y1P7   A0A3Q0EB46   A0A2K6LIX6   A0A2K6QL82   A0A3Q0EGD9   A0A3Q2WLN1   A0A3P8PBC4   A0A3P9B7J5   A0A2K6A7G8   A0A096N8F5   A0A3B4G7Y2   H9Z7G6   A0A2K6DHD1   A0A0D9S3T3   A0A2K5P2P8   G7PPA3   F6TXD2   A0A2K5K4R7   E2B2Y9   I3JYW7   A0A287D3P4   A0A3Q1CUK4   A0A2Y9FKW0   L5KNA0   A0A091NY42   A0A069DU57   G1R739   A0A091J703   A0A1A6FY21   A0A0V0GCI6   A0A091H545   A0A091TNK2   A0A1U8BYM0  

Pubmed

19121390    22118469    26354079    23622113    26227816    24845553    + More
21719571    21347285    29403074    20798317    24508170    30249741    20075255    28648823    27129103    30297745    17495919    24402279    29294181    25474469    21993624    22751099    19393038    25329095    22722832    22398555    16136131    11181995    14702039    16554811    15489334    17974005    11553631    14585971    14752047    15988025    17176114    17974976    17163457    18850719    25362486    25186727    25319552    22002653    17431167    23258410    26334808    28071753   

EMBL

BABH01006661    RSAL01000186    RVE44798.1    ODYU01005874    SOQ47205.1    NWSH01000587    + More
PCG75487.1    AGBW02013021    OWR44085.1    KQ459193    KPJ03077.1    KQ459762    KPJ20126.1    GAIX01004728    JAA87832.1    JTDY01002453    KOB71381.1    KK853156    KDR10491.1    GL887908    EGI69551.1    KQ976692    KYM77827.1    ADTU01018818    KQ981693    KYN37741.1    UFQT01000590    SSX25534.1    KQ982762    KYQ51059.1    PYGN01001366    PSN35356.1    KQ978881    KYN27685.1    GL441871    EFN64089.1    KK107021    QOIP01000011    EZA62381.1    RLU16669.1    AAZX01008221    GEDC01007681    JAS29617.1    LBMM01004498    KMQ92353.1    KZ288191    PBC34418.1    KQ977294    KYN03941.1    NNAY01002826    OXU20486.1    GDRN01081749    JAI61945.1    GDKW01002721    JAI53874.1    KQ761155    OAD58146.1    BEZZ01000023    GCC23153.1    BFAA01004186    GCB65299.1    KQ414592    KOC70199.1    HACG01027088    CEK73953.1    LNIX01000001    OXA64660.1    GEBQ01003976    JAT36001.1    KQ434905    KZC11270.1    JW868162    AFP00680.1    BC109865    KQ435756    KOX75976.1    MKHE01000001    OWK17702.1    LWLT01000015    GBBI01004388    JAC14324.1    JH881271    ELR55374.1    AAQR03130821    AJFE02068598    AJFE02068599    AJFE02068600    AJFE02068601    CABD030081835    AACZ04006739    GABC01008261    GABF01004498    GABD01003767    GABE01011211    NBAG03000239    JAA03077.1    JAA17647.1    JAA29333.1    JAA33528.1    PNI65893.1    PNI65894.1    CH471065    EAW67462.1    AK056362    AK301452    AP002956    AP003391    BC001073    BC001945    BC012856    BC017234    AL080201    BEZZ01000791    GCC36149.1    ABGA01112510    ABGA01112511    NDHI03003374    PNJ75568.1    PNJ75569.1    GECU01019944    JAS87762.1    AEYP01026874    AHZZ02007730    AHZZ02007731    JU475078    AFH31882.1    AQIB01090954    AQIA01022454    AQIA01022455    CM001289    EHH56823.1    JSUE03013533    JU321085    JV043452    CM001266    AFE64841.1    AFI33523.1    EHH23505.1    GL445250    EFN89958.1    AERX01036440    AGTP01052989    KB030665    ELK12063.1    KK645622    KFP98733.1    GBGD01001434    JAC87455.1    ADFV01057075    ADFV01057076    ADFV01057077    ADFV01057078    KK501494    KFP15618.1    LZPO01116378    OBS58494.1    GECL01000430    JAP05694.1    KL521887    KFO89927.1    KK458280    KFQ77648.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000007151    UP000053268    UP000053240    + More
UP000037510    UP000027135    UP000007755    UP000078540    UP000005205    UP000078541    UP000075809    UP000245037    UP000078492    UP000000311    UP000053097    UP000279307    UP000002358    UP000036403    UP000242457    UP000078542    UP000215335    UP000005203    UP000287033    UP000288216    UP000053825    UP000198287    UP000221080    UP000002280    UP000076502    UP000009136    UP000261440    UP000189704    UP000053105    UP000265300    UP000007646    UP000291000    UP000001811    UP000018467    UP000005225    UP000240080    UP000192220    UP000001519    UP000002277    UP000005640    UP000248483    UP000261681    UP000001595    UP000000715    UP000233180    UP000233200    UP000264840    UP000265100    UP000265160    UP000233140    UP000028761    UP000261460    UP000233120    UP000029965    UP000233060    UP000009130    UP000233100    UP000006718    UP000233080    UP000008237    UP000005207    UP000005215    UP000257160    UP000248484    UP000010552    UP000001073    UP000053119    UP000092124    UP000189706   

PRIDE

H9IWH0    Q2TBP2    Q9BQA5   

Pfam

PF00096   zf-C2H2        + More
PF12171   zf-C2H2_jaz

Interpro

IPR013087   Znf_C2H2_type        + More
IPR036236   Znf_C2H2_sf       
IPR011098   G5_dom       
IPR022755   Znf_C2H2_jaz       

SUPFAM

SSF57667   SSF57667       

ProteinModelPortal

H9IWH0   A0A3S2LVC0   A0A2H1W295   A0A2A4JTY3   A0A212ERI1   A0A194QC86   + More
A0A0N0PEM2   S4PXN5   A0A0L7L7V9   A0A067QM51   F4W8R0   A0A195B0K5   A0A158NKF6   A0A195FBI9   A0A336M5I8   A0A151WT41   A0A2P8XTN2   A0A195EHD6   E2AR50   A0A026X2X6   K7IX52   A0A1B6DVB0   A0A0J7KPS0   A0A2A3ERQ5   A0A151IJW6   A0A232EQA6   A0A088ATT2   A0A0P4W0P0   A0A0P4VW84   A0A310SRW5   A0A401RYB6   A0A401NWQ2   A0A0L7RHA3   A0A0B6ZZF7   A0A226F5Q3   A0A2D0QEP7   A0A1B6MJB9   F7D9I7   A0A154PJ93   V9KRB2   Q2TBP2   A0A3B4C617   A0A1U7U8P4   A0A0M9A3Y8   A0A340X466   G3TWB7   A0A212DHQ3   A0A452FPB2   A0A023F0C8   G1T008   L8IIN5   F1MZ17   W5K7M7   H0WW19   A0A2R9CEG2   A0A2I4BJE6   G3SDE8   H2Q4X8   A0A024R3F5   Q9BQA5   A0A401T0H3   A0A2Y9M4Q7   A0A384BAK3   G3TJ02   A0A2J8X0P5   A0A1B6ILH3   M3Y1P7   A0A3Q0EB46   A0A2K6LIX6   A0A2K6QL82   A0A3Q0EGD9   A0A3Q2WLN1   A0A3P8PBC4   A0A3P9B7J5   A0A2K6A7G8   A0A096N8F5   A0A3B4G7Y2   H9Z7G6   A0A2K6DHD1   A0A0D9S3T3   A0A2K5P2P8   G7PPA3   F6TXD2   A0A2K5K4R7   E2B2Y9   I3JYW7   A0A287D3P4   A0A3Q1CUK4   A0A2Y9FKW0   L5KNA0   A0A091NY42   A0A069DU57   G1R739   A0A091J703   A0A1A6FY21   A0A0V0GCI6   A0A091H545   A0A091TNK2   A0A1U8BYM0  

PDB

2I13     E-value=3.82641e-09,     Score=148

KEGG

101735932    no KO assigned | (RefSeq) histone H4 transcription factor-like

GO

GO:0003676   GO:0042393   GO:0045445   GO:0015030   GO:0045893   GO:0001701   GO:0000978   GO:0003713   GO:0019899   GO:0001227   GO:0000077   GO:0006281   GO:0006351   GO:0000083   GO:0045184   GO:0003682   GO:0046872   GO:0005634   GO:0003677   GO:0044212   GO:0006355   GO:0010628   GO:0045892   GO:0005654   GO:0010629   GO:0000981   GO:0000082   GO:0003700   GO:0010468   GO:0009165   GO:0009116   GO:0009156   GO:0044249   GO:0004879   GO:0003707   GO:0016286  

Subcellular location

Nucleus   Associated with discrete nuclear foci.   With evidence from 1 publications.

Length:

551

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0698099999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00690

outside

1  -  551

 

 

Pi

24.174968

Theta

24.732326

Tajima's D

-0.259472

CLR

0.876896

CSRT

0.307884605769711

Interpretation

Uncertain