Gene
KWMTBOMO10815
Annotation
Zinc_finger_protein_16_[Papilio_xuthus]
Full name
Zinc finger protein 431
Alternative Name
Zinc finger protein 932
Transcription factor
Location in the cell
Nuclear Reliability : 4.742
Sequence
CDS
ATGCTATGTGAATCATGTTATAATGAAATCATGAATTTTAATGTTTTCAAGACATGCGTTGACAGAGTAGAAGAAAACTTTCAAAAATATCTTGAGACATATCAAATTACTTTGGATAAGAAAACTGAACTCAAATATGATCAAGATGAAACAAATCAAAATTTATATGATGAAAAGTTTTTTGAAGAACATCGTAAGATACAGTCATCTTCGAATGATTCTGTAGACAATAATCAGAACGTGAGTTATAGCTGTGAAGAATGCGAAAAGATTTTCAAAACTTTAAATTCTTTGTGTGCACATAAAAAGAAGCATGTAAAGAAAGGTAGAATACTTGTGTGTTCTTTTTGCAAAAAGGTATTTAAAAAGTTAAGTCACTTGAAGAGGCATGAGCTCTCCCATAGGCCGAAATCTTACAAATGCACAGATTGCTCTCATACATTTGCTGATGAGAATAGATTTAAAGAACATGTTAACTTTCATATGGGAATTAAACCTCATGTGTGTTTGTTATGTAAGAAATCCTTTCGGAACATGACAGGGCTAAAGAGCCATCTAAAGATTCATTTTGAAGACCACACTTACTTGTGTCCGATTTGTGGAAAAAGATTCAGCTCGTCCGGGAATTTGAATCAGCATGTGAACAGACACACTAACAATCGGTCATATCTGTGTGAAAATTGTCCTAAGAAATTTGTAAGTAAAAGCGACCTTAAAGTGCATATGAAAACACACACGGGCGAGTCTCAGCGTAGGTATGAGTGTCGGGAATGCAATGCTAAATTCACTAGCTGGAGTCGTCTCAGAACGCATAAATATCAACATCTAGGAATAAAGCCTTACAAATGTAATGCCTGCACGAAAAGTTTCCCAAATAACTATAGCCTCGTAAGGCATCACCTTATTCATTCAGGCGAGAGGCCGTACCAGTGTGACCTGTGTGAGCGTGCATTCGCCCAGAAGGAGGGCTTGAATAGGCACAAACGTCTACACACCAGCGATAAATATCACAAGTGTGACCAATGCTCCCAGACATTCCGTCTAAAATCCGACCTACAGCAACACTTGTCGGATCATTACAACGCGCAGACGCAGCTTATAGTTAGGGACGATAATGTCCAAAATAATGGCGTTTCCACCGATACTATTATACCAGAAGCAACGGACAGAGGCTTTGTTATTGTACCAATTAACTCGAATGTGAATGAATAA
Protein
MLCESCYNEIMNFNVFKTCVDRVEENFQKYLETYQITLDKKTELKYDQDETNQNLYDEKFFEEHRKIQSSSNDSVDNNQNVSYSCEECEKIFKTLNSLCAHKKKHVKKGRILVCSFCKKVFKKLSHLKRHELSHRPKSYKCTDCSHTFADENRFKEHVNFHMGIKPHVCLLCKKSFRNMTGLKSHLKIHFEDHTYLCPICGKRFSSSGNLNQHVNRHTNNRSYLCENCPKKFVSKSDLKVHMKTHTGESQRRYECRECNAKFTSWSRLRTHKYQHLGIKPYKCNACTKSFPNNYSLVRHHLIHSGERPYQCDLCERAFAQKEGLNRHKRLHTSDKYHKCDQCSQTFRLKSDLQQHLSDHYNAQTQLIVRDDNVQNNGVSTDTIIPEATDRGFVIVPINSNVNE
Summary
Description
Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1.
Subunit
Interacts (via KRAB domain) with HDAC2; the interaction is direct. Interacts (via KRAB domain) with HDAC1.
Keywords
Complete proteome
Differentiation
Metal-binding
Nucleus
Reference proteome
Repeat
Repressor
Transcription
Transcription regulation
Zinc
Zinc-finger
Feature
chain Zinc finger protein 431
Uniprot
Pubmed
EMBL
Proteomes
Interpro
ProteinModelPortal
PDB
5V3M
E-value=1.19101e-38,
Score=401
Ontologies
GO
Topology
Subcellular location
Nucleus
Length:
403
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00789
outside
1 - 403
Population Genetic Test Statistics
Pi
194.468758
Theta
158.253897
Tajima's D
0.714478
CLR
0.080267
CSRT
0.582170891455427
Interpretation
Uncertain
