Gene

KWMTBOMO09116

Pre Gene Modal

BGIBMGA007534

Annotation

E2F_family_member_8_[Danaus_plexippus]

Location

Bomo_Chr15(+):11539631-11541433      View in EpiBrowser

Full name

Transcription factor E2F7      

Transcription factor

E2F

Location in the cell

Mitochondrial   Reliability : 2.111 Nuclear   Reliability : 1.931

CDS

ATGTATGAAGATGATAACATCACTTGTACCCCAAAGCGTTTTGTGCTCACTGAAGTTACGAATTCATCGAGTTATGTATCGCCGACAGCAAATCTCAAATTACTAACAAATGTCGCGTTACAATATCCTACACCGCCGCCCAGTGCTGTGCAACGCAAAGAGAAATCACTTCAAATATTGTGTGACAGATTCTTACAGCTCTATCCACTCAAAGGTAATGGAACGGTGGAAATTCAGTTGGACAGTACTGCAGCCAGGTTAGGTGTCGAAAAGCGACGTATATACGACATCATTAACATCTTAGAAGCCATGCAATGTGCTGTTCATAAAAGGAAGAATACATATTTGTGGCATGGGGGATCAAGATTAAATTCCTTCTTGAAAATGTTAAAAAAACAAGGGGAGAGCATGAGACTGTCGGAGGCCCTCAGAGGTAAAGCACCAAAGCCTCCAGCGCCTAGACATAAAACATTAGGGGTCCTGGCTCAAAGATTCCTAATGTTGTTCTTAGTAGAACCTCTAAATACATTAATCAATTTAGAAATGGCTGTGAGGGTACTTATTGACACATCTAACAAGAACAAGACAAATCTCTCCCTGGAACAACAGGATCGGCAACATAAATCTAAAGTGAGGAGATTGTATGATATTGCCAATGTATTGATATCCATTGGTCTTATAGAAAAAGTATCCGGAAATTTAATATTAAAGAAACCTGTATTTAAATATGTGGGGCCTTGCAAAATGAAAAAATGTGAAAAAACAATGTTAACAACCCCATCCCCTATTACCCCTGTAACTGTATTGGAAAGCCAGTCTAAGACACCGACATTGCAAGTATTTGCAGGAAAATCTAAACGGAAATTAGAGTTCACTACTCCAAGTTCGACCAAAGAAATGAAACTTGGTATCACAACCCCACCTCACACTCCGTCACACAAATGGGATGAAATCCTGCTCGTAGCTGACATGGAACTGACTAGAATTAACAATGGAGCTGTTTTGTGA

Protein

MYEDDNITCTPKRFVLTEVTNSSSYVSPTANLKLLTNVALQYPTPPPSAVQRKEKSLQILCDRFLQLYPLKGNGTVEIQLDSTAARLGVEKRRIYDIINILEAMQCAVHKRKNTYLWHGGSRLNSFLKMLKKQGESMRLSEALRGKAPKPPAPRHKTLGVLAQRFLMLFLVEPLNTLINLEMAVRVLIDTSNKNKTNLSLEQQDRQHKSKVRRLYDIANVLISIGLIEKVSGNLILKKPVFKYVGPCKMKKCEKTMLTTPSPITPVTVLESQSKTPTLQVFAGKSKRKLEFTTPSSTKEMKLGITTPPHTPSHKWDEILLVADMELTRINNGAVL

Description

Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.

Subunit

Interacts with HIF1A (By similarity). Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA-binding.

Similarity

Belongs to the E2F/DP family.

Keywords

Activator   Alternative splicing   Cell cycle   Complete proteome   DNA damage   DNA-binding   Nucleus   Phosphoprotein   Reference proteome   Repressor   Transcription   Transcription regulation  

Feature

chain  Transcription factor E2F7
splice variant  In isoform 2.

Uniprot

H9JDD7   A0A2H1VMW2   A0A2A4JKR3   A0A212FCN2   A0A0L7LA70   A0A437BGG8   + More
A0A194R7U2   A0A194PL59   K7J4J1   A0A232ENG1   A0A2P8YM49   A0A1B6KZI0   A0A1B6FKL6   F6XM19   A0A1W5BDL8   A0A1W5BHR1   A0A1B6DN63   A0A087XBM3   M3ZVM7   A0A3B4BAK2   A0A3Q3N551   A0A3B3XJ21   A0A3P9PFU2   A0A3Q2VIM8   A0A3P9BNN3   A0A3P8QA10   A0A3Q3QPF2   A0A2I4AIZ9   A0A315USB9   A0A3Q3E5C7   A0A3Q1GCK6   A0A401NS85   B7QG98   A0A329SYE1   A0A3Q1CGF1   Q6NRA1   D8SRS2   A0A1L8GIF4   Q32NV0   A0A3B4X493   A0A3B4UWY3   A0A329SYR9   H2RVT7   A0A1V9ZA47   T2M8C1   Q6S7F2-2   Q6S7F2   A0A093BRA0  

Pubmed

19121390    22118469    26227816    26354079    20075255    28648823    + More
29403074    12481130    15114417    23542700    25463417    25186727    29703783    30297745    21551031    27762356    21551351    25527045    24065732    12893818    16141072    15489334    18194653    22903062    22516201    22802529    23064264    23064266    22180533   

EMBL

BABH01030090    ODYU01003413    SOQ42148.1    NWSH01001151    PCG72376.1    AGBW02009176    + More
OWR51468.1    JTDY01001989    KOB72388.1    RSAL01000065    RVE49438.1    KQ460615    KPJ13717.1    KQ459602    KPI93469.1    AAZX01009232    NNAY01003159    OXU19890.1    PYGN01000498    PSN45327.1    GEBQ01023114    JAT16863.1    GECZ01019044    JAS50725.1    EAAA01001229    GEDC01010898    GEDC01010190    JAS26400.1    JAS27108.1    AYCK01014070    NHOQ01002778    PWA14695.1    BFAA01005383    GCB63758.1    ABJB010103991    ABJB010692593    ABJB010719844    ABJB011002344    ABJB011072064    DS930038    EEC17870.1    MJFZ01000025    RAW41734.1    BC070864    AAH70864.1    GL377636    EFJ12836.1    CM004472    OCT83600.1    BC108466    AAI08467.1    RAW41735.1    JNBS01002161    OQR94874.1    HAAD01001990    CDG68222.1    AY463359    AK031078    AK045040    AK041481    AK143686    CH466539    BC145429    BC150772    KL229496    KFV04718.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000037510    UP000283053    UP000053240    + More
UP000053268    UP000002358    UP000215335    UP000245037    UP000008144    UP000028760    UP000002852    UP000261520    UP000261640    UP000261480    UP000242638    UP000264840    UP000265160    UP000265100    UP000261600    UP000192220    UP000261660    UP000257200    UP000288216    UP000001555    UP000251314    UP000257160    UP000001514    UP000186698    UP000261360    UP000261420    UP000005226    UP000243217    UP000000589   

PRIDE

H9JDD7    Q6S7F2   

Pfam

PF02319   E2F_TDP

Interpro

IPR003316   E2F_WHTH_DNA-bd_dom        + More
IPR036388   WH-like_DNA-bd_sf       
IPR036390   WH_DNA-bd_sf       
IPR015633   E2F       

SUPFAM

SSF46785   SSF46785       

Gene 3D

1.10.10.10    

ProteinModelPortal

H9JDD7   A0A2H1VMW2   A0A2A4JKR3   A0A212FCN2   A0A0L7LA70   A0A437BGG8   + More
A0A194R7U2   A0A194PL59   K7J4J1   A0A232ENG1   A0A2P8YM49   A0A1B6KZI0   A0A1B6FKL6   F6XM19   A0A1W5BDL8   A0A1W5BHR1   A0A1B6DN63   A0A087XBM3   M3ZVM7   A0A3B4BAK2   A0A3Q3N551   A0A3B3XJ21   A0A3P9PFU2   A0A3Q2VIM8   A0A3P9BNN3   A0A3P8QA10   A0A3Q3QPF2   A0A2I4AIZ9   A0A315USB9   A0A3Q3E5C7   A0A3Q1GCK6   A0A401NS85   B7QG98   A0A329SYE1   A0A3Q1CGF1   Q6NRA1   D8SRS2   A0A1L8GIF4   Q32NV0   A0A3B4X493   A0A3B4UWY3   A0A329SYR9   H2RVT7   A0A1V9ZA47   T2M8C1   Q6S7F2-2   Q6S7F2   A0A093BRA0  

PDB

4YO2     E-value=2.84855e-23,     Score=268

KEGG

101740537    K09391 transcription factor E2F7/8 | (RefSeq) transcription factor E2F7-like

GO

GO:0005634   GO:0003677   GO:0005667   GO:0003700   GO:0043565   GO:0051726   GO:0000981   GO:0008134   GO:0000122   GO:0090575   GO:0045944   GO:0001946   GO:0008045   GO:0045892   GO:0002040   GO:0000978   GO:0032466   GO:0060707   GO:0006355   GO:0000987   GO:0060718   GO:2000134   GO:0030330   GO:0003714   GO:0001890   GO:0008285   GO:0042802   GO:0071930   GO:0016607   GO:0032877   GO:0070365   GO:0001227   GO:0000977   GO:0019205   GO:0005739   GO:0016776   GO:0006811   GO:0016020   GO:0016876   GO:0043039  

PANTHER

PTHR12081  

Subcellular location

Nucleus  

Length:

335

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.988089999999999

Exp number, first 60 AAs:

0.0088

Total prob of N-in:

0.08447

outside

1  -  335

 

 

Pi

29.672524

Theta

56.795949

Tajima's D

-2.13712

CLR

4979.149245

CSRT

0.00864956752162392

Interpretation

Uncertain