Gene

KWMTBOMO06125  Validated by peptides from experiments

Annotation

signal_transducer_and_activator_of_transcription_long_isoform_[Bombyx_mori]

Location

Bomo_Chr11(+):753485-782323      View in EpiBrowser

Full name

Signal transducer and activator of transcription      

Transcription factor

STAT

Location in the cell

Nuclear   Reliability : 2.757

CDS

ATGACGCTGTGGACGCGAGCACAGCAGCTGCCCCCTGAGTGCCTTCAAAAGGTACGAATGATATACGTGGATCATTTCCCGATTGAAGTGAGGCATTGTTTGGCGTCTTGGATCGAGAGCAGAATATGGACCGCGGAGCCGGAGGACCAGCAGCGTTCGTTCGTTAACGAACTCGTCCAGGAGATCCAGACGAACGCCGATCTGATGCTGTCCCCGGACATGTTCGTTACGAAGATGAAGCTTCTCGAAGCGGCGAAGAACTTCCACATGCAGTACAGTCACGCCCCCCAGGAGCTGTACGCTTACATGAGGCGTTGTCTCGCCTTAGAGATGGAGGTCATACAGAACGCGATGGGCACTCCGTACGTGGCCCAGCCTCACACCGAGAGGAAGTACAGCGAGCTGATCACGGGCCTGCAGACTGTAAGGCAAAAGGTGAACATAGCCGGCGAGGAAATCCGCAGCCTCCAGGCCAATATTGAATCCCTGTCTCTGCAGTACCACGAGTGCTTGAAGAACAAAGGTCACATGAACTACCTCCAGCAGCAGACGGTGACCACCGAGCGCCGCGACCTGGTGGCCTGTCTGCGCGGACAGATCGAGGACACGGAGAGGAAACTCAACGCGCTGGTGGCGCAGATCACTCAATCTCAAATGGAGCTGGTGGACCACATGAAGGAGAACATCACGAACCTGAGGCAGCTGCAGAGCCAGGTGTTGGACGATGAGCTCATCAAATGGAAAAGGGAGCAACAGCTGAGCGGCAACGGGGTCCCGATGCAGTCCAACCTCAACACGATCCAGGAGTGGTGCGAGCTGCTCGCGGACCTCATCTGGACCACGCGCCAGCAGGTCAACAACGTGGCGCGCATCAACAGCAAGACCATCGTGGAGCTCCGCCAGCCGCACCTCGCCGAGATGCTGGACGACATGAGCAAGCAGGTGACGGGGCTGCTGTCCACGCTGGTGACGTCGACGTTCGTCATAGAGAAACAACCCCCTCAAGTAATGAAGACCAACACGCGATTCACGGCAACTGTTCGTCTGTTGGTTGGCGGACAGCTCAATGTATACATGACCCCGCCGCGCGTCAGCGTTGTGATAATATCGGAGCAGCAGGCTCAGCTTTTACTGAAGAGCGACACGCAGGCCGGCAAGGGCAAGCAGCCCGTGGAGTGCGGGGACATCCTCAACAACACGGGCACCATGGAGTACCAGCCCACCAGCCGACAGCTCAGCGTCAGCTTCAGGAACATGCAGCTGCGCAAGATCAAACGCGCCGAGAAGAAAGGCACCGAGAGCGTTATGGACGAGAAGCTGACGCTGCTGTTCCAGTCGCAGTTCAACGTGGGCGGCGGGGAGCTCGTCTTCCAGGTTTGGACCCTGTCGCTTCCGGTTGTGGTCATAGTCCACGGCAACCAGGAGCCCCACGGGTGGGCCACCGTCACGTGGGACAACGCCTTCAGTCCCCCGGGCAGGGTGCCCTTCGCTGTCCCCGACAAGGTGACCTGGGGCCAGCTCGCGGAGACCCTCAGCCTCAAGTTCAGCTCGGCCACGGGAGGGTCTCTCTCGGAGGACAACCTGAGGTTCTTGGCTGAGAAGATATTCAGAACTAGTCTCCCGCTGAACACCATGGAGCTAAACGCGATGGCGGTCAGCTGGACCCAGTTCTGCAAGGACGCGCTGCCGGAGAGGAACTTCACGTTCTGGGAGTGGTTCTACATGGTCGTCAAGGTCACCAGGGACTACCTGCGGACCCTGTGGTGCGACCGCTTAATAATGGGCTTCATACAGAAGAAGCAAGCTGAGGATATGCTGTCCAAGTGTCCGCCCGGGACCTTCCTGCTGCGGTTCTCGGACTCCGAGCTGGGAGGGATCACCATCGCTTGGACCGGAGACGGCAACGAAGTATTCAGCCTGCAGCCCTTCACGTCGCGCGACCTCATGCTGCGCTCGCTGGCGGACCGCGTGTTCGACCTCACGCAGCTACAGTTCTTGTACCCGAACGTTCCCAAAGACGACGTCTTCTCCAAATATTACACCAAACCTGAAAACGAAATGTTAAAGAACGGCTACGTGAAGCCCGTGTTGGTGACCACGCTGCCCCCTTACATGTCGTCGTCGCCCGCCTACGCGCACTCCCCGGACTCGCACCGGAACACGCCCAGCGTCAACAGCAGTTATTTCGGGGAAGCTACGCCCATTCAGGTGGACAGCCTGATGAATAGCGACTTGTTCGAGCAGATCCGGGCCTACGAACCGGACAATCAATCGGACGATTTCGACATTTACAGTGACATGTGCTTGAAGTGA

Protein

MTLWTRAQQLPPECLQKVRMIYVDHFPIEVRHCLASWIESRIWTAEPEDQQRSFVNELVQEIQTNADLMLSPDMFVTKMKLLEAAKNFHMQYSHAPQELYAYMRRCLALEMEVIQNAMGTPYVAQPHTERKYSELITGLQTVRQKVNIAGEEIRSLQANIESLSLQYHECLKNKGHMNYLQQQTVTTERRDLVACLRGQIEDTERKLNALVAQITQSQMELVDHMKENITNLRQLQSQVLDDELIKWKREQQLSGNGVPMQSNLNTIQEWCELLADLIWTTRQQVNNVARINSKTIVELRQPHLAEMLDDMSKQVTGLLSTLVTSTFVIEKQPPQVMKTNTRFTATVRLLVGGQLNVYMTPPRVSVVIISEQQAQLLLKSDTQAGKGKQPVECGDILNNTGTMEYQPTSRQLSVSFRNMQLRKIKRAEKKGTESVMDEKLTLLFQSQFNVGGGELVFQVWTLSLPVVVIVHGNQEPHGWATVTWDNAFSPPGRVPFAVPDKVTWGQLAETLSLKFSSATGGSLSEDNLRFLAEKIFRTSLPLNTMELNAMAVSWTQFCKDALPERNFTFWEWFYMVVKVTRDYLRTLWCDRLIMGFIQKKQAEDMLSKCPPGTFLLRFSDSELGGITIAWTGDGNEVFSLQPFTSRDLMLRSLADRVFDLTQLQFLYPNVPKDDVFSKYYTKPENEMLKNGYVKPVLVTTLPPYMSSSPAYAHSPDSHRNTPSVNSSYFGEATPIQVDSLMNSDLFEQIRAYEPDNQSDDFDIYSDMCLK

Similarity

Belongs to the transcription factor STAT family.

Feature

chain  Signal transducer and activator of transcription

Uniprot

G0ZEM3   C5J498   G0ZEM4   Q8WSA4   A1E9A7   Q8WSA3   + More
A0A2A4K2K8   A0A2A4K3P5   H9IWV6   A0A0N0PAA1   A0A212EU78   K7IWW4   A0A310S4D7   A0A088AEX7   D6WML4   A0A0M9A970   A0A2A3EDZ7   A0A1Y1LQ65   V9ILC1   A0A232FCQ7   A0A0L7QKS8   A0A2J7Q4J7   A0A1Y1LQJ4   A0A2J7Q4I7   A0A2J7Q4I5   A0A2J7Q4J3   A0A1Y1LN85   A0A1Y1LU59   V5G239   A0A0C9RAN4   E0VNH9   A0A0P5K333   A0A0C9RKF4   E2BNI6   A0A0P5L3W8   A0A0P5LZS6   A0A0P5JLI3   A0A0P5CA65   A0A0P5D556   A0A0P4YV73   A0A0P5SVC6   A0A0P5Y0B0   A0A0P5EA39   A0A0P4YE10   A0A0T6B5L0   A0A0N8A6M6   A0A0P5Y097   A0A0P5TWD0   F4WR54   A0A0P5YSX0   A0A0P5AU31   A0A0P5UGM6   A0A0P5MIE7   A0A0N8AC21   A0A0N8CXD9   A0A0P5VKW9   A0A0P5W9M0   A0A0N8DA70   A0A0P5SPY4   A0A0P5D3T5   A0A195BAR7   A0A158NU76   E9G1W0   A0A0P6BJA0   A0A067RHS1   A0A0P5H4R4   A0A151J362   A0A195FJM4   A0A1B6HUP4   A0A1B6JI17   A0A1B6MMH7   V5H6X7   V5HN64   A0A1E1XNQ8   A0A023F1V6   A0A2R5L506   A0A1E1X7F7   A0A224XK46   A0A0K8T940   A0A0A9YDI8   A0A131XYS3   A0A0V0G7K5   A0A023F353   A0A069DXB3   A0A146LUI3   A0A0A9Z8M5   T1HR32   A0A023GP11   A0A131YY69   A0A293LT13   A0A293LEF1   E9NSU3   A0A3L8DZ65   E2AP84   T1JJU0   A0A224Z8N4   A0A131YV99   A0A0P5GX04  

Pubmed

26592694    18187191    19121390    26354079    22118469    20075255    + More
18362917    19820115    28004739    28648823    20566863    20798317    21719571    21347285    21292972    24845553    25765539    29209593    25474469    28503490    26823975    25401762    26334808    26830274    22859824    30249741    28797301   

EMBL

JF267349    AEL16992.1    FJ997598    ACR61178.1    AEL16991.1    AF329946    + More
AAL37476.1    EF114290    ABL63639.1    AF329947    AAL37477.1    NWSH01000217    PCG78289.1    PCG78290.1    BABH01020999    BABH01021000    BABH01021001    BABH01021002    BABH01021003    BABH01021004    BABH01021005    BABH01021006    BABH01021007    BABH01021008    KQ458725    KPJ05370.1    AGBW02012449    OWR45050.1    AAZX01006908    KQ777939    OAD52032.1    KQ971343    EFA04581.1    KQ435710    KOX79805.1    KZ288287    PBC29396.1    GEZM01051211    JAV75091.1    JR050447    AEY61281.1    NNAY01000459    OXU28238.1    KQ414940    KOC59180.1    NEVH01018378    PNF23499.1    GEZM01051213    JAV75088.1    PNF23500.1    PNF23501.1    PNF23502.1    GEZM01051212    JAV75089.1    GEZM01051214    JAV75086.1    GALX01004401    JAB64065.1    GBYB01013529    JAG83296.1    DS235339    EEB14935.1    GDIQ01191638    JAK60087.1    GBYB01013735    GBYB01013742    JAG83502.1    JAG83509.1    GL449414    EFN82765.1    GDIQ01200290    GDIQ01164500    GDIP01053636    GDIP01045453    GDIQ01084133    GDIQ01084132    JAK51435.1    JAM50079.1    GDIQ01166158    JAK85567.1    GDIQ01198093    GDIQ01186193    GDIQ01116322    JAK53632.1    GDIP01177330    JAJ46072.1    GDIP01162822    JAJ60580.1    GDIP01222667    JAJ00735.1    GDIP01135267    JAL68447.1    GDIP01064699    JAM39016.1    GDIP01149471    JAJ73931.1    GDIP01231562    JAI91839.1    LJIG01009748    KRT82459.1    GDIP01177329    JAJ46073.1    GDIP01064700    JAM39015.1    GDIP01125742    JAL77972.1    GL888284    EGI63281.1    GDIP01053635    JAM50080.1    GDIP01197971    JAJ25431.1    GDIP01113282    JAL90432.1    GDIQ01265164    GDIQ01178841    JAK72884.1    GDIP01162169    JAJ61233.1    GDIP01089535    JAM14180.1    GDIP01148127    GDIP01113334    JAL90380.1    GDIP01089534    GDIP01089533    JAM14182.1    GDIP01053687    GDIP01053634    JAM50028.1    GDIP01140329    JAL63385.1    GDIP01177331    JAJ46071.1    KQ976532    KYM81641.1    ADTU01026284    GL732529    EFX86742.1    GDIP01028297    JAM75418.1    KK852672    KDR18762.1    GDIQ01239079    JAK12646.1    KQ980298    KYN16844.1    KQ981512    KYN40860.1    GECU01029316    GECU01000094    JAS78390.1    JAT07613.1    GECU01008805    GECU01001389    JAS98901.1    JAT06318.1    GEBQ01002830    JAT37147.1    GANP01005648    JAB78820.1    GANP01009325    JAB75143.1    GFAA01002728    JAU00707.1    GBBI01003195    JAC15517.1    GGLE01000435    MBY04561.1    GFAC01004212    JAT94976.1    GFTR01007913    JAW08513.1    GBRD01003787    GDHC01008606    JAG62034.1    JAQ10023.1    GBHO01014448    GBHO01014441    GBHO01014437    GBHO01003399    GBRD01003788    JAG29156.1    JAG29163.1    JAG29167.1    JAG40205.1    JAG62033.1    GEFM01003413    JAP72383.1    GECL01002009    JAP04115.1    GBBI01003146    JAC15566.1    GBGD01000567    JAC88322.1    GDHC01007248    JAQ11381.1    GBHO01018025    GBHO01014450    GBHO01014432    GBHO01003338    JAG25579.1    JAG29154.1    JAG29172.1    JAG40266.1    ACPB03019617    ACPB03019618    GBBM01000563    JAC34855.1    GEDV01005431    JAP83126.1    GFWV01007133    MAA31863.1    GFWV01000345    MAA25075.1    HQ710832    ADU86241.1    QOIP01000002    RLU25734.1    GL441481    EFN64757.1    JH431714    GFPF01011764    MAA22910.1    GEDV01005433    JAP83124.1    GDIQ01241831    JAK09894.1   

Proteomes

UP000218220    UP000005204    UP000053268    UP000007151    UP000002358    UP000005203    + More
UP000007266    UP000053105    UP000242457    UP000215335    UP000053825    UP000235965    UP000009046    UP000008237    UP000007755    UP000078540    UP000005205    UP000000305    UP000027135    UP000078492    UP000078541    UP000015103    UP000279307    UP000000311   

PRIDE

G0ZEM3    C5J498    G0ZEM4    H9IWV6   

Pfam

PF02864   STAT_bind        + More
PF02865   STAT_int
PF00017   SH2
PF01017   STAT_alpha

Interpro

IPR015988   STAT_TF_coiled-coil        + More
IPR000980   SH2       
IPR013801   STAT_TF_DNA-bd       
IPR013800   STAT_TF_alpha       
IPR036860   SH2_dom_sf       
IPR036535   STAT_N_sf       
IPR001217   STAT       
IPR012345   STAT_TF_DNA-bd_N       
IPR008967   p53-like_TF_DNA-bd       
IPR013799   STAT_TF_prot_interaction       

SUPFAM

SSF48092   SSF48092        + More
SSF55550   SSF55550       
SSF49417   SSF49417       
SSF47655   SSF47655       

Gene 3D

1.10.532.10     2.60.40.630     3.30.505.10    

ProteinModelPortal

G0ZEM3   C5J498   G0ZEM4   Q8WSA4   A1E9A7   Q8WSA3   + More
A0A2A4K2K8   A0A2A4K3P5   H9IWV6   A0A0N0PAA1   A0A212EU78   K7IWW4   A0A310S4D7   A0A088AEX7   D6WML4   A0A0M9A970   A0A2A3EDZ7   A0A1Y1LQ65   V9ILC1   A0A232FCQ7   A0A0L7QKS8   A0A2J7Q4J7   A0A1Y1LQJ4   A0A2J7Q4I7   A0A2J7Q4I5   A0A2J7Q4J3   A0A1Y1LN85   A0A1Y1LU59   V5G239   A0A0C9RAN4   E0VNH9   A0A0P5K333   A0A0C9RKF4   E2BNI6   A0A0P5L3W8   A0A0P5LZS6   A0A0P5JLI3   A0A0P5CA65   A0A0P5D556   A0A0P4YV73   A0A0P5SVC6   A0A0P5Y0B0   A0A0P5EA39   A0A0P4YE10   A0A0T6B5L0   A0A0N8A6M6   A0A0P5Y097   A0A0P5TWD0   F4WR54   A0A0P5YSX0   A0A0P5AU31   A0A0P5UGM6   A0A0P5MIE7   A0A0N8AC21   A0A0N8CXD9   A0A0P5VKW9   A0A0P5W9M0   A0A0N8DA70   A0A0P5SPY4   A0A0P5D3T5   A0A195BAR7   A0A158NU76   E9G1W0   A0A0P6BJA0   A0A067RHS1   A0A0P5H4R4   A0A151J362   A0A195FJM4   A0A1B6HUP4   A0A1B6JI17   A0A1B6MMH7   V5H6X7   V5HN64   A0A1E1XNQ8   A0A023F1V6   A0A2R5L506   A0A1E1X7F7   A0A224XK46   A0A0K8T940   A0A0A9YDI8   A0A131XYS3   A0A0V0G7K5   A0A023F353   A0A069DXB3   A0A146LUI3   A0A0A9Z8M5   T1HR32   A0A023GP11   A0A131YY69   A0A293LT13   A0A293LEF1   E9NSU3   A0A3L8DZ65   E2AP84   T1JJU0   A0A224Z8N4   A0A131YV99   A0A0P5GX04  

PDB

1Y1U     E-value=8.97005e-133,     Score=1216

KEGG

100302627    K11224 signal transducer and activator of transcription 5B | (RefSeq) Stat, BmSTAT; signal transduce

PATHWAY

04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0005634   GO:0005737   GO:0003677   GO:0060397   GO:0003700   GO:0000978   GO:0001228   GO:0005829   GO:0042127   GO:0007259   GO:0045944   GO:0006952   GO:0006355   GO:0007165   GO:0030246   GO:0004559   GO:0006013   GO:0015923   GO:0006260  

PANTHER

PTHR11801  

Subcellular location

Cytoplasm  
Nucleus  

Length:

770

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01677

Exp number, first 60 AAs:

0.00011

Total prob of N-in:

0.00053

outside

1  -  770

 

 

Pi

210.111124

Theta

168.877183

Tajima's D

0.316699

CLR

0.952106

CSRT

0.457827108644568

Interpretation

Uncertain