Gene

KWMTBOMO03119

Pre Gene Modal

BGIBMGA005775

Annotation

PREDICTED:_DNA-binding_protein_Ewg_isoform_X4_[Bombyx_mori]

Location

Bomo_Chr5(+):18638393-18652537      View in EpiBrowser

Full name

DNA-binding protein Ewg      

Alternative Name

Protein erect wing

Transcription factor

Nrf1

Location in the cell

Cytoplasmic   Reliability : 1.287 Nuclear   Reliability : 1.634

CDS

ATGGTCCATGAACTGAGATCATCAAAGGAGGTGGGGGAGATAAAACCAGAGATGAACGCCGCCGTCAGCACAGAGTCCATGGACATGACTGAGGAGGATATGTCCCAGGTGGAGGGCTGCGGGTTGAGCGGCGGCTCGGAGGACGAGGACGAGTGCGCCTCGTCTCCGGCCGGCTCCAACTATGACGACGGAAACGACATCATCAAGAATGCCATGAGCGATGAAGTTACAAAGCAACTTGCAGCCGCCGGCATGGCGGCGGCCGCGGCTATCGCCTCGTCGAAGAAACGCAAGCGCCCACACTCCTTCGAGACCAACCCATCCGTCAGGAAGCGACACCAGAACAGATTATTAAGGAAACTTAGACAAACAATCGAAGAGTTCGCGACACGAGTAGGTCAGCAGGCCGTCGTGCTGGTGGCCACTCCCGGCAAGCCCAACACTTCCTATCGTGTGTTCGGCGCCAAGCCGCTCGAGGACGTCGTCAGGAACCTCCGCTGCATGATCATGGAGGAGCTGGAGAACGCTTTGGCGCAGCAGGCGCCGCCTCCTCCTGCTGATGATCCCTCGCTGTTCGAGTTGCCGCCGCTCATCATCGACGGCATCCCCACCCCCGTCGAGAAGATGACCCAGGCGCAGCTGAGAGCCTTCATCCCGCTTATGCTCAAGTACTCGATGGTCCGCGGCAAGCCGGGCTGGGGCCGCGAGTCGACCCGGCCGCCCTGGTGGCCCAAAGACTTGCCCTGGGCCAACGTGCGCATGGACGCTCGGTCTGAAGATGAGAAGCAGAAGATGTCATGGACCCACGCTCTGCGACAGATTGTGATCAACTGCTACAAGTACCACGGAAGAGAGGATCTCCTGCCAGCTTTTACTGAAGAAGACGAGAAAGGACCTCCGACACAACCCATGTCGCAGTACGCTCCCGCCGTGCTGCAGACCATCACCAACCCCGACGGGAGCGTCTCCCTCATCCAGGTGGACCCCAACAACCCCATCATCACGCTGCCCGACGGGACCACCGCGCACGTGATCCAGTCCGGCGAAGGCGGAGCCAGCGTGGTGGGGGCGCTGGACACGGACGGCGCCGTCGCCGTGGACCTCAACGCCGTCGCCGAGGCCACGCTCAACCACGAGGGGCAGATCATCCTCACGGCGGACGACGGGCACGGCTACCCCGTGTCCGTGTCCGGCGTCATCACCGTCCCCGTGTCCGCCTCCGTGTACCAGTCCATGGTCGCCTCCATGCACCACCACGAGGCCGTCTGCGTGGCGCCGCTCGTGCAGGTGGAGCAGGGCGGCGATACGCTGGAGGCGCTGTCGCTGGGCGGCGGCGTGGCGCAGGTCATGCTGCAGAACGGAGACACGCAGGTGCTGCAGGTCCTCAGTCTCAAGGACGCCACCGTCCTCACCAAACATATGCAACAGGTAAAGGCTGAGCGGGAGGCGGTGGTGGCAGACTCGTAG

Protein

MVHELRSSKEVGEIKPEMNAAVSTESMDMTEEDMSQVEGCGLSGGSEDEDECASSPAGSNYDDGNDIIKNAMSDEVTKQLAAAGMAAAAAIASSKKRKRPHSFETNPSVRKRHQNRLLRKLRQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQAPPPPADDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMVRGKPGWGRESTRPPWWPKDLPWANVRMDARSEDEKQKMSWTHALRQIVINCYKYHGREDLLPAFTEEDEKGPPTQPMSQYAPAVLQTITNPDGSVSLIQVDPNNPIITLPDGTTAHVIQSGEGGASVVGALDTDGAVAVDLNAVAEATLNHEGQIILTADDGHGYPVSVSGVITVPVSASVYQSMVASMHHHEAVCVAPLVQVEQGGDTLEALSLGGGVAQVMLQNGDTQVLQVLSLKDATVLTKHMQQVKAEREAVVADS

Description

May function as a positive regulator of transcription in developing and differentiated neurons, regulating common aspects of neuronal differentiation and maintenance. Requirement in the CNS may be higher than in the peripheral system. Vital for development of the indirect flight muscles.

Subunit

Homodimer. Binds DNA as a dimer (By similarity).

Similarity

Belongs to the NRF1/Ewg family.

Keywords

Activator   Alternative splicing   Complete proteome   DNA-binding   Nucleus   Phosphoprotein   Reference proteome   Transcription   Transcription regulation  

Feature

chain  DNA-binding protein Ewg
splice variant  In isoform F and isoform G.

Uniprot

A0A212EQV1   H9J8D3   A0A194PP08   A0A2W1BEM7   A0A2H1VMU3   A0A2A4JD72   + More
A0A0N1PI53   A0A166IWB0   A0A1Y1M5A1   V5GWF5   A0A1Y1M6M1   A0A2A4JCR3   A0A1W4WNY9   A0A1Y1M7F4   A0A139WNW2   U4U3K0   D7EJQ7   A0A1B6D9S5   A0A1B6E352   A0A1Y1M8H7   A0A1B6E089   K7IUL9   E0VWB8   A0A139WNV4   V9IAJ7   A0A0A9X3T6   A0A1B6IC26   A0A1B6JKC6   A0A1B6JPL2   R4WJV8   A0A2J7R3I5   A0A1B6HZV1   A0A232EW29   A0A1B6EVF6   A0A067RFY7   A0A1B6FHF5   N6U6Z3   A0A069DZ72   A0A1B6GZX1   A0A1B6I9D4   A0A1B6J6T5   A0A1W4WNY6   A0A0K8TKT8   A0A0V0GDL1   A0A034V729   Q24312-7   A0A1B0D9M0   A0A0K8WI39   A0A0Q9WYH8   V9ICD7   A0A1J1HFU2   A0A0C9QJ62   A0A1J1HKA6   A0A0T6BAW6   W8AVN3   A0A0A1XI95   A0A1I8Q973   A0A034V734   A0A1I8Q975   A0A2S2PYI5   A0A1D2N4E5   A0A1I8Q964   A0A146KN85   Q24312-8   A0A0C9RDZ1   A0A1S3D2H5   A0A0C9S1V1   A0A1I8MQV0   A0A1I8MQU8   M9NE19   J9K452   T1I8E3   A0A3B0KXR0   A0A224XKM1   A0A3B0KQG6   A0A2S2P5Z1   E9HR68   A0A0K2UDT9   A0A226D9M5   A0A087UHH6   T1JA80   A0A0P4WGH3   A0A0P4WK54   A0A386K0P5   T1KJJ3   A0A2S2P7E0   E9IK57   A0A224Z540   A0A131YNP2   L7MBP2   A0A147BN58   A0A293M3L1   A0A1E1XDV8  

Pubmed

22118469    19121390    26354079    28756777    28004739    18362917    + More
19820115    23537049    20075255    20566863    25401762    23691247    28648823    24845553    26334808    26369729    25348373    8388540    10330140    10731132    12537572    10731137    12537569    17994087    24495485    25830018    27289101    26823975    25315136    12537568    12537573    12537574    16110336    17569856    17569867    21292972    21282665    28797301    26830274    25576852    29652888    28503490   

EMBL

AGBW02013246    OWR43831.1    BABH01027332    KQ459597    KPI95166.1    KZ150156    + More
PZC72771.1    ODYU01003405    SOQ42128.1    NWSH01002037    PCG69343.1    KQ460970    KPJ10190.1    KU364382    ANA11556.1    GEZM01041668    GEZM01041665    JAV80238.1    GALX01002439    JAB66027.1    GEZM01041666    GEZM01041664    JAV80240.1    PCG69344.1    GEZM01041671    GEZM01041669    JAV80235.1    KQ971307    KYB29566.1    KB631602    ERL84560.1    EFA12821.2    GEDC01014902    GEDC01012114    JAS22396.1    JAS25184.1    GEDC01004971    JAS32327.1    GEZM01041670    GEZM01041667    JAV80236.1    GEDC01005968    JAS31330.1    AAZX01002642    AAZX01008756    DS235818    EEB17674.1    KYB29567.1    JR038062    AEY58100.1    GBHO01044514    GBHO01030151    JAF99089.1    JAG13453.1    GECU01023220    GECU01008988    JAS84486.1    JAS98718.1    GECU01008042    GECU01003005    JAS99664.1    JAT04702.1    GECU01007781    GECU01006557    JAS99925.1    JAT01150.1    AK417895    BAN21110.1    NEVH01007819    PNF35380.1    GECU01027516    GECU01006497    JAS80190.1    JAT01210.1    NNAY01001918    OXU22569.1    GECZ01027814    JAS41955.1    KK852486    KDR22791.1    GECZ01020205    JAS49564.1    APGK01047307    APGK01047308    KB741077    ENN74357.1    GBGD01001145    JAC87744.1    GECZ01001796    JAS67973.1    GECU01024165    JAS83541.1    GECU01012821    JAS94885.1    GDAI01002611    JAI14992.1    GECL01000701    JAP05423.1    GAKP01021025    JAC37927.1    L11345    AF135590    AE014298    AL050231    AY089609    AAL90347.1    AJVK01028323    GDHF01001577    JAI50737.1    CH933810    KRF94083.1    JR038063    AEY58101.1    CVRI01000002    CRK86893.1    GBYB01014763    JAG84530.1    CRK86894.1    LJIG01002483    KRT84457.1    GAMC01017777    JAB88778.1    GBXI01003198    JAD11094.1    GAKP01021021    GAKP01021020    JAC37932.1    GGMS01001385    MBY70588.1    LJIJ01000233    ODN00101.1    GDHC01020638    JAP97990.1    GBYB01014764    JAG84531.1    GBYB01014766    JAG84533.1    AFH07159.1    ABLF02021134    ACPB03022678    OUUW01000016    SPP88868.1    GFTR01006058    JAW10368.1    SPP88869.1    GGMR01012254    MBY24873.1    GL732732    EFX65763.1    HACA01018766    CDW36127.1    LNIX01000028    OXA41853.1    KK119807    KFM76815.1    JH431986    GDRN01049244    JAI66588.1    GDRN01049245    GDRN01049243    JAI66587.1    MG519332    AYD78165.1    CAEY01000163    GGMR01012760    MBY25379.1    GL763924    EFZ19038.1    GFPF01010278    MAA21424.1    GEDV01007980    JAP80577.1    GACK01003373    JAA61661.1    GEGO01003502    JAR91902.1    GFWV01009952    MAA34681.1    GFAC01001892    JAT97296.1   

Proteomes

UP000007151    UP000005204    UP000053268    UP000218220    UP000053240    UP000192223    + More
UP000007266    UP000030742    UP000002358    UP000009046    UP000235965    UP000215335    UP000027135    UP000019118    UP000000803    UP000092462    UP000009192    UP000183832    UP000095300    UP000094527    UP000079169    UP000095301    UP000007819    UP000015103    UP000268350    UP000000305    UP000198287    UP000054359    UP000015104   

PRIDE

H9J8D3    Q24312   

Pfam

PF10491   Nrf1_DNA-bind        + More
PF10492   Nrf1_activ_bdg

Interpro

IPR019526   Nrf1_activation-bd        + More
IPR039142   NRF1/Ewg       
IPR019525   Nrf1_NLS/DNA-bd_dimer       

ProteinModelPortal

A0A212EQV1   H9J8D3   A0A194PP08   A0A2W1BEM7   A0A2H1VMU3   A0A2A4JD72   + More
A0A0N1PI53   A0A166IWB0   A0A1Y1M5A1   V5GWF5   A0A1Y1M6M1   A0A2A4JCR3   A0A1W4WNY9   A0A1Y1M7F4   A0A139WNW2   U4U3K0   D7EJQ7   A0A1B6D9S5   A0A1B6E352   A0A1Y1M8H7   A0A1B6E089   K7IUL9   E0VWB8   A0A139WNV4   V9IAJ7   A0A0A9X3T6   A0A1B6IC26   A0A1B6JKC6   A0A1B6JPL2   R4WJV8   A0A2J7R3I5   A0A1B6HZV1   A0A232EW29   A0A1B6EVF6   A0A067RFY7   A0A1B6FHF5   N6U6Z3   A0A069DZ72   A0A1B6GZX1   A0A1B6I9D4   A0A1B6J6T5   A0A1W4WNY6   A0A0K8TKT8   A0A0V0GDL1   A0A034V729   Q24312-7   A0A1B0D9M0   A0A0K8WI39   A0A0Q9WYH8   V9ICD7   A0A1J1HFU2   A0A0C9QJ62   A0A1J1HKA6   A0A0T6BAW6   W8AVN3   A0A0A1XI95   A0A1I8Q973   A0A034V734   A0A1I8Q975   A0A2S2PYI5   A0A1D2N4E5   A0A1I8Q964   A0A146KN85   Q24312-8   A0A0C9RDZ1   A0A1S3D2H5   A0A0C9S1V1   A0A1I8MQV0   A0A1I8MQU8   M9NE19   J9K452   T1I8E3   A0A3B0KXR0   A0A224XKM1   A0A3B0KQG6   A0A2S2P5Z1   E9HR68   A0A0K2UDT9   A0A226D9M5   A0A087UHH6   T1JA80   A0A0P4WGH3   A0A0P4WK54   A0A386K0P5   T1KJJ3   A0A2S2P7E0   E9IK57   A0A224Z540   A0A131YNP2   L7MBP2   A0A147BN58   A0A293M3L1   A0A1E1XDV8  

KEGG

101738034    K11831 nuclear respiratory factor 1 | (RefSeq) DNA-binding protein Ewg

GO

GO:0006357   GO:0003700   GO:0003677   GO:0000978   GO:0005634   GO:0001046   GO:0045886   GO:0007527   GO:0007560   GO:0007517   GO:0007417   GO:0090263   GO:0016021  

PANTHER

PTHR20338  

Subcellular location

Nucleus  

Length:

488

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05349

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00365

outside

1  -  488

 

 

Pi

21.686074

Theta

19.920882

Tajima's D

-0.804998

CLR

1.906174

CSRT

0.171741412929354

Interpretation

Uncertain