Gene

KWMTBOMO02736

Pre Gene Modal

BGIBMGA003479

Annotation

PREDICTED:_protein_grainyhead_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr5(+):9839297-9891523      View in EpiBrowser

Full name

Protein grainyhead      

Alternative Name

DNA-binding protein ELF-1
Element I-binding activity
Protein grainy-head
Transcription factor NTF-1

Transcription factor

CP2

Location in the cell

Cytoplasmic   Reliability : 1.833 Nuclear   Reliability : 1.794

CDS

ATGGATCAGGTTATTAATGTAAACAAGCCGGTATGTTTACATGTATCGATTCGAAGCGAACGTGATGGGAAACGGCCAGAAATTCGAGGTTCAGCCACACAGGGCAGGAGACGCAAAGAGGTGATGGAAGTAGGCGGAGAGACATGGCGCGCGTATTATTCCAGCGGGGCGGATCACCCGCTGAGCGCGGCTACGTCGGCCGTGCTTGGCGTCTCAGATGATCAACAGCCTCAGCCGCTTGTCGCTGATTATTACAAGCTTCCTCCACTCGGACAAGATACCCATCTGCATCTCCACAAGGATGCTAAACTTGTTGATGTCTGGCCGGCCGGCGCAGCACTAAAGGCAGCCAATGGCGCGCACGGGGCGGAGTTGGGCGAACTCTCGGGCCTGCTCCACGCGGGCCTCGTGAAGCGCGAGCCCGAGGACCTGAGCCGCAAGGTGGTCGACGAGCCCGAGCCGCACGCGCTCAAGCCGCCTCGACATAAGGTGGTGGTCGGCGAGCCTGGTGAAGCGGCGTCGCCGTCCCCGGTGCCATCGCGAGCTTCTTCAGCAGGTTCACTACTTCCGGACGCAACGATGTATACCACCCAAATGTTTGCTCCACCGGGCACACCTAGTCCCACCCCCTATGGCGATCAATATTCAAGACAGCCTTCGACTTTTGCGGGTGAACCTTACTACAGAGAATATTTTGTCGGAGAAGGCTACCAGCAGAGAGCTGCACCACCTTATGATGGAGAACCGGCTTCAGGTTCTGCGTTTAGCGAAAGATATGCTGCACCACGGTATCACAGCAAGAGCGTGATCGCAGCAGCCGGACTGACAGTGGACTTGCCATCACCGGATAGTGGCATCGGTGCTGACGCAGTCACCCCTCGGGACCACACTGCCGTGCAGCAGTCGTTCGACTACACGGTAATCTGCCAGCAGCCCGGCGTCGGCGAGGACGGCCGCGGCACCCCATCGGCACATCACTCGCCCGCGCAGGCTCCACGCACGCGACCCTGGCATGACTTTGGAAGACAGAATGACGCCGATAAAATTCAAATCGCTAAATTGTTTTCCCCATATGGGTTCAAATACCATTTGGAAACGGCGAGCAGCAGTTCACAGCGGCGCGAAGACGACCGTATCACGTACATCAACAAGGGCCAGTTCTACGGGATTACACTTGAGTACATACACGATCCCGACAAACCACTTAAAAATCAAACTGTAAAGAGCGTTGTAATGCTGATGTTCAGAGAAGAGAAATCACCAGAAGACGAAATCAAAGCGTGGCAATTCTGGCACGGGAGGCAGCACTCTGTCAAACAAAGGATACTGGACGCTGACACTAAGAACAGCATCGGTTTAGCGGGTTGTATCGAGGAGGTCGCTCACAACGCCATCGCAGTATACTGGAATCCATTGGAGAGTGCTGCAAAGATCAACATTGCAGTGCAATGTTTAAGTACAGACTTCAGCAGTCAAAAAGGCGTTAAGGGTCTTCCATTACATATTCAAATTGACACTTTCGAAGACCCGCGAGACACACAAGTTTATCACAGGGGATATTGTCAAATTAAAGTTTTCTGTGACAAGGGCGCAGAAAGGAAAACTAGAGACGAAGAAAGAAGAGCAGCGAAAAGAAAGATGTCGGCCACAAACAGAAAAAAACTGGACGAAATATACCACCCGGTGACCGAACGGAGCGAATTCTATTCGATGGCGGACTTGTCTAAGCCACCGGTTTTGTTCAGTCCGGCGGAGGACATCGAGAAACTGACCGGAATGGACATACAGGGCTTCTATGGACATGATGACGCATCATTAGCAGAAGCGCATCTAAAGGGTGCCTCACCCTTCCTTCTGCACGCGGCAAAGCCTCAAGCGCCTGCGCTTAAATTCCACAATCACTTCCCACCGGACGCGCCAGGATACCGGGAGGTGGGTGCGTTATCTCCCTATGACCGCAAGGACTCGTTGGAGCTAGAGGGTGTACTGGGTAAGCGGGCGCGCACGTCCACGCCGCCGCTGAGCGAGCGCGTGATGCTATACGTGCGGCAAGACGCGGAGGACGTGTACACGCCTCTCCACGTGGTGCCCCCCACCACGCAGGGACTCATGCATGCGATTGAGAATAAGTACAAAATTTCAAGTTCGGCCATTAATAATCTTTATCGAAAGAACAAGAAAGGGATTACGGCCAAAATTGACGATGACATGCTCGCGTATTACTGCAACGAAGATCTGTTCCTGCTCGAAGTAGTGCCGGCAGGTAACACAGACGACGAACGGCTCTACGACATCATCTTTGTGGAACTGCCCTTAGAGCATTAG

Protein

MDQVINVNKPVCLHVSIRSERDGKRPEIRGSATQGRRRKEVMEVGGETWRAYYSSGADHPLSAATSAVLGVSDDQQPQPLVADYYKLPPLGQDTHLHLHKDAKLVDVWPAGAALKAANGAHGAELGELSGLLHAGLVKREPEDLSRKVVDEPEPHALKPPRHKVVVGEPGEAASPSPVPSRASSAGSLLPDATMYTTQMFAPPGTPSPTPYGDQYSRQPSTFAGEPYYREYFVGEGYQQRAAPPYDGEPASGSAFSERYAAPRYHSKSVIAAAGLTVDLPSPDSGIGADAVTPRDHTAVQQSFDYTVICQQPGVGEDGRGTPSAHHSPAQAPRTRPWHDFGRQNDADKIQIAKLFSPYGFKYHLETASSSSQRREDDRITYINKGQFYGITLEYIHDPDKPLKNQTVKSVVMLMFREEKSPEDEIKAWQFWHGRQHSVKQRILDADTKNSIGLAGCIEEVAHNAIAVYWNPLESAAKINIAVQCLSTDFSSQKGVKGLPLHIQIDTFEDPRDTQVYHRGYCQIKVFCDKGAERKTRDEERRAAKRKMSATNRKKLDEIYHPVTERSEFYSMADLSKPPVLFSPAEDIEKLTGMDIQGFYGHDDASLAEAHLKGASPFLLHAAKPQAPALKFHNHFPPDAPGYREVGALSPYDRKDSLELEGVLGKRARTSTPPLSERVMLYVRQDAEDVYTPLHVVPPTTQGLMHAIENKYKISSSAINNLYRKNKKGITAKIDDDMLAYYCNEDLFLLEVVPAGNTDDERLYDIIFVELPLEH

Description

Binds a CNS-specific regulatory element of the Dopa decarboxylase (Ddc) gene. Also interacts with sequences adjacent to other transcription units, including Ultrabithorax (Ubx) and engrailed (en). Activity in vivo may be required only at high levels transiently to activate the expression of Ddc in the CNS.

Similarity

Belongs to the grh/CP2 family. Grainyhead subfamily.

Keywords

Alternative splicing   Complete proteome   DNA-binding   Nucleus   Reference proteome   Transcription   Transcription regulation  

Feature

chain  Protein grainyhead
splice variant  In isoform O and isoform N.

Uniprot

A0A2A4JZ01   A0A2A4JZ32   A0A2A4JYE2   A0A0L7LV90   A0A2A4JYD6   U4TX38   + More
N6U6K7   A0A139WPR4   A0A1Y1KQ91   A0A1J1J9T6   A0A1J1J870   A0A1Y1KSK1   A0A1I8QEM8   A0A1I8QET7   A0A1I8QEN9   Q17NW0   A0A1I8M236   A0A1I8M241   A0A084WKM4   A0A1B6I7I2   A7UTR5   A0A1B6CAZ2   F5HLW8   Q7Q711   A0A1B6FTF6   A0A0K8UWA7   P13002-3   A0A0P8XPM4   B3NLL1   B4P524   A0A0R1DW17   A0A1W4VDJ6   P13002   A0A1W4V0C2   A0A1W4VCN3   P13002-5   A0A0B4K7F6   B4QBS0   A0A0R1DSG3   B3MHX2   B4HN88   A0A0Q5VYD6   A0A0Q5VZJ9   N6VFR9   P13002-4   A0A0R1DXQ6   A0A0R1DYV1   A0A1S4EW87   A0A0R1DS34   A0A0R1DXT7   A0A1W4VCM2   N6WCU3   A0A0P9BYU7   A0A0Q5VWR6   A0A1W4UZY0   A0A1W4VC78   B5E0Z1   N6VFS6   A0A0R3NW54   N6VFS3   N6W6P9   A0A1W4V0C7   A0A1W4VCM8   A0A2Y9D0W2   A0A139WPH2   A0A1Y1KQY2   J9KTL8   A0A1Y1KKJ5   A0A0P8XPJ8   P13002-1   A0A0B4LFT7   A0A0P9AF88   A0A0P8ZPQ3   A0A0R1DY45   A0A0Q5VK90   A0A0Q5VL15   A0A1W4UZY4  

Pubmed

26227816    23537049    18362917    19820115    28004739    17510324    + More
25315136    24438588    12364791    14747013    17210077    2792757    10731132    12537572    12537569    10731137    2606344    17994087    17550304    12537568    12537573    12537574    16110336    17569856    17569867    15632085    23185243   

EMBL

NWSH01000357    PCG77039.1    PCG77036.1    PCG77041.1    JTDY01000022    KOB79377.1    + More
PCG77037.1    KB631792    ERL86179.1    APGK01047183    KB741077    ENN74192.1    KQ971307    KYB29831.1    GEZM01081149    JAV61845.1    CVRI01000075    CRL08636.1    CRL08637.1    GEZM01081147    JAV61847.1    CH477196    EAT48364.1    ATLV01024126    KE525349    KFB50768.1    GECU01024856    JAS82850.1    AAAB01008960    EDO63687.1    GEDC01026809    JAS10489.1    EGK97280.1    EAA11971.4    GECZ01016304    JAS53465.1    GDHF01031586    GDHF01021357    GDHF01006398    JAI20728.1    JAI30957.1    JAI45916.1    X15657    AE013599    AY052066    BT001414    BT003182    BT029431    AL035312    BT011460    CH902619    KPU76547.1    CH954179    EDV54986.2    CM000158    EDW91725.2    KRK00051.1    AFH08154.1    CM000362    EDX07580.1    KRK00053.1    EDV36959.1    CH480816    EDW48370.1    KQS62050.1    KQS62047.1    CM000071    ENO01895.1    KRK00050.1    KRK00055.1    KRK00054.1    KRK00056.1    KRK00058.1    ENO01904.2    KPU76542.1    KQS62046.1    EDY69433.2    ENO01905.2    KRT03043.1    ENO01900.1    ENO01901.2    ENO01903.2    APCN01004269    KYB29832.1    GEZM01081148    JAV61846.1    ABLF02028235    GEZM01081150    JAV61844.1    KPU76545.1    AHN56347.1    KPU76546.1    KPU76543.1    KRK00052.1    KQS62048.1    KQS62049.1   

Proteomes

UP000218220    UP000037510    UP000030742    UP000019118    UP000007266    UP000183832    + More
UP000095300    UP000008820    UP000095301    UP000030765    UP000007062    UP000000803    UP000007801    UP000008711    UP000002282    UP000192221    UP000000304    UP000001292    UP000001819    UP000075840    UP000007819   

PRIDE

P13002   

Pfam

PF04516   CP2

Interpro

IPR040167   TF_CP2-like        + More
IPR007604   CP2       

ProteinModelPortal

A0A2A4JZ01   A0A2A4JZ32   A0A2A4JYE2   A0A0L7LV90   A0A2A4JYD6   U4TX38   + More
N6U6K7   A0A139WPR4   A0A1Y1KQ91   A0A1J1J9T6   A0A1J1J870   A0A1Y1KSK1   A0A1I8QEM8   A0A1I8QET7   A0A1I8QEN9   Q17NW0   A0A1I8M236   A0A1I8M241   A0A084WKM4   A0A1B6I7I2   A7UTR5   A0A1B6CAZ2   F5HLW8   Q7Q711   A0A1B6FTF6   A0A0K8UWA7   P13002-3   A0A0P8XPM4   B3NLL1   B4P524   A0A0R1DW17   A0A1W4VDJ6   P13002   A0A1W4V0C2   A0A1W4VCN3   P13002-5   A0A0B4K7F6   B4QBS0   A0A0R1DSG3   B3MHX2   B4HN88   A0A0Q5VYD6   A0A0Q5VZJ9   N6VFR9   P13002-4   A0A0R1DXQ6   A0A0R1DYV1   A0A1S4EW87   A0A0R1DS34   A0A0R1DXT7   A0A1W4VCM2   N6WCU3   A0A0P9BYU7   A0A0Q5VWR6   A0A1W4UZY0   A0A1W4VC78   B5E0Z1   N6VFS6   A0A0R3NW54   N6VFS3   N6W6P9   A0A1W4V0C7   A0A1W4VCM8   A0A2Y9D0W2   A0A139WPH2   A0A1Y1KQY2   J9KTL8   A0A1Y1KKJ5   A0A0P8XPJ8   P13002-1   A0A0B4LFT7   A0A0P9AF88   A0A0P8ZPQ3   A0A0R1DY45   A0A0Q5VK90   A0A0Q5VL15   A0A1W4UZY4  

PDB

5MPH     E-value=1.02919e-53,     Score=534

KEGG

101740332    K09275 transcription factor CP2 and related proteins | (RefSeq) protein grainyhead

GO

GO:0006357   GO:0003700   GO:0043565   GO:0005634   GO:0003382   GO:0003677   GO:0061024   GO:0061041   GO:0007426   GO:0042127   GO:0007424   GO:0008543   GO:0007402   GO:0042803   GO:0045944   GO:0007399   GO:0035159   GO:0050767   GO:0007419   GO:0042052   GO:0040003   GO:0007464   GO:0008362  

PANTHER

PTHR11037  

Subcellular location

Nucleus  

Length:

774

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.000810000000000001

Exp number, first 60 AAs:

0.00012

Total prob of N-in:

0.00019

outside

1  -  774

 

 

Pi

247.740462

Theta

192.879537

Tajima's D

0.877973

CLR

0.341656

CSRT

0.624968751562422

Interpretation

Uncertain