Gene

KWMTBOMO00151

Pre Gene Modal

BGIBMGA002000

Annotation

PREDICTED:_nuclear_receptor_subfamily_2_group_E_member_1_[Amyelois_transitella]

Location

Bomo_Chr1(-):4748863-4751663      View in EpiBrowser

Full name

Nuclear receptor subfamily 2 group E member 1      

Alternative Name

Nuclear receptor TLX
Protein tailless homolog

Transcription factor

RXR-like

Location in the cell

Nuclear   Reliability : 3.113

CDS

ATGACAGGTCGCATTCTGTACGATGTGCCATGTGCCGTGTGCCGCGATCACTCGTCGGGAAAGCATTACGGCGTATTTGCATGTGACGGGTGCGCTGGCTTTTTCAAAAGGTCCGTCAGGCGAGACCGTCGCTACACCTGCAAGGCACGCAACCCTGGCGGGTGTGTGGTTGATAAAGCACACCGAAATCAGTGTCGAGCGTGTAGACTTGCCAAATGCCTGGACGCTGGAATGAATAAAGACGCTGTTCAACATGAAAGAGGTCCTAGAAACTCTACGATTAGACGACAAATGGCATTATTTTTGAAGGATCCTGCGTTACCAACACCAGAAATGGGACTCACAGTTCCACCTCCATTAGATTTAGCGGTACCCAAGCACAACTTTATGTCCCCGCCGCAAAATTCCTTATTCCAACATCCGTACCCGTTCAATAGAATTCATATGATTAATCCTTCCGTAGTCAACATATCACTGAAAGCGCCTTCGCCTCCACCTATCACAGCTGCCTTGTTATCTCCAAAGGATCCAGAAGCGATGTGCGAAGCTGCAGCTAGATTACTGTTCATGAACGTTAAATGGGCAAAGAATGTTCCCGCGTTCGCATCATTATCATTACCAGACAGGCTACTGTTATTGGAAGAATCTTGGAAGGATTTGTTCATAATCGGTTCAGCTCAGTTTTTGTACCCATTGGACCTCAAGATTCTATCTGAAGGAAACGCCAGAATAGATAGCCGAGACGTGGAAATGTTCGAAACTTCATTAGCCGAAATTGTTAAAGTCCATCCAGATAGTAACGAGTATGCCTGTTTAAGAGCAATTGTACTGTTCAAAACGAGCTTTGTAGATGTTAATATATTATGCAGAGGTCAGTCACAGATAGGCTCTGAATATAAGAGGCTTCAAGATCTCCCCGCGGTTGCAGCGTTACAAGACCATTCGCAATTAGTACTAAATGAGTATACGACAAGGACCTATCCGCTGGACCCATCTAGACTGAGTCAAATCCTACAGCTACTGCCGGTCATTAAGAGAGTCTCTAATCTCATTATAGTCGAGCTGTTTTTCCGTGCGACCATTGGGGAGATACCTATCGAAAGAATAATCGGTGACATGTATCGTACTACCAAAGATACGATTTAA

Protein

MTGRILYDVPCAVCRDHSSGKHYGVFACDGCAGFFKRSVRRDRRYTCKARNPGGCVVDKAHRNQCRACRLAKCLDAGMNKDAVQHERGPRNSTIRRQMALFLKDPALPTPEMGLTVPPPLDLAVPKHNFMSPPQNSLFQHPYPFNRIHMINPSVVNISLKAPSPPPITAALLSPKDPEAMCEAAARLLFMNVKWAKNVPAFASLSLPDRLLLLEESWKDLFIIGSAQFLYPLDLKILSEGNARIDSRDVEMFETSLAEIVKVHPDSNEYACLRAIVLFKTSFVDVNILCRGQSQIGSEYKRLQDLPAVAALQDHSQLVLNEYTTRTYPLDPSRLSQILQLLPVIKRVSNLIIVELFFRATIGEIPIERIIGDMYRTTKDTI

Description

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). Involved in the regulation of early eye development.
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells.
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). Regulates cell cycle progression in neural stem cells of rhe developing brain. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acid receptor (RAR) regulation in retinal cells.

Subunit

Monomer.
Monomer. Interacts with ATN1; the interaction represses the transcription.
Monomer (By similarity). Interacts with ATN1; the interaction represses the transcription.

Similarity

Belongs to the nuclear hormone receptor family.
Belongs to the nuclear hormone receptor family. NR2 subfamily.

Keywords

Developmental protein   DNA-binding   Metal-binding   Nucleus   Receptor   Transcription   Transcription regulation   Zinc   Zinc-finger   3D-structure   Activator   Alternative splicing   Complete proteome   Reference proteome   Repressor  

Feature

chain  Nuclear receptor subfamily 2 group E member 1
splice variant  In isoform 2.

Uniprot

H9IXL7   A0A212FHL3   A0A194Q4X5   A0A194QUB8   A0A2A4JFI1   A0A2H1W5J9   + More
A0A0L7LQ55   E0VN83   A0A223HFP3   A0A1L2K1L8   T1HSK5   T1IXR5   K1RMW8   A0A1B6DYR5   A0A1S3K559   E9FSF9   A0A026X0Z7   A0A210Q206   A0A0L7QLP5   A0A1W4WHR9   A0A3L8DS59   V4B9S4   A0A1S5UZQ4   A0A221CB25   A0A2C9MAF7   R7V2G4   A0A2A3EG02   A0A336N683   A0A310SRM8   A0A210Q203   A0A1C3H844   E2B5N1   A0A158NLH6   Q7YTB9   A0A221CAY7   A0A0L0CR82   F7GVJ9   G1LNC9   F7AL53   F4WVZ4   G3X050   A0A1I8P1K8   A0A3P4NLI0   A0A384AV39   A0A091HN76   G3X051   A0A2R9BUM6   A0A2K6L017   A0A287DFI2   P70052   A0A2Y9DDC3   B5FW38   H2PJZ1   B1MTJ7   G1LND6   A0A1L8G2R9   B2KI92   A0A2K6CE10   A0A2K5TWE9   G3RWA0   G1RTH4   A0A2K6A7H6   A0A0D9RRH8   G3TBK5   A0A2K5C706   A0A2K6RQ76   A0A2K5NF13   A0A2K5JQS0   A0A2K5RV09   A0A2K6TN09   B0CM45   B0KWH5   H9FZ41   H2QTI2   B6ZGT9   Q9Y466   C1FXW6   A0A0N0BGM8   F1PD89   I3LU21   F7AUI6   A0A2Y9FBE9   A0A2Y9HBM9   A0A337SGB4   A0A2U3XDI7   A0A2Y9KX17   A0A2U3VRU3   M3YEH4   B3RF24   A0A3L7I4P6   Q78ZM1   Q64104   F1MN68   A0A2K6TN08   A0A1L8G913   Q5U7E0   L8IGJ1   B7NZG6   A0A1S3MC09   A0A3Q0EC65  

Pubmed

19121390    22118469    26354079    26227816    20566863    22992520    + More
21292972    24508170    28812685    30249741    23254933    28673513    15562597    20798317    21347285    12837244    26108605    17431167    20010809    17495919    21719571    21709235    22722832    9609825    27762356    25362486    25243066    22002653    25319552    16136131    11181995    9628820    11073974    14702039    14574404    15489334    16341006    19892987    17975172    29704459    10349636    11042159    11076861    11217851    12079282    12466851    12040188    16141073    7720587    10706625    11997145    16702404    17901127    19393038    25315136    22751099   

EMBL

BABH01016006    AGBW02008503    OWR53206.1    KQ459463    KPJ00588.1    KQ461108    + More
KPJ09123.1    NWSH01001724    PCG70334.1    ODYU01006167    SOQ47784.1    JTDY01000353    KOB77575.1    DS235335    EEB14839.1    KX431898    AST48091.1    KU057690    APD25628.1    ACPB03008330    JH431661    JH817099    EKC42940.1    GEDC01006503    JAS30795.1    GL732524    EFX89201.1    KK107063    EZA61059.1    NEDP02005224    OWF42761.1    KQ414914    KOC59552.1    QOIP01000005    RLU22598.1    KB203251    ESO85739.1    KX373874    AQN67833.1    MF360876    ASL70560.1    AMQN01005341    KB295744    ELU12704.1    KZ288262    PBC30414.1    UFQT01002802    SSX34088.1    KQ760632    OAD59698.1    OWF42760.1    LT560244    SAP35443.1    GL445864    EFN89000.1    ADTU01019428    AY313155    AAP79295.1    MF360834    ASL70518.1    JRES01000032    KNC34742.1    JSUE03032518    ACTA01001516    ACTA01009516    ACTA01017516    ACTA01025516    ACTA01033516    ACTA01185505    ACTA01193503    GL888404    EGI61583.1    AEFK01170456    AEFK01170457    AEFK01170458    CYRY02026444    VCW98704.1    KL217557    KFO96572.1    AJFE02085542    AJFE02085543    AGTP01061163    AGTP01061164    U67886    DP000891    ACH53021.1    ABGA01161990    ABGA01161991    ABGA01161992    NDHI03003574    PNJ19655.1    DP000638    ACA57920.1    CM004475    OCT78189.1    DP000716    ACC64552.1    AQIA01049367    CABD030047154    CABD030047155    CABD030047156    CABD030047157    ADFV01115682    ADFV01115683    AQIB01069691    AHZZ02025993    AHZZ02025994    AHZZ02025995    DP000548    ABY56294.1    DP000578    GAMS01006641    GAMS01006640    GAMR01006462    ABY84160.1    JAB16495.1    JAB27470.1    JU336146    JU336147    CM001256    AFE79900.1    EHH18802.1    AC157522    NBAG03000210    PNI87722.1    HQ692846    AB307709    CH471051    ADZ17357.1    BAH02300.1    EAW48385.1    Y13276    AF220532    AF411525    AK131541    AL078596    BC028031    DP001088    ACO71279.1    KQ435775    KOX75042.1    AAEX03008592    AEMK02000001    AANG04003966    AEYP01034120    DP000779    ACE77650.1    RAZU01000099    RLQ73157.1    AF520420    AK132201    CH466540    AAM74229.1    BAE21029.1    EDL05003.1    S77482    BC057104    CM004474    OCT80397.1    AY786187    AAV41874.1    JH881380    ELR54654.1    DP001039    ACJ76603.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000218220    UP000037510    + More
UP000009046    UP000015103    UP000005408    UP000085678    UP000000305    UP000053097    UP000242188    UP000053825    UP000192223    UP000279307    UP000030746    UP000076420    UP000014760    UP000242457    UP000008237    UP000005205    UP000037069    UP000006718    UP000008912    UP000002280    UP000007755    UP000007648    UP000095300    UP000261681    UP000054308    UP000240080    UP000233180    UP000005215    UP000248480    UP000001595    UP000186698    UP000233120    UP000001519    UP000001073    UP000233140    UP000029965    UP000007646    UP000233020    UP000233200    UP000233060    UP000233080    UP000233040    UP000233220    UP000028761    UP000002277    UP000005640    UP000053105    UP000002254    UP000008227    UP000002281    UP000248484    UP000248481    UP000011712    UP000245341    UP000248482    UP000245340    UP000000715    UP000273346    UP000000589    UP000009136    UP000095301    UP000087266    UP000189704   

PRIDE

H9IXL7    Q9Y466    I3LU21    Q64104   

Pfam

PF00104   Hormone_recep        + More
PF00105   zf-C4

Interpro

IPR013088   Znf_NHR/GATA        + More
IPR000536   Nucl_hrmn_rcpt_lig-bd       
IPR001628   Znf_hrmn_rcpt       
IPR035500   NHR-like_dom_sf       
IPR001723   Nuclear_hrmn_rcpt       

SUPFAM

SSF48508   SSF48508       

Gene 3D

1.10.565.10     3.30.50.10    

ProteinModelPortal

H9IXL7   A0A212FHL3   A0A194Q4X5   A0A194QUB8   A0A2A4JFI1   A0A2H1W5J9   + More
A0A0L7LQ55   E0VN83   A0A223HFP3   A0A1L2K1L8   T1HSK5   T1IXR5   K1RMW8   A0A1B6DYR5   A0A1S3K559   E9FSF9   A0A026X0Z7   A0A210Q206   A0A0L7QLP5   A0A1W4WHR9   A0A3L8DS59   V4B9S4   A0A1S5UZQ4   A0A221CB25   A0A2C9MAF7   R7V2G4   A0A2A3EG02   A0A336N683   A0A310SRM8   A0A210Q203   A0A1C3H844   E2B5N1   A0A158NLH6   Q7YTB9   A0A221CAY7   A0A0L0CR82   F7GVJ9   G1LNC9   F7AL53   F4WVZ4   G3X050   A0A1I8P1K8   A0A3P4NLI0   A0A384AV39   A0A091HN76   G3X051   A0A2R9BUM6   A0A2K6L017   A0A287DFI2   P70052   A0A2Y9DDC3   B5FW38   H2PJZ1   B1MTJ7   G1LND6   A0A1L8G2R9   B2KI92   A0A2K6CE10   A0A2K5TWE9   G3RWA0   G1RTH4   A0A2K6A7H6   A0A0D9RRH8   G3TBK5   A0A2K5C706   A0A2K6RQ76   A0A2K5NF13   A0A2K5JQS0   A0A2K5RV09   A0A2K6TN09   B0CM45   B0KWH5   H9FZ41   H2QTI2   B6ZGT9   Q9Y466   C1FXW6   A0A0N0BGM8   F1PD89   I3LU21   F7AUI6   A0A2Y9FBE9   A0A2Y9HBM9   A0A337SGB4   A0A2U3XDI7   A0A2Y9KX17   A0A2U3VRU3   M3YEH4   B3RF24   A0A3L7I4P6   Q78ZM1   Q64104   F1MN68   A0A2K6TN08   A0A1L8G913   Q5U7E0   L8IGJ1   B7NZG6   A0A1S3MC09   A0A3Q0EC65  

PDB

5UAN     E-value=1.11388e-36,     Score=384

KEGG

101739052    K08545 nuclear receptor subfamily 2 group E member 1 | (RefSeq) nuclear receptor subfamily 2 group E

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0043565   GO:0003707   GO:0005634   GO:0003700   GO:0008270   GO:0003677   GO:0046872   GO:0048712   GO:0001662   GO:2000179   GO:0048814   GO:0001227   GO:0045787   GO:0021960   GO:0021764   GO:0002118   GO:0021542   GO:0007601   GO:0042826   GO:0045665   GO:0035176   GO:0045165   GO:0021872   GO:0030198   GO:0060291   GO:0043066   GO:0060164   GO:0021895   GO:0021772   GO:0060041   GO:0001228   GO:0045766   GO:0035019   GO:2000648   GO:2000178   GO:0021819   GO:0090049   GO:0007275   GO:0000981   GO:0006367   GO:0007399   GO:0005654   GO:0021987   GO:0008347   GO:0008284   GO:0007420   GO:0043010   GO:0051128   GO:0019899   GO:0000122   GO:0006355   GO:0043401   GO:0007169   GO:0016021  

Subcellular location

Nucleus  

Length:

381

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.06009

Exp number, first 60 AAs:

0.00434

Total prob of N-in:

0.01077

outside

1  -  381

 

 

Pi

16.774586

Theta

13.205527

Tajima's D

1.046972

CLR

0.002038

CSRT

0.692365381730913

Interpretation

Uncertain