Gene

KWMTBOMO16771

Annotation

PREDICTED:_uncharacterized_protein_LOC106110672?_partial_[Papilio_polytes]

Location

Bomo_Scaf201(-):15540-16025      View in EpiBrowser

Full name

GMP reductase      

Alternative Name

Guanosine 5'-monophosphate oxidoreductase

Location in the cell

Cytoplasmic   Reliability : 1.204 Nuclear   Reliability : 1.429

CDS

ATGAACATAGTGCTTTCTGATAAAATATCAGATAAATTGACTATTATACAAGCATACTCACCAACTGAATCAGAAAAGAAAGACGACATAGCAAAAATAGAAAAGTTCTATGGTGACTTGCAAACAGCTATCGACAATTCATACAGAAACATTATCGTTATGGGCGATTTCAATGGGAAAGTAGGAACCTCTAACAGCGGAGAAGAGTATACGGTTGGCAGATTCGGAATTGGCAAAAGGAGTAAGAACGGAGAAAGATTAGTTACATTTGCCCTAAAAAACAAACTTAGTATTCTCAACCTTCTTCAAGAAAAAAGAAACGAAAAAGTGGACATGGGTCTCTCCGAACGGACTTTATAA

Protein

MNIVLSDKISDKLTIIQAYSPTESEKKDDIAKIEKFYGDLQTAIDNSYRNIIVMGDFNGKVGTSNSGEEYTVGRFGIGKRSKNGERLVTFALKNKLSILNLLQEKRNEKVDMGLSERTL

Description

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

Catalytic Activity

IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH

Subunit

Homotetramer.

Similarity

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Uniprot

A0A3S2NLL1   A0A2W1BNL4   A0A2H1X3Z9   D7F179   W6N9K0   A0A0L7L6C2   + More
A0A0L7LAJ6   A0A183N9K4   A0A0L7LL03   A0A183MDM3   A0A2A4JIH6   A0A183LNZ1   D7F176   A0A183L7X1   A0A2G8JC29   A0A183M8F6   A0A131ZDH5   A0A183MT43   A0A183LE85   A0A183RX47   A0A183PTN8   A0A3Q0J1R0   W4Y2M5   D7F178   D7F177   A0A183LLD6   A0A2G8L7J7   A0A183NAL3   A0A2C9KWR2   C3XQK8   A0A183N405   A0A3B1JKT5   A0A183JYG9   A0A183N0T0   G4VAV4   A0A0B2W3Y4   W6NF02   A0A183N9U4   A0A183LBL3   W4XIJ4   A0A2G8LFQ7   A0A183QT34   A0A183LS61   A0A183MSW5   A0A2G8LQ45   A0A183M2H1   A0A183KYU0   A0A183MD86   A0A2G8K4U3   A0A183MMG7   A0A183NJX9   A0A2H2HZ60   A0A183N0H1   A0A183MWA8   A0A183MWR3   A0A2H1VBB6   A0A183LN25   A0A183MQK9   A0A183K3U9   A0A183LC40   A0A183NCN2   A0A2H1WF27   A0A0N8NZV2   A0A183MZW9   A0A183MX92   A0A183NAJ4   A0A183LZP5   A0A443QYR6   A0A183LEG1   A0A183MRR9   A0A183NBK7   A0A183MZ25   A0A183N4K5   R7VDL6   A0A183M0J5   A0A183SNA9   A0A3B1JJK0   A0A183LY81   A0A183MU96   A0A183LE40   A0A183RLA3   A0A183N653   A0A183NC15   A0A183MZL2   A0A183MQB7   A0A183M1E6   A0A183N9T1   R7VL02   A0A183L906   A0A183MMA0   A0A183M3Z9   A0A183MYL7   A0A183N3S4   A0A183M901   A0A183MYE8   A0A183JY81   A0A183LRY4   A0A183LUU9   A0A3N0YUZ8  

EC Number

1.7.1.7

Pubmed

28756777    20470440    26227816    29023486    26830274    15562597    + More
18563158    25329095    22253936    17994087    23254933   

EMBL

RSAL01000042    RVE50766.1    KZ150049    PZC74456.1    ODYU01013311    SOQ60019.1    + More
FJ265564    ADI61832.1    CAVP010052198    CDL93746.1    JTDY01002723    KOB70849.1    JTDY01001937    KOB72497.1    UZAI01020850    VDP53479.1    JTDY01000715    KOB76117.1    UZAI01013048    VDP10726.1    NWSH01001447    PCG71212.1    UZAI01001916    VDO66484.1    FJ265561    ADI61829.1    UZAK01054878    VDP83084.1    MRZV01002651    PIK33269.1    UZAI01007646    VDO99813.1    GEDV01000266    JAP88291.1    UZAI01017894    VDP30808.1    UZAI01000522    VDO53941.1    UZAL01039177    VDP75021.1    AAGJ04114295    FJ265563    ADI61831.1    FJ265562    ADI61830.1    UZAI01001478    VDO62378.1    MRZV01000183    PIK56232.1    UZAI01021218    VDP54835.1    GG666454    EEN69674.1    UZAI01019470    VDP45570.1    UZAK01032465    VDP27688.1    UZAI01018910    VDP41173.1    HE601624    CCD76535.1    JPKZ01000255    KHN88272.1    CAVP010059514    CDL95876.1    UZAI01020922    VDP53794.1    UZAI01000251    VDO50484.1    AAGJ04122993    MRZV01000093    PIK59088.1    UZAI01002504    VDO72196.1    UZAI01017868    VDP30540.1    MRZV01000013    PIK62383.1    UZAI01005208    VDO89561.1    UZAK01043895    VDP71595.1    UZAI01012167    VDP09784.1    MRZV01000884    PIK43012.1    UZAI01017324    VDP23363.1    UZAL01003327    VDO86857.1    UZAI01018868    VDP40819.1    UZAI01018266    VDP35225.1    UZAI01018331    VDP35931.1    ODYU01001637    SOQ38140.1    UZAI01001756    VDO64998.1    UZAI01017620    VDP27415.1    UZAK01033351    VDP36524.1    UZAI01000298    VDO51048.1    UZAI01022463    VDP58008.1    ODYU01008249    SOQ51673.1    CH902628    KPU75356.1    UZAI01018771    VDP40084.1    UZAI01018403    VDP36691.1    UZAI01021193    VDP54749.1    UZAI01004314    VDO85554.1    NCKU01003098    RWS08177.1    UZAI01000543    VDO54156.1    UZAI01017742    VDP28975.1    UZAI01021626    VDP56003.1    UZAI01018648    VDP38998.1    UZAI01019590    VDP46363.1    AMQN01039158    KB295056    ELU13765.1    UZAI01004561    VDO86877.1    UYSU01033370    VDL92092.1    UZAI01003915    VDO83114.1    UZAI01018025    VDP32285.1    UZAI01000508    VDO53809.1    UZAI01019930    VDP48645.1    UZAI01021903    VDP56786.1    UZAI01018724    VDP39737.1    UZAI01017590    VDP27032.1    UZAI01004852    VDO88081.1    UZAI01020914    VDP53739.1    AMQN01035462    KB292293    ELU17851.1    UZAI01000051    VDO47367.1    UZAI01017309    VDP23203.1    UZAI01005733    VDO91759.1    UZAI01018587    VDP38421.1    UZAI01019431    VDP45292.1    UZAI01007994    VDP00793.1    UZAI01018562    VDP38196.1    UZAK01032432    VDP27341.1    UZAI01002464    VDO71833.1    UZAI01003085    VDO77048.1    RJVU01023003    ROL50012.1   

Proteomes

UP000283053    UP000025227    UP000037510    UP000050790    UP000277204    UP000218220    + More
UP000050789    UP000230750    UP000050792    UP000050791    UP000079169    UP000007110    UP000076420    UP000001554    UP000018467    UP000008854    UP000031036    UP000005237    UP000007801    UP000285301    UP000014760    UP000050788    UP000275846   

PRIDE

D7F179    D7F176    D7F178    D7F177   

Pfam

PF14529   Exo_endo_phos_2        + More
PF00478   IMPDH
PF00078   RVT_1
PF03372   Exo_endo_phos
PF06816   NOD
PF07645   EGF_CA
PF12661   hEGF
PF00066   Notch
PF12796   Ank_2
PF00008   EGF
PF07684   NODP

Interpro

IPR005993   GMPR        + More
IPR015875   IMP_DH/GMP_Rdtase_CS       
IPR001093   IMP_DH_GMPRt       
IPR013785   Aldolase_TIM       
IPR005135   Endo/exonuclease/phosphatase       
IPR036691   Endo/exonu/phosph_ase_sf       
IPR027124   Swc5/CFDP2       
IPR000477   RT_dom       
IPR008297   Notch       
IPR000152   EGF-type_Asp/Asn_hydroxyl_site       
IPR020683   Ankyrin_rpt-contain_dom       
IPR011656   Notch_NODP_dom       
IPR035993   Notch-like_dom_sf       
IPR010660   Notch_NOD_dom       
IPR000742   EGF-like_dom       
IPR036770   Ankyrin_rpt-contain_sf       
IPR013032   EGF-like_CS       
IPR018097   EGF_Ca-bd_CS       
IPR024600   DUF3454_notch       
IPR002110   Ankyrin_rpt       
IPR000800   Notch_dom       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR001881   EGF-like_Ca-bd_dom       

SUPFAM

SSF56219   SSF56219        + More
SSF48403   SSF48403       
SSF90193   SSF90193       
SSF57184   SSF57184       

Gene 3D

3.20.20.70     3.60.10.10     1.25.40.20    

CDD

cd00381  IMPDH
cd00204  ANK

ProteinModelPortal

A0A3S2NLL1   A0A2W1BNL4   A0A2H1X3Z9   D7F179   W6N9K0   A0A0L7L6C2   + More
A0A0L7LAJ6   A0A183N9K4   A0A0L7LL03   A0A183MDM3   A0A2A4JIH6   A0A183LNZ1   D7F176   A0A183L7X1   A0A2G8JC29   A0A183M8F6   A0A131ZDH5   A0A183MT43   A0A183LE85   A0A183RX47   A0A183PTN8   A0A3Q0J1R0   W4Y2M5   D7F178   D7F177   A0A183LLD6   A0A2G8L7J7   A0A183NAL3   A0A2C9KWR2   C3XQK8   A0A183N405   A0A3B1JKT5   A0A183JYG9   A0A183N0T0   G4VAV4   A0A0B2W3Y4   W6NF02   A0A183N9U4   A0A183LBL3   W4XIJ4   A0A2G8LFQ7   A0A183QT34   A0A183LS61   A0A183MSW5   A0A2G8LQ45   A0A183M2H1   A0A183KYU0   A0A183MD86   A0A2G8K4U3   A0A183MMG7   A0A183NJX9   A0A2H2HZ60   A0A183N0H1   A0A183MWA8   A0A183MWR3   A0A2H1VBB6   A0A183LN25   A0A183MQK9   A0A183K3U9   A0A183LC40   A0A183NCN2   A0A2H1WF27   A0A0N8NZV2   A0A183MZW9   A0A183MX92   A0A183NAJ4   A0A183LZP5   A0A443QYR6   A0A183LEG1   A0A183MRR9   A0A183NBK7   A0A183MZ25   A0A183N4K5   R7VDL6   A0A183M0J5   A0A183SNA9   A0A3B1JJK0   A0A183LY81   A0A183MU96   A0A183LE40   A0A183RLA3   A0A183N653   A0A183NC15   A0A183MZL2   A0A183MQB7   A0A183M1E6   A0A183N9T1   R7VL02   A0A183L906   A0A183MMA0   A0A183M3Z9   A0A183MYL7   A0A183N3S4   A0A183M901   A0A183MYE8   A0A183JY81   A0A183LRY4   A0A183LUU9   A0A3N0YUZ8  

KEGG

NA   

GO

GO:0003920   GO:0006144   GO:0006163   GO:0046872   GO:0003964   GO:0004519  

PANTHER

PTHR23227  

Length:

119

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00075

Exp number, first 60 AAs:

0

Total prob of N-in:

0.19443

outside

1  -  119

 

 

Pi

0

Theta

0

Tajima's D

0

CLR

0

CSRT

0

Interpretation

Uncertain