Gene

KWMTBOMO16634

Pre Gene Modal

BGIBMGA012735

Annotation

PREDICTED:_netrin_receptor_UNC5C-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Scaf059(-):28952-33815      View in EpiBrowser

Full name

Netrin receptor unc-5      

Alternative Name

Unc5 netrin receptor

Location in the cell

Extracellular   Reliability : 3.287

CDS

ATGAAAACCATTGATGGTCTTCCAATATTCTTATTAGAACCTAAAAACTCGTATGTCATTAGGAATAAACCAGCCACGATTCTCTGTAGGGCTGCCAATGCTCTTCAAGTGTTCTTCAAATGCAATGACGTGAGAACTGATAAGACAGTACAATACGAACACGTGGATCCTCAGAATGGAGTGAGGGTGGTCGAAGCAGAGCTAAATGTGACCAGAAATGAGTTAGATGAATATTTCGGTGGAAAATACGGGTGTGAGTGCTACGCTTGGAATAGTAAAGGGCGGATTCGCAGTCAGTCCATTTTCATCGAATACGCTTTCATCAAGAAGCATTTCGTGCAGCAACCGCAGTCAGCGACAGTCGAATCAGGCAAGAGCGTCACATTCCGATGTATTCCGCCACAAGCCACACCAGCTCCAAGTCTCAAATGGACAAGAAATGGAGTGCCTATTGAGGCAAAGGACGAAAATTTAGTGCTTCCTAATGTTGGGTTGCAGTGCAAAATATTAAGGTGTTATCACTTTGCGAATTCAATCACAGGACATGACAAACTACACTGTATAGCTGAGAACGTCGCCGGTCGGCGCGAGTCGAACGTGGCCGTGCTCTCTGTATACGTAAATGGAGGCTGGTCAGCCTGGTCTCCGTGGATGCCGTGTCGTTGCGGCTCCAGAATTAGCGGAAGACGTCGCACGAGAACTTGCACAGAGCCTCCGCCGGCCAACGGAGGAGCGCCCTGCAGAGGCCAGGCCTCGCAGAGCGACGAGGAATGCTTACGATGTCAGACCGGTAAGAGTGCGGGTACCAAGACACACTCTTCATGA

Protein

MKTIDGLPIFLLEPKNSYVIRNKPATILCRAANALQVFFKCNDVRTDKTVQYEHVDPQNGVRVVEAELNVTRNELDEYFGGKYGCECYAWNSKGRIRSQSIFIEYAFIKKHFVQQPQSATVESGKSVTFRCIPPQATPAPSLKWTRNGVPIEAKDENLVLPNVGLQCKILRCYHFANSITGHDKLHCIAENVAGRRESNVAVLSVYVNGGWSAWSPWMPCRCGSRISGRRRTRTCTEPPPANGGAPCRGQASQSDEECLRCQTGKSAGTKTHSS

Description

Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5.

Similarity

Belongs to the serpin family.
Belongs to the unc-5 family.

Keywords

Complete proteome   Developmental protein   Disulfide bond   Glycoprotein   Immunoglobulin domain   Membrane   Phosphoprotein   Receptor   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Netrin receptor unc-5

Uniprot

H9JT73   A0A3S2TN21   A0A194RBR7   A0A2W1BV79   A0A2H1V962   A0A2A4JJ15   + More
A0A0L7KYD2   A0A212ETD5   A0A194Q7Z8   A0A212EVY5   A0A194Q8C5   A0A2H1VU71   H9JMZ8   A0A2A4IZN1   A0A2W1BMT9   A0A2W1BXA1   A0A2A4JM37   A0A2A4JLB3   A0A212EZX5   A0A0N1I685   A0A3S2NWX0   A0A194PXF9   A0A154PEH5   A0A0K8TDJ2   A0A146LCK0   A0A0A9VZT2   A0A1W4WEN6   A0A0C9RP90   A0A0L7RHT7   A0A1B6FUU3   A0A1B6EMM1   A0A1B6HQL7   A0A195CJV7   A0A088A971   A0A1B6I2E4   A0A1Y1KGW7   A0A1B6BY64   A0A0M9A636   A0A2S2PSX4   A0A067RP65   A0A1B6LH58   A0A087TC90   A0A1B6KVK9   A0A2H8TRB2   A0A2S2PVW1   J9KU90   E2APQ4   A0A0M9A8F8   A0A0J7KWL4   A0A195EUI3   A0A026VUN0   A0A088AWA8   F4W410   A0A3L8DRW3   A0A151X1E9   A0A158NK16   A0A195CJV1   A0A195B393   T1IHT4   A0A195DVL0   W8B2P2   W8AYM5   A0A158NTE6   A0A154PEA8   A0A0J7LC38   A0A151X1U2   A0A1B6LLD5   F4W406   A0A034W4Y3   A0A195DVW8   A0A195B423   E9GFF4   A0A0A1X6V4   A0A0K8UWV4   B3NQE2   A0A0R1DYH7   A0A182YRJ9   A0A182HYZ6   B4P7E5   A0A0J9RDC3   B4QGG3   A0A182P3D1   A0A182KYQ0   A0A0J9RDG8   E9I9S1   A0A0B4LFH9   Q95TU8   A0A182NAQ6   A0A0L7QTL0   A0A3L8DS02   B4HS32   A0A1W4WCC0   A0A026VX76   B3MEW5   A0A0P9BXV8   A0A182QAL5   A0A182XKK9   A0A0Q9XFX8   B4KS96  

Pubmed

19121390    26354079    28756777    26227816    22118469    26823975    + More
25401762    28004739    24845553    20798317    24508170    21719571    30249741    21347285    24495485    25348373    21292972    25830018    17994087    17550304    25244985    22936249    20966253    21282665    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    11719202    12537569    12765609   

EMBL

BABH01034762    RSAL01000046    RVE50542.1    KQ460416    KPJ14924.1    KZ149907    + More
PZC78261.1    ODYU01001331    SOQ37368.1    NWSH01001320    PCG71708.1    JTDY01004517    KOB68059.1    AGBW02012596    OWR44739.1    KQ459324    KPJ01648.1    AGBW02012107    OWR45646.1    KPJ01644.1    ODYU01004464    SOQ44360.1    BABH01029133    NWSH01004342    PCG65211.1    KZ150134    PZC73003.1    PZC78254.1    NWSH01001062    PCG72846.1    PCG72847.1    AGBW02011206    OWR47055.1    KQ460874    KPJ11666.1    RSAL01000124    RVE46623.1    KQ459586    KPI98031.1    KQ434870    KZC09610.1    GBRD01002257    JAG63564.1    GDHC01018809    GDHC01013807    JAP99819.1    JAQ04822.1    GBHO01043896    JAF99707.1    GBYB01010240    JAG80007.1    KQ414585    KOC70552.1    GECZ01015815    JAS53954.1    GECZ01030599    JAS39170.1    GECU01030740    JAS76966.1    KQ977642    KYN01011.1    GECU01026636    JAS81070.1    GEZM01086422    JAV59460.1    GEDC01031076    JAS06222.1    KQ435727    KOX77995.1    GGMR01019327    MBY31946.1    KK852508    KDR22415.1    GEBQ01016935    JAT23042.1    KK114558    KFM62729.1    GEBQ01024488    JAT15489.1    GFXV01004337    MBW16142.1    GGMS01000443    MBY69646.1    ABLF02041018    GL441572    EFN64605.1    KOX77999.1    LBMM01002575    KMQ94639.1    KQ981979    KYN31539.1    KK107847    EZA47457.1    GL887491    EGI71006.1    QOIP01000005    RLU23185.1    KQ982585    KYQ54241.1    ADTU01018638    ADTU01018639    KYN01006.1    KQ976625    KYM78963.1    JH430009    KQ980295    KYN16881.1    GAMC01015247    JAB91308.1    GAMC01015248    JAB91307.1    ADTU01025884    ADTU01025885    KZC09608.1    LBMM01000010    KMR05368.1    KYQ54236.1    GEBQ01015437    JAT24540.1    EGI71002.1    GAKP01009178    GAKP01009177    GAKP01009176    JAC49774.1    KYN16887.1    KYM78959.1    GL732542    EFX81631.1    GBXI01007470    JAD06822.1    GDHF01025673    GDHF01021499    JAI26641.1    JAI30815.1    CH954179    EDV55918.1    CM000158    KRK00314.1    APCN01005836    EDW92090.1    CM002911    KMY93977.1    CM000362    EDX07201.1    KMY93976.1    GL761846    EFZ22743.1    AE013599    AHN56248.1    AF247762    AY058501    KQ414755    KOC61811.1    RLU23184.1    CH480816    EDW47979.1    EZA47459.1    CH902619    EDV36586.1    KPU76313.1    AXCN02000665    CH933808    KRG04084.1    EDW08378.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000218220    UP000037510    UP000007151    + More
UP000053268    UP000076502    UP000192223    UP000053825    UP000078542    UP000005203    UP000053105    UP000027135    UP000054359    UP000007819    UP000000311    UP000036403    UP000078541    UP000053097    UP000007755    UP000279307    UP000075809    UP000005205    UP000078540    UP000078492    UP000000305    UP000008711    UP000002282    UP000076408    UP000075840    UP000000304    UP000075885    UP000075882    UP000000803    UP000075884    UP000001292    UP000192221    UP000007801    UP000075886    UP000076407    UP000009192   

PRIDE

H9JT73    H9JMZ8    Q95TU8   

Pfam

PF00090   TSP_1        + More
PF17217   UPA
PF00791   ZU5
PF00531   Death
PF07679   I-set
PF00079   Serpin

Interpro

IPR036383   TSP1_rpt_sf        + More
IPR000884   TSP1_rpt       
IPR037936   UNC5       
IPR036179   Ig-like_dom_sf       
IPR003598   Ig_sub2       
IPR013783   Ig-like_fold       
IPR007110   Ig-like_dom       
IPR003599   Ig_sub       
IPR011029   DEATH-like_dom_sf       
IPR000906   ZU5_dom       
IPR000488   Death_domain       
IPR033772   UPA       
IPR013098   Ig_I-set       
IPR042178   Serpin_sf_1       
IPR042185   Serpin_sf_2       
IPR023796   Serpin_dom       
IPR036186   Serpin_sf       

SUPFAM

SSF48726   SSF48726        + More
SSF82895   SSF82895       
SSF47986   SSF47986       
SSF56574   SSF56574       

Gene 3D

2.20.100.10     2.60.40.10     2.30.39.10     3.30.497.10    

ProteinModelPortal

H9JT73   A0A3S2TN21   A0A194RBR7   A0A2W1BV79   A0A2H1V962   A0A2A4JJ15   + More
A0A0L7KYD2   A0A212ETD5   A0A194Q7Z8   A0A212EVY5   A0A194Q8C5   A0A2H1VU71   H9JMZ8   A0A2A4IZN1   A0A2W1BMT9   A0A2W1BXA1   A0A2A4JM37   A0A2A4JLB3   A0A212EZX5   A0A0N1I685   A0A3S2NWX0   A0A194PXF9   A0A154PEH5   A0A0K8TDJ2   A0A146LCK0   A0A0A9VZT2   A0A1W4WEN6   A0A0C9RP90   A0A0L7RHT7   A0A1B6FUU3   A0A1B6EMM1   A0A1B6HQL7   A0A195CJV7   A0A088A971   A0A1B6I2E4   A0A1Y1KGW7   A0A1B6BY64   A0A0M9A636   A0A2S2PSX4   A0A067RP65   A0A1B6LH58   A0A087TC90   A0A1B6KVK9   A0A2H8TRB2   A0A2S2PVW1   J9KU90   E2APQ4   A0A0M9A8F8   A0A0J7KWL4   A0A195EUI3   A0A026VUN0   A0A088AWA8   F4W410   A0A3L8DRW3   A0A151X1E9   A0A158NK16   A0A195CJV1   A0A195B393   T1IHT4   A0A195DVL0   W8B2P2   W8AYM5   A0A158NTE6   A0A154PEA8   A0A0J7LC38   A0A151X1U2   A0A1B6LLD5   F4W406   A0A034W4Y3   A0A195DVW8   A0A195B423   E9GFF4   A0A0A1X6V4   A0A0K8UWV4   B3NQE2   A0A0R1DYH7   A0A182YRJ9   A0A182HYZ6   B4P7E5   A0A0J9RDC3   B4QGG3   A0A182P3D1   A0A182KYQ0   A0A0J9RDG8   E9I9S1   A0A0B4LFH9   Q95TU8   A0A182NAQ6   A0A0L7QTL0   A0A3L8DS02   B4HS32   A0A1W4WCC0   A0A026VX76   B3MEW5   A0A0P9BXV8   A0A182QAL5   A0A182XKK9   A0A0Q9XFX8   B4KS96  

PDB

4V2A     E-value=3.33782e-35,     Score=370

KEGG

101741765    K07521 netrin receptor unc-5 | (RefSeq) netrin receptor UNC5C-like

GO

GO:0005042   GO:0016021   GO:0008045   GO:0007432   GO:0008347   GO:0030335   GO:0007411   GO:0005043   GO:0005515   GO:0008270   GO:0005524   GO:0005536   GO:0005975   GO:0046835   GO:0016773   GO:0006096   GO:0006281   GO:0006259  

PANTHER

PTHR12582  

Subcellular location

Membrane  

Length:

274

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0175

Exp number, first 60 AAs:

0.00036

Total prob of N-in:

0.01132

outside

1  -  274

 

 

Pi

0

Theta

0

Tajima's D

0

CLR

0

CSRT

0

Interpretation

Uncertain