Gene

KWMTBOMO16573  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005628

Annotation

uridine_5'-monophosphate_synthase_[Bombyx_mori]

Location

Bomo_Scaf022(+):64366-66323      View in EpiBrowser

Full name

Uridine 5'-monophosphate synthase      

Alternative Name

Rudimentary-like protein

Location in the cell

Cytoplasmic   Reliability : 1.974

CDS

ATGGGTTTAGATAAACTAGAAGATCTAGCTTTAAAACTATTTTCTATTGATGCCGTGAAATTTGGAGATTTTACTACTAAGACCGGCATCAAAACACCGGCCTATTTTGATTTGAGGGTTATTGTTAGTTATCCCGACATCATGGAGCTTACCTCGAATATGTTGTACGATTTAGCCGTAAAAGACAGCCAATTTGATCATTTGTGTGGAGTTCCATATACTGCCTTGCCCATTGCTACACTACTAAGTATACAAGCGAAAAAACCTATGTTGATGAGAAGGAAAGAAACAAAATCTTATGGAACCAAAAAAAGCATTGAAGGTCATTTTAAAAAAGATGACACATGTCTCATCATCGAGGACGTCATAACATCTGGCTCAAGCATACTGGAAACAGTCAAAGATTTGAAAAATGAAGGGCTCGTAACTACAGAAGCTGCCATTATTTTAGACCGGGAGCAAGGTGGTAGGGAGAACTTAGCTAAAAATGGCATCCATGTAAAATCATTGTTCACAATGAGAACATTGATTGAAATACTTAAAAAACACAAGAAAATAACAGATGAAATTGTAGTTACAGTAAAAAATTACTTGAATGAAACAAAGGCTCCTGTTATAGAAAAACTTATGGAACGTGTTATACTACCATATGAAAAAAGAATAGATTTTGCAACAAATCTTGTAGCCAGGCAACTATTCAACATTATGGCCCCACAAAGAAAACTAATTTATGTCTCTCAGCAGACCTCACCATGA

Protein

MGLDKLEDLALKLFSIDAVKFGDFTTKTGIKTPAYFDLRVIVSYPDIMELTSNMLYDLAVKDSQFDHLCGVPYTALPIATLLSIQAKKPMLMRRKETKSYGTKKSIEGHFKKDDTCLIIEDVITSGSSILETVKDLKNEGLVTTEAAIILDREQGGRENLAKNGIHVKSLFTMRTLIEILKKHKKITDEIVVTVKNYLNETKAPVIEKLMERVILPYEKRIDFATNLVARQLFNIMAPQRKLIYVSQQTSP

Catalytic Activity

diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate
H(+) + orotidine 5'-phosphate = CO2 + UMP

Similarity

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
In the C-terminal section; belongs to the OMP decarboxylase family.

Keywords

Complete proteome   Decarboxylase   Glycosyltransferase   Lyase   Multifunctional enzyme   Pyrimidine biosynthesis   Reference proteome   Transferase  

Feature

chain  Uridine 5'-monophosphate synthase

Uniprot

H9J7Y6   Q2F642   A0A2A4JS88   A0A2H1V5H1   D0ABA9   A0A3S2M065   + More
A0A0L7LET4   A0A194QGS7   A0A212EIU5   A0A194QXI0   S4NGX6   A0A0C9QBM4   A0A1L8DY49   K7IX88   A0A154PPC3   W5JU62   A0A2M4BL31   A0A1B0CG08   A0A2M4BL32   T1DQ66   A0A2M3Z341   A0A182SJA8   A0A2M4AG61   A0A023ES01   A0A0M8ZX99   A0A232FC27   T1GJV6   D1ZZL8   A0A182YGP3   A0A1B6K1V9   A0A1I8QBG3   B4JSX4   E2AMC4   A0A0K8TMZ9   A0A067RKE1   N6ST75   B0W331   A0A182QCX4   A0A1Q3F1P9   Q16QF3   A0A1S4FSU7   A0A182LTP8   A0A182IR66   A0A182HBI2   A0A1B6EQX9   A0A1B6G5N9   A0A340TBA6   A8HN92   E0VTC0   A0A2G8KIM2   A0A2A3E9E0   Q7QB57   B4R153   A0A182UWE0   B4IKL7   A0A182U319   Q01637   A0A336KMV5   B3P2Y9   A0A200PSJ9   A0A1W4VZ99   A0A0L0CLW6   C3ZXV8   A0A1B0A7K6   W4XIB1   Q293K2   A0A2P8Z2I2   A0A1A9YAD0   U5EU74   A0A182FSD4   A0A1L8ECV2   A0A182RYP4   A0A1B6KY40   R7U604   A0A3B0JMA6   B4NH48   A0A0B4J2P4   U5CZ43   B3M2W9   A0A1A9V6T5   A0A158NHC2   A0A2K3E7W9   B4GM06   A0A2I0K5N0   A0A026VYJ3   F4X083   A0A1B0FG80   A0A2I0X6A6   E9IMV3   B4M4V8   E9J1A5   A0A195D1G3   A0A182P6S0   S8DJP2   A0A0M3QXY6   A0A182NLC8   B4KE16   A0A2J7PLT5   A0A2J7PLS4   A0A182JTD1  

Pubmed

19121390    26227816    26354079    22118469    23622113    20075255    + More
20920257    23761445    24945155    28648823    18362917    19820115    25244985    17994087    20798317    26369729    24845553    23537049    17510324    26483478    17932292    20566863    29023486    12364791    14747013    17210077    8444350    10731132    12537572    12537569    2122228    28552780    26108605    18563158    15632085    29403074    23254933    24357323    21347285    24508170    30249741    21719571    26754549    28902843    21282665    23855885   

EMBL

BABH01020166    DQ311230    ABD36175.1    NWSH01000703    PCG74689.1    ODYU01000778    + More
SOQ36083.1    FP102341    CBH09304.1    RSAL01000090    RVE48080.1    JTDY01001365    KOB74068.1    KQ459232    KPJ02651.1    AGBW02014579    OWR41391.1    KQ461155    KPJ08281.1    GAIX01014549    JAA78011.1    GBYB01011813    JAG81580.1    GFDF01002899    JAV11185.1    AAZX01000583    KQ435010    KZC13745.1    ADMH02000361    ETN66833.1    GGFJ01004639    MBW53780.1    AJWK01010631    GGFJ01004638    MBW53779.1    GAMD01002719    JAA98871.1    GGFM01002107    MBW22858.1    GGFK01006452    MBW39773.1    GAPW01001603    JAC11995.1    KQ435837    KOX71473.1    NNAY01000465    OXU28182.1    CAQQ02123440    KQ971338    EFA01834.2    GECU01002298    JAT05409.1    CH916373    EDV94864.1    GL440811    EFN65415.1    GDAI01002303    JAI15300.1    KK852421    KDR24287.1    APGK01057391    KB741280    KB631604    ENN70894.1    ERL84613.1    DS231830    EDS30739.1    AXCN02000121    GFDL01013586    JAV21459.1    CH477750    EAT36623.1    AXCM01003761    JXUM01032039    JXUM01032040    KQ560942    KXJ80255.1    GECZ01029408    JAS40361.1    GECZ01012037    JAS57732.1    DS496108    EDP09488.1    DS235761    EEB16626.1    MRZV01000554    PIK47842.1    KZ288313    PBC28347.1    AAAB01008880    EAA08525.3    CM000364    EDX12140.1    CH480853    EDW51621.1    L00968    AE014297    AY058714    X54230    UFQS01000645    UFQT01000410    UFQT01000645    SSX05697.1    SSX24054.1    CH954181    EDV48303.1    MVGT01004176    OVA01166.1    JRES01000211    KNC33256.1    GG666717    EEN42618.1    AAGJ04046045    AAGJ04046046    AAGJ04046047    CM000070    EAL29213.1    PYGN01000224    PSN50714.1    GANO01001613    JAB58258.1    GFDG01002333    JAV16466.1    GEBQ01023656    JAT16321.1    AMQN01001733    KB305005    ELU01511.1    OUUW01000007    SPP83397.1    CH964272    EDW84545.1    KI392503    ERN15444.1    CH902617    EDV43499.1    ADTU01015566    CM008962    PNW88880.1    CH479185    EDW38580.1    PGOL01000914    PKI63016.1    KK107566    QOIP01000006    EZA48873.1    RLU21950.1    GL888493    EGI60148.1    CCAG010021081    KZ502111    PKU83433.1    GL764255    EFZ18097.1    CH940652    EDW59669.1    GL767586    EFZ13419.1    KQ976973    KYN06707.1    AUSU01008136    EPS59712.1    CP012526    ALC46689.1    CH933806    EDW16037.1    NEVH01024423    PNF17279.1    PNF17277.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000037510    UP000053268    UP000007151    + More
UP000053240    UP000002358    UP000076502    UP000000673    UP000092461    UP000075901    UP000053105    UP000215335    UP000015102    UP000007266    UP000076408    UP000095300    UP000001070    UP000000311    UP000027135    UP000019118    UP000030742    UP000002320    UP000075886    UP000008820    UP000075883    UP000075880    UP000069940    UP000249989    UP000075920    UP000009046    UP000230750    UP000242457    UP000007062    UP000000304    UP000075903    UP000001292    UP000075902    UP000000803    UP000008711    UP000195402    UP000192221    UP000037069    UP000001554    UP000092445    UP000007110    UP000001819    UP000245037    UP000092443    UP000069272    UP000075900    UP000014760    UP000268350    UP000007798    UP000005203    UP000017836    UP000007801    UP000078200    UP000005205    UP000006906    UP000008744    UP000233551    UP000053097    UP000279307    UP000007755    UP000092444    UP000233837    UP000008792    UP000078542    UP000075885    UP000092553    UP000075884    UP000009192    UP000235965    UP000075881   

PRIDE

H9J7Y6    Q2F642    Q01637   

Pfam

PF00156   Pribosyltran        + More
PF00215   OMPdecase
PF02138   Beach
PF00400   WD40
PF01728   FtsJ
PF06479   Ribonuc_2-5A
PF00069   Pkinase

Interpro

IPR013785   Aldolase_TIM        + More
IPR004467   Or_phspho_trans_dom       
IPR023031   OPRT       
IPR014732   OMPdecase       
IPR011060   RibuloseP-bd_barrel       
IPR000836   PRibTrfase_dom       
IPR018089   OMPdecase_AS       
IPR001754   OMPdeCOase_dom       
IPR029057   PRTase-like       
IPR036372   BEACH_dom_sf       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR036322   WD40_repeat_dom_sf       
IPR000409   BEACH_dom       
IPR002877   rRNA_MeTrfase_FtsJ_dom       
IPR015507   rRNA-MeTfrase_E       
IPR029063   SAM-dependent_MTases       
IPR033523   IRE2       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR010513   KEN_dom       
IPR018997   PUB_domain       
IPR018391   PQQ_beta_propeller_repeat       
IPR038357   KEN_sf       
IPR011047   Quinoprotein_ADH-like_supfam       
IPR000719   Prot_kinase_dom       

SUPFAM

SSF53271   SSF53271        + More
SSF51366   SSF51366       
SSF50978   SSF50978       
SSF81837   SSF81837       
SSF53335   SSF53335       
SSF56112   SSF56112       
SSF50998   SSF50998       

Gene 3D

3.20.20.70     1.10.1540.10     2.130.10.10     1.20.1440.180    

CDD

cd06223  PRTases_typeI

ProteinModelPortal

H9J7Y6   Q2F642   A0A2A4JS88   A0A2H1V5H1   D0ABA9   A0A3S2M065   + More
A0A0L7LET4   A0A194QGS7   A0A212EIU5   A0A194QXI0   S4NGX6   A0A0C9QBM4   A0A1L8DY49   K7IX88   A0A154PPC3   W5JU62   A0A2M4BL31   A0A1B0CG08   A0A2M4BL32   T1DQ66   A0A2M3Z341   A0A182SJA8   A0A2M4AG61   A0A023ES01   A0A0M8ZX99   A0A232FC27   T1GJV6   D1ZZL8   A0A182YGP3   A0A1B6K1V9   A0A1I8QBG3   B4JSX4   E2AMC4   A0A0K8TMZ9   A0A067RKE1   N6ST75   B0W331   A0A182QCX4   A0A1Q3F1P9   Q16QF3   A0A1S4FSU7   A0A182LTP8   A0A182IR66   A0A182HBI2   A0A1B6EQX9   A0A1B6G5N9   A0A340TBA6   A8HN92   E0VTC0   A0A2G8KIM2   A0A2A3E9E0   Q7QB57   B4R153   A0A182UWE0   B4IKL7   A0A182U319   Q01637   A0A336KMV5   B3P2Y9   A0A200PSJ9   A0A1W4VZ99   A0A0L0CLW6   C3ZXV8   A0A1B0A7K6   W4XIB1   Q293K2   A0A2P8Z2I2   A0A1A9YAD0   U5EU74   A0A182FSD4   A0A1L8ECV2   A0A182RYP4   A0A1B6KY40   R7U604   A0A3B0JMA6   B4NH48   A0A0B4J2P4   U5CZ43   B3M2W9   A0A1A9V6T5   A0A158NHC2   A0A2K3E7W9   B4GM06   A0A2I0K5N0   A0A026VYJ3   F4X083   A0A1B0FG80   A0A2I0X6A6   E9IMV3   B4M4V8   E9J1A5   A0A195D1G3   A0A182P6S0   S8DJP2   A0A0M3QXY6   A0A182NLC8   B4KE16   A0A2J7PLT5   A0A2J7PLS4   A0A182JTD1  

PDB

2WNS     E-value=5.21507e-47,     Score=471

KEGG

692850    K13421 uridine monophosphate synthetase [EC:2.4.2.10 4.1.1.23] | (RefSeq) uridine 5'-monophosphate s

PATHWAY

00240    Pyrimidine metabolism - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004590   GO:0009116   GO:0006207   GO:0044205   GO:0004588   GO:0006221   GO:0006222   GO:0019856   GO:0008168   GO:0001510   GO:0005829   GO:0046686   GO:0016036   GO:0005524   GO:0004540   GO:0006397   GO:0004672   GO:0016021   GO:0016500   GO:0004930   GO:0006915   GO:0016651   GO:0046835   GO:0006281   GO:0006259  

PANTHER

PTHR13954:SF15  

Length:

251

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.36901

Exp number, first 60 AAs:

0.0052

Total prob of N-in:

0.01597

outside

1  -  251

 

 

Pi

0

Theta

0

Tajima's D

0

CLR

0

CSRT

0

Interpretation

Uncertain