Gene

KWMTBOMO16564  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012083

Annotation

PREDICTED:_ancient_ubiquitous_protein_1-like_[Bombyx_mori]

Location

Bomo_Scaf018(+):7236-15598      View in EpiBrowser

Full name

Ancient ubiquitous protein 1      

Location in the cell

Mitochondrial   Reliability : 1.853 PlasmaMembrane   Reliability : 1.336

CDS

ATGGTGATCAGAATATTCCTGGGTGTGATATTATGGATTGCATCAATTATATTGCCCAACAAATGGGCAGTCAGTCACATGTTAACTACTTTGGCTTGTTGGACTTTTGGTGTCTATGTGAAGCTCAAAGGACAAAGAGACCCAAGATGTAGTGTGTTGGTTGCTAACTATGTGACATGTTTCGATTCTCTTGCAGCTGCACATGTCTTTGGTACCATAAGTTTGAAAAGATGGAAGTTGCCACCATTTTTCGCATCGACGTTGGGTATAAAGAACGCCTCACAATTTTCTAAAAAGCAACATTTCTCTGAGGTGCCAACAAAGCCTGTGTTGATACAACCAGAAAGTGGACCCACGAACGGTAAAGCGGTGTTACGTTTCACAGATTGGCCATTCCAGATTAAAAGCAATGTGCAGCCGGTCGCCATCACCGTGGAGCGCGCCTTCACGCGTGCGACGGTGCAGCGGCGCCAGTACAGCGCGCGCTTCCCGTGGCGCGACGCGGCGTGGTTCCTGCTGTCGCCCGCCACCGTGTACACGCTGCACGCGCTGCCGCCGCTGCGCTGGGACGCGGGGGACGTCGGGGACCGCTGCCGGGCCGCCGTCGCAGAGGCGCTGCAGGTGGAAGTGTCGGAGCTGACGTGGGACGAGTTGTTCGCGGGGAGGCGCGTCCGGGCCGTCGCCGACCGCGCCGCCCCGCTCGTGCGCCTCGGGAACCAGGTCAAGGAAGTGTTGCCAGCCGTCCCACTCAAAACTATTCTCCAGGATTTAGAAAGAACTGGAAGCGTCGACATGACGATCACGAATTTCCTCGAGGGCGTGACTCCGTACGTCCCCGAAGATGCGGCCCCCGGACCGCAGCCCGGGCCCTCGGCGCCGCGCTACGTCGCGCCGCCGCCCACAGGAACCTTCCCGAAGACGGCCAAGGAACGACAGCTGAGCTTCGAGGAGCGAAAAGCTCAGATGATAGCGGAAGCTCGCAGGAGATATATCGAGAAACACGGACTGAACGTAACGTAG

Protein

MVIRIFLGVILWIASIILPNKWAVSHMLTTLACWTFGVYVKLKGQRDPRCSVLVANYVTCFDSLAAAHVFGTISLKRWKLPPFFASTLGIKNASQFSKKQHFSEVPTKPVLIQPESGPTNGKAVLRFTDWPFQIKSNVQPVAITVERAFTRATVQRRQYSARFPWRDAAWFLLSPATVYTLHALPPLRWDAGDVGDRCRAAVAEALQVEVSELTWDELFAGRRVRAVADRAAPLVRLGNQVKEVLPAVPLKTILQDLERTGSVDMTITNFLEGVTPYVPEDAAPGPQPGPSAPRYVAPPPTGTFPKTAKERQLSFEERKAQMIAEARRRYIEKHGLNVT

Description

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.

Subunit

Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM.

Similarity

Belongs to the AUP1 family.

Keywords

Complete proteome   Endoplasmic reticulum   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Ubl conjugation pathway   3D-structure   Acetylation   Alternative splicing   Phosphoprotein  

Feature

chain  Ancient ubiquitous protein 1
splice variant  In isoform 2.

Uniprot

H9JRC3   A0A2A4K845   A0A212F821   A0A194QR67   A0A3S2M9U1   A0A194QAY6   + More
D6WWW6   A0A2Z6FLD7   V5GFZ1   A0A1Y1N0D0   N6UAT9   A0A2J7QR91   A0A2J7QR90   E1ZXZ9   A0A023FAJ5   A0A224XQZ4   A0A0P4W545   R4FME3   A0A1W7RAY6   A0A232EKD5   A0A1B6G5A6   A0A069DU96   A0A0V0G4S0   A0A1B6KFF7   A0A0J7NCH3   A0A1S3H109   A0A2A3E6B4   A0A088AAK4   A0A0T6B5Y3   E2BUN6   A0A0A9VVG2   F4WCN5   M3Y9Q9   C3Y446   A0A151WY16   A0A195DFA4   A0A1S3GQ43   A0A195CVE3   A0A3B5BN49   A0A195ET26   A0A3Q3JQE0   K7JAV3   A0A158NHT8   A0A3B4YNB6   A0A3B4UHM2   V3ZNU5   H2T0T8   A0A195BVU4   A0A0L7QT10   A0A026W5G1   G5AXE7   A0A0P6J812   A0A0F8AFJ3   H0W5Z0   Q6PBN5   A0A3P9N8C1   A0A3Q1ES39   A0A3B3CBZ7   A0A3P8XIG9   A0A1A8G5G4   A0A1A8PKL4   A0A3B3XAY8   A0A1A8S2A2   A0A0P7WQI8   A0A2I4BDP7   A0A1W4ZMB1   A0A1A8B639   A0A146MZT2   A0A315VJZ4   A0A250YHG6   A0A1A8KZ50   A0A2U3VU15   H3AR98   A0A384CV96   A0A1A7Z196   A0A3Q7NS71   A0A3Q7V5L5   A0A1A8EGW0   F6XB90   R7U2I7   A0A2U3XV97   A0A2Y9HT56   W4ZDZ0   I3LXV8   M3W781   G1PU68   L9KS43   A0A2Y9JHL8   A0A341D3Z8   A0A384A9U6   A0A2F0B593   H0WHT3   G1T9C1   H2QI70   Q9Y679   A0A2Y9ETB8   A8KAQ6  

Pubmed

19121390    22118469    26354079    18362917    19820115    28004739    + More
23537049    20798317    25474469    27129103    28648823    26334808    25401762    26823975    21719571    18563158    20075255    21347285    23254933    21551351    24508170    30249741    21993625    25835551    21993624    29451363    25069045    29703783    28087693    9215903    16341006    17975172    23385571    16136131    11042152    14702039    15489334    12042322    18691976    18669648    18711132    19413330    20068231    21269460    22223895    22814378    23186163   

EMBL

BABH01016087    BABH01016088    BABH01016089    NWSH01000052    PCG80176.1    AGBW02009812    + More
OWR49859.1    KQ461185    KPJ07465.1    RSAL01000006    RVE54334.1    KQ459252    KPJ02155.1    KQ971361    EFA08762.1    LC384850    BBE28993.1    GALX01005567    JAB62899.1    GEZM01016147    JAV91362.1    APGK01042192    KB741002    KB631903    ENN75747.1    ERL87036.1    NEVH01011922    PNF31095.1    PNF31096.1    GL435158    EFN73939.1    GBBI01000774    JAC17938.1    GFTR01006027    JAW10399.1    GDKW01000097    JAI56498.1    ACPB03009974    GAHY01001043    JAA76467.1    GFAH01000076    JAV48313.1    NNAY01003812    OXU18819.1    GECZ01012276    JAS57493.1    GBGD01001612    JAC87277.1    GECL01003066    JAP03058.1    GEBQ01029806    JAT10171.1    LBMM01006854    KMQ90275.1    KZ288374    PBC26709.1    LJIG01009574    KRT82808.1    GL450732    EFN80589.1    GBHO01045401    GBRD01014303    GDHC01015658    JAF98202.1    JAG51523.1    JAQ02971.1    GL888070    EGI68215.1    AEYP01010579    GG666484    EEN65072.1    KQ982662    KYQ52647.1    KQ980905    KYN11522.1    KQ977259    KYN04605.1    KQ981979    KYN31311.1    AAZX01017979    ADTU01001748    KB201977    ESO93048.1    KQ976398    KYM92702.1    KQ414755    KOC61777.1    KK107403    QOIP01000011    EZA51312.1    RLU16719.1    JH167395    EHB01708.1    GEBF01003241    JAO00392.1    KQ042260    KKF16702.1    AAKN02036835    BC065447    BC059643    HAEB01019811    SBQ66338.1    HAEF01002135    HAEG01008467    SBR81945.1    HAEI01004260    HAEH01021019    SBS11683.1    JARO02007574    KPP63794.1    HADY01023465    HAEJ01010811    SBP61950.1    GCES01161149    JAQ25173.1    NHOQ01001578    PWA23482.1    GFFW01001711    JAV43077.1    HAED01001599    HAEE01016879    SBR36929.1    AFYH01154083    AFYH01154084    AFYH01154085    AFYH01154086    AFYH01154087    AFYH01154088    AFYH01154089    AFYH01154090    AFYH01154091    AFYH01154092    HADX01014430    SBP36662.1    HADZ01005287    HAEA01015844    SBQ44325.1    AAEX03010965    AMQN01009657    KB305899    ELU00555.1    AAGJ04129253    AGTP01057538    AANG04002548    AAPE02033107    KB320756    ELW63997.1    NTJE010074777    MBV98137.1    AAQR03101800    AAGW02006964    AACZ04063590    GABC01004058    GABF01009060    GABD01004021    GABE01005718    NBAG03000335    JAA07280.1    JAA13085.1    JAA29079.1    JAA39021.1    PNI38888.1    AF100754    AF100753    AF100746    AF165515    AK023983    CH471053    BC001658    BC033646    AK293121    BAF85810.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000283053    UP000053268    + More
UP000007266    UP000019118    UP000030742    UP000235965    UP000000311    UP000015103    UP000215335    UP000036403    UP000085678    UP000242457    UP000005203    UP000008237    UP000007755    UP000000715    UP000001554    UP000075809    UP000078492    UP000081671    UP000078542    UP000261400    UP000078541    UP000261600    UP000002358    UP000005205    UP000261360    UP000261420    UP000030746    UP000005226    UP000078540    UP000053825    UP000053097    UP000279307    UP000006813    UP000005447    UP000000437    UP000242638    UP000257200    UP000261560    UP000265140    UP000261480    UP000034805    UP000192220    UP000192224    UP000265000    UP000245340    UP000008672    UP000261680    UP000286641    UP000286642    UP000002254    UP000014760    UP000245341    UP000248481    UP000007110    UP000005215    UP000011712    UP000001074    UP000011518    UP000248482    UP000252040    UP000261681    UP000005225    UP000001811    UP000002277    UP000005640    UP000248484   

PRIDE

H9JRC3    Q9Y679    A8KAQ6   

Pfam

PF02845   CUE

Interpro

IPR003892   CUE        + More
IPR002123   Plipid/glycerol_acylTrfase       

ProteinModelPortal

H9JRC3   A0A2A4K845   A0A212F821   A0A194QR67   A0A3S2M9U1   A0A194QAY6   + More
D6WWW6   A0A2Z6FLD7   V5GFZ1   A0A1Y1N0D0   N6UAT9   A0A2J7QR91   A0A2J7QR90   E1ZXZ9   A0A023FAJ5   A0A224XQZ4   A0A0P4W545   R4FME3   A0A1W7RAY6   A0A232EKD5   A0A1B6G5A6   A0A069DU96   A0A0V0G4S0   A0A1B6KFF7   A0A0J7NCH3   A0A1S3H109   A0A2A3E6B4   A0A088AAK4   A0A0T6B5Y3   E2BUN6   A0A0A9VVG2   F4WCN5   M3Y9Q9   C3Y446   A0A151WY16   A0A195DFA4   A0A1S3GQ43   A0A195CVE3   A0A3B5BN49   A0A195ET26   A0A3Q3JQE0   K7JAV3   A0A158NHT8   A0A3B4YNB6   A0A3B4UHM2   V3ZNU5   H2T0T8   A0A195BVU4   A0A0L7QT10   A0A026W5G1   G5AXE7   A0A0P6J812   A0A0F8AFJ3   H0W5Z0   Q6PBN5   A0A3P9N8C1   A0A3Q1ES39   A0A3B3CBZ7   A0A3P8XIG9   A0A1A8G5G4   A0A1A8PKL4   A0A3B3XAY8   A0A1A8S2A2   A0A0P7WQI8   A0A2I4BDP7   A0A1W4ZMB1   A0A1A8B639   A0A146MZT2   A0A315VJZ4   A0A250YHG6   A0A1A8KZ50   A0A2U3VU15   H3AR98   A0A384CV96   A0A1A7Z196   A0A3Q7NS71   A0A3Q7V5L5   A0A1A8EGW0   F6XB90   R7U2I7   A0A2U3XV97   A0A2Y9HT56   W4ZDZ0   I3LXV8   M3W781   G1PU68   L9KS43   A0A2Y9JHL8   A0A341D3Z8   A0A384A9U6   A0A2F0B593   H0WHT3   G1T9C1   H2QI70   Q9Y679   A0A2Y9ETB8   A8KAQ6  

PDB

2EKF     E-value=1.95073e-08,     Score=140

KEGG

101737172    K19716 ancient ubiquitous protein 1 | (RefSeq) ancient ubiquitous protein 1-like

GO

GO:0016021   GO:0030176   GO:0043130   GO:0000839   GO:0030433   GO:0097027   GO:0016020   GO:0016746   GO:0030970   GO:0005737   GO:0070062   GO:0005515   GO:0007186   GO:0016500   GO:0004930   GO:0006915   GO:0016651   GO:0046835   GO:0006281   GO:0006259  

Subcellular location

Endoplasmic reticulum membrane  

Length:

339

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

54.19903

Exp number, first 60 AAs:

41.0672

Total prob of N-in:

0.90839

POSSIBLE N-term signal

sequence

inside

1  -  1

TMhelix

2  -  19

outside

20  -  22

TMhelix

23  -  40

inside

41  -  52

TMhelix

53  -  75

outside

76  -  339

 

 

Pi

2.960212

Theta

24.572353

Tajima's D

-0.487858

CLR

0.136295

CSRT

0.251487425628719

Interpretation

Uncertain