SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO16488
Pre Gene Modal
BGIBMGA005633
Annotation
PREDICTED:_thrombospondin_type-1_domain-containing_protein_7A-like_[Bombyx_mori]
Full name
Thrombospondin type-1 domain-containing protein 7A      
Location in the cell
Extracellular   Reliability : 3.591
 

Sequence

CDS
ATGCGATTAGTGCACGGCGGACCCAGCTGTGGCCCTCGACAAGAGACCAGAGACTGTCCTGTAGCCAAGACCTGCAGGTCTAAAGACGCAGTCTGGATCGCCGGAGAGTGGAGTACTTGCAAACTGTCTCCCGACGAGAGGTGCGGCGTTGGACTAAGGATCAGAAGTATCTGGTGCGGTTCAGATTCACATAGAGTAGAAGCTGGTGCCTGTGCTGGACAGTTAATACCTCGCAGCGTGGCCGACTGTCAGGTGCCTTGTGAACACTCCTCGCCTCCCACTTGCGATGTCATCTGCGCTGATCCGTTAAGATACTTGGACGCCTCAGATCCAGACATCATGAGTTGCGTCTGCAAGAATGTTTCCTTAGAGTTGTTGCCGGCCGACTCCGACTGCATCCTTCCTCCAGGATTGGAATGTGGAGAGGGTAGGGCTCTGCGCGCGGCTCGTTGTATGGTGGCTGGACGAGATGTGCCCATGGACGTATGCAAGAAATTTCATCCACTCACAGGACCCAGCAGGGTTCGTGAAGCGACAACCGACGGATACTCGTACGACAATGAGTTCCTGAGTCTGCTCCGTGGGGCGTGCACGGTGCGCTGTGCGCGCGACTGTACCACCGGGGAGTGGGGCGAGTGGGGACCGTGCAATGCAGAGCCCGGCTCGCGGGCCGCCTTTAGATTCAGAACAAGGGAAGTGATGGAGGAGGGTTCCGCGGGGGGCCGCGAGTGCGGCGCGACCCTGCAGCGCTCGTCCTGCTCGGTGGGGTCCCCCCGCTGGGCCGTGGGCGAGTGGGCCCCCTGCACGCCGCCCGACGCGCTGTGCGGACATGCCGTAATCAACCGGACCGTTTCCTGCGTCGACGCAGACGGCAAGTGGCTGGAAGACGCGACTTGTGAGGCGTCCGGCGCGGGACCAGCGCCGGCGCGCGAGGCCACCTGCCGGGCCCCGTGTCCCGGGGACTGCGTCGTCAGCGCCTGGTCAGATTGGAGTCCTTGCGAGCAGACAAAGTGGGGGGGGCGCCGCGACCGTACGCGCGTGGTGCTGCGGGGAGCGCGGGCGGGCGGGGGTGCGTGCCCGCACCTCGTGGCGGCCGAGCGGTGCGCGCCCCACGCACACTCCTGGCACCTCGCGCCCTGGGACGACTGTCAGCCTCTCGGTGGTTCGCCTTGTGGCGAAGGGACGAAAAAACGCGCCGTTCGATGTCTGCGCGGCGATGGGAAATTCGTTAACGACTCTTTCTGCCCTAACAAAACGGCGATAGAAGCCAAAGAATCGTGGTGCTACGTGCCGTGCGGCGTCGACTGTGAGGTCGGAGAGTGGAGCGGCTGGGACAGCTCTGCTTGCTCCTGCGGAGACGCTTCCTCCGCAAGACACATGCGCCGGACCAGGTAA
Protein
MRLVHGGPSCGPRQETRDCPVAKTCRSKDAVWIAGEWSTCKLSPDERCGVGLRIRSIWCGSDSHRVEAGACAGQLIPRSVADCQVPCEHSSPPTCDVICADPLRYLDASDPDIMSCVCKNVSLELLPADSDCILPPGLECGEGRALRAARCMVAGRDVPMDVCKKFHPLTGPSRVREATTDGYSYDNEFLSLLRGACTVRCARDCTTGEWGEWGPCNAEPGSRAAFRFRTREVMEEGSAGGRECGATLQRSSCSVGSPRWAVGEWAPCTPPDALCGHAVINRTVSCVDADGKWLEDATCEASGAGPAPAREATCRAPCPGDCVVSAWSDWSPCEQTKWGGRRDRTRVVLRGARAGGGACPHLVAAERCAPHAHSWHLAPWDDCQPLGGSPCGEGTKKRAVRCLRGDGKFVNDSFCPNKTAIEAKESWCYVPCGVDCEVGEWSGWDSSACSCGDASSARHMRRTR

Summary

Description
Thrombospondin type-1 domain-containing protein 7A: Plays a role in actin cytoskeleton rearrangement.
Thrombospondin type-1 domain-containing protein 7A, soluble form: The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.
Keywords
Angiogenesis   Cell membrane   Cell projection   Coiled coil   Complete proteome   Differentiation   Disulfide bond   Glycoprotein   Membrane   Polymorphism   Reference proteome   Repeat   Secreted   Signal   Transmembrane   Transmembrane helix  
Feature
chain  Thrombospondin type-1 domain-containing protein 7A
sequence variant  In dbSNP:rs2074599.
EMBL
BABH01020186    BABH01020187    BABH01020188    BABH01020189    NWSH01000227    PCG78210.1    + More
RSAL01000090    RVE48087.1    AGBW02013517    OWR43277.1    ODYU01001380    SOQ37470.1    KQ459232    KPJ02643.1    KQ461155    KPJ08289.1    KC469893    AGC92705.2    FP102340    FP102341    CBH09295.1    JTDY01000925    KOB75410.1    GEDC01006947    JAS30351.1    GGMS01016719    MBY85922.1    GGMS01001126    MBY70329.1    GFXV01004083    MBW15888.1    ABLF02039066    GGMR01017097    MBY29716.1    LRGB01000158    KZS20544.1    GDIP01019162    JAM84553.1    GDIP01079827    JAM23888.1    GDIP01195364    JAJ28038.1    GDIP01235857    GDIP01154068    GDIP01152470    GDIP01122771    GDIP01119175    GDIP01111530    GDIP01079826    JAI87544.1    GDIP01202913    GDIP01083972    GDIP01059531    JAM44184.1    GDIP01195363    JAJ28039.1    GDIP01079825    JAM23890.1    GDIP01235859    GDIP01153319    GDIP01122772    GDIP01119174    GDIP01111529    GDIP01079828    JAM23887.1    GDIP01235858    JAI87543.1    NEVH01001345    PNF43027.1    GDIP01229809    GDIP01169962    GDIP01062879    GDIP01061526    JAM40836.1    GDIP01159616    GDIP01083973    GDIP01059533    JAJ63786.1    GDIP01229808    GDIP01169961    GDIP01062878    GDIP01061525    JAM40837.1    PNF43028.1    PNF43026.1    GDIQ01113873    JAL37853.1    GDIP01105269    JAL98445.1    GDIP01105270    JAL98444.1    GL732578    EFX75023.1    KK852427    KDR24128.1    GDIP01182213    JAJ41189.1    GDIP01182214    JAJ41188.1    GDIQ01069381    JAN25356.1    JH432003    CM004482    OCT63440.1    CAAE01014699    CAG02749.1    HACA01004433    CDW21794.1    GDIQ01039751    JAN54986.1    GG666481    EEN65523.1    KE163803    EPQ13839.1    AAGJ04102198    AAGJ04102199    AAGJ04102200    AAGJ04102201    AAGJ04102202    AAGJ04102203    AMGL01085905    AMGL01085906    AMGL01085907    AMGL01085908    AMGL01085909    AMGL01085910    AMGL01085911    AMGL01085912    AACZ04068618    AACZ04068619    AC188550    AC188559    AC191956    AJFE02087991    AJFE02087992    AJFE02087993    AJFE02087994    JH881229    ELR55631.1    AC004141    AC004160    AC004614    AC010908    AC073109    AK092252    AB023177    NBAG03000259    PNI57866.1    PNI57867.1    KF510969    AEYP01013169    AEYP01013170    AEYP01013171    AEYP01013172    AEYP01013173    AEYP01013174    AEYP01013175    AEYP01013176    AEYP01013177    AEYP01013178    AHZZ02022988    AHZZ02022989    AHZZ02022990    AHZZ02022991    JSUE03028733    JSUE03028734    JSUE03028735    JSUE03028736    JSUE03028737    JSUE03028738    JSUE03028739    JSUE03028740    JSUE03028741    CABD030049880    CABD030049881    CABD030049882    CABD030049883    CABD030049884    CABD030049885    CABD030049886    CABD030049887    CABD030049888    CABD030049889    CM001255    EHH17482.1    AKHW03006853    KYO18076.1    AANG04003224    CM001278    EHH52309.1    AQIA01047103    AQIA01047104    AQIA01047105    AQIA01047106    AQIA01047107    AQIA01047108    AQIA01047109    AQIA01047110    AQIA01047111    AQIA01047112    JU333416    AFE77171.1    ADFV01001234    ADFV01001235    ADFV01001236    ADFV01001237    ADFV01001238    ADFV01001239    ADFV01001240    ADFV01001241    ADFV01001242    ADFV01001243    AQIB01018610    AAPE02008895    AAPE02008896    AAPE02008897    AAPE02008898    AAPE02008899   
Pfam
PF00090   TSP_1
Interpro
IPR000884   TSP1_rpt        + More
IPR036383   TSP1_rpt_sf       
SUPFAM
SSF82895   SSF82895       
Gene 3D

Ontologies

Topology

Subcellular location
Cell membrane   Detected on podocyte foot processes.   With evidence from 1 publications.
Cell projection   Detected on podocyte foot processes.   With evidence from 1 publications.
Secreted   Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form.   With evidence from 4 publications.
Length:
464
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00019
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00688
outside
1  -  464
 
 

Population Genetic Test Statistics

Pi
22.638602
Theta
31.117866
Tajima's D
-0.859383
CLR
0.054346
CSRT
0.164041797910104
Interpretation
Uncertain
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