Gene

KWMTBOMO16417

Pre Gene Modal

BGIBMGA013834

Annotation

UDP-glycosyltransferase_UGT340C2_precursor_[Bombyx_mori]

Location

Bomo_Chr28(-):9125613-9133816      View in EpiBrowser

Full name

UDP-glucuronosyltransferase       + More
Ecdysteroid UDP-glucosyltransferase      

Location in the cell

PlasmaMembrane   Reliability : 2.298

CDS

ATGAAGTCAATAGCTTTATACTTCTTGTTATCAATTTTCGGTGTAGAATCGGCTAGGATTTTAGGAGTGTTTCCTATGCCATCAATAAGTCATCAAGTTGTCTTTCGAGCTCTGAGCATGGAGCTAGCCAGGAGAGGACACGAATTGGTGATCATAACGACAGACCCTGCCCTGCCAAAGAATAGACCGAAAGATAATATTACTGAGATAGATATTAGTCGTTCTTACCAACTTTTGCGTAAATTCGATGAATATGCTGAAAAAACTCAGCCGATTCAGAAACGTGGAGTGATTTCTGGAGTGGAAATAATGATCAGTGAGCATGCTGCAGGGGCCATGTTTATGCTGATGGCGGAAGTATTCAACAGCGAAGAAGTGAACCAGTTACTTCAAGACAAGAACCAGAAGTTCGATTTAATCATATCAGAAGCCATTATGAGTTTCCATTTGATAATCGGGAAAATCTTCAACGCGCCAGTTATTCTATTCTCGTCTTTGTATGGTCTTCCTGAAACTTTCGAAACAGTGGGGGCCGTGACGCGCCATCCGATTTTATATCCCCATTTATTTAGGAATAAGTTTACAGATTTAACATTATTCGAGAAAATCCGCGAGGTCTACTATGAGGCTCGATTGACCTTGCTGTATTGGGGTCTTCAGAATGCTGAAAATAATTACCTGAAGTCCCGTTTCGGAGAGAACGCACCTACAGTACAACAATTAAGGGAGAATGTCTGTATGGTGTTTTTGAATTCGTTCCCTCTCTTTGATAACAACCGACCGGTGCCACCTAATGTGGTGTATTTGGGAGCTTTGCACTTGCAACCTGTTAAGGAATTGCCTGAGGACCTAAAGACATATCTGGATAACTCTAAACGTGGTGTGGTATACGCCAGCTTGGGGACGAACGTGCGTGCTTCAGCCATGAGCAAGGAGTTTCTGGAAACTTTCATCAAAGCTTTCGAAGCTCTTCCCTATGACATATTGTGGAAAATCGATGGAGATGACATAAAGGCGTTTCCAAAGAATGTTCGTGTGCAAAAATGGTTCCCCCAAAGAGATTTATTAGTTCATCCAAACATTGTGGCCTTTGTCACACAAGGCGGGCTCCAATCAACTGATGAAGCGATTGATGCCGGAGTACCTCTAGTCGGAATACCTTTAATCGCAGATCAGTGGTACAATGTTAATAAATACAAAGAACTTGGAATCGGTATCAGTTTGGATTCATTCACAGTTAATGCTGAAGAATTGGCTCAAGCTGTCAAAACTGTGGCTACAGACAAAAGTTTTAAGAACAACATCGCGAAAATCAAAACCCTGATGCACGATCAGCCTCTGAAGCCATTAGAACGCGCGGTCTGGTGGACGGAGCATGTTCTTCGAAACGGAGGATCCAAACACCTTCGTTCGCCAGCGGCCAACATGAATTACTCAGAATATTTAATGTTAGACGTTGTCTTAGCCTTATTATTTTTATTCTTTACTGTGATATCGATACTCGCTCTCATTGCGTACAAGCTTTTTGGTATATTAAAGAAAATGACCTTTAGTGGTAAATTAAAAAGTAGCTGA

Protein

MKSIALYFLLSIFGVESARILGVFPMPSISHQVVFRALSMELARRGHELVIITTDPALPKNRPKDNITEIDISRSYQLLRKFDEYAEKTQPIQKRGVISGVEIMISEHAAGAMFMLMAEVFNSEEVNQLLQDKNQKFDLIISEAIMSFHLIIGKIFNAPVILFSSLYGLPETFETVGAVTRHPILYPHLFRNKFTDLTLFEKIREVYYEARLTLLYWGLQNAENNYLKSRFGENAPTVQQLRENVCMVFLNSFPLFDNNRPVPPNVVYLGALHLQPVKELPEDLKTYLDNSKRGVVYASLGTNVRASAMSKEFLETFIKAFEALPYDILWKIDGDDIKAFPKNVRVQKWFPQRDLLVHPNIVAFVTQGGLQSTDEAIDAGVPLVGIPLIADQWYNVNKYKELGIGISLDSFTVNAEELAQAVKTVATDKSFKNNIAKIKTLMHDQPLKPLERAVWWTEHVLRNGGSKHLRSPAANMNYSEYLMLDVVLALLFLFFTVISILALIAYKLFGILKKMTFSGKLKSS

Description

Catalyzes the transfer of glucose from UDP-glucose to ecdysteroids which are insect molting hormones.

Catalytic Activity

glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP

Similarity

Belongs to the UDP-glycosyltransferase family.

Feature

chain  UDP-glucuronosyltransferase

Uniprot

G9LPT6   H9JWC0   G9LPT5   A0A1L8D6H9   A0A2H4WB54   A0A2H4WB68   + More
A0A3S2NVG0   A0A2H4WB70   A0A2H4WB72   A0A1L8D6H2   A0A1L8D6H1   A0A0L7L568   A0A3S2TGR4   A0A2W1BL20   G9LPP3   A0A2H1W7S2   M4M1W9   G9LPS4   A0A2W1B9W6   G9LPN5   G9LPS9   A0A140EA35   B7TZA3   G9LPP4   A0A191T2J5   A0A191T1N0   A0A191T1K8   G9LPN7   A0A2A4JWQ0   A0A191T1L8   A0A0N1IB27   G9LPP0   G9LPP1   A0A2W1BCY8   A0A2W1BDA5   A0A2W1BHP8   A0A2W1B3X2   A0A024AGF9   G9LPP5   A0A191T1K4   A0A2H1VUM4   G9LPS6   A0A2H1WTF5   A0A191T2G3   H9JWB9   A0A191T2J2   A0A024AG00   A0A191T2F8   A0A191T1L3   A0A2W1B485   G9LPN9   A0A2W1B475   A0A2W1BEB8   A0A0N0P9C8   A0A0N0PE43   G9LPN6   G9LPN2   A0A024AH14   A0A2W1B7N5   A0A2W1BE55   A0A2H4WB73   A0A2W1B3V4   A0A2W1B8D3   A0A2H4WB75   G9LPT1   A0A2W1BEA5   A0A2W1BHY3   G9LPS5   A0A2W1B675   A0A0N1ICS6   A0A1L8D6T8   A0A2W1B8G2   G9LPN8   A0A2W1BBH1   A0A2I6RJL8   Q1HPX7   A0A2A4IVU8   G9LPN3   A0A0N1I2R8   A0A346TPQ3   A0A024AGL3   A0A2W1BA70   A0A2H1V761   G9LPS8   A0A2H1VUS4   A0A191T1L2   G9LPP2   A0A191T1M4   F1DG68   G9LPS2   G9LPN4   G9LPS7   A0A2H1VU94   H9JWE6   A0A2W1B6A2   Q0IKX4   A0A191T2G1   A0A2H1WSA7   G9LPS3   A0A2H1W0F9  

EC Number

2.4.1.17
2.4.1.-

Pubmed

22155036    19121390    29027758    26227816    28756777    26873292    + More
26354079    24698447    17763934    17141348   

EMBL

JQ070243    AEW43159.1    BABH01029259    JQ070242    AEW43158.1    GEYN01000078    + More
JAV02051.1    KY202924    AUC64268.1    KY202939    AUC64283.1    RSAL01000157    RVE45575.1    KY202938    AUC64282.1    KY202941    AUC64285.1    GEYN01000077    JAV02052.1    GEYN01000081    JAV02048.1    JTDY01002875    KOB70560.1    RVE45576.1    KZ150193    PZC72373.1    JQ070200    AEW43116.1    ODYU01006890    SOQ49139.1    JQ747500    AGG36457.1    JQ070231    AEW43147.1    PZC72369.1    JQ070192    AEW43108.1    BABH01029271    JQ070236    AEW43152.1    KU214506    AMK97472.1    FJ418685    ACJ48963.1    JQ070201    AEW43117.1    KU680289    ANI21995.1    KU680291    ANI21997.1    KU680282    ANI21988.1    JQ070194    AEW43110.1    NWSH01000435    PCG76447.1    KU680281    ANI21987.1    KQ459547    KPJ00043.1    JQ070197    AEW43113.1    JQ070198    AEW43114.1    KZ150360    PZC71197.1    PZC72371.1    PZC71193.1    PZC71202.1    KF777110    AHY99681.1    JQ070202    AEW43118.1    KU680283    ANI21989.1    ODYU01004546    SOQ44549.1    JQ070233    AEW43149.1    ODYU01010933    SOQ56350.1    KU680290    ANI21996.1    BABH01029260    KU680284    ANI21990.1    KF777109    AHY99680.1    KU680280    ANI21986.1    KU680288    ANI21994.1    PZC71199.1    JQ070196    AEW43112.1    PZC71189.1    PZC71200.1    KPJ00042.1    KQ459937    KPJ19195.1    JQ070193    AEW43109.1    JQ070189    AEW43105.1    KF777111    AHY99682.1    KZ150704    PZC70374.1    PZC71196.1    KY202933    AUC64277.1    PZC71192.1    PZC71191.1    KY202945    AUC64289.1    JQ070238    AEW43154.1    PZC71190.1    PZC72370.1    JQ070232    AEW43148.1    PZC70375.1    KPJ00041.1    GEYN01000079    JAV02050.1    PZC71201.1    JQ070195    AEW43111.1    PZC71194.1    KY304474    AUN86405.1    DQ443275    ABF51364.1    NWSH01005967    PCG63789.1    JQ070190    AEW43106.1    KPJ00048.1    MH124167    AXU41563.1    KF777112    AHY99683.1    PZC71195.1    ODYU01001030    SOQ36683.1    JQ070235    AEW43151.1    SOQ44548.1    KU680287    ANI21993.1    JQ070199    AEW43115.1    KU680286    ANI21992.1    HQ833816    ADY17534.1    JQ070229    AEW43145.1    JQ070191    AEW43107.1    JQ070234    AEW43150.1    ODYU01004485    SOQ44409.1    BABH01029273    BABH01029274    PZC71198.1    AY394490    AAR28909.1    KU680285    ANI21991.1    ODYU01010294    SOQ55304.1    JQ070230    AEW43146.1    ODYU01005543    SOQ46493.1   

Proteomes

UP000005204    UP000283053    UP000037510    UP000218220    UP000053268    UP000053240    + More
UP000201737   

PRIDE

G9LPT6    H9JWC0    G9LPT5    G9LPS4    G9LPS9    B7TZA3    + More
G9LPS6    H9JWB9    G9LPT1    G9LPS5    Q1HPX7    G9LPS8    F1DG68    G9LPS2    G9LPS7    H9JWE6    G9LPS3   

Pfam

PF00201   UDPGT

Interpro

IPR002213   UDP_glucos_trans        + More
IPR035595   UDP_glycos_trans_CS       
IPR006326   UDPGT_MGT       
IPR016224   Ecdysteroid_UDP-Glc_Trfase       

ProteinModelPortal

G9LPT6   H9JWC0   G9LPT5   A0A1L8D6H9   A0A2H4WB54   A0A2H4WB68   + More
A0A3S2NVG0   A0A2H4WB70   A0A2H4WB72   A0A1L8D6H2   A0A1L8D6H1   A0A0L7L568   A0A3S2TGR4   A0A2W1BL20   G9LPP3   A0A2H1W7S2   M4M1W9   G9LPS4   A0A2W1B9W6   G9LPN5   G9LPS9   A0A140EA35   B7TZA3   G9LPP4   A0A191T2J5   A0A191T1N0   A0A191T1K8   G9LPN7   A0A2A4JWQ0   A0A191T1L8   A0A0N1IB27   G9LPP0   G9LPP1   A0A2W1BCY8   A0A2W1BDA5   A0A2W1BHP8   A0A2W1B3X2   A0A024AGF9   G9LPP5   A0A191T1K4   A0A2H1VUM4   G9LPS6   A0A2H1WTF5   A0A191T2G3   H9JWB9   A0A191T2J2   A0A024AG00   A0A191T2F8   A0A191T1L3   A0A2W1B485   G9LPN9   A0A2W1B475   A0A2W1BEB8   A0A0N0P9C8   A0A0N0PE43   G9LPN6   G9LPN2   A0A024AH14   A0A2W1B7N5   A0A2W1BE55   A0A2H4WB73   A0A2W1B3V4   A0A2W1B8D3   A0A2H4WB75   G9LPT1   A0A2W1BEA5   A0A2W1BHY3   G9LPS5   A0A2W1B675   A0A0N1ICS6   A0A1L8D6T8   A0A2W1B8G2   G9LPN8   A0A2W1BBH1   A0A2I6RJL8   Q1HPX7   A0A2A4IVU8   G9LPN3   A0A0N1I2R8   A0A346TPQ3   A0A024AGL3   A0A2W1BA70   A0A2H1V761   G9LPS8   A0A2H1VUS4   A0A191T1L2   G9LPP2   A0A191T1M4   F1DG68   G9LPS2   G9LPN4   G9LPS7   A0A2H1VU94   H9JWE6   A0A2W1B6A2   Q0IKX4   A0A191T2G1   A0A2H1WSA7   G9LPS3   A0A2H1W0F9  

PDB

2O6L     E-value=2.23856e-27,     Score=305

KEGG

100862810    K00699 glucuronosyltransferase [EC:2.4.1.17] | (RefSeq) UGT340C2; UDP-glycosyltransferase UGT340C2

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00830    Retinol metabolism - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
00980    Metabolism of xenobiotics by cytochrome P450 - Bombyx mori (domestic silkworm)
00982    Drug metabolism - cytochrome P450 - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0015020   GO:0016999   GO:0016758   GO:0016757   GO:0008152   GO:0008270   GO:0043565   GO:0005839   GO:0051603   GO:0046835   GO:0006281   GO:0006259  

Subcellular location

Membrane  

SignalP

Position:   1 - 17,         Likelihood:  0.959017

 

 

Length:

524

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

31.17238

Exp number, first 60 AAs:

6.2206

Total prob of N-in:

0.25406

outside

1  -  485

TMhelix

486  -  508

inside

509  -  524

 

 

Pi

199.344303

Theta

159.292021

Tajima's D

0.74547

CLR

0.721074

CSRT

0.581270936453177

Interpretation

Uncertain