Gene

KWMTBOMO16414

Pre Gene Modal

BGIBMGA013836

Annotation

vitellin-degrading_protease_precursor_[Bombyx_mori]

Location

Bomo_Chr28(-):8948738-8952758      View in EpiBrowser

Full name

Vitellin-degrading protease       + More
Trypsin-1      
Trypsin-3      

Alternative Name

Antryp1

Location in the cell

Cytoplasmic   Reliability : 2.431

CDS

ATGGAGACGGCCTCATCCCCCACAAAACCCATCGGGGATATAAGGATCGTGGGAGGTGAAGACATCGTCATCACAGAGGCGCCGTACCAAGTATCAGTCATGTTCCGAGGAGCCCATTCTTGCGGTGGAACCTTAGTCGCTGCTGACATCGTTGTTACTGCCGCACACTGTGTCATGAGTTTTGCTCCAGAAGACTACAGGATCAGAGTAGGATCTTCCTTCCATCAACGAGATGGAATGCTTTACGATGTAGGAGATCTAGCTTGGCACCCAGATTTCAATTTTGCGTCAATGGATAATGATATCGCCATTTTATGGTTGCCAAAACCAGTCATGTTCGGGGATACAGTGGAAGCTATCGAGATGGTAGAAACTAATTCCGAGATCCCCGATGGAGATATTACAATTGTAACTGGATGGGGCCATATGGAGGAAGGCGGTGGTAACCCTTCTGTTCTTCAAAGAGTTATAGTCCCTAAAATCAACGAAGCTGCGTGCGCCGAGGCTTACTCACCGATTTACGCAATAACCCCCAGAATGCTATGCGCTGGAACGCCTGAAGGTGGCAAAGACGCGTGTCAGGGTGACAGTGGTGGTCCTTTGGTCCATAAAAAGAAATTGGCCGGCATCGTTTCTTGGGGGCTTGGCTGTGCGAGACCAGAATACCCAGGGGTCTACACGAAGGTGTCCGCGCTAAGGGAATGGGTCGACGAAAACATAACCAATCTGAGACTGAAGCATATTTTAAGGAGATTTTAA

Protein

METASSPTKPIGDIRIVGGEDIVITEAPYQVSVMFRGAHSCGGTLVAADIVVTAAHCVMSFAPEDYRIRVGSSFHQRDGMLYDVGDLAWHPDFNFASMDNDIAILWLPKPVMFGDTVEAIEMVETNSEIPDGDITIVTGWGHMEEGGGNPSVLQRVIVPKINEAACAEAYSPIYAITPRMLCAGTPEGGKDACQGDSGGPLVHKKKLAGIVSWGLGCARPEYPGVYTKVSALREWVDENITNLRLKHILRRF

Description

Major function may be to aid in digestion of the blood meal.
Constitutive trypsin that is expressed 2 days after emergence, coinciding with host seeking behavior of the female.

Catalytic Activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Similarity

Belongs to the peptidase S1 family.
Belongs to the UDP-glycosyltransferase family.

Keywords

Complete proteome   Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Protease   Reference proteome   Serine protease   Signal   Zymogen   Digestion   Secreted  

Feature

propeptide  Activation peptide
chain  Beta-VTN protease

Uniprot

Q07943   H9JWC2   A0A2H1W7U3   A0A0N1IMR2   A0A2W1BAP5   A0A0N0P9P8   + More
A0A212F6W7   A0A0N0P9D3   A0A0N1IPZ5   A0A2A4JCM0   A0A1E1WNB4   G9B5J0   B0ZBM9   G9B5I9   Q0IF85   G9B5I2   G9B5I8   G9B5H7   G9B5I4   G9B5H9   G5DGE0   G9B5I1   G9B5H8   G9B5J3   G9B5I6   G9B5I7   A0A1L8DQP6   G9B5H5   G9B5I5   A0A084VY00   G9B5G8   A0A1Q3FTA7   A0A1L8DQG9   G9B5G4   A0A084VY03   A0A182G8J0   G9B5J6   G9B5J2   Q27J28   G9B5J4   A0A182KHH7   G9B5F2   G9B5H4   G9B5E8   G9B5J5   G9B5F4   G9B5J8   G9B5F5   G9B5F1   G9B5G0   G9B5G5   G9B5I0   G9B5F7   A0A1I8MBP6   A0A1Y9J184   A0A1Y9GLX5   G9B5E7   P35035   U5EZ49   G9B5J7   A0A1Y9J180   E3NYI2   A0A182TJQ8   A0A1L8DQU1   G9B5J1   G9B5G1   G9B5F3   A0A1S4GXU9   G9B5G7   P35037   A0A1A9VW11   G9B5E6   X0N9I5   A0A1L8DQQ8   A0A1L8DQE6   W8C3D6   G9B5H2   G9B5F9   B4KFB8   A0A0K8VJE5   A0A059W0J0   T1DN08   A0A182V8D5   A0A182VG56   G9B5H1   G9B5F8   G9B5F6   B4G9F7   A0A2C9GTY9   A0A1I8P6D9   A0A182TKI7   A0A1Y9GKU7   A0A1I8N7Q1   Q29MC6   A0A182T760   A0A084VY04   A0A0A1XQQ7   A0A0K8U381  

EC Number

3.4.21.-
3.4.21.4

Pubmed

1764920    19121390    26354079    28756777    22118469    22727120    + More
18477240    17510324    24438588    26483478    25315136    8335004    7498434    12364791    24744334    24495485    17994087    24926050    20966253    15632085    25830018   

EMBL

D16232    D16233    BABH01029238    BABH01029239    BABH01029240    ODYU01006890    + More
SOQ49140.1    KQ459547    KPJ00051.1    KZ150339    PZC71315.1    KPJ00050.1    AGBW02009962    OWR49473.1    KPJ00049.1    KQ459937    KPJ19194.1    NWSH01001878    PCG69825.1    GDQN01002535    JAT88519.1    HM480750    AEI58596.1    EU339295    ABZ04009.1    HM480749    AEI58595.1    CH477389    EAT42001.1    HM480736    HM480742    AEI58588.1    HM480748    AEI58594.1    HM480737    AEI58583.1    HM480744    AEI58590.1    HM480739    AEI58585.1    JN662341    AEQ55298.1    HM480741    AEI58587.1    HM480738    AEI58584.1    HM480753    AEI58599.1    HM480743    HM480746    AEI58592.1    HM480747    AEI58593.1    GFDF01005377    JAV08707.1    HM480735    AEI58581.1    HM480745    AEI58591.1    ATLV01018234    KE525226    KFB42844.1    HM480728    AEI58574.1    GFDL01004392    JAV30653.1    GFDF01005378    JAV08706.1    HM480724    AEI58570.1    ATLV01018235    KFB42847.1    JXUM01047815    KQ561534    KXJ78237.1    HM480756    AEI58602.1    HM480752    AEI58598.1    DQ396618    ABD57312.1    HM480754    AEI58600.1    HM480712    AEI58558.1    HM480734    AEI58580.1    HM480708    HM480729    AEI58554.1    HM480755    AEI58601.1    HM480714    HM480722    HM480723    HM480726    AEI58560.1    HM480758    AEI58604.1    HM480715    AEI58561.1    HM480711    AEI58557.1    HM480720    AEI58566.1    HM480725    AEI58571.1    HM480740    AEI58586.1    HM480717    AEI58563.1    APCN01000798    HM480707    AEI58553.1    Z18889    Z22930    AAAB01008964    GANO01001434    JAB58437.1    HM480757    AEI58603.1    EF672103    ABW17548.1    GFDF01005369    JAV08715.1    HM480751    AEI58597.1    HM480721    AEI58567.1    HM480713    AEI58559.1    HM480727    AEI58573.1    HM480706    AEI58552.1    AXDB02000024    EXU90043.1    GFDF01005370    JAV08714.1    GFDF01005398    JAV08686.1    GAMC01002772    JAC03784.1    HM480732    AEI58578.1    HM480719    AEI58565.1    CH933807    EDW12018.1    GDHF01013298    JAI39016.1    CP007574    AIA01361.1    GAMD01003270    JAA98320.1    HM480731    AEI58577.1    HM480718    AEI58564.1    HM480716    AEI58562.1    CH479180    EDW28987.1    CH379060    EAL33768.1    KFB42848.1    GBXI01001399    JAD12893.1    GDHF01031554    JAI20760.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000053240    UP000218220    UP000008820    + More
UP000030765    UP000069940    UP000249989    UP000075881    UP000095301    UP000076407    UP000075840    UP000007062    UP000075902    UP000078200    UP000019597    UP000009192    UP000026918    UP000075903    UP000008744    UP000075882    UP000095300    UP000001819    UP000075901   

PRIDE

Q07943    H9JWC2    P35035   

Pfam

PF00089   Trypsin        + More
PF00201   UDPGT

Interpro

IPR033116   TRYPSIN_SER        + More
IPR001314   Peptidase_S1A       
IPR009003   Peptidase_S1_PA       
IPR001254   Trypsin_dom       
IPR018114   TRYPSIN_HIS       
IPR002213   UDP_glucos_trans       
IPR035595   UDP_glycos_trans_CS       

SUPFAM

SSF50494   SSF50494       

CDD

cd00190  Tryp_SPc

ProteinModelPortal

Q07943   H9JWC2   A0A2H1W7U3   A0A0N1IMR2   A0A2W1BAP5   A0A0N0P9P8   + More
A0A212F6W7   A0A0N0P9D3   A0A0N1IPZ5   A0A2A4JCM0   A0A1E1WNB4   G9B5J0   B0ZBM9   G9B5I9   Q0IF85   G9B5I2   G9B5I8   G9B5H7   G9B5I4   G9B5H9   G5DGE0   G9B5I1   G9B5H8   G9B5J3   G9B5I6   G9B5I7   A0A1L8DQP6   G9B5H5   G9B5I5   A0A084VY00   G9B5G8   A0A1Q3FTA7   A0A1L8DQG9   G9B5G4   A0A084VY03   A0A182G8J0   G9B5J6   G9B5J2   Q27J28   G9B5J4   A0A182KHH7   G9B5F2   G9B5H4   G9B5E8   G9B5J5   G9B5F4   G9B5J8   G9B5F5   G9B5F1   G9B5G0   G9B5G5   G9B5I0   G9B5F7   A0A1I8MBP6   A0A1Y9J184   A0A1Y9GLX5   G9B5E7   P35035   U5EZ49   G9B5J7   A0A1Y9J180   E3NYI2   A0A182TJQ8   A0A1L8DQU1   G9B5J1   G9B5G1   G9B5F3   A0A1S4GXU9   G9B5G7   P35037   A0A1A9VW11   G9B5E6   X0N9I5   A0A1L8DQQ8   A0A1L8DQE6   W8C3D6   G9B5H2   G9B5F9   B4KFB8   A0A0K8VJE5   A0A059W0J0   T1DN08   A0A182V8D5   A0A182VG56   G9B5H1   G9B5F8   G9B5F6   B4G9F7   A0A2C9GTY9   A0A1I8P6D9   A0A182TKI7   A0A1Y9GKU7   A0A1I8N7Q1   Q29MC6   A0A182T760   A0A084VY04   A0A0A1XQQ7   A0A0K8U381  

PDB

4BNR     E-value=3.64385e-41,     Score=421

KEGG

692746    K01312 trypsin [EC:3.4.21.4] | (RefSeq) VDP; vitellin-degrading protease

PATHWAY

04080    Neuroactive ligand-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0004252   GO:0016021   GO:0016758   GO:0005576   GO:0007586   GO:0008236   GO:0006508   GO:0006355   GO:0008270   GO:0043565   GO:0005839   GO:0051603   GO:0046835   GO:0006281   GO:0006259  

Subcellular location

Secreted  

Length:

252

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.821669999999998

Exp number, first 60 AAs:

0.76848

Total prob of N-in:

0.08225

outside

1  -  252

 

 

Pi

273.581074

Theta

206.643791

Tajima's D

0.704763

CLR

0

CSRT

0.574171291435428

Interpretation

Uncertain