Gene

KWMTBOMO16413

Pre Gene Modal

BGIBMGA013836

Annotation

UDP-glycosyltransferase_UGT33K1_precursor_[Bombyx_mori]

Location

Bomo_Chr28(-):8928634-8934638      View in EpiBrowser

Full name

UDP-glucuronosyltransferase      

Location in the cell

PlasmaMembrane   Reliability : 1.957

CDS

ATGTGTTGGAAAGTAGAAAGTGCTAGAATTTTAGCTGTCGTCCCTACACCTTCGATCAGCCATCAAGTTGTGTTTCGACCTGTTACTCAAGAGCTGGCCAGAAGAGGACACCAAGTCACTGTCATCACAACTGACCCTGCGTTCCCAAAAGGTCAAACTCCGGACAATTTGACAGAAATCGATCTTCACGATTTGTCATACGGCCTTTGGTCGAGAATGTTCTTGAACATTACTCCGACTATTTCTAAAGTTGGTGCTTATGAAATGATGAAATCAGCCTACGAGTCGTTCAACGTGATATTCGAAAATCAAATGAATAGTGATGAGGTACAAAAAATACTAAACGATAGGAGGAAGGTATTCGATTTGCTGATTGTCGAAGCGTGTGTAAGACCAGCTCTAGTGCTCTCTTATAAATACAAAGTTCCATTAATATTATTCAGCTCGTTTGGCACTGTCCATGGTTCTTTAGAAGCTGTTACAGGACCGTTCCATGCCTTCTTGAATCCGGGCCAAATGCAAAGGAGAGTTCACAAATTGACCACGTGGGAGAAAATTAAAGAGATTTGGGTACAATATAAGTTCCAGAGAGTTTTAAAGGAATTAGAAGAGCCTGAGACGGAAATGGGAAGAAAGCTATTCGGTCCTGAGGTACCGCACATAACCGAGTTGATGAATAACGTGGATCTGTTGTTTTTAAACGTTCACGCTTCGTGGGACAACAATAGATCGGTACCACCGAGTTTAATATATTTGGGAGGTTTACCCCAAAAACCAGGCAAGGAGCTACCAAAGACCCTCAAATCCTATATGGACTCATCACGAAAAGGTATCATTTACATCAGTTTTGGTACGAACGTTTTGACCTCTCTGTTGCCCAAGGACAAAGTGAACGTTCTGTTTAGAGCAATCTCAGTTTTACCACACAACGTTATTTTGAAGTGGGACGCGGACAAAATGCCCGGACTTCCCGAGAACGTTTTAATGGGAAAATGGTTCCCGCAATCCGATTTATTAAAGCATCGAAATGTTAAATTATTCATAACCCAGGGAGGTCTCCAATCGACCGATGAATCCATAACAGCTGGAGTGCCGCTAATAGGCATACCGATGATAGGAGACCAGTGGTACAACGTTGAACAGTATGTCAAGTTTGGCATCGGCGTGGGCTTAGACCTGGAGTCCTTGACTAAGGCGGACCTGCTAGAAGCGATTCACAAAGTCATTGGTGATGAAAGCTACCGTCAAAACATAGCTTGTCTCCGGCGCCAGATGTACGACCAGCCCCAGAGCTCGTTGGAGCGCGCCGTGTGGTGGACTGAGTACGTGCTGCGTCACGGAGGAGCCAAGCATCTCCGTTCGCCAGCAGCCAATATGAGCTTGACCCAATACTTGGAGCTAGACCTATTATCCCTATTATTACTTCTAGTCTGTATCATCCTATTTGTAATCGGTTTAACAGTTTACAACATTGGGAACTTTTTAAGGATTACACAAAAAAATAAAATAAAAAGATATTGA

Protein

MCWKVESARILAVVPTPSISHQVVFRPVTQELARRGHQVTVITTDPAFPKGQTPDNLTEIDLHDLSYGLWSRMFLNITPTISKVGAYEMMKSAYESFNVIFENQMNSDEVQKILNDRRKVFDLLIVEACVRPALVLSYKYKVPLILFSSFGTVHGSLEAVTGPFHAFLNPGQMQRRVHKLTTWEKIKEIWVQYKFQRVLKELEEPETEMGRKLFGPEVPHITELMNNVDLLFLNVHASWDNNRSVPPSLIYLGGLPQKPGKELPKTLKSYMDSSRKGIIYISFGTNVLTSLLPKDKVNVLFRAISVLPHNVILKWDADKMPGLPENVLMGKWFPQSDLLKHRNVKLFITQGGLQSTDESITAGVPLIGIPMIGDQWYNVEQYVKFGIGVGLDLESLTKADLLEAIHKVIGDESYRQNIACLRRQMYDQPQSSLERAVWWTEYVLRHGGAKHLRSPAANMSLTQYLELDLLSLLLLLVCIILFVIGLTVYNIGNFLRITQKNKIKRY

Catalytic Activity

glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP

Similarity

Belongs to the UDP-glycosyltransferase family.
Belongs to the peptidase S1 family.

Feature

chain  UDP-glucuronosyltransferase

Uniprot

G9LPT0   H9JWC2   A0A2W1BHP8   G9LPN7   G9LPT1   A0A191T1L8   + More
A0A191T1K8   A0A024AG00   A0A2W1BA70   M4M1W9   G9LPP3   A0A2W1BL20   A0A2H1W7S2   G9LPP0   G9LPN6   A0A191T1K4   A0A2H1VU94   A0A2W1B3V4   A0A191T2J5   A0A2W1BE55   A0A2W1BCY8   A0A2W1BEB8   A0A2W1B8G2   G9LPN9   A0A2W1B8D3   G9LPN8   G9LPN2   A0A191T2F8   A0A2H1WTF5   G9LPP2   A0A2W1B3X2   A0A2W1B675   G9LPP1   A0A2W1B485   B7TZA3   G9LPS9   G9LPN3   A0A191T1L3   A0A2W1BEA5   A0A2H1VUM4   A0A2W1B7N5   A0A191T2J2   G9LPP4   A0A2A4JWQ0   A0A2W1BBH1   A0A2A4IVU8   A0A2W1B6A2   G9LPP5   A0A2W1B475   A0A0N0PE43   A0A2W1BHY3   A0A024AH14   A0A2W1BDA5   A0A2H4WB75   A0A140EA35   A0A024AGF9   H9JWB9   G9LPS4   G9LPN4   G9LPN5   G9LPS7   A0A191T1L2   G9LPS8   G9LPS6   A0A0N1I2R8   A0A2I6RJL8   A0A191T2G1   A0A2W1B9W6   A0A024AGL3   A0A2H4WB73   G9LPP6   A0A1L8D6T8   A0A2W1BAD4   A0A2H1WSA7   A0A2H1VUS4   A0A2H1V761   A0A191T1M4   Q1HPX7   G9LPS5   A0A191T1N0   G9LPS2   H9JWE6   G9LPS3   F1DG68   G9LPP7   A0A2W1BQP4   H9JWB7   A0A2A4JXE4   A0A2H1W0F9   A0A0N1IB27   A0A191T2G3   A0A0N0P9C8   A0A0L7LF59   A0A0N1ICS6   A0A0L7LGK1   A0A1L8D6R8   A0A0N1IMZ0   A0A0N1PE65   D2JLK8   A0A0N0P9D1  

EC Number

2.4.1.17

Pubmed

22155036    19121390    28756777    24698447    26354079    29027758    + More
26873292    26227816    19954531    21505429   

EMBL

JQ070237    AEW43153.1    BABH01029238    BABH01029239    BABH01029240    KZ150360    + More
PZC71193.1    JQ070194    AEW43110.1    JQ070238    AEW43154.1    KU680281    ANI21987.1    KU680282    ANI21988.1    KF777109    AHY99680.1    PZC71195.1    JQ747500    AGG36457.1    JQ070200    AEW43116.1    KZ150193    PZC72373.1    ODYU01006890    SOQ49139.1    JQ070197    AEW43113.1    JQ070193    AEW43109.1    KU680283    ANI21989.1    ODYU01004485    SOQ44409.1    PZC71192.1    KU680289    ANI21995.1    PZC71196.1    PZC71197.1    PZC71200.1    PZC71201.1    JQ070196    AEW43112.1    PZC71191.1    JQ070195    AEW43111.1    JQ070189    AEW43105.1    KU680280    ANI21986.1    ODYU01010933    SOQ56350.1    JQ070199    AEW43115.1    PZC71202.1    KZ150704    PZC70375.1    JQ070198    AEW43114.1    PZC71199.1    FJ418685    ACJ48963.1    BABH01029271    JQ070236    AEW43152.1    JQ070190    AEW43106.1    KU680288    ANI21994.1    PZC71190.1    ODYU01004546    SOQ44549.1    PZC70374.1    KU680284    ANI21990.1    JQ070201    AEW43117.1    NWSH01000435    PCG76447.1    PZC71194.1    NWSH01005967    PCG63789.1    PZC71198.1    JQ070202    AEW43118.1    PZC71189.1    KQ459937    KPJ19195.1    PZC72370.1    KF777111    AHY99682.1    PZC72371.1    KY202945    AUC64289.1    KU214506    AMK97472.1    KF777110    AHY99681.1    BABH01029259    BABH01029260    JQ070231    AEW43147.1    JQ070191    AEW43107.1    JQ070192    AEW43108.1    JQ070234    AEW43150.1    KU680287    ANI21993.1    JQ070235    AEW43151.1    JQ070233    AEW43149.1    KQ459547    KPJ00048.1    KY304474    AUN86405.1    KU680285    ANI21991.1    PZC72369.1    KF777112    AHY99683.1    KY202933    AUC64277.1    JQ070203    AEW43119.1    GEYN01000079    JAV02050.1    PZC72372.1    ODYU01010294    SOQ55304.1    SOQ44548.1    ODYU01001030    SOQ36683.1    KU680286    ANI21992.1    DQ443275    ABF51364.1    JQ070232    AEW43148.1    KU680291    ANI21997.1    JQ070229    AEW43145.1    BABH01029273    BABH01029274    JQ070230    AEW43146.1    HQ833816    ADY17534.1    JQ070204    AEW43120.1    KZ149974    PZC75964.1    BABH01029269    BABH01029270    PCG76446.1    ODYU01005543    SOQ46493.1    KPJ00043.1    KU680290    ANI21996.1    KPJ00042.1    JTDY01001352    KOB74102.1    KPJ00041.1    JTDY01001195    KOB74582.1    GEYN01000099    JAV02030.1    KPJ00054.1    KPJ00045.1    GQ915324    ACZ97418.2    KPJ00052.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000037510   

PRIDE

G9LPT0    H9JWC2    G9LPT1    B7TZA3    G9LPS9    H9JWB9    + More
G9LPS4    G9LPS7    G9LPS8    G9LPS6    Q1HPX7    G9LPS5    G9LPS2    H9JWE6    G9LPS3    F1DG68    H9JWB7   

Pfam

PF00201   UDPGT        + More
PF00089   Trypsin

Interpro

IPR002213   UDP_glucos_trans        + More
IPR035595   UDP_glycos_trans_CS       
IPR033116   TRYPSIN_SER       
IPR001314   Peptidase_S1A       
IPR009003   Peptidase_S1_PA       
IPR001254   Trypsin_dom       
IPR018114   TRYPSIN_HIS       
IPR006326   UDPGT_MGT       

SUPFAM

SSF50494   SSF50494       

CDD

cd00190  Tryp_SPc

ProteinModelPortal

G9LPT0   H9JWC2   A0A2W1BHP8   G9LPN7   G9LPT1   A0A191T1L8   + More
A0A191T1K8   A0A024AG00   A0A2W1BA70   M4M1W9   G9LPP3   A0A2W1BL20   A0A2H1W7S2   G9LPP0   G9LPN6   A0A191T1K4   A0A2H1VU94   A0A2W1B3V4   A0A191T2J5   A0A2W1BE55   A0A2W1BCY8   A0A2W1BEB8   A0A2W1B8G2   G9LPN9   A0A2W1B8D3   G9LPN8   G9LPN2   A0A191T2F8   A0A2H1WTF5   G9LPP2   A0A2W1B3X2   A0A2W1B675   G9LPP1   A0A2W1B485   B7TZA3   G9LPS9   G9LPN3   A0A191T1L3   A0A2W1BEA5   A0A2H1VUM4   A0A2W1B7N5   A0A191T2J2   G9LPP4   A0A2A4JWQ0   A0A2W1BBH1   A0A2A4IVU8   A0A2W1B6A2   G9LPP5   A0A2W1B475   A0A0N0PE43   A0A2W1BHY3   A0A024AH14   A0A2W1BDA5   A0A2H4WB75   A0A140EA35   A0A024AGF9   H9JWB9   G9LPS4   G9LPN4   G9LPN5   G9LPS7   A0A191T1L2   G9LPS8   G9LPS6   A0A0N1I2R8   A0A2I6RJL8   A0A191T2G1   A0A2W1B9W6   A0A024AGL3   A0A2H4WB73   G9LPP6   A0A1L8D6T8   A0A2W1BAD4   A0A2H1WSA7   A0A2H1VUS4   A0A2H1V761   A0A191T1M4   Q1HPX7   G9LPS5   A0A191T1N0   G9LPS2   H9JWE6   G9LPS3   F1DG68   G9LPP7   A0A2W1BQP4   H9JWB7   A0A2A4JXE4   A0A2H1W0F9   A0A0N1IB27   A0A191T2G3   A0A0N0P9C8   A0A0L7LF59   A0A0N1ICS6   A0A0L7LGK1   A0A1L8D6R8   A0A0N1IMZ0   A0A0N1PE65   D2JLK8   A0A0N0P9D1  

PDB

2O6L     E-value=2.77399e-25,     Score=287

KEGG

100862805    K00699 glucuronosyltransferase [EC:2.4.1.17] | (RefSeq) UGT33K1; UDP-glycosyltransferase UGT33K1

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00830    Retinol metabolism - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
00980    Metabolism of xenobiotics by cytochrome P450 - Bombyx mori (domestic silkworm)
00982    Drug metabolism - cytochrome P450 - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0015020   GO:0016021   GO:0004252   GO:0016758   GO:0016999   GO:0008152   GO:0006355   GO:0008270   GO:0043565   GO:0005839   GO:0051603   GO:0046835   GO:0006281   GO:0006259  

Subcellular location

Membrane  

Length:

506

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.79132

Exp number, first 60 AAs:

0.07832

Total prob of N-in:

0.04242

outside

1  -  468

TMhelix

469  -  491

inside

492  -  506

 

 

Pi

162.261218

Theta

160.849691

Tajima's D

0.857339

CLR

0

CSRT

0.621568921553922

Interpretation

Uncertain