Gene

KWMTBOMO16409

Pre Gene Modal

BGIBMGA013837

Annotation

PREDICTED:_WD_repeat-containing_protein_48_homolog_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr28(-):8693912-8700498      View in EpiBrowser

Full name

WD repeat-containing protein 48 homolog      

Location in the cell

Cytoplasmic   Reliability : 1.361 Nuclear   Reliability : 1.86

CDS

ATGGGTACCACGATGCGTAAGAAAACTCAAGTGTCGTTTGTTATTCGTGACGAAGAAGAAAGGAAGCATAAAAACGGTGTAAGCTCATTGCAGCTCGATCCCGTCCAGGGTAGGCTATATTCAGCCGGCAGAGATGGAATTATTAGGGTATGGAACACTGCGACAGGCGTACAAGATAGATACATTCAAAGTATGGAACACCACACCGATTGGGTTAACGATATAGTGCTGTGCTGCGGCGGAAAAAATCTTATTAGTGCATCTTCTGATACAACCGTAAAGGTATGGAACGCCCCCAAGGGCTTTTGCATGTCGACTTTACGAACTCACAAAGACTACGTACGGACTCTAGCATACGCTAAAGATAAGGAACAGGTGGCTAGTGCTGGCTTAGACCGAGCTATATTCCTGTGGGACGTGAACACTTTGACTGCATTAACTGCCAGTAATAACACAGTTACGACGTCAAGTCTCGTCGGCAACAAAGAATCAATATACAGCTTAGCCATGAATCCACCAGGCACAGTTCTTGTTAGTGGTTCTACAGAGAAAGTCCTCAGGGTTTGGGACCCTCGTAATTGCTCTAGACTTATGAAGTTGAAAGGGCATTGTGATAATGTTAAAGCACTGGTCGTAAGCCGAGATGGAACTCAATGTGTCTCAGGAAGTTCGGACGGCACAATAAAATTGTGGTCTGTGTCACAGCAAAGGTGTGTTTCGACAATCCGAGTCCATTCAGAGGCGGTATGGGCATTAATAGCTACCGATACCTTTTCTCATGTCATATCTGGAGGCCGCGATCGCCTAGTCATTATAACGGAATTACGGAATCCAGAAAACTTTATGATTGTCTGTGAGGAGACAAGTCCCATTCTCAAATTATGCTTTACAGCTGACCAGCAAGGAATATGGGTGTCGACGTCTGATTCAGATGTTCGTTGCTGGAAACTACCGCCATTATCAACATTGACTTCAGAGACATACGACCAGAACAGTTACAACACTAATAATGTCTATCAAAGAATGCCATTACATAACATTCCTGGTGGACCTGCAATAAGGCATTTCACAGTATTGAATGATAAAAGACATGTCATAACAAAAGACTCCGCTAATAATATAGCTTTATTTGATGTTTTGAAAGCGTGTAAACTTGAGGACTTGGGTCAAGTAGACTATGAGGAAGAAGTGAAGAAAAGGTTTAAGATGGTGTATGTACCAAATTGGTTTAATGTTGACTTGAAGACTGGAATGCTGACGATACATCTGGGTCAGGATGAAACAGATTGCCTGAGCGCTTGGGTCAGTGCCAAAGAAGCTGGATTGACTATAGAAAACGATCAGAAAGTTAACTTCGGTGCTTTACTCCTGCAAGCTCTGTTGGAGCATTGGAACCATCGAAACCGAGTGAATGAGGCGGGTCAGAGGGTGGTCGGAAACAATTACTTTAGTGTACCTTTGCACACTCCTCTTATTTTCAGTGAAGTCGGAGGAAGAACACTATATAGGTTACAGGTTGGTGATGCAGGCGGTGAGACTGAAGGAAACCTGCTTGGAGAAACAGTACCCTCGTGGGTTGAGGATGTCGCTATAGAATTAGCTGCTCCCAAGCTAAACAAGCTCCCGTTTTATTTGCTCCCACATTCTAGCTGTCAGAGCAAGCAGGATCGACAGAAGAAGCAGGATCGTCTGGTTGCCAATGATTTCATACAATGCCGCAAGATTGCCGAACATGTCGTGGAAAAAATAGTTGGCGGTGGGGATGTAAATGGGGCCAGTGCGGGAAGCGGAAAGGGGAGTGCTAATGAGGACAGCGGAAACGATGGCTCCCCTGAGGAAAAAGTTGAGCTGCTGTGTTGCGATCAGGTCCTGGACCCAAATATGGACCTAAGAACGGTCCGCCATTTCATTTGGAAGTCCAACGTCGAGTTCACGCTACACTATCGTATATTAAAACAATGA

Protein

MGTTMRKKTQVSFVIRDEEERKHKNGVSSLQLDPVQGRLYSAGRDGIIRVWNTATGVQDRYIQSMEHHTDWVNDIVLCCGGKNLISASSDTTVKVWNAPKGFCMSTLRTHKDYVRTLAYAKDKEQVASAGLDRAIFLWDVNTLTALTASNNTVTTSSLVGNKESIYSLAMNPPGTVLVSGSTEKVLRVWDPRNCSRLMKLKGHCDNVKALVVSRDGTQCVSGSSDGTIKLWSVSQQRCVSTIRVHSEAVWALIATDTFSHVISGGRDRLVIITELRNPENFMIVCEETSPILKLCFTADQQGIWVSTSDSDVRCWKLPPLSTLTSETYDQNSYNTNNVYQRMPLHNIPGGPAIRHFTVLNDKRHVITKDSANNIALFDVLKACKLEDLGQVDYEEEVKKRFKMVYVPNWFNVDLKTGMLTIHLGQDETDCLSAWVSAKEAGLTIENDQKVNFGALLLQALLEHWNHRNRVNEAGQRVVGNNYFSVPLHTPLIFSEVGGRTLYRLQVGDAGGETEGNLLGETVPSWVEDVAIELAAPKLNKLPFYLLPHSSCQSKQDRQKKQDRLVANDFIQCRKIAEHVVEKIVGGGDVNGASAGSGKGSANEDSGNDGSPEEKVELLCCDQVLDPNMDLRTVRHFIWKSNVEFTLHYRILKQ

Description

Regulator of deubiquitinating complexes. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (By similarity).

Similarity

Belongs to the WD repeat WDR48 family.

Keywords

Complete proteome   Reference proteome   Repeat   Ubl conjugation pathway   WD repeat  

Feature

chain  WD repeat-containing protein 48 homolog

Uniprot

H9JWC3   A0A2A4K5Y1   A0A3S2N7R4   A0A2W1B9D6   A0A2H1W447   A0A0N1PKG3   + More
A0A0N0P9P5   A0A212F5L4   A0A1E1VYG9   A0A0L7LCU0   A0A2J7Q5L5   A0A067RM25   A0A232FGG6   A0A1B6DBC4   A0A158NP77   A0A1B6FP98   A0A026WB77   A0A195CGF2   A0A154PG04   A0A1B6MI01   A0A1Y1NE17   D1ZZU2   A0A224XL35   A0A1W4XCN3   A0A0L7QQM4   A0A139WJ49   A0A0A9WH40   E2B8Z6   E2AYP8   A0A195AY12   F4WF27   A0A2A3E4B4   A0A195F9T3   A0A3L8DKS1   A0A1A9VD04   A0A1Q3F0G4   A0A1Q3F0N7   A0A336L9T7   A0A1L8DNB1   A0A1I8Q6B0   A0A131XBL9   A0A131YIG8   L7M794   Q16MY0   E9GAM8   A0A0J7KKA0   A0A1B0G957   A0A1S3HXK4   T1JLA6   A0A1Q3F242   A0A1Q3F376   T1I2Z7   A0A210R464   A0A1I8M2T8   A0A0M8ZS90   A0A1S3D5Q9   A0A293LFK8   B7PIF1   V5IFQ4   A0A2R5LJS8   C3YKN6   B4MFM2   A0A182YA79   W8AYA3   A0A0K8U426   A0A034VM50   B4KRQ4   V3ZNY0   A0A182SAQ9   A0A0A1WCY4   B4J8H6   A0A3B0J0R3   R7UW60   A0A088A8Z9   A0A2T7PG33   E0VW21   Q28YY2   B4GIJ0   S4RRY9   S4RRY8   B3MET8   A0A0M5JA20   A0A1W4UIB8   A0A0J9RBB4   B4QB64   B4HND9   B3NSK1   B4P7H8   A0A0B4KET0   Q1LZ08   A0A286XGG0   A0A151PDE3   A0A1U7RZH8   F7AKD8   G9KXT0   A0A093GPX8   K9IZ71   A0A341DEA8   F6ZZI8   A0A2U3V459  

Pubmed

19121390    28756777    26354079    22118469    26227816    24845553    + More
28648823    21347285    24508170    28004739    18362917    19820115    25401762    20798317    21719571    30249741    28049606    26830274    25576852    17510324    21292972    28812685    25315136    25765539    18563158    17994087    25244985    24495485    25348373    23254933    25830018    20566863    15632085    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    21993624    22293439    18464734    23236062    19892987   

EMBL

BABH01029218    NWSH01000108    PCG79469.1    RSAL01000236    RVE43721.1    KZ150201    + More
PZC72279.1    ODYU01005899    SOQ47264.1    KQ459680    KPJ20470.1    KQ459547    KPJ00040.1    AGBW02010189    OWR48999.1    GDQN01011320    JAT79734.1    JTDY01001741    KOB73026.1    NEVH01017557    PNF23865.1    KK852428    KDR24078.1    NNAY01000293    OXU29417.1    GEDC01014356    JAS22942.1    ADTU01022271    GECZ01017769    JAS52000.1    KK107347    EZA52289.1    KQ977791    KYM99820.1    KQ434896    KZC10747.1    GEBQ01004431    JAT35546.1    GEZM01005719    JAV95969.1    KQ971338    EFA02422.2    GFTR01007685    JAW08741.1    KQ414786    KOC60927.1    KYB27959.1    GBHO01035842    JAG07762.1    GL446405    EFN87830.1    GL443983    EFN61411.1    KQ976703    KYM77138.1    GL888115    EGI67078.1    KZ288379    PBC26545.1    KQ981727    KYN36809.1    QOIP01000007    RLU20438.1    GFDL01014067    JAV20978.1    GFDL01013922    JAV21123.1    UFQS01001396    UFQT01001396    SSX10668.1    SSX30350.1    GFDF01006142    JAV07942.1    GEFH01005061    JAP63520.1    GEDV01009498    JAP79059.1    GACK01005114    JAA59920.1    CH477846    GL732537    EFX83279.1    LBMM01006385    KMQ90649.1    CCAG010018436    JH431917    GFDL01013477    JAV21568.1    GFDL01013035    JAV22010.1    ACPB03014821    NEDP02000483    OWF55772.1    KQ435878    KOX70085.1    GFWV01000755    MAA25485.1    ABJB010894807    DS718559    EEC06373.1    GANP01008032    JAB76436.1    GGLE01005451    MBY09577.1    GG666523    EEN59104.1    CH940667    GAMC01020719    JAB85836.1    GDHF01030827    JAI21487.1    GAKP01015780    JAC43172.1    CH933808    KB203188    ESO86022.1    GBXI01017478    GBXI01004893    JAC96813.1    JAD09399.1    CH916367    OUUW01000001    SPP74594.1    AMQN01006040    KB297448    ELU10512.1    PZQS01000004    PVD32388.1    DS235816    EEB17577.1    CM000071    CH479183    CH902619    CP012524    ALC41481.1    CM002911    KMY92953.1    KMY92954.1    CM000362    CH480816    CH954179    CM000158    AE013599    AGB93419.1    BT001736    BT025218    AAKN02049260    AKHW03000487    KYO46990.1    JP021111    AES09709.1    KL216326    KFV69107.1    GABZ01004819    JAA48706.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000053268    UP000007151    + More
UP000037510    UP000235965    UP000027135    UP000215335    UP000005205    UP000053097    UP000078542    UP000076502    UP000007266    UP000192223    UP000053825    UP000008237    UP000000311    UP000078540    UP000007755    UP000242457    UP000078541    UP000279307    UP000078200    UP000095300    UP000008820    UP000000305    UP000036403    UP000092444    UP000085678    UP000015103    UP000242188    UP000095301    UP000053105    UP000079169    UP000001555    UP000001554    UP000008792    UP000076408    UP000009192    UP000030746    UP000075901    UP000001070    UP000268350    UP000014760    UP000005203    UP000245119    UP000009046    UP000001819    UP000008744    UP000245300    UP000007801    UP000092553    UP000192221    UP000000304    UP000001292    UP000008711    UP000002282    UP000000803    UP000005447    UP000050525    UP000189705    UP000002279    UP000053875    UP000252040    UP000002281    UP000245320   

PRIDE

H9JWC3    Q16MY0    B4MFM2    B4KRQ4    B4J8H6    B4GIJ0    + More
B3MET8    B4QB64    B4HND9    B3NSK1    B4P7H8    Q1LZ08   

Pfam

PF00400   WD40        + More
PF11816   DUF3337
PF03144   GTP_EFTU_D2
PF00009   GTP_EFTU
PF03143   GTP_EFTU_D3
PF10545   MADF_DNA_bdg
PF03520   KCNQ_channel

Interpro

IPR001680   WD40_repeat        + More
IPR017986   WD40_repeat_dom       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR036322   WD40_repeat_dom_sf       
IPR019775   WD40_repeat_CS       
IPR021772   WDR48/Bun107       
IPR020472   G-protein_beta_WD-40_rep       
IPR009000   Transl_B-barrel_sf       
IPR027417   P-loop_NTPase       
IPR004160   Transl_elong_EFTu/EF1A_C       
IPR004161   EFTu-like_2       
IPR041709   EF-Tu_GTP-bd       
IPR033720   EFTU_2       
IPR031157   G_TR_CS       
IPR009001   Transl_elong_EF1A/Init_IF2_C       
IPR005225   Small_GTP-bd_dom       
IPR000795   TF_GTP-bd_dom       
IPR006578   MADF-dom       
IPR013821   K_chnl_volt-dep_KCNQ_C       

SUPFAM

SSF50978   SSF50978        + More
SSF50465   SSF50465       
SSF50447   SSF50447       
SSF52540   SSF52540       

Gene 3D

2.130.10.10    

CDD

cd01884  EF_Tu
cd03697  EFTU_II

ProteinModelPortal

H9JWC3   A0A2A4K5Y1   A0A3S2N7R4   A0A2W1B9D6   A0A2H1W447   A0A0N1PKG3   + More
A0A0N0P9P5   A0A212F5L4   A0A1E1VYG9   A0A0L7LCU0   A0A2J7Q5L5   A0A067RM25   A0A232FGG6   A0A1B6DBC4   A0A158NP77   A0A1B6FP98   A0A026WB77   A0A195CGF2   A0A154PG04   A0A1B6MI01   A0A1Y1NE17   D1ZZU2   A0A224XL35   A0A1W4XCN3   A0A0L7QQM4   A0A139WJ49   A0A0A9WH40   E2B8Z6   E2AYP8   A0A195AY12   F4WF27   A0A2A3E4B4   A0A195F9T3   A0A3L8DKS1   A0A1A9VD04   A0A1Q3F0G4   A0A1Q3F0N7   A0A336L9T7   A0A1L8DNB1   A0A1I8Q6B0   A0A131XBL9   A0A131YIG8   L7M794   Q16MY0   E9GAM8   A0A0J7KKA0   A0A1B0G957   A0A1S3HXK4   T1JLA6   A0A1Q3F242   A0A1Q3F376   T1I2Z7   A0A210R464   A0A1I8M2T8   A0A0M8ZS90   A0A1S3D5Q9   A0A293LFK8   B7PIF1   V5IFQ4   A0A2R5LJS8   C3YKN6   B4MFM2   A0A182YA79   W8AYA3   A0A0K8U426   A0A034VM50   B4KRQ4   V3ZNY0   A0A182SAQ9   A0A0A1WCY4   B4J8H6   A0A3B0J0R3   R7UW60   A0A088A8Z9   A0A2T7PG33   E0VW21   Q28YY2   B4GIJ0   S4RRY9   S4RRY8   B3MET8   A0A0M5JA20   A0A1W4UIB8   A0A0J9RBB4   B4QB64   B4HND9   B3NSK1   B4P7H8   A0A0B4KET0   Q1LZ08   A0A286XGG0   A0A151PDE3   A0A1U7RZH8   F7AKD8   G9KXT0   A0A093GPX8   K9IZ71   A0A341DEA8   F6ZZI8   A0A2U3V459  

PDB

5K1B     E-value=0,     Score=1821

KEGG

101740773    K15361 WD repeat-containing protein 48 | (RefSeq) WD repeat-containing protein 48 homolog

PATHWAY

03460    Fanconi anemia pathway - Bombyx mori (domestic silkworm)

GO

GO:0003924   GO:0005525   GO:1903003   GO:0043130   GO:0016905   GO:0016579   GO:0005634   GO:0048568   GO:0048705   GO:0035264   GO:0007283   GO:1902525   GO:0072520   GO:0007338   GO:0043588   GO:0050679   GO:0000724   GO:0048872   GO:0005515   GO:0006355   GO:0008270   GO:0043565   GO:0005839   GO:0051603   GO:0046835   GO:0006281   GO:0006259  

Length:

653

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0239

Exp number, first 60 AAs:

0.00014

Total prob of N-in:

0.00582

outside

1  -  653

 

 

Pi

224.474947

Theta

170.289134

Tajima's D

1.038062

CLR

0.677

CSRT

0.677466126693665

Interpretation

Uncertain