SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO16396  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA013842
Annotation
PREDICTED:_cleavage_and_polyadenylation_specificity_factor_subunit_1_[Bombyx_mori]
Full name
Cleavage and polyadenylation specificity factor subunit 1      
Alternative Name
Cleavage and polyadenylation specificity factor 160 kDa subunit
Location in the cell
PlasmaMembrane   Reliability : 2.269
 

Sequence

CDS
ATGTTTTCGATTTGTCGAACGACTCATCCAGCGACTGGTATAGAGCACGCGGTTAGCTGTTATTTCTTTAACAATGACGAGGTTTGTCTGGTCACCGCCGGTGCCAATATCATCAAGGTCTTCAGGCTGCTGCCCGAAGGCCACACAAAAGAGATTAATGCAGCCGGTCAGCCGATTCCCCCGAAGATGAAGTTGGAATGCTTAGCGACATATACATTATGGGGTAATGTGATGTCTTTAGCTTCTGTACGCTGTCAAAGTTCTGGTCGAGATATCCTGTTGGTTTCATTCAAAGAAGCTAAACTATCTGTGCTCCAATATGATCCACAGACCAATAACTTGGTGACATTGAGTATGCATTATTTTGAAGAGGATGATATGAAGGGCGGTTGGACAACTCATCCTCATATACCATGGATCAGAGTAGATCCTGAGTTCCGATGTGCTGTGATGTTGTTGTATGGGAAGAAACTTGCAGTCCTTCCGTTTAGGAAGGACATTACCTCTGAAGAAGGGGATCCTCTTGAGGCCAAACCCCTCTCTGACACAAAGAAAAATCAAGCAGCTCATACTATGAACAGGGCACCAACACTGGCCTCATACATAATAATACTCAAGGACCTAGACGAGAAGATTGATAACATATTAGACATACAATTCTTGCATGGCTATTACGAGCCTACTTTGCTACTGCTCTATGAGCCTGTCAGAACATTTCCTGGTCGCACGGCGGTTCGCAACGACACCTGCGCGATGGCGGGCGTCAGTCTGAACATGTCAGCTCGGGTGCACCCGGTCATCTGGTCCACCTCAGGTCTGCCCTTCGACTGTCTCCAAGCCGTGCCCGTACCGAAACCACTAGGTGGCTGTTTGATAATGGCCGTCAACTCATTGATATATTTAAATCAATCGGTTCCACCTTACGGCGTCTCACTGAACAGTGTTGCCACACACACCACAAATTTTCCCCTGAGGATCCAGGAGGGCGTGTGCATGACGCTGGAGGGCGCGTGCGTGGCGCGGCTGTCGGACGCCGTGTTCGCGGTGTCTCTGCGCGGCGGCCAGCTGTACGTTGTGGCGCTGCTGGCGGACAGTGTGCGCTCCGTCAGAAGCTTCCACATCGACCGCGCCGCCGCCTCCGTGCTCACCACCTGCATGTGCGTTATAGAAGAGGACTTCCTTTTCCTGGGGTCGCGGCTCGGAAACTCGCTGCTGCTGCGAGTTACCGAGCGAGAGAACCGGATGCTGTTCTCCGTTGACAAGCCCCTGGAAGCGACGGTCGATCTGACCGTGGCCGAAACCGAACGAGAGCAGAGCAGAGAGAAGGAGCAGCCCGACCCGGCCTCGAAGCGGCGGCGCATGGACACCATCAGCGACTGCGTGGCCTCCAACGTCATCGAGATCAGCGACGGAGACGAGCTCGAGGTGTACGGCAGCGACATACGCACCTCCACAAGACTCACCAGCTACGTGTTCGAGGTATGCGATTCGCTGTTAAACATATGTCCGATCGGCGACGTGTCTATGGGAGAGCCCCAGCTCCTCTCCGAGGAGTACAGCAGGCAGCAGGAGAATCCTCTGGTAGAACTGGTGACCTGTAGTGGCAGGGGGAAGAACGGCGCCCTGACCGTGCTGCAGAGGACGGTCAGACCTCAGCTGATTACTGCTTTCAATTTACCCGGCTGTATCGACATGTGGTCGGTTTTCGGAGAGAGCGAAAGCACCAGAGAAAACGAAGGGACGCACGCGTATTTGATACTGACGCAGGACGACTCCTCCATGGTTCTGCAAACTGGCCAAGAGATCAACGAGGTGGACAACTCTGGCTTCATGACGGGTTCGCCCACCATCTTCGCCGGAAACCTCGGGAATAACAAATTCATGGTGCAGGTCACCACCACCACCATTCGACTCATCAAGGGCGGCGTGCAGCTGCAGTCGATCCAGCTGGAGTGGACGGCGCAGTACGCGGCCGTCGCGGACCCCTACCTGTGCGTCACGTCCAGCTGCGGCCGCGCCATCGTGCTGGCCCTGAGAGAGATCAGGGGGAAGGACGGGCAGCCGTCGGGTCGGCTGGCGCCCACGCGGCAGTGCGTCCCCGCGCGGCCCCCGCTCGTGCGCGCCGCCCCGCACCGCGACCTCAGCGGACTGTTCGCGCCAGACCTCGCCGAGCCCGGCCACCAGGTCAAAGGTGAGTTCACCGGTAAGCTGAAGGAGAACGTGAAGAAGGAGGCCTTCAAGCCCGGCGTGGTCTATGAGCTGAACGACGAAGACGAGATGCTGTACGGAGGCGACCAGACACCTGCATCCATGGCCAGCATAATGCTGGCGGAGCAAAGCAAGAATCCAGGGGTTCCGCGTCGGATGTCGCGCTGGTGGAAGAAGTACCTGCAGGAGGTGAAGCCCACGTACTGGCTGTTCTGCGTTCGCGACAACGGCAACCTGGAGATATACTCGTTGCCGGAAATGAGGTTGAGTTTCCTGGTGAGAGACTCGTGCGCTGGAAACAGGATATTGGCGGACAGCCTGGAGTCCGTCCCGATGTCAGACAGCATGGAGGACGAGGACATCAGCGCGCCGTCACACAACGCTGATGCTGAGAAGCTCAAGGAACTGTGCGTCGTCGGTCTGGGGCACAAGGGTTCCAGGGTGATACTGATGCTGAGGATGCAAAATGAATTGATGATTTATCAGGCGTACAAATACCCCCGGGGGAATCTCAAGCTGCGGTTCTGCCGGGTGACTGTCTCGTTCCCGTTTGGGTACGAGAGCGTGCCCAGCACCGCACAGAGCGCCGACACCTACGAGACGGCCGGCGTGCGGGACGGGGTGCGGCAGCTGCGGTACTTTGGCAACGTGGGCGGGTACAGCGGCGTGTTCGTCTGCGGCGCGACCCCCTACATGATGTTCTTGTCTGCGCGCGGCGAGCTGCGCCTGCACCCGCTGCACGCCGACCGACCGCCCGTGCACACGTTCGCGCCCTTCAACAACACCAATTGTCCGCAGGGCTTCCTGTACTTTAACGCCGAGTCGTCGCTCCGCATCTGCGCGCTGCCGTCGCACCTGTCGTACGACGCGGCGTGGGCGGTGCGCAAGGTGCCCATCCGCATGACGCCGCACTACGTCACGTTCCACCTGGAGTCCAGGACCTACTGCCTCGTGGCCTCCACCTCGCAGCCCACCACGGTCTACTACAAGTTCAACGGCGAGGACAAGGAGAAGTCTGCCGAGAACAAAGGGGACAGGTTCCCGTACCCGATGCTGGATCGCTTCTCGGTGATGCTGTTCTCCCCCGTCTCCTGGGAGATCATACCGAACACCAAGATCGAGCTGGACGAGTGGGAGCACGTGACGTGTCTCAAGAACGTGTCGCTGTCGTACGAAGGAACCAGATCCGGTCTCCGCGGTTACATAGCGATAGGAACTAATTATAATTACAGCGAGGATATCACTTCTAGGGGGCGGATAATAATCTACGACATAATCGACGTGGTCCCGGAGCCCGGGCAGCCGCTGACCAAGAACCGGTTCAAGGAGATCTACTCCAAGGAGCAGAAGGGTCCGGTGACCGCGCTCACGCAGGTGCTCGGCTACCTCATATCCGCCGTCGGACAGAAGATATACATATGGCAGCTGAAGGACAACGACCTAGTGGGCGTCGCGTTCATCGACACCCAGATATACGTGCACCGCATGCTGGCCGTCAAGAACCTCATCCTGGTGGCCGACGTCTACAAGTCCATCTCGCTGCTGCGCTACCAGCCCGCGCACAGGACGCTCTCGCTGGTCTCCAGGGACTTCAGGACCGCGCAGATATACGATATGGAGTTCATGGTGGATAATACGAATCTCGGTTTCCTGGTCAGCGAAGCCGAGGGGAACTTCGCGCTGTTCATGTACCAGCCGCAGGCCAGGGAGAGCTACGGAGGCCAGCGGCTGATACGCAAGAGCGACTACCACCTGGGCCAGCAGGTGCACGCCATGTTCCGCATCAACGTGCGCTCGCTGCCAGACTCCGACAACTCGCACAAGCGACACGTCAGCATGTTCACGACCCTGGACGGCGCCATAGGCTACGTGCTGCCGGTCACGGAGAAGATGTACCGGCGCCTACTGATGTTGCAGAACGTCATGAACAACTACTACTGCCACATAGCCGGCCTCAACCCGAGGGCCTTTCGCACGTACAAGGCGTCGCGGCGCGCGGCGGGGGGCGGGGCGGCGCGGGGCGTGCTGGACGGGGACCTGGTGGCGCTGTACGCCGCCATGCCGCGCGCCGACCAGCACGACATCGCAAAGAAAATCGGTACAAAAGTCGAGGAGATAATGTCGGACTTGTACGAGATAGACAGACTGACCGCGCATTTTTAG
Protein
MFSICRTTHPATGIEHAVSCYFFNNDEVCLVTAGANIIKVFRLLPEGHTKEINAAGQPIPPKMKLECLATYTLWGNVMSLASVRCQSSGRDILLVSFKEAKLSVLQYDPQTNNLVTLSMHYFEEDDMKGGWTTHPHIPWIRVDPEFRCAVMLLYGKKLAVLPFRKDITSEEGDPLEAKPLSDTKKNQAAHTMNRAPTLASYIIILKDLDEKIDNILDIQFLHGYYEPTLLLLYEPVRTFPGRTAVRNDTCAMAGVSLNMSARVHPVIWSTSGLPFDCLQAVPVPKPLGGCLIMAVNSLIYLNQSVPPYGVSLNSVATHTTNFPLRIQEGVCMTLEGACVARLSDAVFAVSLRGGQLYVVALLADSVRSVRSFHIDRAAASVLTTCMCVIEEDFLFLGSRLGNSLLLRVTERENRMLFSVDKPLEATVDLTVAETEREQSREKEQPDPASKRRRMDTISDCVASNVIEISDGDELEVYGSDIRTSTRLTSYVFEVCDSLLNICPIGDVSMGEPQLLSEEYSRQQENPLVELVTCSGRGKNGALTVLQRTVRPQLITAFNLPGCIDMWSVFGESESTRENEGTHAYLILTQDDSSMVLQTGQEINEVDNSGFMTGSPTIFAGNLGNNKFMVQVTTTTIRLIKGGVQLQSIQLEWTAQYAAVADPYLCVTSSCGRAIVLALREIRGKDGQPSGRLAPTRQCVPARPPLVRAAPHRDLSGLFAPDLAEPGHQVKGEFTGKLKENVKKEAFKPGVVYELNDEDEMLYGGDQTPASMASIMLAEQSKNPGVPRRMSRWWKKYLQEVKPTYWLFCVRDNGNLEIYSLPEMRLSFLVRDSCAGNRILADSLESVPMSDSMEDEDISAPSHNADAEKLKELCVVGLGHKGSRVILMLRMQNELMIYQAYKYPRGNLKLRFCRVTVSFPFGYESVPSTAQSADTYETAGVRDGVRQLRYFGNVGGYSGVFVCGATPYMMFLSARGELRLHPLHADRPPVHTFAPFNNTNCPQGFLYFNAESSLRICALPSHLSYDAAWAVRKVPIRMTPHYVTFHLESRTYCLVASTSQPTTVYYKFNGEDKEKSAENKGDRFPYPMLDRFSVMLFSPVSWEIIPNTKIELDEWEHVTCLKNVSLSYEGTRSGLRGYIAIGTNYNYSEDITSRGRIIIYDIIDVVPEPGQPLTKNRFKEIYSKEQKGPVTALTQVLGYLISAVGQKIYIWQLKDNDLVGVAFIDTQIYVHRMLAVKNLILVADVYKSISLLRYQPAHRTLSLVSRDFRTAQIYDMEFMVDNTNLGFLVSEAEGNFALFMYQPQARESYGGQRLIRKSDYHLGQQVHAMFRINVRSLPDSDNSHKRHVSMFTTLDGAIGYVLPVTEKMYRRLLMLQNVMNNYYCHIAGLNPRAFRTYKASRRAAGGGAARGVLDGDLVALYAAMPRADQHDIAKKIGTKVEEIMSDLYEIDRLTAHF

Summary

Description
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity).
Subunit
Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of at least Clp, Cpsf73, Cpsf100 and Cpsf160.
Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3'UTR of selected pre-mRNAs (By similarity). Interacts with TENT2/GLD2.
Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, TENT2/GLD2 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3'UTR of selected pre-mRNAs (By similarity).
Similarity
Belongs to the CPSF1 family.
Keywords
Alternative splicing   Complete proteome   mRNA processing   Nucleus   Reference proteome   RNA-binding   Phosphoprotein   Direct protein sequencing  
Feature
chain  Cleavage and polyadenylation specificity factor subunit 1
splice variant  In isoform B.
EMBL
BABH01029195    BABH01029196    NWSH01000450    PCG76329.1    KK853149    KDR10643.1    + More
NEVH01025648    PNF15214.1    PNF15210.1    KQ761323    OAD57895.1    KZ288309    PBC28675.1    GL434618    EFN74734.1    ADTU01005136    QOIP01000003    RLU24961.1    AAZX01006832    KQ971319    EFA00240.2    GEBQ01030988    JAT08989.1    GECZ01012880    JAS56889.1    GEZM01066160    JAV68121.1    GL888624    EGI58789.1    DS235843    EEB18312.1    KQ977394    KYN02985.1    APGK01017648    APGK01017649    KB740047    KB631866    ENN81834.1    ERL86808.1    GL765434    EFZ16427.1    KQ981856    KYN34588.1    ACPB03006649    GDHC01005061    JAQ13568.1    KQ434879    KZC09982.1    NNAY01000983    OXU25621.1    KQ982557    KYQ55105.1    KQ980624    KYN15033.1    GFTR01008780    JAW07646.1    GFDL01003149    JAV31896.1    ATLV01013242    KE524847    KFB37564.1    JXUM01069058    JXUM01069059    KQ562533    KXJ75685.1    CH477202    EAT48120.1    AAAB01008816    EAA05261.4    AXCM01009566    ADMH02000205    ETN67373.1    JH431841    GGFK01003976    MBW37297.1    LBMM01000214    KMR04458.1    APCN01004490    GAKP01018577    JAC40375.1    GDHF01011246    JAI41068.1    GL453904    EFN75271.1    GBXI01006305    JAD07987.1    KQ976440    KYM86555.1    CVRI01000002    CRK86785.1    CH902619    EDV37560.1    CM000071    EAL25170.2    CH479181    EDW32048.1    CH940648    EDW60602.2    CP012524    ALC41041.1    OUUW01000001    SPP75313.1    CM000158    EDW91032.1    CH954179    EDV56024.1    CH933808    EDW09580.2    CM002911    KMY93778.1    CH480816    EDW47868.1    AF241364    AF241365    AF241366    AE013599    AY051896    CH964282    EDW85820.1    GDRN01103447    JAI58086.1    GEDV01003275    JAP85282.1    CM000362    EDX07094.1    GFPF01006807    MAA17953.1    CH916375    EDV98226.1    CCAG010002095    GEBF01006266    JAN97366.1    KRG00299.1    IACF01002475    LAB68128.1    KN122397    KFO30625.1    JH173457    EHB16887.1    AAQR03179256    AAQR03179257    AAQR03179258    GFFV01000319    JAV39626.1    AC139605    BC168713    AAI68713.1    GBEX01000729    JAI13831.1    AF322193    BC056388    JT406405    AHH37581.1    AQIB01115377    AQIB01115378    X83097    NDHI03003691    PNJ08062.1    PNJ08063.1   
Pfam
PF03178   CPSF_A        + More
PF13649   Methyltransf_25
Interpro
IPR015943   WD40/YVTN_repeat-like_dom_sf        + More
IPR004871   Cleavage/polyA-sp_fac_asu_C       
IPR002048   EF_hand_dom       
IPR011992   EF-hand-dom_pair       
IPR029063   SAM-dependent_MTases       
IPR041698   Methyltransf_25       
IPR036322   WD40_repeat_dom_sf       
SUPFAM
SSF47473   SSF47473        + More
SSF53335   SSF53335       
SSF50978   SSF50978       
Gene 3D
PDB
6FUW     E-value=0,     Score=3162

Ontologies

Topology

Subcellular location
Nucleus  
  
Length:
1456
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.347160000000001
Exp number, first 60 AAs:
0.03345
Total prob of N-in:
0.00238
outside
1  -  1456
 
 

Population Genetic Test Statistics

Pi
321.567235
Theta
182.022243
Tajima's D
2.998455
CLR
0.146645
CSRT
0.978651067446628
Interpretation
Uncertain
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