Gene

KWMTBOMO16361

Pre Gene Modal

BGIBMGA013751

Annotation

PREDICTED:_serine_protease_easter-like_[Bombyx_mori]

Location

Bomo_Chr28(-):7217368-7219882      View in EpiBrowser

Full name

CLIP domain-containing serine protease 2      

Alternative Name

BzArgOEtase

Location in the cell

Extracellular   Reliability : 2.228

CDS

ATGAGATATGTCTGCCTGTTAATTGTTAAGTTAATGATATCCTCTTGGAGACTAATACACCAAGACCCCTGGCTGGTTCTGCTCGAGTACCACCGTGAAGGAAGACGCACAGGTGCCAGGTGTGGAGGTACGCTGGTCGGACCCCGTCACGTCATCACTGCTGCTCACTGCGTCAGGAACGCCTTCTTGGATCGGTTAACCGTACGCTTGGGGGAATACGATACGGCCTCTAAAATTGACTGCTCTGAAGGTGTTTGTTCTGACAAAGTTGTTCGTATCAATGTCACCGAGATCTTCGCGCATCCAGACTACGTTGATAAACAAAATGACATCGCTGTGTTGAAGCTAGAGAAGGATGCTCCTTATACTGATTTCATCCGTCCTGTTTGTCTTCCTACTGGAACGTTAAGTCCTAGGACATTGTTCTTGGCCTCAGGATGGGGACAGCAAGCAAACGGCTTATATAGTCACATCAAAAAGCTGATACCATTACCGAACTGGTCGATTGAAGATTGCCAAGCAATGTACAAGCAAACAAAGTTGCCCGATAAAATCATTTGTGCTGGTGGCGAAAGAGGAATGGACACGTGCCGCGGGGATTCCGGTGGGCCATTGGTGGTCATGAAGAGGAGATCTGAGTTGTGGGGCATCACCAGCGCCGGCCACGTCCATTGCGGTTCACAAGGATATCCCGGGATTTATACGAATGTTACCATGTTCTTGGACTGGATCGGAGATGTAATGAAGATTTGA

Protein

MRYVCLLIVKLMISSWRLIHQDPWLVLLEYHREGRRTGARCGGTLVGPRHVITAAHCVRNAFLDRLTVRLGEYDTASKIDCSEGVCSDKVVRINVTEIFAHPDYVDKQNDIAVLKLEKDAPYTDFIRPVCLPTGTLSPRTLFLASGWGQQANGLYSHIKKLIPLPNWSIEDCQAMYKQTKLPDKIICAGGERGMDTCRGDSGGPLVVMKRRSELWGITSAGHVHCGSQGYPGIYTNVTMFLDWIGDVMKI

Description

Endopeptidase with selective post-Arg cleavage site (PubMed:16399077, PubMed:7737188). Might play a role in innate immunity in response to fungal and Gram-positive bacterial infections (PubMed:16399077).

Subunit

In the active form, heterodimer of a light chain and a heavy chain; disulfide-linked.

Similarity

Belongs to the peptidase S1 family.
Belongs to the peptidase S1 family. CLIP subfamily.

Keywords

Calcium   Cleavage on pair of basic residues   Complete proteome   Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Metal-binding   Protease   Reference proteome   Secreted   Serine protease   Signal   Zymogen  

Feature

chain  CLIP domain-containing serine protease 2 light chain

Uniprot

Q5MPC4   A0A2H1WEH9   A0A2H1W881   A0A2A4JQ35   A0A2A4JXI6   A0A3S2P3X8   + More
Q5MPC7   Q5MGE4   A0A1I8PP27   A0A1J1J5N3   A0A139WN30   A0A2H1WUN7   D6W9Z5   A0A3S2M731   A0A2C9GW66   Q17B76   A0A2C9GWT4   A0A1B0DG63   A0A023EPR7   Q2VG86   E2C8L2   A0A0K8UPH0   A0A0K8VIH4   A0A0M9A7E2   A0A023EQV6   A0A1I8N0W4   A0A0L7QXF0   Q49QW0   A0A2A4JWX6   A0A1I8JTB4   A0A026WIN7   A0A212F949   A0A182G5Z0   A0A182G580   Q9Y1K6   A0A084W8U9   A0A023EQB0   A0A0M4F7H7   A0A3L8D7J0   A0A290U615   A0A182GNZ3   A0A1A9UFJ1   Q7QKL2   A0A1A9ZT35   B3F5B1   A0A1Y1KDT6   A0A290U627   A0A173GPF2   A0A2A4JQA1   N6TWW7   A0A212FEW0   A0A0L0CE89   A0A0U1WT79   A0A2A3EA55   A0A182GH79   A0A1W7R8M0   A0A1I8PEC5   A0A1B0B4Z6   A0A1A9YQ00   A0A0M4EWB3   E2AV85   T1P924   B4N925   D6WUF7   A0A151WR74   B4MBJ7   D3TMC5   A0A0C9QZC0   A0A182GNY7   A0A182INH2   A0A182VAF6   A0A1B0FFU3   B1B5K1   A0A2H1VCQ7   S4PKY1   F4WPR9   A0A088A359   A0A2H1VTY9   A0A1I8NE97   A0A154P5I7   A0A1I8PE36   A0A0M4EMT4   A0A2H1V1Q2   A0A0J7NWE6   A0A2C9GVA1   A0A1Y1NG54   A0A3B0KH63   A0A0B4KGQ4   A0A1Y1NG56   A0A1S4F560   B4KCX7   Q49QW1   U4U606   A0A1Y1NL68   B3P1Y6   A0A1A9WC15   A0A195FEH3   A0A158NI84   A0A1Y1NJX5  

EC Number

3.4.21.-

Pubmed

15944088    16023793    18362917    19820115    17510324    24945155    + More
16399077    19121390    7737188    20798317    25315136    24508170    22118469    26483478    10646969    24438588    30249741    28953952    12364791    14747013    17210077    28004739    23537049    26108605    17994087    20353571    18195005    23622113    21719571    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    19557749    21347285   

EMBL

AY672786    AAV91008.1    ODYU01008137    SOQ51490.1    ODYU01006975    SOQ49305.1    + More
NWSH01000925    PCG73522.1    NWSH01000467    PCG76213.1    RSAL01000029    RVE51737.1    AY672783    AAV91005.1    AY829842    AAV91456.1    CVRI01000070    CRL07282.1    KQ971312    KYB29266.1    ODYU01011137    SOQ56686.1    EEZ99203.2    RSAL01000017    RVE52975.1    AXCN02000165    CH477325    EAT43491.1    AJVK01059305    GAPW01002593    JAC11005.1    AB035418    AY061936    DQ157441    BABH01019990    AAL31707.1    ABB58762.1    BAE73254.1    GL453666    EFN75742.1    GDHF01024094    GDHF01019994    JAI28220.1    JAI32320.1    GDHF01013623    JAI38691.1    KQ435719    KOX78755.1    GAPW01002093    JAC11505.1    KQ414704    KOC63285.1    AY677082    AAW24481.1    PCG76208.1    APCN01002147    KK107185    EZA55838.1    AGBW02009640    OWR50264.1    JXUM01044209    JXUM01044210    KQ561391    KXJ78725.1    JXUM01042955    JXUM01042956    KQ561344    KXJ78893.1    AF117749    AAD38335.1    ATLV01021515    KE525319    KFB46643.1    GAPW01001836    JAC11762.1    CP012526    ALC47832.1    QOIP01000012    RLU16063.1    KY680243    ATD13324.1    JXUM01015012    JXUM01015013    KQ560420    KXJ82504.1    AAAB01008794    EAA03566.2    EF614332    ABU98654.1    GEZM01087707    JAV58521.1    KY680241    ATD13322.1    KT006136    ANH58161.1    NWSH01000833    PCG73946.1    APGK01057809    KB741282    ENN70807.1    AGBW02008891    OWR52286.1    JRES01000503    KNC30561.1    JQ581597    AFX82593.1    KZ288322    PBC28172.1    JXUM01063272    KQ562240    KXJ76328.1    GEHC01000168    JAV47477.1    JXJN01008576    ALC47792.1    GL443059    EFN62639.1    KA645202    AFP59831.1    CH964232    EDW81572.2    KQ971352    EFA07559.2    KQ982813    KYQ50307.1    CH940656    EDW58468.1    EZ422577    ADD18853.1    GBYB01001065    JAG70832.1    JXUM01015001    KXJ82498.1    CCAG010004727    AB363980    BAG14262.2    ODYU01001850    SOQ38623.1    GAIX01004295    JAA88265.1    GL888255    EGI63810.1    ODYU01004434    SOQ44299.1    KQ434809    KZC06390.1    ALC45838.1    ODYU01000283    SOQ34775.1    LBMM01001207    KMQ96720.1    GEZM01003115    JAV96914.1    OUUW01000013    SPP87780.1    AE014297    AGB95978.1    GEZM01003116    JAV96913.1    CH933806    EDW16999.2    AY677081    AAW24480.1    KB631684    ERL85365.1    GEZM01003113    JAV96916.1    CH954181    EDV47759.1    KQ981636    KYN38803.1    ADTU01016095    GEZM01003114    JAV96915.1   

Proteomes

UP000218220    UP000283053    UP000095300    UP000183832    UP000007266    UP000075886    + More
UP000008820    UP000075900    UP000092462    UP000005204    UP000008237    UP000053105    UP000095301    UP000053825    UP000075840    UP000053097    UP000007151    UP000069940    UP000249989    UP000030765    UP000092553    UP000279307    UP000078200    UP000007062    UP000092445    UP000019118    UP000037069    UP000242457    UP000092460    UP000092443    UP000000311    UP000007798    UP000075809    UP000008792    UP000075880    UP000075903    UP000092444    UP000007755    UP000005203    UP000076502    UP000036403    UP000075884    UP000268350    UP000000803    UP000009192    UP000030742    UP000008711    UP000091820    UP000078541    UP000005205   

PRIDE

Q2VG86   

Pfam

PF00089   Trypsin        + More
PF12032   CLIP
PF13019   Sde2_N_Ubi

Interpro

IPR033116   TRYPSIN_SER        + More
IPR001254   Trypsin_dom       
IPR018114   TRYPSIN_HIS       
IPR001314   Peptidase_S1A       
IPR009003   Peptidase_S1_PA       
IPR038565   CLIP_sf       
IPR022700   CLIP       
IPR024974   Sde2_N       
IPR029071   Ubiquitin-like_domsf       

SUPFAM

SSF50494   SSF50494        + More
SSF54236   SSF54236       

Gene 3D

2.20.20.90    

CDD

cd00190  Tryp_SPc

ProteinModelPortal

Q5MPC4   A0A2H1WEH9   A0A2H1W881   A0A2A4JQ35   A0A2A4JXI6   A0A3S2P3X8   + More
Q5MPC7   Q5MGE4   A0A1I8PP27   A0A1J1J5N3   A0A139WN30   A0A2H1WUN7   D6W9Z5   A0A3S2M731   A0A2C9GW66   Q17B76   A0A2C9GWT4   A0A1B0DG63   A0A023EPR7   Q2VG86   E2C8L2   A0A0K8UPH0   A0A0K8VIH4   A0A0M9A7E2   A0A023EQV6   A0A1I8N0W4   A0A0L7QXF0   Q49QW0   A0A2A4JWX6   A0A1I8JTB4   A0A026WIN7   A0A212F949   A0A182G5Z0   A0A182G580   Q9Y1K6   A0A084W8U9   A0A023EQB0   A0A0M4F7H7   A0A3L8D7J0   A0A290U615   A0A182GNZ3   A0A1A9UFJ1   Q7QKL2   A0A1A9ZT35   B3F5B1   A0A1Y1KDT6   A0A290U627   A0A173GPF2   A0A2A4JQA1   N6TWW7   A0A212FEW0   A0A0L0CE89   A0A0U1WT79   A0A2A3EA55   A0A182GH79   A0A1W7R8M0   A0A1I8PEC5   A0A1B0B4Z6   A0A1A9YQ00   A0A0M4EWB3   E2AV85   T1P924   B4N925   D6WUF7   A0A151WR74   B4MBJ7   D3TMC5   A0A0C9QZC0   A0A182GNY7   A0A182INH2   A0A182VAF6   A0A1B0FFU3   B1B5K1   A0A2H1VCQ7   S4PKY1   F4WPR9   A0A088A359   A0A2H1VTY9   A0A1I8NE97   A0A154P5I7   A0A1I8PE36   A0A0M4EMT4   A0A2H1V1Q2   A0A0J7NWE6   A0A2C9GVA1   A0A1Y1NG54   A0A3B0KH63   A0A0B4KGQ4   A0A1Y1NG56   A0A1S4F560   B4KCX7   Q49QW1   U4U606   A0A1Y1NL68   B3P1Y6   A0A1A9WC15   A0A195FEH3   A0A158NI84   A0A1Y1NJX5  

PDB

2OLG     E-value=1.51039e-38,     Score=398

KEGG

101740313    no KO assigned | (RefSeq) serine protease easter-like

GO

GO:0004252   GO:0008236   GO:0004175   GO:0005576   GO:0046872   GO:0006508   GO:0005615   GO:0035006   GO:0016021   GO:0005840   GO:0006412   GO:0033557   GO:0005839   GO:0051603   GO:0046835   GO:0006281   GO:0006259  

Subcellular location

Secreted   Secreted in the hemolymph.   With evidence from 6 publications.

Length:

250

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0901

Exp number, first 60 AAs:

0.05747

Total prob of N-in:

0.07155

outside

1  -  250

 

 

Pi

452.730681

Theta

230.547233

Tajima's D

3.174413

CLR

0.155368

CSRT

0.986300684965752

Interpretation

Uncertain