Gene

KWMTBOMO16358  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013793

Annotation

juvenile_hormone_epoxide_hydrolase-like_protein_4_[Bombyx_mori]

Location

Bomo_Chr28(+):6724544-6737538      View in EpiBrowser

Full name

Epoxide hydrolase       + More
Glutathione peroxidase      
Juvenile hormone epoxide hydrolase      
Juvenile hormone epoxide hydrolase 1      
Juvenile hormone epoxide hydrolase 2      

Alternative Name

CfEH1
Juvenile hormone epoxide hydrolase I
Juvenile hormone-specific epoxide hydrolase I
Juvenile hormone-specific epoxide hydrolase
CfEH2
Juvenile hormone epoxide hydrolase II
Juvenile hormone-specific epoxide hydrolase II

Location in the cell

PlasmaMembrane   Reliability : 2.127

CDS

ATGAGTAAAAAAACTAAAAATAAAAGTGTTAATGTTAATAATTTAGATAAAAATGAAAAATCTAAAACAACTAAAGATTCTTCGAAATTCAAGCTCGTATTCGGGGTATTTTCAAAAATAATCTCGTATTTATTTGTGGTTAAAGCATTATTTACGATTTACGGTATTTATCTGGTGTACGTGTCGCTGACGAACGTTCCTGATTTGCCCAAAGTCGACGTCAATCTACGATGGGGCGTCGATAATAACACGCACGACACCAGAATAAGGCCCTACAGGGTGATATTTAGTGACGCGATGGAATCTGAAATCAGGGCGCTTTTTGAAGACTACCGTCTCATGGAGAGGAAGATAAAGAGCTTCAAAAACACGGCTTGGACCTATGGCGTTCATTCAGATGCGTTTGCACAGTTCTTCTCACATTGGATATTCAAATACAAGTTCAGGGAACGTGTGAAGTTTTTAAATAAATACGATCATTTCTTGACTAATATTCAGGGTTTGGATATACATTTTGTTCGTGTTAAGCCGAAAGCTGATAAAAATGTTAAGGTGGTACCCCTTCTACTTCTGCACGGCTGGCCAGGTTCTGTTAGAGAATTTTACGAAGCAATTCCACTTCTAACTACTCCGAGACCAGATTACGATTTTGTGTTCGAAGTAATAGCTCCAAGTTTACCGGGCTTCGTGTTTTCTGAGGCGCCAACACGACCCGGATTAGACACGTACGAAATGGCCATAATAATGCGAAACTTGATGCGTAGACTCGGCTACACCCAATACTACATTCAAGGCGGCGATTTCGGGCACATGATCGGATCCCATATCGCCACGATCTTCCCCTCAGAAGTACTTGGCTTCCACACGAATTTCCCAGCTAACACATCCAAATTGTCTTTATTGACTTGGCTCCTGGGCGGATTGTTGTGGCCTTCGTATTTCGGTAACGGCATTGAGGACAGAATGTATCCTCTGAAAGACAAATTGGAGTTTTATTTGGAGGAGACCGGGTATTCGCATCTGCAATCAACGAAACCAGATACAATTGGTATTGTCCTAACTGATTCACCGGTAGCCTTAGGATCATATATCTTGGATAGGTTCATGATCTTTACGAACCATACCAATAAGTTTGAAGATGAAGGCGGCATTGACAAGTATTACGATTTTGACAAGTTACTGGACAACATAATGTTATATTGGGCCTCCGGGAGTATAACCACGTCACTGAGGATTTACAAGGAGACCTTCGCAGGTTCGAGGTTGAATAATCTGGCTCAGGTCCCAACTTCAGTTCCAACATGGGCGCTTCGTTTGAAATACGAGCTTTTCCAACACCCAGACTATATGCTTCGTTGGAAGTACACTAACCTCTTGGGCTCTACCAATTTGGACTACGGAGGTCATTTTGCCGCTTTCGAACGACCGAAGGACTTCAGCGATGACGTGTTTAAAGCTGTAAAAGCTTTTAGAAATTTTAAGTGA

Protein

MSKKTKNKSVNVNNLDKNEKSKTTKDSSKFKLVFGVFSKIISYLFVVKALFTIYGIYLVYVSLTNVPDLPKVDVNLRWGVDNNTHDTRIRPYRVIFSDAMESEIRALFEDYRLMERKIKSFKNTAWTYGVHSDAFAQFFSHWIFKYKFRERVKFLNKYDHFLTNIQGLDIHFVRVKPKADKNVKVVPLLLLHGWPGSVREFYEAIPLLTTPRPDYDFVFEVIAPSLPGFVFSEAPTRPGLDTYEMAIIMRNLMRRLGYTQYYIQGGDFGHMIGSHIATIFPSEVLGFHTNFPANTSKLSLLTWLLGGLLWPSYFGNGIEDRMYPLKDKLEFYLEETGYSHLQSTKPDTIGIVLTDSPVALGSYILDRFMIFTNHTNKFEDEGGIDKYYDFDKLLDNIMLYWASGSITTSLRIYKETFAGSRLNNLAQVPTSVPTWALRLKYELFQHPDYMLRWKYTNLLGSTNLDYGGHFAAFERPKDFSDDVFKAVKAFRNFK

Description

Catalyzes juvenile hormone hydrolysis.
Catalyzes juvenile hormone hydrolysis. Degrades juvenile hormone III (JH III) about 3 times and 5 times slower than juvenile hormone I (JH I) and II (JH II), respectively. Degrades cis-stilbene oxide and trans-stilbene oxide about 18 and 43 times slower than JH III, respectively.

Catalytic Activity

1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol
cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin

Biophysicochemical Properties

0.52 uM for juvenile hormone III

Subunit

Homodimer.

Similarity

Belongs to the peptidase S33 family.
Belongs to the glutathione peroxidase family.

Keywords

3D-structure   Aromatic hydrocarbons catabolism   Complete proteome   Endoplasmic reticulum   Hydrolase   Membrane   Microsome   Reference proteome   Transmembrane   Transmembrane helix   Direct protein sequencing  

Feature

chain  Epoxide hydrolase

Uniprot

C6KWM8   H9JW79   A0A0L7LT60   A0A2A4JV24   A0A2H1VAR3   A0A3S2NQU9   + More
A0A0N0P9P2   A0A212EXY4   A0A0N0PF52   A0A3S2NYE4   A0A2W1BCV7   A0A088M9L0   A0A0N0PD06   A0A2W1B6Y8   C0KH33   H9JWL6   A0A0N0PEI4   A0A2A4JKY8   Q6U6J0   Q1W696   A0A2A4K8F5   A0A3S2LEJ8   H9JWT0   C6KWM7   O44124   A0A2A4K9D8   A0A212F9W9   Q94806   A0A194PZ48   A0A0N1IBG8   L7R9X8   A0A194Q5D4   V5G055   A0A194Q0T4   A0A212F9X4   A0A2A4JGM0   A0A3S2P9A9   A0A1Y1K345   A0A2W1BA00   A0A2H1VIT3   A0A2W1B2C5   A0A2H1VS44   A0A212F9Y7   A0A0P0ELB6   A0A194PZ44   A0A2W1B693   D4Q9H4   A0A1Y1K079   A0A087ZVE8   A0A194PZ55   A0A0N1ICQ7   A0A1Z2RRH4   A0A1V0M8A5   A0A2J7PHG7   A0A195DS73   A0A346LWB4   A0A0F6SIA8   A0A3L8DM46   A0A151I9X6   A0A2A3E8M7   Q8MZR6   C6KWM6   K7IW06   A0A151WUE8   A0A2C9DK11   Q25489   D6WGJ2   A0A1W5KJY8   A0A310SIX1   Q8MZR5   A0A212EN45   A0A067QLM6   A0A194PYB3   A0A0T6BH94   A0A195EXA2   D0W012   U5EUG0   A0A0N1IIM0   I4DKH4   V5G602   Q7Q8D4   J3JY41   A0A154PRH0   A0A2M4BMN3   F4WV40   A0A2M4BM54   C6KWM5   A0A182KYJ1   A0A3G6VF49   R4G4K1   A0A0V0G516   A0A026W213   A0A2C9GS53   D0W011   A0A182USI7   A0A069DUW8   A0A2M4CM88   A0A0L7QRY7   D6WGJ1   A0A224XNL2  

EC Number

3.3.2.9

Pubmed

20622465    19121390    26227816    26354079    22118469    28756777    + More
26385554    15681225    25143157    9927177    23276675    28004739    26445454    28605547    28349297    30249741    12125060    20075255    28536442    8645304    18362917    19820115    24845553    22651552    12364791    14747013    17210077    22516182    21719571    20966253    24508170    26334808   

EMBL

AB293557    BAH97091.1    BABH01025470    BABH01025471    JTDY01000179    KOB78426.1    + More
NWSH01000520    PCG75887.1    ODYU01001536    SOQ37891.1    RSAL01000008    RVE53920.1    KQ459547    KPJ00030.1    AGBW02011642    OWR46350.1    KQ459680    KPJ20462.1    RSAL01000025    RVE52162.1    KZ150476    PZC70740.1    KJ579233    AIN34709.1    KQ460417    KPJ14867.1    KZ150418    PZC70941.1    FJ602793    ACM78602.2    BABH01018379    KQ459764    KPJ20089.1    NWSH01001212    PCG72103.1    AY377854    AB362775    AAQ87024.1    BAF81491.1    DQ431847    ABD85119.1    NWSH01000031    PCG80507.1    RSAL01000177    RVE45005.1    BABH01018608    AB293556    BAH97090.1    AF035482    AAB88192.1    PCG80508.1    AGBW02009550    OWR50536.1    U73680    AAB18243.1    KQ459583    KPI98607.1    KQ459630    KPJ20526.1    JX681816    AGC00788.1    KPI98605.1    GALX01005126    JAB63340.1    KPI98604.1    OWR50537.1    NWSH01001648    PCG70570.1    RVE45007.1    GEZM01096422    JAV54921.1    KZ150192    PZC72389.1    ODYU01002601    SOQ40322.1    PZC70942.1    ODYU01004100    SOQ43618.1    OWR50538.1    KT261710    ALJ30250.1    KPI98602.1    KZ150284    PZC70943.1    PZC71622.1    AB299279    BAI94514.1    GEZM01096421    JAV54922.1    KPI98601.1    KPJ20092.1    KY938806    ASA46447.1    KU755500    ARD71210.1    NEVH01025136    PNF15772.1    KQ980530    KYN15652.1    MF996338    AXQ01059.1    KP271046    AKF11871.1    QOIP01000006    RLU21451.1    KQ978260    KYM95872.1    KZ288345    PBC27632.1    AF503908    AAM22694.1    AB293555    BAH97089.1    KQ982745    KYQ51387.1    KX855995    ARE68677.1    U46682    KQ971321    EFA00568.1    KU941586    AMR44689.1    KQ762207    OAD56030.1    AF503909    AAM22695.1    AGBW02013730    OWR42903.1    KK853182    KDR10172.1    KQ459588    KPI97739.1    LJIG01000290    KRT86650.1    KQ981953    KYN32509.1    AB534186    BAI49687.1    GANO01002338    JAB57533.1    KPJ20091.1    AK401792    BAM18414.1    GALX01002976    JAB65490.1    AAAB01008944    EAA10122.2    BT128165    AEE63126.1    KQ435007    KZC13710.1    GGFJ01005082    MBW54223.1    GL888384    EGI61928.1    GGFJ01005028    MBW54169.1    AB293554    BAH97088.1    MH932586    AZB52850.1    ACPB03008739    GAHY01001290    JAA76220.1    GECL01002991    JAP03133.1    KK107485    EZA50110.1    APCN01000682    AB534185    BAI49686.1    GBGD01001402    JAC87487.1    GGFL01002133    MBW66311.1    KQ414766    KOC61382.1    EFA00567.1    GFTR01006406    JAW10020.1   

Proteomes

UP000005204    UP000037510    UP000218220    UP000283053    UP000053268    UP000007151    + More
UP000053240    UP000005203    UP000235965    UP000078492    UP000279307    UP000078542    UP000242457    UP000002358    UP000075809    UP000007266    UP000027135    UP000078541    UP000007062    UP000076502    UP000007755    UP000075882    UP000015103    UP000053097    UP000075840    UP000075903    UP000053825   

PRIDE

C6KWM8    H9JW79    H9JWL6    Q6U6J0    H9JWT0    C6KWM7    + More
D4Q9H4    A0A087ZVE8    C6KWM6    C6KWM5   

Pfam

PF06441   EHN        + More
PF00255   GSHPx
PF14529   Exo_endo_phos_2
PF00078   RVT_1

Interpro

IPR000639   Epox_hydrolase-like        + More
IPR010497   Epoxide_hydro_N       
IPR029058   AB_hydrolase       
IPR016292   Epoxide_hydrolase       
IPR000889   Glutathione_peroxidase       
IPR029760   GPX_CS       
IPR036249   Thioredoxin-like_sf       
IPR029759   GPX_AS       
IPR005135   Endo/exonuclease/phosphatase       
IPR036691   Endo/exonu/phosph_ase_sf       
IPR000477   RT_dom       

SUPFAM

SSF53474   SSF53474        + More
SSF52833   SSF52833       
SSF56219   SSF56219       

Gene 3D

3.40.50.1820     3.60.10.10    

CDD

cd00340  GSH_Peroxidase

ProteinModelPortal

C6KWM8   H9JW79   A0A0L7LT60   A0A2A4JV24   A0A2H1VAR3   A0A3S2NQU9   + More
A0A0N0P9P2   A0A212EXY4   A0A0N0PF52   A0A3S2NYE4   A0A2W1BCV7   A0A088M9L0   A0A0N0PD06   A0A2W1B6Y8   C0KH33   H9JWL6   A0A0N0PEI4   A0A2A4JKY8   Q6U6J0   Q1W696   A0A2A4K8F5   A0A3S2LEJ8   H9JWT0   C6KWM7   O44124   A0A2A4K9D8   A0A212F9W9   Q94806   A0A194PZ48   A0A0N1IBG8   L7R9X8   A0A194Q5D4   V5G055   A0A194Q0T4   A0A212F9X4   A0A2A4JGM0   A0A3S2P9A9   A0A1Y1K345   A0A2W1BA00   A0A2H1VIT3   A0A2W1B2C5   A0A2H1VS44   A0A212F9Y7   A0A0P0ELB6   A0A194PZ44   A0A2W1B693   D4Q9H4   A0A1Y1K079   A0A087ZVE8   A0A194PZ55   A0A0N1ICQ7   A0A1Z2RRH4   A0A1V0M8A5   A0A2J7PHG7   A0A195DS73   A0A346LWB4   A0A0F6SIA8   A0A3L8DM46   A0A151I9X6   A0A2A3E8M7   Q8MZR6   C6KWM6   K7IW06   A0A151WUE8   A0A2C9DK11   Q25489   D6WGJ2   A0A1W5KJY8   A0A310SIX1   Q8MZR5   A0A212EN45   A0A067QLM6   A0A194PYB3   A0A0T6BH94   A0A195EXA2   D0W012   U5EUG0   A0A0N1IIM0   I4DKH4   V5G602   Q7Q8D4   J3JY41   A0A154PRH0   A0A2M4BMN3   F4WV40   A0A2M4BM54   C6KWM5   A0A182KYJ1   A0A3G6VF49   R4G4K1   A0A0V0G516   A0A026W213   A0A2C9GS53   D0W011   A0A182USI7   A0A069DUW8   A0A2M4CM88   A0A0L7QRY7   D6WGJ1   A0A224XNL2  

PDB

4QLA     E-value=8.74254e-108,     Score=998

KEGG

100307011    K10719 juvenile hormone epoxide hydrolase | (RefSeq) Jheh-lp4; juvenile hormone epoxide hydrolase-li

PATHWAY

00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0033961   GO:0019439   GO:0005789   GO:0004601   GO:0004602   GO:0006979   GO:0016740   GO:0016787   GO:0003824   GO:0005622   GO:0005840   GO:0006412   GO:0033557   GO:0005839   GO:0051603   GO:0046835   GO:0006281   GO:0006259  

Subcellular location

Endoplasmic reticulum membrane  
Microsome membrane  

Length:

494

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

29.90992

Exp number, first 60 AAs:

22.22063

Total prob of N-in:

0.96650

POSSIBLE N-term signal

sequence

inside

1  -  31

TMhelix

32  -  54

outside

55  -  494

 

 

Pi

239.480266

Theta

152.947643

Tajima's D

2.420147

CLR

0.063039

CSRT

0.937803109844508

Interpretation

Uncertain