Gene

KWMTBOMO16356  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013791

Annotation

PREDICTED:_nuclear_pore_glycoprotein_p62_isoform_X2_[Papilio_xuthus]

Location

Bomo_Chr28(+):6709514-6713828      View in EpiBrowser

Full name

Nuclear pore glycoprotein p62       + More
Tetraspanin      

Alternative Name

62 kDa nucleoporin

Location in the cell

Cytoplasmic   Reliability : 1.151 Extracellular   Reliability : 1.127 Nuclear   Reliability : 1.804

CDS

ATGCCCACTTTGACTGCAACAACTACTGCAGCTGCACCAGTTCCACCTCAACCGATAACTTCGATAACATTTGCACAATTAGAGGAGAATATCAACAAATGGACCTTAGAATTGGAAGAGCAGGAACGGACGTTCATCAACCAAGCTACCCAGATTAATGCTTGGGACACATTACTAATAGCGAACGGAGAGAAGATCGTAGAACTAAACGAAGCAGTCGAGACCGTTAAAAACGAACAGCAATCACTGGAACATGAATTAGACTTTGTACTGGCACAACAAAAAGAATTGGAAGATCTATTAGGACCGATGGAGAAACAGTTACTGCAAGAGAACAATGACCGTATCAAAGATCCGGAAAGAGAACATATGTATTCACTAGCCGAAAATTTGGATTCTCAACTACATCAGATGTCCGAAGATTTGAAGGAAGTTATAGAGCATCTCAATGAGACAAACAGAAGTCAAGATGGCAACGATCCAATTGTCCAAATCGGTCGCATACTAAACGCTCACATGTCGTCGATGCATTGGATAGACAACTCCATAGCTCAGATATCCAATAAGCTGGATCAATTGAAGAGCGTTCACGACACGCTCAGGAAGGATAACGAGAGATCATTTCAATTGACTTACAATTAA

Protein

MPTLTATTTAAAPVPPQPITSITFAQLEENINKWTLELEEQERTFINQATQINAWDTLLIANGEKIVELNEAVETVKNEQQSLEHELDFVLAQQKELEDLLGPMEKQLLQENNDRIKDPEREHMYSLAENLDSQLHQMSEDLKEVIEHLNETNRSQDGNDPIVQIGRILNAHMSSMHWIDNSIAQISNKLDQLKSVHDTLRKDNERSFQLTYN

Description

Essential component of the nuclear pore complex (By similarity). The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of Nup62 to the pore complex (By similarity). Binds to transcriptionally active genes (PubMed:20144760). Negatively regulates chromatin attachment to the nuclear envelope, probably by preventing chromatin tethering by Nup154 (PubMed:26341556).

Similarity

Belongs to the nucleoporin NSP1/NUP62 family.
Belongs to the tetraspanin (TM4SF) family.

Keywords

Chromosome   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   mRNA transport   Nuclear pore complex   Nucleus   Protein transport   Reference proteome   Repeat   Translocation   Transport  

Feature

chain  Nuclear pore glycoprotein p62

Uniprot

H9JW77   A0A1E1W6E3   A0A2H1W918   S4NNB7   A0A2A4K3C0   A0A212FIT7   + More
A0A2P8Y4S0   A0A2J7PU48   A0A067R7T3   A0A2W1BR89   A0A0C9QMH9   A0A232FC93   K7IZH2   A0A0L7QX93   A0A026WE14   A0A3L8E3V4   A0A1Q3EZD3   A0A0N0U6A3   Q17N90   E9IGK8   A0A023EPW4   A0A182G4X3   A0A151WP34   A0A195DQE5   F4X182   A0A195CW61   A0A154NZA6   A0A158NFI2   Q7QH06   E2AU26   A0A0J7L7J2   A0A2M4AXU0   A0A182IV95   A0A182SLU7   A0A182JTB7   A0A182WUK6   E2C4C3   B0WBD7   A0A182RXT2   A0A182HVW6   A0A182WE40   A0A182U6F5   A0A182V3T9   A0A084V9V3   A0A182KKF4   A0A195BDM6   A0A182FV53   A0A182PZF2   A0A182LXG4   A0A182Y9L8   A0A2M4BQD5   W5JW11   A0A2M4BQD6   A0A2M4BQD3   A0A2M4BQP3   A0A182PU39   A0A2A3EPB3   A0A088A0Q7   A0A182N2P4   A0A0K2U5K0   A0A151JYE2   A0A1S3IM90   A0A034W378   A0A1I8PAU8   A0A1A9X959   A0A1B0C5B1   A0A1B6JJ42   A0A1S3IMP6   A0A1S3IP95   A0A1A9UP00   A0A0K8TWR7   A0A1B0GBX5   A0A1I8N1N5   A0A1B6KP56   A0A1B6H1X7   A0A1A9ZW81   A0A0L0BLL3   B3NPJ6   A0A1W4UZ09   A0A0J9U3L1   B4HSX0   Q7JXF5   A0A1J1IHI3   B4P681   B4KRT3   A0A0M4EV94   W5NCR7   F7CVP0   G2HGU7   W8C512   A0A210R4K2   A0A1B0EW10   B4MPF9   A0A2F0BHT9   B4MFP8   A0A218UKP5   A0A1A9X3K1   B4GAB7   Q291T0  

Pubmed

19121390    23622113    22118469    29403074    24845553    28756777    + More
28648823    20075255    24508170    30249741    17510324    21282665    24945155    26483478    21719571    21347285    12364791    20798317    24438588    20966253    25244985    20920257    23761445    25348373    25315136    26108605    17994087    22936249    10731132    12537572    12537569    7641726    20144760    26341556    17550304    17495919    21484476    24495485    28812685    15632085   

EMBL

BABH01025468    BABH01025469    GDQN01008530    JAT82524.1    ODYU01007096    SOQ49560.1    + More
GAIX01012314    JAA80246.1    NWSH01000196    PCG78516.1    AGBW02008341    OWR53630.1    PYGN01000933    PSN39248.1    NEVH01021208    PNF19859.1    KK852880    KDR14424.1    KZ150002    PZC75280.1    GBYB01001822    JAG71589.1    NNAY01000430    OXU28446.1    KQ414705    KOC63181.1    KK107260    EZA54158.1    QOIP01000001    RLU27354.1    GFDL01014391    JAV20654.1    KQ435732    KOX77374.1    CH477201    EAT48164.1    GL763048    EFZ20295.1    GAPW01002533    JAC11065.1    JXUM01007480    KQ560240    KXJ83650.1    KQ982893    KYQ49590.1    KQ980662    KYN14704.1    GL888528    EGI59754.1    KQ977279    KYN04394.1    KQ434783    KZC04953.1    ADTU01014511    AAAB01008823    EAA05457.4    GL442767    EFN63069.1    LBMM01000354    KMQ99508.1    GGFK01012296    MBW45617.1    GL452440    EFN77218.1    DS231879    EDS42376.1    APCN01001433    ATLV01000457    KE523882    KFB34747.1    KQ976514    KYM82285.1    AXCN02001081    AXCM01004000    GGFJ01006156    MBW55297.1    ADMH02000284    ETN67119.1    GGFJ01006154    MBW55295.1    GGFJ01006155    MBW55296.1    GGFJ01006152    MBW55293.1    KZ288201    PBC33557.1    HACA01016132    CDW33493.1    KQ981494    KYN40939.1    GAKP01010205    JAC48747.1    JXJN01025920    GECU01008773    JAS98933.1    GDHF01033789    JAI18525.1    CCAG010005900    GEBQ01026752    GEBQ01015618    JAT13225.1    JAT24359.1    GECZ01001075    JAS68694.1    JRES01001693    KNC20936.1    CH954179    EDV55763.1    CM002911    KMY94255.1    CH480816    EDW48134.1    AE013599    AY094707    AAM11060.1    CVRI01000050    CRK99226.1    CM000158    EDW91931.1    CH933808    EDW08353.1    CP012524    ALC41507.1    AHAT01016873    AK305961    BAK62955.1    GAMC01005149    JAC01407.1    NEDP02000388    OWF56003.1    AJVK01024542    CH963849    EDW73998.1    NTJE010210143    MBW02573.1    CH940667    EDW57219.1    MUZQ01000241    OWK54359.1    CH479181    EDW31869.1    CM000071    EAL25032.2   

Proteomes

UP000005204    UP000218220    UP000007151    UP000245037    UP000235965    UP000027135    + More
UP000215335    UP000002358    UP000053825    UP000053097    UP000279307    UP000053105    UP000008820    UP000069940    UP000249989    UP000075809    UP000078492    UP000007755    UP000078542    UP000076502    UP000005205    UP000007062    UP000000311    UP000036403    UP000075880    UP000075901    UP000075881    UP000076407    UP000008237    UP000002320    UP000075900    UP000075840    UP000075920    UP000075902    UP000075903    UP000030765    UP000075882    UP000078540    UP000069272    UP000075886    UP000075883    UP000076408    UP000000673    UP000075885    UP000242457    UP000005203    UP000075884    UP000078541    UP000085678    UP000095300    UP000092443    UP000092460    UP000078200    UP000092444    UP000095301    UP000092445    UP000037069    UP000008711    UP000192221    UP000001292    UP000000803    UP000183832    UP000002282    UP000009192    UP000092553    UP000018468    UP000002280    UP000242188    UP000092462    UP000007798    UP000008792    UP000197619    UP000091820    UP000008744    UP000001819   

PRIDE

H9JW77    Q7JXF5   

Pfam

PF05064   Nsp1_C        + More
PF12906   RINGv
PF00335   Tetraspanin
PF00472   RF-1

Interpro

IPR007758   Nucleoporin_NSP1_C        + More
IPR026010   NSP1/NUP62       
IPR011016   Znf_RING-CH       
IPR013083   Znf_RING/FYVE/PHD       
IPR033072   NUP62_met       
IPR018499   Tetraspanin/Peripherin       
IPR000301   Tetraspanin       
IPR008952   Tetraspanin_EC2_sf       
IPR000352   Pep_chain_release_fac_I_II       

SUPFAM

SSF48652   SSF48652       

Gene 3D

3.30.40.10    

ProteinModelPortal

H9JW77   A0A1E1W6E3   A0A2H1W918   S4NNB7   A0A2A4K3C0   A0A212FIT7   + More
A0A2P8Y4S0   A0A2J7PU48   A0A067R7T3   A0A2W1BR89   A0A0C9QMH9   A0A232FC93   K7IZH2   A0A0L7QX93   A0A026WE14   A0A3L8E3V4   A0A1Q3EZD3   A0A0N0U6A3   Q17N90   E9IGK8   A0A023EPW4   A0A182G4X3   A0A151WP34   A0A195DQE5   F4X182   A0A195CW61   A0A154NZA6   A0A158NFI2   Q7QH06   E2AU26   A0A0J7L7J2   A0A2M4AXU0   A0A182IV95   A0A182SLU7   A0A182JTB7   A0A182WUK6   E2C4C3   B0WBD7   A0A182RXT2   A0A182HVW6   A0A182WE40   A0A182U6F5   A0A182V3T9   A0A084V9V3   A0A182KKF4   A0A195BDM6   A0A182FV53   A0A182PZF2   A0A182LXG4   A0A182Y9L8   A0A2M4BQD5   W5JW11   A0A2M4BQD6   A0A2M4BQD3   A0A2M4BQP3   A0A182PU39   A0A2A3EPB3   A0A088A0Q7   A0A182N2P4   A0A0K2U5K0   A0A151JYE2   A0A1S3IM90   A0A034W378   A0A1I8PAU8   A0A1A9X959   A0A1B0C5B1   A0A1B6JJ42   A0A1S3IMP6   A0A1S3IP95   A0A1A9UP00   A0A0K8TWR7   A0A1B0GBX5   A0A1I8N1N5   A0A1B6KP56   A0A1B6H1X7   A0A1A9ZW81   A0A0L0BLL3   B3NPJ6   A0A1W4UZ09   A0A0J9U3L1   B4HSX0   Q7JXF5   A0A1J1IHI3   B4P681   B4KRT3   A0A0M4EV94   W5NCR7   F7CVP0   G2HGU7   W8C512   A0A210R4K2   A0A1B0EW10   B4MPF9   A0A2F0BHT9   B4MFP8   A0A218UKP5   A0A1A9X3K1   B4GAB7   Q291T0  

PDB

5IJO     E-value=2.17382e-56,     Score=551

KEGG

101736306    K14306 nuclear pore complex protein Nup62 | (RefSeq) nuclear pore glycoprotein p62

PATHWAY

03013    RNA transport - Bombyx mori (domestic silkworm)

GO

GO:0017056   GO:0005643   GO:0016021   GO:0008270   GO:0044613   GO:0005543   GO:0006606   GO:0030717   GO:0031490   GO:0097298   GO:0000785   GO:0097240   GO:0015031   GO:0051028   GO:0005737   GO:0005815   GO:0005635   GO:0000922   GO:0003747  

PANTHER

PTHR12084   PTHR12084:SF12  

Subcellular location

Nucleus   Central region of the nuclear pore, within the transporter (By similarity). Associates with chromatin (PubMed:20144760).   With evidence from 1 publications.
Chromosome   Central region of the nuclear pore, within the transporter (By similarity). Associates with chromatin (PubMed:20144760).   With evidence from 1 publications.
Nucleus envelope   Central region of the nuclear pore, within the transporter (By similarity). Associates with chromatin (PubMed:20144760).   With evidence from 1 publications.
Nuclear pore complex   Central region of the nuclear pore, within the transporter (By similarity). Associates with chromatin (PubMed:20144760).   With evidence from 1 publications.
Cytoplasm   Central region of the nuclear pore, within the transporter (By similarity). Associates with chromatin (PubMed:20144760).   With evidence from 1 publications.
Cytoskeleton   Central region of the nuclear pore, within the transporter (By similarity). Associates with chromatin (PubMed:20144760).   With evidence from 1 publications.
Spindle pole   Central region of the nuclear pore, within the transporter (By similarity). Associates with chromatin (PubMed:20144760).   With evidence from 1 publications.
Microtubule organizing center   Central region of the nuclear pore, within the transporter (By similarity). Associates with chromatin (PubMed:20144760).   With evidence from 1 publications.
Centrosome   Central region of the nuclear pore, within the transporter (By similarity). Associates with chromatin (PubMed:20144760).   With evidence from 1 publications.
Membrane  

Length:

213

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00206

Exp number, first 60 AAs:

0.00191

Total prob of N-in:

0.13474

outside

1  -  213

 

 

Pi

299.160807

Theta

209.345645

Tajima's D

1.249243

CLR

0

CSRT

0.731613419329034

Interpretation

Possibly Positive selection