SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO16318
Pre Gene Modal
BGIBMGA013776
Annotation
PREDICTED:_multiple_C2_and_transmembrane_domain-containing_protein_1-like_[Bombyx_mori]
Full name
Multiple C2 and transmembrane domain-containing protein      
Location in the cell
Cytoplasmic   Reliability : 2.124
 

Sequence

CDS
ATGGACCTTGATACAAGGTCGAGTGACCCTTATTGTAAGTTTAGGTTAGGTAACGAAAAATACAAGAGTAAAGTGGTGTGGAAAACGCTACATCCGTCGTGGCTGGAGCAATTCGATTTACATTTGTACGACGACCAGGAACAAGTTCTGGAAGTGACCGTATGGGACAAGGATAAGCAGACCAAAGACGATTTTTTAGGGCGATGCACAATAGACTTATCGAAATTGGAAAGAGAGAAGACTCACAGTATGTGGAAGGAACTGGAAGATGGAAATGGACAAATCTTTTTATTGTTAACGATAAGCGGAACAACGCAGTCCGAAACAATAACCGATTTGACGAGCTACAAGGAAAATCCACGGGACTTGGAAATCATCGAACGTAGATATACGTGGTACAGATTAAACGAAACATCAGCCGGGGTCGGTTGGCTATGCGTCAAGGTGTACGGTGCCAAAGGTCTGGCTGCAGCCGATCTGGGCGGGAAATCCGACCCGTTCTGCGTATTGGAGCTTGGTAATGCGAGACTGCAAACACATACCGAATACAAGACCTTGACACCGAATTGGATGAAGATATTCACTTTCACGGTAAAAGACATAAGCTCGATATTGGAATTGACCGTGTATGACGAGGATCACGACCACAAAGTCGAGTTTCTAGGTAAACTGGCCATACCGCTTTTGAACATAAGGAACGGTGAGAAGAGATGGTACGCTCTGAAGGACAAGAAGATGAGGGCGCGAGCGAAAGGGAACTACCCTCAGATATTACTGGAGATGTTGGTCGTATGGAATCCGCTAAAAGGCGCGATCCGAGTTGTGAATCCAAAAGAGCCAAAGTACATGCACCAAGAGGCCAAATTCAAGAGGCAGTTGTTCATAAGAAATGTTATGAGGCTGAAAGCCATAATTATGTGGTTCATTGAAGTCGGCAAGATCTTGCAGGATTGTTTTGAATGGGAATCAAGGATCCGATCGTTTCTGGGCCTCCTCGCTTGGCTAGCCTTTTGTTATTATTACGAAATGTGGATGCTTCCCTTCATGCTGCTCATGTTCTTCGCTAGGAACTGGCTTGTTTATAGATTGACAGGGGGTAACCCTTTGCTAGTTCCGGTTGACGATGATGATCTCTTGGCTGAAGAAGACGACGAAGAGGAAATAGATAAGGAAGAAAAGAAATCTCTTAAAGAAAGATTGCAAGCTATACAGGAAGTAACACAAACAGTCCAAAACGCCATAGGTTATGTCGCGTCGCTGGGTGAAGCTGTCAAAAATTTAATGAACTTCACTGTGCCATATCTGAGCTATTTAGCGATTACAATGTTATTCGGGGCGATGTTGGTACTATACGTAATACCTTTGAGGTACCTCCTAATGGCTTGGGGAATAAATAAATTTGCGAGAAAAATTTTAAGACCACACACGATACCAAACAATGAGGTTTTGGATTTGTTATCGAGAGTACCAGACGATGAGACTCTTTTGGACTGCAGAGAACTGAAGACGCATCCACCGAATGAGCGAAAAGACGCTAGAAAAAAACATAAAGCATCCTAG
Protein
MDLDTRSSDPYCKFRLGNEKYKSKVVWKTLHPSWLEQFDLHLYDDQEQVLEVTVWDKDKQTKDDFLGRCTIDLSKLEREKTHSMWKELEDGNGQIFLLLTISGTTQSETITDLTSYKENPRDLEIIERRYTWYRLNETSAGVGWLCVKVYGAKGLAAADLGGKSDPFCVLELGNARLQTHTEYKTLTPNWMKIFTFTVKDISSILELTVYDEDHDHKVEFLGKLAIPLLNIRNGEKRWYALKDKKMRARAKGNYPQILLEMLVVWNPLKGAIRVVNPKEPKYMHQEAKFKRQLFIRNVMRLKAIIMWFIEVGKILQDCFEWESRIRSFLGLLAWLAFCYYYEMWMLPFMLLMFFARNWLVYRLTGGNPLLVPVDDDDLLAEEDDEEEIDKEEKKSLKERLQAIQEVTQTVQNAIGYVASLGEAVKNLMNFTVPYLSYLAITMLFGAMLVLYVIPLRYLLMAWGINKFARKILRPHTIPNNEVLDLLSRVPDDETLLDCRELKTHPPNERKDARKKHKAS

Summary

Description
Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity (PubMed:28485711).
Cofactor
Ca(2+)
Keywords
Alternative splicing   Calcium   Complete proteome   Endoplasmic reticulum   Membrane   Reference proteome   Repeat   Transmembrane   Transmembrane helix  
Feature
chain  Multiple C2 and transmembrane domain-containing protein
splice variant  In isoform 2.
EMBL
BABH01025337    BABH01025338    NWSH01000040    PCG80354.1    KZ150109    PZC73376.1    + More
PCG80353.1    ODYU01007596    SOQ50513.1    KQ459992    KPJ18581.1    KQ459166    KPJ03575.1    AGBW02010634    OWR48139.1    GECZ01028281    JAS41488.1    KQ971352    EFA07297.2    KYB26752.1    GEZM01043135    JAV79286.1    GEZM01043132    JAV79290.1    GEZM01043131    JAV79292.1    KK852859    KDR14857.1    KYB26751.1    KQ773232    OAD52398.1    ACPB03005944    JTDY01001713    KOB73098.1    GBYB01000914    GBYB01006426    JAG70681.1    JAG76193.1    ADTU01021618    ADTU01021619    APGK01034847    APGK01034848    APGK01034849    APGK01034850    KB740923    ENN78073.1    KB632339    ERL92928.1    NNAY01000316    OXU29270.1    DS235442    EEB15778.1    JR040572    AEY59192.1    KQ435732    KOX77403.1    JR040571    AEY59191.1    KQ434783    KZC04883.1    KZ288212    PBC32861.1    GL444028    EFN61345.1    UFQT01001061    SSX28680.1    QOIP01000013    RLU15249.1    KQ414705    KOC63159.1    KQ978273    KYM95768.1    JXUM01079729    JXUM01079730    JXUM01079731    JXUM01079732    GDUN01000054    JAN95865.1    GFDL01000254    JAV34791.1    GFDL01000258    JAV34787.1    GFDL01000251    JAV34794.1    GFDL01000252    JAV34793.1    CH477410    EAT41473.1    ATLV01012371    KE524785    KFB36651.1    AXCN02000592    GDHF01011734    JAI40580.1    GAKP01015775    JAC43177.1    AXCM01001910    APCN01000218    GAMC01021074    GAMC01021071    JAB85484.1    AAAB01008807    EAL41731.2    GEDC01020165    GEDC01015264    JAS17133.1    JAS22034.1    JXJN01000456    GBXI01009905    GBXI01009819    GBXI01003706    JAD04387.1    JAD04473.1    JAD10586.1    CCAG010001058    CCAG010001059    CM000362    EDX07735.1    AE013599    AY071153    AAF57640.2    AAL48775.1    CH480816    EDW48517.1    GEFH01001542    JAP67039.1    GEDC01009115    JAS28183.1    GFAC01005038    JAT94150.1    GEDC01016561    JAS20737.1    GFAA01003656    JAT99778.1    GFPF01007410    MAA18556.1    GEDC01004734    JAS32564.1    GEZM01043134    JAV79287.1    GACK01006817    JAA58217.1    GEDC01000524    JAS36774.1    GEZM01043133    JAV79289.1    CVRI01000075    CRL08658.1    CM002911    KMY94937.1    CH954179    EDV55134.2    GEDC01019587    JAS17711.1    GGLE01000436    MBY04562.1    GEZM01043137    JAV79284.1    GEDC01010549    JAS26749.1    CM000158    EDW91577.2   
Pfam
PF08372   PRT_C        + More
PF00168   C2
PF06398   Pex24p
Interpro
IPR000008   C2_dom        + More
IPR013583   PRibTrfase_C       
IPR035892   C2_domain_sf       
IPR001565   Synaptotagmin       
IPR010482   Peroxin       
Gene 3D
PDB
2EP6     E-value=5.30743e-29,     Score=319

Ontologies

Topology

Subcellular location
Endoplasmic reticulum membrane  
Length:
519
Number of predicted TMHs:
2
Exp number of AAs in TMHs:
48.8588
Exp number, first 60 AAs:
0
Total prob of N-in:
0.23869
outside
1  -  331
TMhelix
332  -  354
inside
355  -  432
TMhelix
433  -  455
outside
456  -  519
 
 

Population Genetic Test Statistics

Pi
182.944247
Theta
144.324939
Tajima's D
0.629259
CLR
0.30574
CSRT
0.553572321383931
Interpretation
Uncertain
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