Gene

KWMTBOMO16318

Pre Gene Modal

BGIBMGA013776

Annotation

PREDICTED:_multiple_C2_and_transmembrane_domain-containing_protein_1-like_[Bombyx_mori]

Location

Bomo_Chr28(+):5286159-5299565      View in EpiBrowser

Full name

Multiple C2 and transmembrane domain-containing protein      

Location in the cell

Cytoplasmic   Reliability : 2.124

CDS

ATGGACCTTGATACAAGGTCGAGTGACCCTTATTGTAAGTTTAGGTTAGGTAACGAAAAATACAAGAGTAAAGTGGTGTGGAAAACGCTACATCCGTCGTGGCTGGAGCAATTCGATTTACATTTGTACGACGACCAGGAACAAGTTCTGGAAGTGACCGTATGGGACAAGGATAAGCAGACCAAAGACGATTTTTTAGGGCGATGCACAATAGACTTATCGAAATTGGAAAGAGAGAAGACTCACAGTATGTGGAAGGAACTGGAAGATGGAAATGGACAAATCTTTTTATTGTTAACGATAAGCGGAACAACGCAGTCCGAAACAATAACCGATTTGACGAGCTACAAGGAAAATCCACGGGACTTGGAAATCATCGAACGTAGATATACGTGGTACAGATTAAACGAAACATCAGCCGGGGTCGGTTGGCTATGCGTCAAGGTGTACGGTGCCAAAGGTCTGGCTGCAGCCGATCTGGGCGGGAAATCCGACCCGTTCTGCGTATTGGAGCTTGGTAATGCGAGACTGCAAACACATACCGAATACAAGACCTTGACACCGAATTGGATGAAGATATTCACTTTCACGGTAAAAGACATAAGCTCGATATTGGAATTGACCGTGTATGACGAGGATCACGACCACAAAGTCGAGTTTCTAGGTAAACTGGCCATACCGCTTTTGAACATAAGGAACGGTGAGAAGAGATGGTACGCTCTGAAGGACAAGAAGATGAGGGCGCGAGCGAAAGGGAACTACCCTCAGATATTACTGGAGATGTTGGTCGTATGGAATCCGCTAAAAGGCGCGATCCGAGTTGTGAATCCAAAAGAGCCAAAGTACATGCACCAAGAGGCCAAATTCAAGAGGCAGTTGTTCATAAGAAATGTTATGAGGCTGAAAGCCATAATTATGTGGTTCATTGAAGTCGGCAAGATCTTGCAGGATTGTTTTGAATGGGAATCAAGGATCCGATCGTTTCTGGGCCTCCTCGCTTGGCTAGCCTTTTGTTATTATTACGAAATGTGGATGCTTCCCTTCATGCTGCTCATGTTCTTCGCTAGGAACTGGCTTGTTTATAGATTGACAGGGGGTAACCCTTTGCTAGTTCCGGTTGACGATGATGATCTCTTGGCTGAAGAAGACGACGAAGAGGAAATAGATAAGGAAGAAAAGAAATCTCTTAAAGAAAGATTGCAAGCTATACAGGAAGTAACACAAACAGTCCAAAACGCCATAGGTTATGTCGCGTCGCTGGGTGAAGCTGTCAAAAATTTAATGAACTTCACTGTGCCATATCTGAGCTATTTAGCGATTACAATGTTATTCGGGGCGATGTTGGTACTATACGTAATACCTTTGAGGTACCTCCTAATGGCTTGGGGAATAAATAAATTTGCGAGAAAAATTTTAAGACCACACACGATACCAAACAATGAGGTTTTGGATTTGTTATCGAGAGTACCAGACGATGAGACTCTTTTGGACTGCAGAGAACTGAAGACGCATCCACCGAATGAGCGAAAAGACGCTAGAAAAAAACATAAAGCATCCTAG

Protein

MDLDTRSSDPYCKFRLGNEKYKSKVVWKTLHPSWLEQFDLHLYDDQEQVLEVTVWDKDKQTKDDFLGRCTIDLSKLEREKTHSMWKELEDGNGQIFLLLTISGTTQSETITDLTSYKENPRDLEIIERRYTWYRLNETSAGVGWLCVKVYGAKGLAAADLGGKSDPFCVLELGNARLQTHTEYKTLTPNWMKIFTFTVKDISSILELTVYDEDHDHKVEFLGKLAIPLLNIRNGEKRWYALKDKKMRARAKGNYPQILLEMLVVWNPLKGAIRVVNPKEPKYMHQEAKFKRQLFIRNVMRLKAIIMWFIEVGKILQDCFEWESRIRSFLGLLAWLAFCYYYEMWMLPFMLLMFFARNWLVYRLTGGNPLLVPVDDDDLLAEEDDEEEIDKEEKKSLKERLQAIQEVTQTVQNAIGYVASLGEAVKNLMNFTVPYLSYLAITMLFGAMLVLYVIPLRYLLMAWGINKFARKILRPHTIPNNEVLDLLSRVPDDETLLDCRELKTHPPNERKDARKKHKAS

Description

Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity (PubMed:28485711).

Cofactor

Ca(2+)

Keywords

Alternative splicing   Calcium   Complete proteome   Endoplasmic reticulum   Membrane   Reference proteome   Repeat   Transmembrane   Transmembrane helix  

Feature

chain  Multiple C2 and transmembrane domain-containing protein
splice variant  In isoform 2.

Uniprot

H9JW63   A0A2A4K8X0   A0A2W1BKK6   A0A2A4K984   A0A2H1WBS6   A0A0N1IGC7   + More
A0A0N0P9T6   A0A212F325   A0A1B6EUE0   D6WUE3   A0A139WFN8   A0A1Y1M5V4   A0A1Y1M3S5   A0A1Y1M0D1   A0A067QZE1   A0A139WFX4   A0A310S7H1   T1I1Y3   A0A0L7LC75   A0A0C9RHL5   A0A158NNP2   N6TJP3   U4UKD4   A0A232FFH3   E0VQX2   V9IEV3   K7IS27   A0A0M9A7A8   V9IFE7   A0A154NZ39   A0A2A3EPA0   E2AYX5   A0A336MFH5   A0A3L8D4S5   A0A0L7QX92   A0A151I9P9   A0A1S4FEV1   A0A182GQ57   A0A0P6IW11   A0A1Q3G4R3   A0A1Q3G4Q9   A0A1Q3G4S1   A0A1Q3G4S2   Q174I5   A0A084VFA7   A0A182Q4S6   A0A182J121   A0A182XZH8   A0A182JQQ1   A0A1I8PKK1   A0A0K8VPT3   A0A182RFQ2   A0A182UEL5   A0A034VM56   A0A182P9V6   A0A182MA45   A0A182I3R3   A0A182X6G0   A0A182WIT4   A0A182VKM5   A0A182KRV2   A0A1I8PKP5   A0A1I8MDV2   A0A182NHJ8   A0A1A9XHA5   W8B6U0   A0A1I8MDU5   A0A1A9WYX3   Q5TX35   A0A1B6CV73   A0A1A9URC3   A0A1B0AMI4   A0A0A1XHY1   A0A1B0G1V4   B4QD30   Q7JZN2   B4HP15   A0A131XIT3   A0A1B6DRF0   A0A1E1X4F5   A0A1B6D4Y6   A0A1E1XKP4   A0A224YLR7   A0A1B6E3S6   A0A1Y1M7K1   L7M2Y5   A0A1B6EFX5   A0A1B0AFR2   A0A1Y1M0F1   A0A1J1J9C9   A1ZBD6-3   A0A0J9RG79   A1ZBD6   A1ZBD6-2   B3NKB2   A0A1B6CWF9   A0A2R5L500   A0A1Y1M080   A0A1B6DM47   B4P491  

Pubmed

19121390    28756777    26354079    22118469    18362917    19820115    + More
28004739    24845553    26227816    21347285    23537049    28648823    20566863    20075255    20798317    30249741    26483478    26999592    17510324    24438588    25244985    25348373    20966253    25315136    24495485    12364791    25830018    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    28049606    28503490    29209593    28797301    25576852    28485711    22936249    17550304   

EMBL

BABH01025337    BABH01025338    NWSH01000040    PCG80354.1    KZ150109    PZC73376.1    + More
PCG80353.1    ODYU01007596    SOQ50513.1    KQ459992    KPJ18581.1    KQ459166    KPJ03575.1    AGBW02010634    OWR48139.1    GECZ01028281    JAS41488.1    KQ971352    EFA07297.2    KYB26752.1    GEZM01043135    JAV79286.1    GEZM01043132    JAV79290.1    GEZM01043131    JAV79292.1    KK852859    KDR14857.1    KYB26751.1    KQ773232    OAD52398.1    ACPB03005944    JTDY01001713    KOB73098.1    GBYB01000914    GBYB01006426    JAG70681.1    JAG76193.1    ADTU01021618    ADTU01021619    APGK01034847    APGK01034848    APGK01034849    APGK01034850    KB740923    ENN78073.1    KB632339    ERL92928.1    NNAY01000316    OXU29270.1    DS235442    EEB15778.1    JR040572    AEY59192.1    KQ435732    KOX77403.1    JR040571    AEY59191.1    KQ434783    KZC04883.1    KZ288212    PBC32861.1    GL444028    EFN61345.1    UFQT01001061    SSX28680.1    QOIP01000013    RLU15249.1    KQ414705    KOC63159.1    KQ978273    KYM95768.1    JXUM01079729    JXUM01079730    JXUM01079731    JXUM01079732    GDUN01000054    JAN95865.1    GFDL01000254    JAV34791.1    GFDL01000258    JAV34787.1    GFDL01000251    JAV34794.1    GFDL01000252    JAV34793.1    CH477410    EAT41473.1    ATLV01012371    KE524785    KFB36651.1    AXCN02000592    GDHF01011734    JAI40580.1    GAKP01015775    JAC43177.1    AXCM01001910    APCN01000218    GAMC01021074    GAMC01021071    JAB85484.1    AAAB01008807    EAL41731.2    GEDC01020165    GEDC01015264    JAS17133.1    JAS22034.1    JXJN01000456    GBXI01009905    GBXI01009819    GBXI01003706    JAD04387.1    JAD04473.1    JAD10586.1    CCAG010001058    CCAG010001059    CM000362    EDX07735.1    AE013599    AY071153    AAF57640.2    AAL48775.1    CH480816    EDW48517.1    GEFH01001542    JAP67039.1    GEDC01009115    JAS28183.1    GFAC01005038    JAT94150.1    GEDC01016561    JAS20737.1    GFAA01003656    JAT99778.1    GFPF01007410    MAA18556.1    GEDC01004734    JAS32564.1    GEZM01043134    JAV79287.1    GACK01006817    JAA58217.1    GEDC01000524    JAS36774.1    GEZM01043133    JAV79289.1    CVRI01000075    CRL08658.1    CM002911    KMY94937.1    CH954179    EDV55134.2    GEDC01019587    JAS17711.1    GGLE01000436    MBY04562.1    GEZM01043137    JAV79284.1    GEDC01010549    JAS26749.1    CM000158    EDW91577.2   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000007266    + More
UP000027135    UP000015103    UP000037510    UP000005205    UP000019118    UP000030742    UP000215335    UP000009046    UP000002358    UP000053105    UP000076502    UP000242457    UP000000311    UP000279307    UP000053825    UP000078542    UP000069940    UP000008820    UP000030765    UP000075886    UP000075880    UP000076408    UP000075881    UP000095300    UP000075900    UP000075902    UP000075885    UP000075883    UP000075840    UP000076407    UP000075920    UP000075903    UP000075882    UP000095301    UP000075884    UP000092443    UP000091820    UP000007062    UP000078200    UP000092460    UP000092444    UP000000304    UP000000803    UP000001292    UP000092445    UP000183832    UP000008711    UP000002282   

PRIDE

H9JW63    Q7JZN2    L7M2Y5    A1ZBD6   

Pfam

PF08372   PRT_C        + More
PF00168   C2
PF06398   Pex24p

Interpro

IPR000008   C2_dom        + More
IPR013583   PRibTrfase_C       
IPR035892   C2_domain_sf       
IPR001565   Synaptotagmin       
IPR010482   Peroxin       

Gene 3D

2.60.40.150    

ProteinModelPortal

H9JW63   A0A2A4K8X0   A0A2W1BKK6   A0A2A4K984   A0A2H1WBS6   A0A0N1IGC7   + More
A0A0N0P9T6   A0A212F325   A0A1B6EUE0   D6WUE3   A0A139WFN8   A0A1Y1M5V4   A0A1Y1M3S5   A0A1Y1M0D1   A0A067QZE1   A0A139WFX4   A0A310S7H1   T1I1Y3   A0A0L7LC75   A0A0C9RHL5   A0A158NNP2   N6TJP3   U4UKD4   A0A232FFH3   E0VQX2   V9IEV3   K7IS27   A0A0M9A7A8   V9IFE7   A0A154NZ39   A0A2A3EPA0   E2AYX5   A0A336MFH5   A0A3L8D4S5   A0A0L7QX92   A0A151I9P9   A0A1S4FEV1   A0A182GQ57   A0A0P6IW11   A0A1Q3G4R3   A0A1Q3G4Q9   A0A1Q3G4S1   A0A1Q3G4S2   Q174I5   A0A084VFA7   A0A182Q4S6   A0A182J121   A0A182XZH8   A0A182JQQ1   A0A1I8PKK1   A0A0K8VPT3   A0A182RFQ2   A0A182UEL5   A0A034VM56   A0A182P9V6   A0A182MA45   A0A182I3R3   A0A182X6G0   A0A182WIT4   A0A182VKM5   A0A182KRV2   A0A1I8PKP5   A0A1I8MDV2   A0A182NHJ8   A0A1A9XHA5   W8B6U0   A0A1I8MDU5   A0A1A9WYX3   Q5TX35   A0A1B6CV73   A0A1A9URC3   A0A1B0AMI4   A0A0A1XHY1   A0A1B0G1V4   B4QD30   Q7JZN2   B4HP15   A0A131XIT3   A0A1B6DRF0   A0A1E1X4F5   A0A1B6D4Y6   A0A1E1XKP4   A0A224YLR7   A0A1B6E3S6   A0A1Y1M7K1   L7M2Y5   A0A1B6EFX5   A0A1B0AFR2   A0A1Y1M0F1   A0A1J1J9C9   A1ZBD6-3   A0A0J9RG79   A1ZBD6   A1ZBD6-2   B3NKB2   A0A1B6CWF9   A0A2R5L500   A0A1Y1M080   A0A1B6DM47   B4P491  

PDB

2EP6     E-value=5.30743e-29,     Score=319

KEGG

101738650    no KO assigned | (RefSeq) multiple C2 and transmembrane domain-containing protein 1-like

GO

GO:0016021   GO:0030672   GO:0005509   GO:0046928   GO:0048168   GO:0005789   GO:0005515   GO:0009116   GO:0004850   GO:0005737   GO:0009166   GO:0005839   GO:0051603   GO:0046835   GO:0006281   GO:0006259  

Subcellular location

Endoplasmic reticulum membrane  

Length:

519

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

48.8588

Exp number, first 60 AAs:

0

Total prob of N-in:

0.23869

outside

1  -  331

TMhelix

332  -  354

inside

355  -  432

TMhelix

433  -  455

outside

456  -  519

 

 

Pi

182.944247

Theta

144.324939

Tajima's D

0.629259

CLR

0.30574

CSRT

0.553572321383931

Interpretation

Uncertain