Gene

KWMTBOMO16312

Pre Gene Modal

BGIBMGA013774

Annotation

PREDICTED:_uridine_phosphorylase_1-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr28(+):5132951-5159913      View in EpiBrowser

Full name

Uridine phosphorylase      

Location in the cell

Cytoplasmic   Reliability : 3.106

CDS

ATGCGTAGAGCTAGATCAAAGTTAGATTCTGTTGCTCTTGAAGAAAGACGCAAAAAGGACCGAGAAAGTAATAAAATGAAGTGTAATTGTGATTACGTTCTTCATTGCAACACTTTGGAGCCGCATTACGACAACTGTGCTACCGTATGGGAGACATCGCACCCAGGAAAGGAATACCCGAAAAACGAAGATGGTACCATCCGCTTGCCAAATAAGAACTTGGATAAGTTGGAATCCGATGTATTGTATCATTTGGGCTTGGATACGAAAAATTACGATCTGCCCGCTTTGTTCGGTGATGTCAAGTTCGTATGTATAGGCGGCACAAAGCATAGAATGAGAGAATTCGCGGAATTTGTTTCATTTAATGTTTTCCATGGAAAAAACATGAAATTGGTTAACCTTACGAAGCATTCGCATCGTTACGCGACTTACAAAGTTGGACCAGTCCTAAGTGTCAGTCACGGGATCGGTATACCGTCGATGACAACGGCCCTACAAGAGATCATTAAGCTGCTGCATTACGCCAAGGCTGTCGACCCTATAGTGTTCAGAATTGGCACGTCGGGGGGGCTCGGTATACCACCAGGTTCCGTCGTTGTATCGAGCTGGGGCCTCAACGGATATTTGGAGAAGAGTTACGATATTCCGGTTATGGGTCGATCATTAAAGCTACCCGCTATTTTAGATAAAAGATTGAGTCAGGAAATATATTCTATGGCATCTGAGGAGGATGAGTTTCAAACATATCTCGGAGGCACGATGGGCGCCGATGATTTTTACAGAGGTCAAGCCCGTTTGGATGGACCTTTCTGTGATCACACAGAAGAGGACAAGCTGGAATTCCTTGAGAAATTATCAGAAATGGGTGTGAGGAATATAGAGATGGAGGCGCCCGCTTTTGCGGCGTTAACAAAAGAAGCCGGCATACGAGGGGCGATCGTTTGTGTTACTCTAATAAACAGACTTGAAGGAGATCAGGTAAGCACCGAGAAGGGTACTTTGTTGCAGTGGCAGAAGAGACCAATGGCTATTGTGGCCAAATTTATATCTAAATACTTAGATAGTATGAACGGATGGAAATAG

Protein

MRRARSKLDSVALEERRKKDRESNKMKCNCDYVLHCNTLEPHYDNCATVWETSHPGKEYPKNEDGTIRLPNKNLDKLESDVLYHLGLDTKNYDLPALFGDVKFVCIGGTKHRMREFAEFVSFNVFHGKNMKLVNLTKHSHRYATYKVGPVLSVSHGIGIPSMTTALQEIIKLLHYAKAVDPIVFRIGTSGGLGIPPGSVVVSSWGLNGYLEKSYDIPVMGRSLKLPAILDKRLSQEIYSMASEEDEFQTYLGGTMGADDFYRGQARLDGPFCDHTEEDKLEFLEKLSEMGVRNIEMEAPAFAALTKEAGIRGAIVCVTLINRLEGDQVSTEKGTLLQWQKRPMAIVAKFISKYLDSMNGWK

Description

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic Activity

phosphate + uridine = alpha-D-ribose 1-phosphate + uracil

Similarity

Belongs to the PNP/UDP phosphorylase family.

Uniprot

H9JW61   A0A2H1VDS7   A0A2A4JF92   A0A2H1VST5   A0A0N1IHY1   A0A0N1IBT0   + More
A0A3S2M604   N6TC60   A0A1B6E436   A0A232F9X7   V5GTE6   A0A1B6DDL4   V5GHK9   A0A0C9RSZ0   A0A023F5G7   A0A069DYM6   A0A023GIU3   T1HDV8   K7IX68   A0A0T6B3J4   A0A336M4H0   A0A162SIL1   B4JRW5   A0A336KHJ2   A0A0K8TFY7   A0A1S3ID96   A0A2S2QKU5   E9GTM3   A0A1B6KFU3   A0A023EQI1   A0A0A9W2Y6   A0A336KKR0   A0A0P4YSK4   A0A0P5S1P2   A0A0Q9XCR7   A0A067QX58   A0A2R7WS35   A0A2A3E7V8   A0A1I8NAW4   T1PEU7   A0A2J7QZT9   B4K898   A0A146LJI9   A0A1Q3FZS6   A0A154PIC4   A0A084VNU7   A0A182J5Y0   A0A0A9Z8J9   A0A1S4FC12   Q178N8   A0A1Q3G579   A0A146L6D1   A0A182P2A8   A0A2S2NMA6   A0A1S6J0Z4   A0A182N1K9   V9IDR4   A0A0P6I8D6   A0A087ZWP1   Q7PFX7   A0A1E1XIE6   A0A0K8TEY3   A0A182VAL4   A0A182HIB7   A0A182X800   A0A182U4M6   A0A182MVH1   A0A2C9GJV1   A0A0L0C6U7   A0A182QKN0   A0A2A4K1Z2   A0A0Q9WSV4   A0A3B0K7Z1   B4QWT9   B4IC10   A0A2J7QZT7   B4LX04   A0A1B0CE83   A0A182W501   A0A1Y1KPY8   B0X890   Q8IMQ8   A0A0M4F4T1   D6WB44   A0A0Q9WGY3   Q9VBA0   A0A182YQ65   J9K4G6   A0A3B0JLB0   B4NA28   A0A182K465   A0A182R7I4   A0A1L8ED75   A0A212FID5   A0A1I8PMF4   I5AN36   A0A1B6HN66   A0A1B6F7G6   A0A1I8PMD6  

EC Number

2.4.2.3

Pubmed

19121390    26354079    23537049    28648823    25474469    26334808    + More
20075255    17994087    26823975    26383154    21292972    24945155    25401762    24845553    25315136    24438588    17510324    27414796    12364791    14747013    17210077    28503490    26108605    28004739    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    18362917    19820115    25244985    22118469    15632085    23185243   

EMBL

BABH01025325    ODYU01001826    SOQ38562.1    NWSH01001676    PCG70446.1    ODYU01004209    + More
SOQ43836.1    KQ459992    KPJ18578.1    KQ459166    KPJ03577.1    RSAL01000029    RVE51754.1    APGK01043564    KB741015    ENN75323.1    GEDC01022789    GEDC01020497    GEDC01005374    GEDC01004624    JAS14509.1    JAS16801.1    JAS31924.1    JAS32674.1    NNAY01000643    OXU27233.1    GALX01004968    JAB63498.1    GEDC01028640    GEDC01013514    GEDC01006288    GEDC01002289    JAS08658.1    JAS23784.1    JAS31010.1    JAS35009.1    GALX01004967    JAB63499.1    GBYB01011750    JAG81517.1    GBBI01002313    JAC16399.1    GBGD01002125    JAC86764.1    GBBM01001607    JAC33811.1    ACPB03023190    AAZX01000598    LJIG01015983    KRT81967.1    UFQS01000433    UFQT01000433    SSX03876.1    SSX24241.1    LRGB01000024    KZS21337.1    CH916373    EDV94505.1    SSX03877.1    SSX24242.1    GBRD01001776    GDHC01018041    JAG64045.1    JAQ00588.1    GGMS01009141    MBY78344.1    GL732564    EFX77188.1    GEBQ01029650    JAT10327.1    GAPW01001751    JAC11847.1    GBHO01044384    GBHO01037687    JAF99219.1    JAG05917.1    SSX03875.1    SSX24240.1    GDIP01223175    JAJ00227.1    GDIQ01093496    JAL58230.1    CH933806    KRG02161.1    KK852865    KDR14775.1    KK855399    PTY22378.1    KZ288354    PBC27269.1    KA646437    KA646438    AFP61067.1    NEVH01009067    PNF34098.1    EDW16480.1    GDHC01010451    JAQ08178.1    GFDL01001988    JAV33057.1    KQ434924    KZC11562.1    ATLV01014923    KE524996    KFB39641.1    GBHO01037693    GBHO01002022    GBRD01009849    JAG05911.1    JAG41582.1    JAG55975.1    CH477361    EAT42652.1    GFDL01000083    JAV34962.1    GDHC01014625    JAQ04004.1    GGMR01005686    MBY18305.1    KU764443    AQS60689.1    JR038970    AEY58469.1    GDIQ01008074    JAN86663.1    AAAB01008846    EAA45146.4    GFAC01000078    JAT99110.1    GBRD01001777    JAG64044.1    APCN01003925    AXCM01001441    JRES01000835    KNC27961.1    AXCN02002448    NWSH01000241    PCG78079.1    CH964232    KRF99317.1    OUUW01000005    SPP81121.1    CM000364    EDX14606.1    CH480828    EDW45168.1    PNF34097.1    CH940650    EDW67751.1    AJWK01008658    GEZM01080281    JAV62230.1    DS232478    EDS42359.1    AE014297    BT099788    AAN14095.1    ACV91625.1    CP012526    ALC46432.1    KQ971311    EEZ98936.1    KRF83442.1    BT004884    AAF56642.2    AAO45240.1    ABLF02040899    ABLF02040913    SPP81122.1    EDW80671.1    GFDG01002109    JAV16690.1    AGBW02008396    OWR53503.1    CM000070    EIM52371.1    KRS99772.1    GECU01031587    JAS76119.1    GECZ01023698    JAS46071.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000283053    UP000019118    + More
UP000215335    UP000015103    UP000002358    UP000076858    UP000001070    UP000085678    UP000000305    UP000009192    UP000027135    UP000242457    UP000095301    UP000235965    UP000076502    UP000030765    UP000075880    UP000008820    UP000075885    UP000075884    UP000005203    UP000007062    UP000075903    UP000075840    UP000076407    UP000075902    UP000075883    UP000037069    UP000075886    UP000007798    UP000268350    UP000000304    UP000001292    UP000008792    UP000092461    UP000075920    UP000002320    UP000000803    UP000092553    UP000007266    UP000076408    UP000007819    UP000075881    UP000075900    UP000007151    UP000095300    UP000001819   

PRIDE

H9JW61    Q8IMQ8    Q9VBA0   

Pfam

PF01048   PNP_UDP_1

Interpro

IPR010059   Uridine_phosphorylase_euk        + More
IPR035994   Nucleoside_phosphorylase_sf       
IPR000845   Nucleoside_phosphorylase_d       
IPR017893   DBB_domain       
IPR018016   Nucleoside_phosphorylase_CS       

SUPFAM

SSF53167   SSF53167       

Gene 3D

3.40.50.1580    

ProteinModelPortal

H9JW61   A0A2H1VDS7   A0A2A4JF92   A0A2H1VST5   A0A0N1IHY1   A0A0N1IBT0   + More
A0A3S2M604   N6TC60   A0A1B6E436   A0A232F9X7   V5GTE6   A0A1B6DDL4   V5GHK9   A0A0C9RSZ0   A0A023F5G7   A0A069DYM6   A0A023GIU3   T1HDV8   K7IX68   A0A0T6B3J4   A0A336M4H0   A0A162SIL1   B4JRW5   A0A336KHJ2   A0A0K8TFY7   A0A1S3ID96   A0A2S2QKU5   E9GTM3   A0A1B6KFU3   A0A023EQI1   A0A0A9W2Y6   A0A336KKR0   A0A0P4YSK4   A0A0P5S1P2   A0A0Q9XCR7   A0A067QX58   A0A2R7WS35   A0A2A3E7V8   A0A1I8NAW4   T1PEU7   A0A2J7QZT9   B4K898   A0A146LJI9   A0A1Q3FZS6   A0A154PIC4   A0A084VNU7   A0A182J5Y0   A0A0A9Z8J9   A0A1S4FC12   Q178N8   A0A1Q3G579   A0A146L6D1   A0A182P2A8   A0A2S2NMA6   A0A1S6J0Z4   A0A182N1K9   V9IDR4   A0A0P6I8D6   A0A087ZWP1   Q7PFX7   A0A1E1XIE6   A0A0K8TEY3   A0A182VAL4   A0A182HIB7   A0A182X800   A0A182U4M6   A0A182MVH1   A0A2C9GJV1   A0A0L0C6U7   A0A182QKN0   A0A2A4K1Z2   A0A0Q9WSV4   A0A3B0K7Z1   B4QWT9   B4IC10   A0A2J7QZT7   B4LX04   A0A1B0CE83   A0A182W501   A0A1Y1KPY8   B0X890   Q8IMQ8   A0A0M4F4T1   D6WB44   A0A0Q9WGY3   Q9VBA0   A0A182YQ65   J9K4G6   A0A3B0JLB0   B4NA28   A0A182K465   A0A182R7I4   A0A1L8ED75   A0A212FID5   A0A1I8PMF4   I5AN36   A0A1B6HN66   A0A1B6F7G6   A0A1I8PMD6  

PDB

3NBQ     E-value=3.81214e-75,     Score=715

KEGG

101744496    K00757 uridine phosphorylase [EC:2.4.2.3] | (RefSeq) uridine phosphorylase 1-like

PATHWAY

00240    Pyrimidine metabolism - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0009166   GO:0004850   GO:0009116   GO:0044206   GO:0042332   GO:0003824   GO:0005839   GO:0051603   GO:0046835   GO:0006281   GO:0006259  

Length:

361

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.14148

Exp number, first 60 AAs:

0

Total prob of N-in:

0.10416

outside

1  -  361

 

 

Pi

235.901952

Theta

188.584136

Tajima's D

-2.654927

CLR

164.93995

CSRT

0.000149992500374981

Interpretation

Possibly Positive selection