Gene

KWMTBOMO16309  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013773

Annotation

PREDICTED:_NSFL1_cofactor_p47-like_[Bombyx_mori]

Location

Bomo_Chr28(+):5104651-5118120      View in EpiBrowser

Full name

NSFL1 cofactor p47      

Alternative Name

p97 cofactor p47

Location in the cell

Nuclear   Reliability : 3.471

CDS

ATGTCTGCGAATAGAGAAGATACATTACGTCAGTTTTGTGATGTTACCGGTGCTGACGAAGATCGCAGTAAATTCTTTTTAGAATCCTCAAACTGGCAATTAGATGTTGCTCTTTCAAGTTTCTATGAGAACGGTGGTAATGCAGATGAGGCTCCAGCTAATCCAACGAGTGCGGCATCATTCTCTGTTCTGCCAGACAGCGATATGGAATCACCGCCCGTCTCACCTCAGGTACAAAAGTCCCAGAAAAAAGAAAAAAAGAAAACCTCAAATACAAAGTTTGGGACCATAGGATCGCTGCAGCAGGAAAGCTCAAGCGATGAGGAAGAAGGTCAGGCATTTTATGCTGGGGGCTCAGAACGGTCCGGGCAACAGATCTTAGGGCCAAGTAAAGGCAGGAAAGATATCGTCTCTGAAATGTTCAAGAGCGTCAGAGAGCGAGGAGCAGTCGTCTTTGAAGACGAACCAACATCCAGTAGAGGCCGTGGTCGAGGGGGCCTCTTCGCCGGAGTTGGCTATAGATTAGGACAAACTGCAGATGATCACGAGCCAGTGTCTGCATCGAATCCACAACAACAAGAGCAAGTGAGACTGGTGAGACTGTGTCTGTACCGCGAAGGCTTCACGGTGGACGCGGGTCCGCTGCGCCACTACAGCGACCCGGAGAACGCGGAGTTCCTGAGCTGCATACGTCGCGGTGAGATTCCGTCGGAGTTGTCGGGGCAGGGGGTCTCGGTCCGGGTGAGCCTCGAGGACAGCAGACACGAGGAGTGTCCCCGGCACGTGGTCAAGCCGCAGGCCTTCGCCGGGAAAGGGCACATGCTGGGCAGTCCCACGCCCCCCACGGTGGGCGCCACAGCCGCCGTGGCGGGCGACCAGGCCGACCGCGCGGCCAACCTCCGCGCCGCACAGAGCGCCGTCACACTCGACGAAACGCAACCCGTCACTACGCTGCAGTTCCGACTGGCCGACGGCACCCGCATCACGGGCCGGTTCAACCACAGCCACACGGTCGGCGCGCTGAGGGAGTTCGTGTCGCGAGCGGAGCCGGCGTACCAGCTGCGGCCATTCAGTCTGCTGACGGCCTTCCCGAGCGCGGAGCTGGGTGACGACGCCGCGACCCTGGCGCAGGCGAACCTGCTCAACTCGACGGTCATGCAGCGGCTCAAGTAG

Protein

MSANREDTLRQFCDVTGADEDRSKFFLESSNWQLDVALSSFYENGGNADEAPANPTSAASFSVLPDSDMESPPVSPQVQKSQKKEKKKTSNTKFGTIGSLQQESSSDEEEGQAFYAGGSERSGQQILGPSKGRKDIVSEMFKSVRERGAVVFEDEPTSSRGRGRGGLFAGVGYRLGQTADDHEPVSASNPQQQEQVRLVRLCLYREGFTVDAGPLRHYSDPENAEFLSCIRRGEIPSELSGQGVSVRVSLEDSRHEECPRHVVKPQAFAGKGHMLGSPTPPTVGATAAVAGDQADRAANLRAAQSAVTLDETQPVTTLQFRLADGTRITGRFNHSHTVGALREFVSRAEPAYQLRPFSLLTAFPSAELGDDAATLAQANLLNSTVMQRLK

Description

Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.

Similarity

Belongs to the NSFL1C family.

Keywords

Complete proteome   Cytoplasm   Cytoskeleton   Golgi apparatus   Lipid-binding   Nucleus   Reference proteome  

Feature

chain  NSFL1 cofactor p47

Uniprot

A0A2A4J2R8   A0A3S2P3Y6   S4PY40   A0A2H1VIJ3   A0A2A4J3Y5   A0A1E1WA73   + More
A0A2W1BD25   A0A1B6KXR7   A0A2J7PD98   A0A2J7PDA4   A0A1Y1L4L0   D6WT40   A0A151IV27   A0A3L8DFP9   A0A195F004   E2AKL7   F4WAT6   A0A151XDM5   A0A195BWY2   A0A151IH76   A0A158P3K4   E9J8R6   A0A182GLM9   Q1HRG9   A0A0J7LAA6   A0A087ZQ92   A0A162D7N3   A0A232FC07   A0A1W4WTH1   A0A2A3EJ17   V9IDV9   A0A310S969   E2BNT9   K7J497   A0A0M9A2E6   E9FYH5   U5EYU9   A0A0K8TSI9   A0A0P4W4J8   A0A0P5CXR9   A0A182FH85   A0A154PIP1   V5H138   A0A1I8M796   T1PDZ5   A0A2Y9F8U5   A0A2Y9PSG9   A0A341B7H5   A0A2U3V8Q1   A0A084W9K5   A0A2M4BQM0   A0A2M4ADL1   A0A067R7M4   A0A2M4BQE1   A0A2Y9PTH9   A0A0L7R492   A0A2Y9F790   A0A341BAU6   A0A2U3V8B0   A0A1S2ZQU1   A0A2U4CLV0   A0A341BAU0   A0A2Y9PYU9   A0A340Y1D4   C3Y288   W5JP15   A0A3Q2XMI0   A0A182N810   A0A182LUC3   A0A182RTP1   A0A131Y645   A0A0B6YA19   B7PEL3   A0A1Q3FBD0   Q5ZK10   A0A1L8EII4   A0A1A9X3S0   D3TRN7   A0A1L8EIS2   A0A3M0JA46   B5FYZ6   B5KFR1   A0A1L8EIN0   A0A1A7XN86   A0A226NJI6   H0Z9A8   A0A3L8SAB3   Q7Q9P4   A0A218UT36   B0WHN1   A0A1B0A9G6   J3JUH8   A0A182HP69   A0A182WAA6   A0A2I4BBC2   A0A1A9USQ5   A0A3S1ABH4  

Pubmed

23622113    28756777    28004739    18362917    19820115    30249741    + More
20798317    21719571    21347285    21282665    26483478    17204158    28648823    20075255    21292972    26369729    25315136    24438588    24845553    18563158    20920257    23761445    15642098    20353571    17018643    20360741    30282656    12364791    14747013    17210077    22516182   

EMBL

NWSH01003367    PCG66447.1    RSAL01000029    RVE51751.1    GAIX01003953    JAA88607.1    + More
ODYU01002757    SOQ40647.1    PCG66446.1    GDQN01007215    JAT83839.1    KZ150264    PZC71714.1    GEBQ01023739    JAT16238.1    NEVH01026392    PNF14316.1    PNF14314.1    GEZM01064873    GEZM01064872    JAV68623.1    KQ971354    EFA05869.1    KQ980924    KYN11414.1    QOIP01000008    RLU19224.1    KQ981880    KYN33900.1    GL440320    EFN66021.1    GL888053    EGI68692.1    KQ982268    KYQ58465.1    KQ976394    KYM93139.1    KQ977636    KYN01145.1    ADTU01008167    GL769036    EFZ10817.1    JXUM01072366    KQ562717    KXJ75261.1    DQ440125    ABF18158.1    LBMM01000143    KMR04773.1    LRGB01002371    KZS08034.1    NNAY01000441    OXU28374.1    KZ288229    PBC31717.1    JR039309    AEY58631.1    KQ767768    OAD53308.1    GL449507    EFN82622.1    AAZX01007448    KQ435756    KOX75895.1    GL732527    EFX87766.1    GANO01000061    JAB59810.1    GDAI01000266    JAI17337.1    GDRN01085026    JAI61413.1    GDIP01163948    JAJ59454.1    KQ434904    KZC11188.1    GALX01001913    JAB66553.1    KA646924    AFP61553.1    ATLV01021829    KE525324    KFB46899.1    GGFJ01006163    MBW55304.1    GGFK01005553    MBW38874.1    KK852647    KDR19517.1    GGFJ01006138    MBW55279.1    KQ414658    KOC65644.1    GG666480    EEN65978.1    ADMH02000991    ETN64499.1    AXCM01000363    GEFM01001946    JAP73850.1    HACG01005435    CEK52300.1    ABJB010223645    DS695957    EEC05035.1    GFDL01010242    JAV24803.1    AJ720274    GFDG01000282    JAV18517.1    EZ424089    ADD20365.1    GFDG01000280    JAV18519.1    QRBI01000184    RMB95763.1    DQ214244    ACH44257.1    EF191934    ACH46409.1    GFDG01000281    JAV18518.1    HADW01018152    HADX01010320    SBP19552.1    MCFN01000030    OXB67833.1    ABQF01028308    QUSF01000037    RLV98843.1    AAAB01008900    EAA09447.4    MUZQ01000152    OWK56590.1    DS231938    EDS27880.1    BT126892    AEE61854.1    APCN01002922    RQTK01000108    RUS87533.1   

Proteomes

UP000218220    UP000283053    UP000235965    UP000007266    UP000078492    UP000279307    + More
UP000078541    UP000000311    UP000007755    UP000075809    UP000078540    UP000078542    UP000005205    UP000069940    UP000249989    UP000036403    UP000005203    UP000076858    UP000215335    UP000192223    UP000242457    UP000008237    UP000002358    UP000053105    UP000000305    UP000069272    UP000076502    UP000095301    UP000248484    UP000248483    UP000252040    UP000245320    UP000030765    UP000027135    UP000053825    UP000079721    UP000265300    UP000001554    UP000000673    UP000264820    UP000075884    UP000075883    UP000075900    UP000001555    UP000000539    UP000091820    UP000269221    UP000198323    UP000007754    UP000276834    UP000007062    UP000197619    UP000002320    UP000092445    UP000075840    UP000075920    UP000192220    UP000078200    UP000271974   

PRIDE

Q5ZK10   

Pfam

PF08059   SEP        + More
PF00789   UBX

Interpro

IPR036241   NSFL1C_SEP_dom_sf        + More
IPR012989   SEP_domain       
IPR029071   Ubiquitin-like_domsf       
IPR009060   UBA-like_sf       
IPR001012   UBX_dom       
IPR005637   TAP_C_dom       
IPR000626   Ubiquitin_dom       

SUPFAM

SSF46934   SSF46934        + More
SSF102848   SSF102848       
SSF54236   SSF54236       

Gene 3D

3.30.420.210    

ProteinModelPortal

A0A2A4J2R8   A0A3S2P3Y6   S4PY40   A0A2H1VIJ3   A0A2A4J3Y5   A0A1E1WA73   + More
A0A2W1BD25   A0A1B6KXR7   A0A2J7PD98   A0A2J7PDA4   A0A1Y1L4L0   D6WT40   A0A151IV27   A0A3L8DFP9   A0A195F004   E2AKL7   F4WAT6   A0A151XDM5   A0A195BWY2   A0A151IH76   A0A158P3K4   E9J8R6   A0A182GLM9   Q1HRG9   A0A0J7LAA6   A0A087ZQ92   A0A162D7N3   A0A232FC07   A0A1W4WTH1   A0A2A3EJ17   V9IDV9   A0A310S969   E2BNT9   K7J497   A0A0M9A2E6   E9FYH5   U5EYU9   A0A0K8TSI9   A0A0P4W4J8   A0A0P5CXR9   A0A182FH85   A0A154PIP1   V5H138   A0A1I8M796   T1PDZ5   A0A2Y9F8U5   A0A2Y9PSG9   A0A341B7H5   A0A2U3V8Q1   A0A084W9K5   A0A2M4BQM0   A0A2M4ADL1   A0A067R7M4   A0A2M4BQE1   A0A2Y9PTH9   A0A0L7R492   A0A2Y9F790   A0A341BAU6   A0A2U3V8B0   A0A1S2ZQU1   A0A2U4CLV0   A0A341BAU0   A0A2Y9PYU9   A0A340Y1D4   C3Y288   W5JP15   A0A3Q2XMI0   A0A182N810   A0A182LUC3   A0A182RTP1   A0A131Y645   A0A0B6YA19   B7PEL3   A0A1Q3FBD0   Q5ZK10   A0A1L8EII4   A0A1A9X3S0   D3TRN7   A0A1L8EIS2   A0A3M0JA46   B5FYZ6   B5KFR1   A0A1L8EIN0   A0A1A7XN86   A0A226NJI6   H0Z9A8   A0A3L8SAB3   Q7Q9P4   A0A218UT36   B0WHN1   A0A1B0A9G6   J3JUH8   A0A182HP69   A0A182WAA6   A0A2I4BBC2   A0A1A9USQ5   A0A3S1ABH4  

PDB

1S3S     E-value=9.79086e-19,     Score=229

KEGG

101747177    K14012 UBX domain-containing protein 1 | (RefSeq) NSFL1 cofactor p47-like

PATHWAY

04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0005634   GO:0051028   GO:0007030   GO:0005829   GO:0031468   GO:0043130   GO:0061025   GO:0043161   GO:0000045   GO:0045111   GO:0005654   GO:0005815   GO:0000132   GO:1904780   GO:0046604   GO:0005886   GO:0005795   GO:0008289   GO:0005515   GO:0035023   GO:0003676   GO:0008270   GO:0005839   GO:0051603   GO:0046835   GO:0006281   GO:0006259  

Subcellular location

Nucleus   Predominantly nuclear in interphase cells. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase.   With evidence from 1 publications.
Golgi apparatus   Predominantly nuclear in interphase cells. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase.   With evidence from 1 publications.
Golgi stack   Predominantly nuclear in interphase cells. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase.   With evidence from 1 publications.
Cytoplasm   Predominantly nuclear in interphase cells. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase.   With evidence from 1 publications.
Cytoskeleton   Predominantly nuclear in interphase cells. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase.   With evidence from 1 publications.
Microtubule organizing center   Predominantly nuclear in interphase cells. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase.   With evidence from 1 publications.
Centrosome   Predominantly nuclear in interphase cells. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase.   With evidence from 1 publications.

Length:

390

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00237

Exp number, first 60 AAs:

0

Total prob of N-in:

0.03915

outside

1  -  390

 

 

Pi

229.446622

Theta

192.973395

Tajima's D

1.620957

CLR

0.544854

CSRT

0.814609269536523

Interpretation

Uncertain