Gene

KWMTBOMO16293

Pre Gene Modal

BGIBMGA014014

Annotation

PREDICTED:_uncharacterized_protein_LOC101742377_[Bombyx_mori]

Location

Bomo_Chr28(+):4327367-4331031      View in EpiBrowser

Full name

Juvenile hormone acid O-methyltransferase      

Alternative Name

Juvenile hormone acid methyltransferase

Location in the cell

Cytoplasmic   Reliability : 2.223 Nuclear   Reliability : 1.654

CDS

ATGAGCGAACAAAACAGTCAGAACTACAAGGCAAAGAGTTTCGCAATGAACGATGACGCTGCCTTGTACCAGAAAAGTAATTGTTATCCTAGACGCGACGCTGTTGACGTATTGACAGAATTCCTACCCAAATTCAGATGGAAGGAAGGCAAAAAGAGGATCTTTGATATCGGCTGTGCCGATGGTAGCGTCACTAATATTATTAGCGCGTTTTGTAACAACGATTACGAAGTGTTCGAAGCGTGTGACATAAATGAACGGGCCGTGAAATACGCTACAGAATACTACGGAACTGACAAAATGATTTTCCGCGTGATGGACATAGAGGGGCAACTGCCGAAAGAGATGAATGGGAAGTTTGATAACGTTTTCTCGTTCTATACGCTGCAGTGGATCAAGAATCAAGAGAAAGCATTTCAAAACATCTACGACTTGATGGCAAAGGACGGTGAATGCCTGTTGACTCTCCTGGCTCGGATACCTGTATACAGCCTCTTCAATGCACTAAAGGATACCGACACATGGGGATATTTGCTTAAATACATCAATCAATTCATCTCGCCTTACCATGATGTTTCCGATCCAGACGTGATAATACAGTCGTTATTGGAGAAAGTTGGCTTCCAGTATGTGGACGTGCGTTGCAGACAAAAGAAATATGAATTCAAGGACATACAACAGCTGAGAAATATATTAGAAGCTGTAAGCCCCTTCAATGTGGACAAAAAACTCTACGAGCAATTCTTTGACGATATCATGGAAGTCGCGGAAGATATGAGAATCATTGATAGACGCACAAAGACCGCCACATTTCACTACAATTTAATTGTTATACACTGTAGGAAATGA

Protein

MSEQNSQNYKAKSFAMNDDAALYQKSNCYPRRDAVDVLTEFLPKFRWKEGKKRIFDIGCADGSVTNIISAFCNNDYEVFEACDINERAVKYATEYYGTDKMIFRVMDIEGQLPKEMNGKFDNVFSFYTLQWIKNQEKAFQNIYDLMAKDGECLLTLLARIPVYSLFNALKDTDTWGYLLKYINQFISPYHDVSDPDVIIQSLLEKVGFQYVDVRCRQKKYEFKDIQQLRNILEAVSPFNVDKKLYEQFFDDIMEVAEDMRIIDRRTKTATFHYNLIVIHCRK

Description

O-methyltransferase that transfers a methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis (PubMed:14530389). Also able to methylate farnesoate to methyl farnesoate (PubMed:14530389).
O-methyltransferase that transfers a methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis (PubMed:18549957). Also able to methylate farnesoate to methyl farnesoate (PubMed:18549957).

Catalytic Activity

(2E,6E)-farnesoate + S-adenosyl-L-methionine = methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine
juvenile hormone III carboxylate + S-adenosyl-L-methionine = juvenile hormone III + S-adenosyl-L-homocysteine

Biophysicochemical Properties

3.32 uM for juvenile hormone III acid
0.18 uM for farnesoate

Similarity

Belongs to the methyltransferase superfamily.

Keywords

Complete proteome   Methyltransferase   Reference proteome   S-adenosyl-L-methionine   Transferase  

Feature

chain  Juvenile hormone acid O-methyltransferase

Uniprot

H9JWV0   H9JLJ1   Q767F1   Q1KN64   A0A2H1VCR6   A0A1P1ENW6   + More
A5LFV6   A0A173GZJ8   A0A194R0H9   A0A194PH70   A0A2A4K0R4   A5LFV5   A0A212F9H0   A0A2H1VCN4   Q9U4Z8   D2Y4U6   A0A3S2M9U8   A0A2A4JYY3   A0A0R5ZNF1   A0A1W5ZM45   A0A0L7L836   A0A2J7RC57   A0A024BT15   R4IKD3   A0A1A9Z807   A0A1B0G4E2   A0A146IWP0   A0A1A9VCC9   B4MZR7   B4LVM0   A0A2R4N6F4   A0A1I8MHF6   A0A034W1Z2   A0A0A1WN75   T1GFV4   A0A1W4VJN5   A0A1B0D0M7   A0A1A9XET3   A0A1B0BCZ1   A0A3B0K301   A0A1W4VSL6   A0A0M3QU49   A0A3S5X9D4   W8BZU3   A0A0L0C8K2   B4G7P2   Q29LS0   A0A1L2BNI6   B3MUK9   Q206L4   B4KKK5   B4P880   A0A0J9TPF7   Q9VJK8   B4I231   A0A1A9WKH6   A0A1I8MED4   A0A1I8MHL4   B3NNG6   B4JZ63   A0A084VUE9   A0A182PFZ1   A0A1B3PDM2   A0A1I8NU96   A0A0K8U8D4   A0A182M749   B2DCQ0   A0A182KF39   A0A146KYR9   A0A0A9XHP0   A0A182HNS9   Q7Q9F0   A0A182ILY4   A0A0K8S8Y3   A0A0K8TS48   A0A0A7ERV5   A0A1B3PD94   A0A336L491   A0A075W3Z0   A0A182T4X4   A0A182YBZ0   A0A182RP42   A0A0P6GX36   A0A1J0I2X3   A0A182N9N0   A0A146J3Z5   A0A1I8PV71   A0A182X8H7   C6KTH2   A0A182PZH2   A0A182LGS6   A0A182WMH0   A0A1I8MGC1   A0A182U4K2   A0A1J1HJD8   A0A0K8W5Y7   A0A2M3Z4F9  

EC Number

2.1.1.325

Pubmed

19121390    14530389    18839418    26354079    22118469    10620045    + More
28382786    26227816    23499946    17994087    25315136    25348373    25830018    24495485    26108605    15632085    17510324    17550304    22936249    18549957    10731132    12537572    12537569    24438588    18435763    18362917    19820115    26823975    25401762    12364791    14747013    17210077    26369729    25101838    25244985    26894583    21292972    25721056    20966253   

EMBL

BABH01018740    BABH01005671    AB113578    JN851817    DQ465408    ABE98256.1    + More
ODYU01001839    SOQ38586.1    BABH01005674    AB127945    BAF63630.1    KX289532    ANI21405.1    KQ460883    KPJ11207.1    KQ459603    KPI92751.1    NWSH01000345    PCG77232.1    AB127944    BAF63629.1    AGBW02009587    OWR50378.1    SOQ38587.1    AF117590    AAF16712.1    GU323798    ADA83703.1    RSAL01000003    RVE54742.1    PCG77231.1    KM926339    AJR27469.1    KY421777    ARI71313.1    JTDY01002391    KOB71509.1    NEVH01005887    PNF38426.1    KJ188030    AHZ20738.1    JX291120    AFQ01089.1    CCAG010005611    LC049616    BAU78328.1    CH963920    EDW77852.1    CH940649    EDW64414.1    MG269999    AVX28147.1    GAKP01009356    JAC49596.1    GBXI01014449    JAC99842.1    CAQQ02017873    CAQQ02017874    CAQQ02017875    CAQQ02017876    CAQQ02017877    CAQQ02017878    AJVK01009988    JXJN01012210    OUUW01000004    SPP79391.1    CP012523    ALC40009.1    KT869353    ALO17567.1    GAMC01001658    JAC04898.1    JRES01000751    KNC28768.1    CH479180    EDW29313.1    CH379060    EAL33975.2    KU159280    ALT10380.1    CH902624    EDV33538.1    DQ409061    CH477383    ABD65474.1    EAT42177.1    CH933807    EDW11655.1    CM000158    EDW90127.1    CM002910    KMY90515.1    AB113579    AE014134    AY075194    CH480820    EDW54588.1    CH954179    EDV56617.1    CH916379    EDV94172.1    ATLV01016737    KE525103    KFB41593.1    KU660028    AOG17826.1    GDHF01029498    JAI22816.1    AXCM01012846    AB360763    KQ971338    BAG30999.1    EFA02917.1    GDHC01017106    JAQ01523.1    GBHO01024463    GBHO01010623    GDHC01003517    JAG19141.1    JAG32981.1    JAQ15112.1    APCN01002761    AAAB01008900    EAA09331.1    GBRD01016222    JAG49604.1    GDAI01000627    JAI16976.1    KJ200310    AIY69118.1    KU659901    AOG17700.1    UFQS01000997    UFQT01000997    SSX08344.1    SSX28367.1    KM212828    AIG94926.1    GDIQ01027709    JAN67028.1    KT947473    APC62652.1    LC055463    BAU79434.1    AB222845    GL732523    BAH86593.1    EFX90188.1    AXCN02001010    CVRI01000001    CRK86582.1    GDHF01005837    JAI46477.1    GGFM01002660    MBW23411.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000283053    + More
UP000037510    UP000235965    UP000092445    UP000092444    UP000078200    UP000007798    UP000008792    UP000095301    UP000015102    UP000192221    UP000092462    UP000092443    UP000092460    UP000268350    UP000092553    UP000037069    UP000008744    UP000001819    UP000007801    UP000008820    UP000009192    UP000002282    UP000000803    UP000001292    UP000091820    UP000008711    UP000001070    UP000030765    UP000075885    UP000095300    UP000075883    UP000007266    UP000075881    UP000075840    UP000007062    UP000075880    UP000079169    UP000075901    UP000076408    UP000075900    UP000075884    UP000076407    UP000000305    UP000075886    UP000075882    UP000075920    UP000075902    UP000183832   

PRIDE

H9JWV0    H9JLJ1    Q767F1    Q9VJK8   

Pfam

PF13847   Methyltransf_31        + More
PF13649   Methyltransf_25
PF08241   Methyltransf_11
PF08242   Methyltransf_12
PF00071   Ras

Interpro

IPR029063   SAM-dependent_MTases        + More
IPR025714   Methyltranfer_dom       
IPR041698   Methyltransf_25       
IPR013216   Methyltransf_11       
IPR013217   Methyltransf_12       
IPR001806   Small_GTPase       
IPR027417   P-loop_NTPase       
IPR037872   Rab3       
IPR005225   Small_GTP-bd_dom       

SUPFAM

SSF53335   SSF53335        + More
SSF52540   SSF52540       

CDD

cd01865  Rab3

ProteinModelPortal

H9JWV0   H9JLJ1   Q767F1   Q1KN64   A0A2H1VCR6   A0A1P1ENW6   + More
A5LFV6   A0A173GZJ8   A0A194R0H9   A0A194PH70   A0A2A4K0R4   A5LFV5   A0A212F9H0   A0A2H1VCN4   Q9U4Z8   D2Y4U6   A0A3S2M9U8   A0A2A4JYY3   A0A0R5ZNF1   A0A1W5ZM45   A0A0L7L836   A0A2J7RC57   A0A024BT15   R4IKD3   A0A1A9Z807   A0A1B0G4E2   A0A146IWP0   A0A1A9VCC9   B4MZR7   B4LVM0   A0A2R4N6F4   A0A1I8MHF6   A0A034W1Z2   A0A0A1WN75   T1GFV4   A0A1W4VJN5   A0A1B0D0M7   A0A1A9XET3   A0A1B0BCZ1   A0A3B0K301   A0A1W4VSL6   A0A0M3QU49   A0A3S5X9D4   W8BZU3   A0A0L0C8K2   B4G7P2   Q29LS0   A0A1L2BNI6   B3MUK9   Q206L4   B4KKK5   B4P880   A0A0J9TPF7   Q9VJK8   B4I231   A0A1A9WKH6   A0A1I8MED4   A0A1I8MHL4   B3NNG6   B4JZ63   A0A084VUE9   A0A182PFZ1   A0A1B3PDM2   A0A1I8NU96   A0A0K8U8D4   A0A182M749   B2DCQ0   A0A182KF39   A0A146KYR9   A0A0A9XHP0   A0A182HNS9   Q7Q9F0   A0A182ILY4   A0A0K8S8Y3   A0A0K8TS48   A0A0A7ERV5   A0A1B3PD94   A0A336L491   A0A075W3Z0   A0A182T4X4   A0A182YBZ0   A0A182RP42   A0A0P6GX36   A0A1J0I2X3   A0A182N9N0   A0A146J3Z5   A0A1I8PV71   A0A182X8H7   C6KTH2   A0A182PZH2   A0A182LGS6   A0A182WMH0   A0A1I8MGC1   A0A182U4K2   A0A1J1HJD8   A0A0K8W5Y7   A0A2M3Z4F9  

KEGG

101738236    K10718 juvenile hormone-III synthase [EC:2.1.1.325] | (RefSeq) uncharacterized LOC101738236

PATHWAY

00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0006718   GO:0035049   GO:0032259   GO:0019010   GO:0008168   GO:0016740   GO:0008049   GO:0005525   GO:0003924  

Length:

282

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02084

Exp number, first 60 AAs:

0.00266

Total prob of N-in:

0.17753

outside

1  -  282

 

 

Pi

159.442763

Theta

208.174504

Tajima's D

-0.973754

CLR

6.502889

CSRT

0.145342732863357

Interpretation

Uncertain