Gene

KWMTBOMO16284

Pre Gene Modal

BGIBMGA014005

Annotation

PREDICTED:_neuronal_acetylcholine_receptor_subunit_beta-3-like?_partial_[Papilio_xuthus]

Location

Bomo_Chr28(+):3946072-3965207      View in EpiBrowser

Full name

Mitochondrial genome maintenance exonuclease 1      

Location in the cell

PlasmaMembrane   Reliability : 3.565

CDS

ATGAAACGGACTGTGTTCATAATCTGGTTACTCGCATGTGTGTGTACAGTTAGAATGGATAATTTCACTTATAGTTACAAAGATGCGATGCGCTGTAAAGAGCATATCTGTAGACACGGTTACAGTTACGAAACTTTCTACCGGGTGGACGCGAACGAAATGAGGAGCATCAACGTTGACCCTCATTCAGTCTTCGAGATGCACATCGCGATCCAAGCCGCCAGCAACGGACACATAGTGCTCTCTGAAATCCCTAATCCTGGCGTCAGTGATCCAGTTTACGAAATTGTGGTCGGCGGTGGAGGGAACAAGTTCACCGAACTACGCCGCAACCTGCGACGCAATGCCAAGAGCTCCGTCACCACACCCCAAATATTGTCCCCTATAGAACTCAGAGGCTTCTACATCAAAATATCTGAAGATGGCCTGGTAGAATTCGGTAGAGAAGGACAGGCACTACCTTTGATAAGCTTCAATGATGTCGACCCATTATCCGTGAAGTACTTCAGCTTCGCGGCCTGGAACGGCGTTGAAGCCAAATTCTTGTACGACTGCCCTATACCCGGAGACACGTCTATTGAAGACATCCCTAACTCCCACCCAGAAGAGCCCAAGCTAACTCCTACGGACAAGTTAAAGCGGACTTTGCTAATGGGTCGGCTTCCCTCTGTCCCGCCCAATCCCGTCATGGAAGTAAAACTCGGATTTAAACTAACCAGCTTTCGGTATAACACTTTGGACTCCAAATTGACGACCACAGCGGCTGTTGTCGTGTCATGGGAAGATGATAGCATGGCGTGGAATCCGGACAAATTCAACGGAACCACCAACATCAAATTACGACAAGGCCAGATTTGGAAACCCTCGTTCTACGTTTTAAATTCGGATGGATATGGCGCGATGGATTCAACGAATCCGGATACAATTTCGTTGGCCAGCAGCGGGGAGGCGACATTGCACTTTCAGACCCAAACGCAGAACTATTGCTTCGATACAACAACGACTTACAGCAGATGGCCGCATGATGTATACCAGTGTCTGATCGTCATAGAGCCTTGGGAGGCCCACGAAAACATAAAAATTGAAATACTCGACGAGACTGATGCGAAGTTCGAAATGTTTTCAGATATTGACACTGTCATCCATAACGAATGGCAAATCATGACAGAGCAAGTCACTCTTGATTCAGCGATGTGGAACGAGATCATCGACCTCATCAACAGCGAGGAGGTTCTGAACACCCATTTAAGTGACAAGATGATCATCACTGTGGACTTAGCCAAAAACCCTGACTTGTACAACCTGGTGTTCTACGTGCCTATGTTGGTCCTAAACACGTTCGTCTTAATATCGTTCTGGACGGAGCCACTGACAATGTCAAGGATATGGTTCTACGTAGCCTGTGTGGTGTCTATCTGTTTTGGACTCTGCTATATCGATTATTTAATACCGATTCATGCGATACCTACCATAATGGTGCTGTACGTGACGGTCTTGTTTGGACTAATGACTGCTGTGATGGCCAACGTGCTCCTAATATCGAACTTCGGTGAGGCGTTGGGGAAGTCGTCAGCAATGAAACAAGTCCTGACCTGCGGCGTTGTACGAGCGGTCTTCTGTTTGCCTTCCATGAAGAAAGCCGCCAATGGGGATTACTCGGTCCAAGAAGATGAGGACTCTAGTTACATAGTGGATTCGCGGGAAGGCGTTGAAGAGATGGAGAGGAGTGACAAAGAAATAAAATACGGTGACAAGGCCGAACTAGCGGTGGTCGTTGATAAAATCCTTTTCGTTGTCTACCTTATTGTTTTTGTCGGAATGTTGGCAGCGCATTACTGA

Protein

MKRTVFIIWLLACVCTVRMDNFTYSYKDAMRCKEHICRHGYSYETFYRVDANEMRSINVDPHSVFEMHIAIQAASNGHIVLSEIPNPGVSDPVYEIVVGGGGNKFTELRRNLRRNAKSSVTTPQILSPIELRGFYIKISEDGLVEFGREGQALPLISFNDVDPLSVKYFSFAAWNGVEAKFLYDCPIPGDTSIEDIPNSHPEEPKLTPTDKLKRTLLMGRLPSVPPNPVMEVKLGFKLTSFRYNTLDSKLTTTAAVVVSWEDDSMAWNPDKFNGTTNIKLRQGQIWKPSFYVLNSDGYGAMDSTNPDTISLASSGEATLHFQTQTQNYCFDTTTTYSRWPHDVYQCLIVIEPWEAHENIKIEILDETDAKFEMFSDIDTVIHNEWQIMTEQVTLDSAMWNEIIDLINSEEVLNTHLSDKMIITVDLAKNPDLYNLVFYVPMLVLNTFVLISFWTEPLTMSRIWFYVACVVSICFGLCYIDYLIPIHAIPTIMVLYVTVLFGLMTAVMANVLLISNFGEALGKSSAMKQVLTCGVVRAVFCLPSMKKAANGDYSVQEDEDSSYIVDSREGVEEMERSDKEIKYGDKAELAVVVDKILFVVYLIVFVGMLAAHY

Description

Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.

Similarity

Belongs to the glycosyl hydrolase 18 family.
Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Belongs to the MGME1 family.

Uniprot

A0A2A4J1J6   A0A194PWK2   A0A2W1BIB0   A0A3S2PBC3   A0A0N1I8C1   A0A139WFG7   + More
A0A139WFS6   A0A1Y1KLR1   A0A2P8YKE5   A0A1Q3FMQ8   A0A1B6EI03   N6T616   A0A1B6FWE9   B0WG41   A0A023EXS4   A0A182GUM0   A0A0P4VUH2   A0A1W5YMS4   A0A0P6K120   J9JMD6   A0A0N8AQU7   A0A0P5GAT8   A0A0P5ADJ4   A0A1S4F984   Q17BJ5   A0A0P6I592   A0A2Z4N5W6   A0A146LI87   A0A0M4EIV7   A0A0N8DLD4   B4P8A1   A0A0M3QVI3   B4LNF1   A0A1I8MXG6   A0A0L0CQE0   A0A0M5J6Q8   B3NND4   A0A224XKR8   B4I805   A0A1W4V0S7   A0A1A9YKU4   A0A0A1X6Z4   A0A146KW52   H8F4S1   Q9W288   B4KMU7   A0A0B4K8A6   B4MNS9   A0A182JN83   B4QH26   A0A1A9V5D9   B4H6X9   A0A1I8PIZ3   E0VC57   B3MBI7   Q28WM6   A0A1A9WIU0   A0A034W0B7   B4J8I8   A0A182KD66   A0A182P8G7   A0A1B0G7M4   A0A1S4H4F3   A0A3B0J1L1   A0A182HFQ8   A0A182X1U3   A0A182MYE1   A0A1A9ZGK1   A0A0K8ULU6  

EC Number

3.1.-.-

Pubmed

26354079    28756777    18362917    19820115    28004739    29403074    + More
23537049    25474469    26483478    27129103    26999592    17510324    26823975    17994087    17550304    25315136    26108605    25830018    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    22936249    20566863    15632085    25348373    12364791   

EMBL

NWSH01003745    PCG65861.1    KQ459588    KPI97751.1    KZ150026    PZC74799.1    + More
RSAL01000126    RVE46553.1    KQ460417    KPJ14879.1    KQ971352    KYB26738.1    KYB26739.1    GEZM01084981    JAV60346.1    PYGN01000530    PSN44731.1    GFDL01006210    JAV28835.1    GECZ01032221    JAS37548.1    APGK01051097    APGK01051098    APGK01051099    APGK01051100    KB741181    ENN73093.1    GECZ01015300    JAS54469.1    DS231923    EDS26737.1    GBBI01004921    JAC13791.1    JXUM01089653    JXUM01089654    JXUM01089655    JXUM01089656    KQ563786    KXJ73306.1    GDKW01002108    JAI54487.1    KX426067    ARI45492.1    GDUN01000307    JAN95612.1    ABLF02036863    GDIQ01251883    JAJ99841.1    GDIQ01248929    JAK02796.1    GDIP01213390    JAJ10012.1    CH477321    EAT43615.1    GDIQ01009267    JAN85470.1    MF612141    AWX65629.1    GDHC01012449    JAQ06180.1    CP012524    ALC42797.1    GDIP01022375    JAM81340.1    CM000158    EDW91141.1    ALC42433.1    CH940648    EDW61103.1    JRES01000171    KNC33654.1    ALC40474.1    CH954179    EDV55558.1    GFTR01006008    JAW10418.1    CH480824    EDW56730.1    GBXI01007864    JAD06428.1    GDHC01018764    JAP99864.1    BT133311    AFD10758.1    AE013599    AAF46805.1    CH933808    EDW09869.2    AFH08210.1    CH963848    EDW73768.2    CM000362    CM002911    EDX08172.1    KMY95727.1    CH479216    EDW33615.1    DS235047    EEB10963.1    CH902619    EDV37118.1    CM000071    EAL26641.2    GAKP01011352    JAC47600.1    CH916367    EDW01255.1    CCAG010016887    AAAB01008933    OUUW01000001    SPP72752.1    APCN01005565    GDHF01024788    JAI27526.1   

Proteomes

UP000218220    UP000053268    UP000283053    UP000053240    UP000007266    UP000245037    + More
UP000019118    UP000002320    UP000069940    UP000249989    UP000007819    UP000008820    UP000092553    UP000002282    UP000008792    UP000095301    UP000037069    UP000008711    UP000001292    UP000192221    UP000092443    UP000000803    UP000009192    UP000007798    UP000075880    UP000000304    UP000078200    UP000008744    UP000095300    UP000009046    UP000007801    UP000001819    UP000091820    UP000001070    UP000075881    UP000075885    UP000092444    UP000268350    UP000075840    UP000076407    UP000075884    UP000092445   

PRIDE

H8F4S1    Q9W288   

Pfam

PF02931   Neur_chan_LBD        + More
PF12248   Methyltransf_FA
PF00704   Glyco_hydro_18
PF01607   CBM_14
PF02932   Neur_chan_memb
PF10283   zf-CCHH
PF06087   Tyr-DNA_phospho
PF12705   PDDEXK_1

Interpro

IPR006201   Neur_channel        + More
IPR022041   Methyltransf_FA       
IPR036734   Neur_chan_lig-bd_sf       
IPR006202   Neur_chan_lig-bd       
IPR017853   Glycoside_hydrolase_SF       
IPR036508   Chitin-bd_dom_sf       
IPR011583   Chitinase_II       
IPR029070   Chitinase_insertion_sf       
IPR001223   Glyco_hydro18_cat       
IPR001579   Glyco_hydro_18_chit_AS       
IPR002557   Chitin-bd_dom       
IPR036719   Neuro-gated_channel_TM_sf       
IPR006029   Neurotrans-gated_channel_TM       
IPR038726   PDDEXK_AddAB-type       
IPR019406   APLF_PBZ       
IPR026970   MGME1       
IPR027415   TDP_C       
IPR010347   Tdp1       

SUPFAM

SSF63712   SSF63712        + More
SSF54556   SSF54556       
SSF51445   SSF51445       
SSF57625   SSF57625       
SSF90112   SSF90112       

Gene 3D

2.70.170.10     3.10.50.10     3.30.870.20    

ProteinModelPortal

A0A2A4J1J6   A0A194PWK2   A0A2W1BIB0   A0A3S2PBC3   A0A0N1I8C1   A0A139WFG7   + More
A0A139WFS6   A0A1Y1KLR1   A0A2P8YKE5   A0A1Q3FMQ8   A0A1B6EI03   N6T616   A0A1B6FWE9   B0WG41   A0A023EXS4   A0A182GUM0   A0A0P4VUH2   A0A1W5YMS4   A0A0P6K120   J9JMD6   A0A0N8AQU7   A0A0P5GAT8   A0A0P5ADJ4   A0A1S4F984   Q17BJ5   A0A0P6I592   A0A2Z4N5W6   A0A146LI87   A0A0M4EIV7   A0A0N8DLD4   B4P8A1   A0A0M3QVI3   B4LNF1   A0A1I8MXG6   A0A0L0CQE0   A0A0M5J6Q8   B3NND4   A0A224XKR8   B4I805   A0A1W4V0S7   A0A1A9YKU4   A0A0A1X6Z4   A0A146KW52   H8F4S1   Q9W288   B4KMU7   A0A0B4K8A6   B4MNS9   A0A182JN83   B4QH26   A0A1A9V5D9   B4H6X9   A0A1I8PIZ3   E0VC57   B3MBI7   Q28WM6   A0A1A9WIU0   A0A034W0B7   B4J8I8   A0A182KD66   A0A182P8G7   A0A1B0G7M4   A0A1S4H4F3   A0A3B0J1L1   A0A182HFQ8   A0A182X1U3   A0A182MYE1   A0A1A9ZGK1   A0A0K8ULU6  

PDB

4PIR     E-value=8.42924e-05,     Score=111

KEGG

101737467    no KO assigned | (RefSeq) neuronal acetylcholine receptor subunit alpha-5

GO

GO:0016021   GO:0004888   GO:0005230   GO:0005975   GO:0005576   GO:0004553   GO:0008061   GO:0006030   GO:0016740   GO:0008081   GO:0043504   GO:0005634   GO:0008297   GO:0005739   GO:0006811   GO:0016020   GO:0006810   GO:0005515   GO:0005839   GO:0051603   GO:0046835   GO:0006281   GO:0006259  

PANTHER

PTHR18945   PTHR12415  

Subcellular location

Mitochondrion  

SignalP

Position:   1 - 19,         Likelihood:  0.981931

 

 

Length:

612

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

94.64836

Exp number, first 60 AAs:

5.27883

Total prob of N-in:

0.26125

outside

1  -  431

TMhelix

432  -  454

inside

455  -  462

TMhelix

463  -  485

outside

486  -  490

TMhelix

491  -  513

inside

514  -  587

TMhelix

588  -  610

outside

611  -  612

 

 

Pi

165.759904

Theta

150.419812

Tajima's D

0.21695

CLR

236.630448

CSRT

0.429778511074446

Interpretation

Uncertain