Gene

KWMTBOMO16268  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013998

Annotation

heme_oxygenase_[Bombyx_mori]

Location

Bomo_Chr28(+):3293678-3296230      View in EpiBrowser

Full name

Heme oxygenase      

Location in the cell

PlasmaMembrane   Reliability : 0.97

CDS

ATGTCTGAACAAGATCTATTCACGACACGCATGAGAAAAGCGACTCGGAAAATACATTCTGTCAGCGATGCCTTGGTCAATGCGAAATTTGCGATATCGTTGAGAGACCATACAGTATGGGGTGGAGGCCTGTTTGTCTTCTACCATATTTTTGCATATCTTGAAGATGCAAAAGAGAGATTAAATATGCCAGAATTTAATAAGCTGTTTGTGCATGAAATTCTTTACAGAAAGAAGGCATTTGAGCAAGATCTGCAACACTACCTTGGTGACAACTGGAGGTCAATACCTAAATCCTTGGCTCTAGAGAACTATCTACAACATTTACAAGACCTGGAAAGAGACAATCCCAAGCTCTTAATGGCCTATGTCTATCATTTGTATTTAGGACTCCTGAGCGGTGGACAGATTTTAGCCAAGAAGAGGAGGGTATTTGGTGAAAAAAACGAACAACCAAACACATATTATGTAGACAAAGTAACTGATTTTGCTGCTGTAGACATAAATAAATTGAAAAATGAGTTCCGTGAAGCAATGAACCAAATAGCGACGACAATGTCTTCAGAGGAGCAAGCGACATTCATAGAGGAGAGCAATCAGGTGTTCATTATGAACAATCTGATAGTGAACTCTGTTGAGGGCCAGAATAAGGTTCTATATGGCTTGTTGTGCAAAGCCTCAGCTGTAGTTTTTGTTGTTGCAAGTTTATTGTTTGCATATAAGTTACACAGAGGATAA

Protein

MSEQDLFTTRMRKATRKIHSVSDALVNAKFAISLRDHTVWGGGLFVFYHIFAYLEDAKERLNMPEFNKLFVHEILYRKKAFEQDLQHYLGDNWRSIPKSLALENYLQHLQDLERDNPKLLMAYVYHLYLGLLSGGQILAKKRRVFGEKNEQPNTYYVDKVTDFAAVDINKLKNEFREAMNQIATTMSSEEQATFIEESNQVFIMNNLIVNSVEGQNKVLYGLLCKASAVVFVVASLLFAYKLHRG

Description

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.

Catalytic Activity

heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]

Similarity

Belongs to the heme oxygenase family.

Feature

chain  Heme oxygenase

Uniprot

H9JWT4   Q1HQ88   A0A3S2KXE7   A0A0N1PJJ5   S4PGT7   A0A2H1WKS1   + More
A0A194PXK0   A0A2W1BEA0   A0A2A4K4X3   A0A1E1WAK5   A0A212FK21   A0A0L7KW73   A0A2P8ZKI2   A0A067RJG4   A0A1B6C8V1   A0A2J7R571   A0A0N0U3J5   A0A1B6ETY8   F4W989   A0A1L8E3U7   Q5TLD7   A0A1L8E474   A0A1B6HPS2   A0A158P0W8   A0A1L8E3V0   A0A195EDG8   A0A1B0CBZ9   A0A195B5N6   A0A195F3Y0   E9G4H8   A0A151WKN2   A0A0J7NNN9   A0A0V0G7B8   R4FMI9   A0A0P4VW67   A0A232EG42   A0A023F7K9   V9IKM8   A0A151I6M0   A0A310SFS4   E2BP77   A0A069DRB2   E2AD16   A0A026WAY5   A0A0P4W056   A0A2A3EI81   A0A0L7RI50   A0A0P5WZE6   A0A162NAK8   A0A0P6EIW5   A0A0P6EG08   A0A0P6ENQ7   A0A0N8E5F7   A0A0P5MHP3   A0A0P6ICX8   A0A2M3ZAF0   A0A2M3ZAJ4   A0A2M4BYS2   A0A2M4BXZ5   A0A2M4BY79   A0A154PL88   E0VSF5   A0A2M4AWX0   A0A182XXP1   A0A182I8B1   A0A2M4AWT3   A0A084W5A2   A0A182XH41   A0A182RQR0   B0WJ98   A0A2M3ZJ28   A0A1J1HG10   A0A182KMS3   A0A182VQJ0   Q7Q288   A0A0K8TTS5   A0A1D2MRU4   A0A023EM51   A0A182PV80   A0A0M4F9F3   A0A182K6C7   A0A182MNG4   A0A0P5CES4   A0A182GTG3   A0A182SVW9   W5J6V1   A0A182GGC0   A0A182QT58   A0A182FL47   A0A0P6DY31   Q16ZP2   U5ETL2   A0A1Q3FK27   A0A1Q3FKD8   A0A182J5N0   A0A2P2I5Q5   A0A0P6CIP9   A0A2S2PW34  

EC Number

1.14.14.18

Pubmed

19121390    26354079    23622113    28756777    22118469    26227816    + More
29403074    24845553    21719571    21347285    21292972    27129103    28648823    25474469    20798317    26334808    24508170    30249741    20566863    25244985    24438588    20966253    12364791    14747013    17210077    26369729    27289101    24945155    26483478    20920257    23761445    17510324   

EMBL

BABH01018618    DQ443164    ABF51253.1    RSAL01001752    RSAL01000025    RVE40713.1    + More
RVE52155.1    KQ460417    KPJ14876.1    GAIX01006070    JAA86490.1    ODYU01009271    SOQ53566.1    KQ459588    KPI97748.1    KZ150355    PZC71236.1    NWSH01000142    PCG79119.1    GDQN01007097    JAT83957.1    AGBW02008152    OWR54095.1    JTDY01005150    KOB67316.1    PYGN01000029    PSN57003.1    KK852433    KDR23962.1    GEDC01027638    GEDC01011784    JAS09660.1    JAS25514.1    NEVH01007395    PNF35979.1    KQ435876    KOX70144.1    GECZ01028421    JAS41348.1    GL888002    EGI69271.1    GFDF01000664    JAV13420.1    AB194707    BAD69622.1    GFDF01000665    JAV13419.1    GECU01031055    JAS76651.1    ADTU01001034    GFDF01000666    JAV13418.1    KQ979039    KYN23253.1    AJWK01006018    KQ976598    KYM79585.1    KQ981855    KYN34882.1    GL732532    EFX85559.1    KQ983002    KYQ48404.1    LBMM01002990    KMQ94105.1    GECL01002121    JAP04003.1    ACPB03004822    GAHY01001699    JAA75811.1    GDKW01001669    JAI54926.1    NNAY01004881    OXU17304.1    GBBI01001482    JAC17230.1    JR051871    AEY61580.1    KQ978479    KYM93663.1    KQ760478    OAD60242.1    GL449553    EFN82497.1    GBGD01002702    JAC86187.1    GL438658    EFN68652.1    KK107293    QOIP01000005    EZA53267.1    RLU22326.1    GDRN01103429    JAI58087.1    KZ288234    PBC31427.1    KQ414590    KOC70406.1    GDIP01079964    JAM23751.1    LRGB01000568    KZS17819.1    GDIQ01075761    JAN18976.1    GDIQ01075760    JAN18977.1    GDIQ01060011    JAN34726.1    GDIQ01060012    JAN34725.1    GDIQ01158040    JAK93685.1    GDIQ01006383    JAN88354.1    GGFM01004677    MBW25428.1    GGFM01004744    MBW25495.1    GGFJ01008737    MBW57878.1    GGFJ01008741    MBW57882.1    GGFJ01008740    MBW57881.1    KQ434960    KZC12641.1    DS235750    EEB16311.1    GGFK01011934    MBW45255.1    APCN01002686    GGFK01011935    MBW45256.1    ATLV01020564    KE525303    KFB45396.1    DS231958    EDS29033.1    GGFM01007699    MBW28450.1    CVRI01000002    CRK86965.1    AAAB01008978    EAA13618.5    GDAI01000055    JAI17548.1    LJIJ01000643    ODM95621.1    GAPW01004214    JAC09384.1    KP994552    ALC74332.1    AXCM01001966    GDIP01175254    JAJ48148.1    JXUM01087050    JXUM01087051    KQ563607    KXJ73601.1    ADMH02002130    ETN58590.1    JXUM01010916    KQ560320    KXJ83074.1    AXCN02000286    GDIQ01071416    JAN23321.1    CH477487    EAT40116.1    GANO01002728    JAB57143.1    GFDL01007064    JAV27981.1    GFDL01007050    JAV27995.1    IACF01003739    LAB69349.1    GDIP01007898    JAM95817.1    GGMS01000554    MBY69757.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000053268    UP000218220    UP000007151    + More
UP000037510    UP000245037    UP000027135    UP000235965    UP000053105    UP000007755    UP000005203    UP000005205    UP000078492    UP000092461    UP000078540    UP000078541    UP000000305    UP000075809    UP000036403    UP000015103    UP000215335    UP000078542    UP000008237    UP000000311    UP000053097    UP000279307    UP000242457    UP000053825    UP000076858    UP000076502    UP000009046    UP000076408    UP000075840    UP000030765    UP000076407    UP000075900    UP000002320    UP000183832    UP000075882    UP000075920    UP000007062    UP000094527    UP000075885    UP000075881    UP000075883    UP000069940    UP000249989    UP000075901    UP000000673    UP000075886    UP000069272    UP000008820    UP000075880   

PRIDE

H9JWT4    Q1HQ88   

Pfam

PF01126   Heme_oxygenase

Interpro

IPR016053   Haem_Oase-like        + More
IPR002051   Haem_Oase       
IPR016084   Haem_Oase-like_multi-hlx       

SUPFAM

SSF48613   SSF48613       

Gene 3D

1.20.910.10    

CDD

cd00232  HemeO

ProteinModelPortal

H9JWT4   Q1HQ88   A0A3S2KXE7   A0A0N1PJJ5   S4PGT7   A0A2H1WKS1   + More
A0A194PXK0   A0A2W1BEA0   A0A2A4K4X3   A0A1E1WAK5   A0A212FK21   A0A0L7KW73   A0A2P8ZKI2   A0A067RJG4   A0A1B6C8V1   A0A2J7R571   A0A0N0U3J5   A0A1B6ETY8   F4W989   A0A1L8E3U7   Q5TLD7   A0A1L8E474   A0A1B6HPS2   A0A158P0W8   A0A1L8E3V0   A0A195EDG8   A0A1B0CBZ9   A0A195B5N6   A0A195F3Y0   E9G4H8   A0A151WKN2   A0A0J7NNN9   A0A0V0G7B8   R4FMI9   A0A0P4VW67   A0A232EG42   A0A023F7K9   V9IKM8   A0A151I6M0   A0A310SFS4   E2BP77   A0A069DRB2   E2AD16   A0A026WAY5   A0A0P4W056   A0A2A3EI81   A0A0L7RI50   A0A0P5WZE6   A0A162NAK8   A0A0P6EIW5   A0A0P6EG08   A0A0P6ENQ7   A0A0N8E5F7   A0A0P5MHP3   A0A0P6ICX8   A0A2M3ZAF0   A0A2M3ZAJ4   A0A2M4BYS2   A0A2M4BXZ5   A0A2M4BY79   A0A154PL88   E0VSF5   A0A2M4AWX0   A0A182XXP1   A0A182I8B1   A0A2M4AWT3   A0A084W5A2   A0A182XH41   A0A182RQR0   B0WJ98   A0A2M3ZJ28   A0A1J1HG10   A0A182KMS3   A0A182VQJ0   Q7Q288   A0A0K8TTS5   A0A1D2MRU4   A0A023EM51   A0A182PV80   A0A0M4F9F3   A0A182K6C7   A0A182MNG4   A0A0P5CES4   A0A182GTG3   A0A182SVW9   W5J6V1   A0A182GGC0   A0A182QT58   A0A182FL47   A0A0P6DY31   Q16ZP2   U5ETL2   A0A1Q3FK27   A0A1Q3FKD8   A0A182J5N0   A0A2P2I5Q5   A0A0P6CIP9   A0A2S2PW34  

PDB

4RAJ     E-value=1.92223e-25,     Score=285

KEGG

732895    K21418 heme oxygenase 2 [EC:1.14.14.18] | (RefSeq) heme oxygenase

PATHWAY

00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004392   GO:0016021   GO:0046872   GO:0006788   GO:0020037   GO:0055072   GO:0006979   GO:0016020   GO:0042167   GO:0009116   GO:0016763   GO:0005515   GO:0005839   GO:0051603   GO:0046835   GO:0006281   GO:0006259   GO:0055114  

PANTHER

PTHR10720  

Length:

245

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

53.42187

Exp number, first 60 AAs:

14.32657

Total prob of N-in:

0.68348

POSSIBLE N-term signal

sequence

inside

1  -  36

TMhelix

37  -  54

outside

55  -  118

TMhelix

119  -  138

inside

139  -  217

TMhelix

218  -  240

outside

241  -  245

 

 

Pi

350.033113

Theta

225.132327

Tajima's D

1.68556

CLR

0.212406

CSRT

0.826458677066147

Interpretation

Uncertain