Gene

KWMTBOMO16258  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013898

Annotation

proteasome_zeta_subunit_[Bombyx_mori]

Location

Bomo_Chr28(-):3204480-3206577      View in EpiBrowser

Full name

Proteasome endopeptidase complex       + More
Proteasome subunit alpha type      

Location in the cell

Cytoplasmic   Reliability : 2.231

CDS

ATGTTTCTCACACGTTCCGAGTATGATCGCGGCGTCAACACATTCAGCCCTGAAGGAAGGCTGTTCCAGGTGGAATACGCCATAGAAGCTATCAAACTTGGCTCCACTGCAATTGGCATTTGTACTTCGGAGGGAGTTGTTTTGGCGGTGGAAAAAAGGATAACTTCAACTTTGATGGAACCCACGACCATCGAAAAGATTGTTGAAGTAGATCGACACATCGCTTGCGCCGTTTCGGGTCTAATGGCCGACTCCAGGACCTTAGTTGAAAGGGCCCGAGTTGAATGTCAAAACCACTGGTTTGTGTACAATGAGCGTATGAGTGTAGAATCATGTGCTCAGGCCGTTTCCAACTTAGCTATACAGTTTGGAGACAGTGACGATGATAGCGGAACAGCCATGTCACGGCCATTTGGTGTTGCTGTTATGTTTGCAGGCATTGATGAGAAAGGCCCTCAACTGTTTCATATGGACCCGAGTGGTACATTTGTGCAGTATGATGCCAAGGCCATTGGTTCTGGCAGTGAAGGTGCCCAGCAGAGTTTGAAGGAGATTTATCACAAGTCGATGACCCTCAAAGAGGCCATCAAGTCTGCACTCACCATACTGAAGCAGGTCATGGAGGAAAAGCTCTCGGAGAACAATGTTGAAGTAGTGACAATGACTCCTGGATCATTGTTCCACATGTTCACAAGGGAACAACTTGCTGAGGTTATCAAAGACATACCTTAA

Protein

MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGICTSEGVVLAVEKRITSTLMEPTTIEKIVEVDRHIACAVSGLMADSRTLVERARVECQNHWFVYNERMSVESCAQAVSNLAIQFGDSDDDSGTAMSRPFGVAVMFAGIDEKGPQLFHMDPSGTFVQYDAKAIGSGSEGAQQSLKEIYHKSMTLKEAIKSALTILKQVMEEKLSENNVEVVTMTPGSLFHMFTREQLAEVIKDIP

Description

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.

Catalytic Activity

Cleavage of peptide bonds with very broad specificity.

Subunit

The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

Similarity

Belongs to the peptidase T1A family.

Uniprot

H9JWI4   Q2F661   A0A2A4JJ31   A0A2H1VS21   A0A1E1W968   S4PBH6   + More
A0A2W1B5X0   A0A2A4JKH8   A0A194Q2V7   A0A212FER0   E9IFI5   A0A151IK79   A0A139WFD4   A0A1S6Q5L3   F4X885   A0A158NBQ2   D6WT31   E2BCA4   A0A026WC60   A0A0L7QU49   A0A2J7Q9G1   A0A2P8Z4B7   A0A067RTL6   A0A0M9A518   E2A1P1   A0A087ZZN8   A0A195FD54   A0A151X9I5   A0A195BG81   A0A195DS04   A0A1Y1N7Z0   A0A0J7K3A1   K7IUK2   J3JTS6   N6TD48   A0A1B6CPF7   A0A232F5X5   A0A0P5IE39   A0A154P3U7   E9HGR7   A0A0P5G816   A0A0P4ZDQ8   A0A0P6E054   A0A0P5G0X2   A0A0N8C4N2   A0A0P6FYK7   A0A0P6EKE3   A0A0P5S5S9   A0A0P5JKP0   A0A0P5ASF6   A0A1B6EX92   A0A0P5HLG0   A0A0P6DJ38   A0A1B6H9C8   A0A0P6GW73   A0A0P5VCU5   A0A0P5KUL8   A0A0P5NHZ6   A0A0P4XSD7   A0A1B6L3Y8   T1JK43   A0A0P5SI01   A0A0P5G1X0   A0A0K8RHF0   A0A0P5V5N8   A0A0P5NQ08   T1DEV5   A0A0P5A6A2   Q1HQN1   A0A182GLM4   A0A023GGP0   G3MMH6   A0A1E1X441   E0VDI1   A0A2R5LG22   A0A0P6G830   A0A293MYB5   A0A023FK49   A0A023FXX5   A0A3S3PEI0   A0A1S4JRU4   A0A0P5SHE8   A0A310SRT7   A0A131XDD5   A0A226EMH8   A0A1D2MQC3   A0A224YRP6   A0A131Z3A6   L7M5R1   V4AEP3   B0WTL4   U5EMA6   A0A023EN66   S4REA7   A0A1Z5KXE3   A0A1Q3FDE8   C3ZPP8   A0A0P5VYK8   Q3TUI9   A0A1S3GET8  

EC Number

3.4.25.1

Pubmed

19121390    23622113    28756777    26354079    22118469    21282665    + More
18362917    19820115    21719571    21347285    20798317    24508170    30249741    29403074    24845553    28004739    20075255    22516182    23537049    28648823    21292972    24330624    17204158    17510324    26483478    22216098    28503490    20566863    28049606    27289101    28797301    26830274    25576852    23254933    24945155    28528879    18563158    10349636    11042159    11076861    11217851    12466851    16141073   

EMBL

BABH01018608    DQ311211    ABD36156.1    NWSH01001212    PCG72105.1    ODYU01004100    + More
SOQ43619.1    GDQN01007541    JAT83513.1    GAIX01004616    JAA87944.1    KZ150476    PZC70741.1    PCG72104.1    KQ459588    KPI97740.1    AGBW02008912    OWR52198.1    GL762841    EFZ20649.1    KQ977242    KYN04674.1    KQ971354    KYB26545.1    KY628452    AQV09455.1    GL888932    EGI57220.1    ADTU01011278    EFA05871.2    GL447257    EFN86640.1    KK107276    QOIP01000004    EZA53647.1    RLU24036.1    KQ414740    KOC62084.1    NEVH01016358    PNF25218.1    PYGN01000203    PSN51317.1    KK852471    KDR23179.1    KQ435756    KOX76009.1    GL435766    EFN72714.1    KQ981673    KYN38333.1    KQ982373    KYQ56980.1    KQ976500    KYM83214.1    KQ980581    KYN15299.1    GEZM01010547    GEZM01010546    JAV94001.1    LBMM01015431    KMQ84812.1    AAZX01007579    BT126635    AEE61598.1    APGK01035321    KB740923    KB632333    ENN78269.1    ERL92699.1    GEDC01022053    JAS15245.1    NNAY01000846    OXU26221.1    GDIQ01214655    JAK37070.1    KQ434809    KZC06615.1    GL732643    EFX69073.1    GDIQ01244959    GDIQ01242661    GDIQ01152233    GDIQ01107049    LRGB01000626    JAK06766.1    KZS17458.1    GDIP01215741    JAJ07661.1    GDIQ01084712    JAN10025.1    GDIQ01247808    JAK03917.1    GDIQ01115203    JAL36523.1    GDIQ01041277    JAN53460.1    GDIQ01061321    JAN33416.1    GDIQ01092550    JAL59176.1    GDIQ01197020    JAK54705.1    GDIP01196297    GDIP01195098    JAJ28304.1    GECZ01027170    JAS42599.1    GDIQ01231710    JAK20015.1    GDIQ01078213    JAN16524.1    GECU01036484    JAS71222.1    GDIQ01038275    JAN56462.1    GDIP01102105    JAM01610.1    GDIQ01179022    JAK72703.1    GDIQ01145842    JAL05884.1    GDIP01237247    JAI86154.1    GEBQ01021733    JAT18244.1    AFFK01019071    GDIP01139705    JAL64009.1    GDIQ01247809    JAK03916.1    GADI01003879    JAA69929.1    GDIP01105008    JAL98706.1    GDIP01232197    GDIQ01160921    JAI91204.1    JAK90804.1    GALA01000902    JAA93950.1    GDIP01207894    JAJ15508.1    DQ440413    CH477299    ABF18446.1    EAT44303.1    JXUM01168979    KQ577807    KXJ67791.1    GBBM01002296    JAC33122.1    JO843077    AEO34694.1    GFAC01005392    JAT93796.1    DS235078    EEB11437.1    GGLE01004350    MBY08476.1    GDIQ01047583    JAN47154.1    GFWV01021075    MAA45803.1    GBBK01003479    JAC21003.1    GBBL01001770    JAC25550.1    NCKU01015899    RWR99284.1    GDIP01139706    JAL64008.1    KQ761155    OAD58116.1    GEFH01003994    JAP64587.1    LNIX01000003    OXA58842.1    LJIJ01000693    ODM95267.1    GFPF01005498    MAA16644.1    GEDV01002673    JAP85884.1    GACK01005837    JAA59197.1    KB201656    ESO95327.1    DS232088    EDS34463.1    GANO01001115    JAB58756.1    GAPW01003784    JAC09814.1    GFJQ02007342    JAV99627.1    GFDL01009506    JAV25539.1    GG666659    EEN45469.1    GDIP01093363    JAM10352.1    AK160741    BAE35982.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000078542    UP000007266    + More
UP000007755    UP000005205    UP000008237    UP000053097    UP000279307    UP000053825    UP000235965    UP000245037    UP000027135    UP000053105    UP000000311    UP000005203    UP000078541    UP000075809    UP000078540    UP000078492    UP000036403    UP000002358    UP000019118    UP000030742    UP000215335    UP000076502    UP000000305    UP000076858    UP000008820    UP000069940    UP000249989    UP000009046    UP000285301    UP000198287    UP000094527    UP000030746    UP000002320    UP000245300    UP000001554    UP000081671   

PRIDE

H9JWI4    Q2F661    G3MMH6    L7M5R1    Q3TUI9   

Pfam

PF10584   Proteasome_A_N        + More
PF00227   Proteasome

Interpro

IPR023332   Proteasome_alpha-type        + More
IPR001353   Proteasome_sua/b       
IPR029055   Ntn_hydrolases_N       
IPR033812   Proteasome_alpha_type_5       
IPR000426   Proteasome_asu_N       

SUPFAM

SSF56235   SSF56235       

Gene 3D

3.60.20.10    

CDD

cd03753  proteasome_alpha_type_5

ProteinModelPortal

H9JWI4   Q2F661   A0A2A4JJ31   A0A2H1VS21   A0A1E1W968   S4PBH6   + More
A0A2W1B5X0   A0A2A4JKH8   A0A194Q2V7   A0A212FER0   E9IFI5   A0A151IK79   A0A139WFD4   A0A1S6Q5L3   F4X885   A0A158NBQ2   D6WT31   E2BCA4   A0A026WC60   A0A0L7QU49   A0A2J7Q9G1   A0A2P8Z4B7   A0A067RTL6   A0A0M9A518   E2A1P1   A0A087ZZN8   A0A195FD54   A0A151X9I5   A0A195BG81   A0A195DS04   A0A1Y1N7Z0   A0A0J7K3A1   K7IUK2   J3JTS6   N6TD48   A0A1B6CPF7   A0A232F5X5   A0A0P5IE39   A0A154P3U7   E9HGR7   A0A0P5G816   A0A0P4ZDQ8   A0A0P6E054   A0A0P5G0X2   A0A0N8C4N2   A0A0P6FYK7   A0A0P6EKE3   A0A0P5S5S9   A0A0P5JKP0   A0A0P5ASF6   A0A1B6EX92   A0A0P5HLG0   A0A0P6DJ38   A0A1B6H9C8   A0A0P6GW73   A0A0P5VCU5   A0A0P5KUL8   A0A0P5NHZ6   A0A0P4XSD7   A0A1B6L3Y8   T1JK43   A0A0P5SI01   A0A0P5G1X0   A0A0K8RHF0   A0A0P5V5N8   A0A0P5NQ08   T1DEV5   A0A0P5A6A2   Q1HQN1   A0A182GLM4   A0A023GGP0   G3MMH6   A0A1E1X441   E0VDI1   A0A2R5LG22   A0A0P6G830   A0A293MYB5   A0A023FK49   A0A023FXX5   A0A3S3PEI0   A0A1S4JRU4   A0A0P5SHE8   A0A310SRT7   A0A131XDD5   A0A226EMH8   A0A1D2MQC3   A0A224YRP6   A0A131Z3A6   L7M5R1   V4AEP3   B0WTL4   U5EMA6   A0A023EN66   S4REA7   A0A1Z5KXE3   A0A1Q3FDE8   C3ZPP8   A0A0P5VYK8   Q3TUI9   A0A1S3GET8  

PDB

6AVO     E-value=1.96325e-104,     Score=966

KEGG

692836    K02729 20S proteasome subunit alpha 5 [EC:3.4.25.1] | (RefSeq) proteasome zeta subunit

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0019773   GO:0043161   GO:0004298   GO:0005634   GO:0005737   GO:0010498   GO:0004175   GO:0010499   GO:0005839   GO:0016021   GO:0006511   GO:0051603   GO:0046835   GO:0006281   GO:0006259  

Subcellular location

Nucleus  
Cytoplasm  

Length:

243

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0970099999999999

Exp number, first 60 AAs:

0.09541

Total prob of N-in:

0.07766

outside

1  -  243

 

 

Pi

273.653854

Theta

223.273863

Tajima's D

0.705439

CLR

0

CSRT

0.581120943952802

Interpretation

Uncertain