Gene

KWMTBOMO16238

Pre Gene Modal

BGIBMGA013987

Annotation

DNA_polymerase_epsilon_subunit_2_[Papilio_xuthus]

Location

Bomo_Chr28(+):2671634-2673309      View in EpiBrowser

Full name

DNA polymerase epsilon subunit       + More
DNA polymerase epsilon subunit 2      

Alternative Name

DNA polymerase II subunit 2
DNA polymerase epsilon subunit B

Location in the cell

Nuclear   Reliability : 1.942

CDS

ATGACTCCACATGAACGACGGGCAATTCTTGACAAGTTAACTTCACACATTTTAAAACAATGTATTTCACAGCCCGTATTAGAGAAAGAACACCTGGAAATCGCCTTCAAAGAATGCTCTGCATCGGGTCTTGAAGAGACCGAAACTGTTTTAAACGTAATCGACGCTTTTAACATTCCCAAACTGAGTTACGACAATGAGAGAAATAAGTTCGTTAAATCTGTACATAAGAACAATTTATATCCAGAACCGAAGTGGAAAGCGCAATTCTTGATAGACAGATACGAAATAATATGGCAAAGAACTGTTAGGAATAAATTGTTTGCTCAAGAAGCCTTGCCTTCATTGGCCGAGGAGAAATATTTCCAATTGCGCAAAATCGAAGCGCTGCTAAGCTCTTCTAGTCGAATCGATGATGTGATTGTGCTCGGTCTTTTAATACAGTTGACAGAAGGAAAATATTACTTGGAAGATCCAACTGGCAGTGTTGTTCTCGATATGTCACAAACAAGGTACCACTCAGGCTTATTCACTGAATATAGCTTCGTTTTAGTTGAAGGTTATTATGATGACAAGGTATTAAATGTTATGGGCCTTGTGCTACCGCCGCCGGAAAGCAGAGCCTCGTCACTGCCATTTTTTGGTAATTTAAATACATTTGGTGGAAATTCTAAGACTTTACTTAAAAACTCTAAGTCATTGCTAAAGATTGAACAGGAAAATAAAGAAGGAATGATTATATTCTTATCTGATGTTTGGATAGACACATTGAAAGTTATGAATAACTTAAGAACATTATTTAGTGGCTACAATGATTTTCCACCTGTGGCTATCGTGTTCATGGGTGAATTCCTCTCGTGTCCGTATGGTCAGGAGCATTGCACACAGCTACGAATGGCATTATCAAACTTAGGTGAAATAATAGCTCAATTCAAGAAATTGAAAGATGAATGCAAATTTATCTTTGTACCTGGCAGATCGGATCCTTGTGCTGCCAATGTTTTACCAAGACCAGCAATTCCAAGTTCCATAACACAAGGTATAAGAGAAAAATTAGGTGATGCAGTCATTTTCACAACGAACCCATGCAGAATACAATACTGTACACAAGAGATAGTAGTTTTCAGGCAAGATTTAGTAATGAAAATGTGTAGGAATTCTGTACATTTTCCGGAGACTGGTGATATTCCTGATCATTTGGTGAAGACTTTGTTTAGTCAATGTACACTGTCACCATTGTCATTAGCTATACAACCAGTGTATTGGAAGCATTCGGATTCTTTAAGTTTGTATCCGATGCCGGATTTGGTAGTGATTGGCGACCATTTCCAACCTTATACTCGCTCATATCAAAACTCGCAGATTATGAACCCTGGGTCTTTTCCGCGAACTGAGTTCTCATTTAAAGTGTATGTACCAAGTACGAAAACAGTTGAAGATTCACAAATACCGAAAGATGATGGATGA

Protein

MTPHERRAILDKLTSHILKQCISQPVLEKEHLEIAFKECSASGLEETETVLNVIDAFNIPKLSYDNERNKFVKSVHKNNLYPEPKWKAQFLIDRYEIIWQRTVRNKLFAQEALPSLAEEKYFQLRKIEALLSSSSRIDDVIVLGLLIQLTEGKYYLEDPTGSVVLDMSQTRYHSGLFTEYSFVLVEGYYDDKVLNVMGLVLPPPESRASSLPFFGNLNTFGGNSKTLLKNSKSLLKIEQENKEGMIIFLSDVWIDTLKVMNNLRTLFSGYNDFPPVAIVFMGEFLSCPYGQEHCTQLRMALSNLGEIIAQFKKLKDECKFIFVPGRSDPCAANVLPRPAIPSSITQGIREKLGDAVIFTTNPCRIQYCTQEIVVFRQDLVMKMCRNSVHFPETGDIPDHLVKTLFSQCTLSPLSLAIQPVYWKHSDSLSLYPMPDLVVIGDHFQPYTRSYQNSQIMNPGSFPRTEFSFKVYVPSTKTVEDSQIPKDDG

Description

Participates in DNA repair and in chromosomal DNA replication.

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Subunit

Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4.
Consists of four subunits: POLE, POLE2, POLE3 and POLE4.

Miscellaneous

In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.

Similarity

Belongs to the DNA polymerase epsilon subunit B family.

Keywords

3D-structure   Alternative splicing   Complete proteome   DNA replication   DNA-binding   DNA-directed DNA polymerase   Nucleotidyltransferase   Nucleus   Polymorphism   Reference proteome   Transferase  

Feature

chain  DNA polymerase epsilon subunit 2
splice variant  In isoform 2.
sequence variant  In dbSNP:rs34857719.

Uniprot

H9JWS3   A0A0N1IN55   A0A0N1IFG7   A0A1E1WDM0   A0A3S2TG39   A0A212EKM9   + More
A0A0L7LN72   A0A2A4JXT9   A0A2H1WB86   A0A212FF07   A0A067QG57   A0A2P8XZD3   A0A210PQ05   A0A2J7PDH2   V4A559   A0A2C9JIZ0   W4YG06   A0A1B6EGQ5   T1FST1   A0A1B6LQV0   A0A1B0GQJ6   A0A1B0CS94   A0A182NML0   A0A1B6M9S3   A0A1B6LUI4   A0A384AZP2   A0A182YET4   A0A0A9X6F9   I3M8Z7   A0A182Q0Z7   P56282   F1SHZ5   A0A2K5JNE0   Q9DGB4   E2RCT9   A0A336M4A5   A0A2K6B0N7   A0A2K5LZS5   A0A2Y9MVC1   A0A3Q7NWF1   G1RN11   G3RX47   A0A2U3V0L9   A0A2R9ATT1   A0A341A9T5   A0A0D9RRV3   G7MXP9   A0A2Y9EN08   A0A2C9JIX3   A0A1L8F9Q8   A0A2J7PDF8   G1NLS9   A0A2Y9I4B9   A0A2U3XDY1   J9PBE8   A0A2J8WKD0   A0A3B3QMI3   H0V2V0   Q5BJ62   A0A340WDB8   A0A336MRN2   A0A2K6P4M8   M3WAU8   A0A182VPQ8   A0A096NUT6   A0A3Q7T7M8   K7C803   W5N091   H9G4G4   A0A2K5S983   A0A2K5U0M8   A0A2K5U0N6   H2Q891   A0A1S3HPG0   A0A182PSQ3   Q3TA87   A0A2T7NYS2   M3Y0R0   F7ET97   A0A3Q7Y075   U3DJM7   A0A091DH04   W5QHE5   Q5ZKQ6   A0A2Y9I667   A0A2U3XDY2   A0A1Q3EVR8   A0A384CCH0   A0A2Y9IRC2   F1MKI8   A0A2K5CWV8   A0A3Q7NWI2   U3IIN1   S4RLY7   G9KHP1   A7YWS7   O54956   A0A2K6LRW4   F6ZV13   A0A182GFR6  

EC Number

2.7.7.7

Pubmed

19121390    26354079    22118469    26227816    24845553    29403074    + More
28812685    23254933    15562597    25244985    25401762    26823975    9405441    9443964    11433027    14702039    12508121    15489334    10801849    30723633    11296256    16341006    22398555    22722832    22002653    27762356    20838655    29240929    21993624    25362486    17975172    21881562    16136131    10349636    11042159    11076861    11217851    12466851    16141073    25243066    20809919    15642098    19393038    23749191    23236062    16141072    17431167    26483478   

EMBL

BABH01018560    KQ459166    KPJ03544.1    KQ460689    KPJ12746.1    GDQN01005974    + More
JAT85080.1    RSAL01000177    RVE45027.1    AGBW02014237    OWR42041.1    JTDY01000478    KOB76998.1    NWSH01000468    PCG76202.1    ODYU01007498    SOQ50320.1    AGBW02008869    OWR52329.1    KK853567    KDR06663.1    PYGN01001128    PSN37360.1    NEDP02005562    OWF38563.1    NEVH01026387    PNF14373.1    KB202481    ESO90150.1    AAGJ04112717    GEDC01019285    GEDC01000244    JAS18013.1    JAS37054.1    AMQM01003729    KB096275    ESO06951.1    GEBQ01013907    JAT26070.1    AJVK01017154    AJWK01025807    GEBQ01007306    JAT32671.1    GEBQ01012655    JAT27322.1    GBHO01029196    GBHO01020976    GDHC01007572    JAG14408.1    JAG22628.1    JAQ11057.1    AGTP01067338    AGTP01067339    AGTP01067340    AGTP01067341    AGTP01067342    AXCN02001597    AF025840    AF036899    AF387034    AF387021    AF387022    AF387023    AF387024    AF387025    AF387026    AF387027    AF387028    AF387029    AF387030    AF387031    AF387032    AF387033    EF506887    AK293163    AL139099    AL591767    BC112962    BC126218    BC126220    AEMK02000004    DQIR01027653    DQIR01205437    DQIR01312570    HCZ83128.1    BC097773    AB048257    AAH97773.1    BAB12726.1    AAEX03005717    AAEX03005718    UFQT01000542    SSX25106.1    ADFV01039976    ADFV01039977    ADFV01039978    ADFV01039979    ADFV01039980    CABD030092223    CABD030092224    CABD030092225    CABD030092226    CABD030092227    CABD030092228    CABD030092229    CABD030092230    AJFE02112244    AJFE02112245    AJFE02112246    AJFE02112247    AJFE02112248    AJFE02112249    AQIB01058976    AQIB01058977    AQIB01058978    AQIB01058979    AQIB01058980    AQIB01058981    AQIB01058982    AQIB01058983    AQIB01058984    CM001259    EHH27857.1    CM004480    OCT68329.1    PNF14374.1    NDHI03003386    PNJ70225.1    AAKN02027602    AAKN02027603    AAKN02027604    BC091608    AAH91608.1    UFQS01001948    UFQT01001948    SSX12769.1    SSX32211.1    AANG04004459    AHZZ02032139    AHZZ02032140    AHZZ02032141    GABF01007108    JAA15037.1    AHAT01003708    AAWZ02030255    AAWZ02030256    AQIA01064818    AQIA01064819    AQIA01064820    AC191868    NBAG03000214    PNI83282.1    AK172024    BAE42782.1    PZQS01000008    PVD26327.1    AEYP01003513    AEYP01003514    AEYP01003515    AEYP01003516    GAMP01005684    JAB47071.1    GAMS01009545    JAB13591.1    KN122569    KFO29738.1    AMGL01102946    AJ720028    GFDL01015653    JAV19392.1    ADON01057939    JP015818    AES04416.1    BC134762    AK077592    BC063772    AF036898    JSUE03039694    JXUM01060178    JXUM01060179    KQ562091    KXJ76713.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000283053    UP000007151    UP000037510    + More
UP000218220    UP000027135    UP000245037    UP000242188    UP000235965    UP000030746    UP000076420    UP000007110    UP000015101    UP000092462    UP000092461    UP000075884    UP000261681    UP000076408    UP000005215    UP000075886    UP000005640    UP000008227    UP000233080    UP000002254    UP000233120    UP000233060    UP000248483    UP000286641    UP000001073    UP000001519    UP000245320    UP000240080    UP000252040    UP000029965    UP000248484    UP000186698    UP000001645    UP000248481    UP000245341    UP000261540    UP000005447    UP000265300    UP000233200    UP000011712    UP000075920    UP000028761    UP000286640    UP000018468    UP000001646    UP000233040    UP000233100    UP000002277    UP000085678    UP000075885    UP000245119    UP000000715    UP000008225    UP000286642    UP000028990    UP000002356    UP000000539    UP000261680    UP000248482    UP000009136    UP000233020    UP000016666    UP000245300    UP000000589    UP000233180    UP000006718    UP000069940    UP000249989   

PRIDE

H9JWS3    P56282    F1SHZ5    Q5ZKQ6    A7YWS7    O54956    + More

Pfam

PF04042   DNA_pol_E_B        + More
PF12213   Dpoe2NT

Interpro

IPR007185   DNA_pol_a/d/e_bsu        + More
IPR024639   DNA_pol_e_bsu_N       
IPR016266   POLE2       
IPR036700   BOBF_sf       

SUPFAM

SSF101756   SSF101756       

ProteinModelPortal

H9JWS3   A0A0N1IN55   A0A0N1IFG7   A0A1E1WDM0   A0A3S2TG39   A0A212EKM9   + More
A0A0L7LN72   A0A2A4JXT9   A0A2H1WB86   A0A212FF07   A0A067QG57   A0A2P8XZD3   A0A210PQ05   A0A2J7PDH2   V4A559   A0A2C9JIZ0   W4YG06   A0A1B6EGQ5   T1FST1   A0A1B6LQV0   A0A1B0GQJ6   A0A1B0CS94   A0A182NML0   A0A1B6M9S3   A0A1B6LUI4   A0A384AZP2   A0A182YET4   A0A0A9X6F9   I3M8Z7   A0A182Q0Z7   P56282   F1SHZ5   A0A2K5JNE0   Q9DGB4   E2RCT9   A0A336M4A5   A0A2K6B0N7   A0A2K5LZS5   A0A2Y9MVC1   A0A3Q7NWF1   G1RN11   G3RX47   A0A2U3V0L9   A0A2R9ATT1   A0A341A9T5   A0A0D9RRV3   G7MXP9   A0A2Y9EN08   A0A2C9JIX3   A0A1L8F9Q8   A0A2J7PDF8   G1NLS9   A0A2Y9I4B9   A0A2U3XDY1   J9PBE8   A0A2J8WKD0   A0A3B3QMI3   H0V2V0   Q5BJ62   A0A340WDB8   A0A336MRN2   A0A2K6P4M8   M3WAU8   A0A182VPQ8   A0A096NUT6   A0A3Q7T7M8   K7C803   W5N091   H9G4G4   A0A2K5S983   A0A2K5U0M8   A0A2K5U0N6   H2Q891   A0A1S3HPG0   A0A182PSQ3   Q3TA87   A0A2T7NYS2   M3Y0R0   F7ET97   A0A3Q7Y075   U3DJM7   A0A091DH04   W5QHE5   Q5ZKQ6   A0A2Y9I667   A0A2U3XDY2   A0A1Q3EVR8   A0A384CCH0   A0A2Y9IRC2   F1MKI8   A0A2K5CWV8   A0A3Q7NWI2   U3IIN1   S4RLY7   G9KHP1   A7YWS7   O54956   A0A2K6LRW4   F6ZV13   A0A182GFR6  

PDB

5VBN     E-value=1.53604e-123,     Score=1134

KEGG

101735493    K02325 DNA polymerase epsilon subunit 2 [EC:2.7.7.7] | (RefSeq) DNA polymerase epsilon subunit 2

PATHWAY

03030    DNA replication - Bombyx mori (domestic silkworm)
03410    Base excision repair - Bombyx mori (domestic silkworm)
03420    Nucleotide excision repair - Bombyx mori (domestic silkworm)

GO

GO:0003677   GO:0008622   GO:0003887   GO:0006261   GO:0006260   GO:0005634   GO:0042276   GO:0016604   GO:0032201   GO:0006270   GO:0005654   GO:0043231   GO:0000082   GO:0006281   GO:0001678   GO:0005536   GO:0046835   GO:0006259  

PANTHER

PTHR12708  

Subcellular location

Nucleus  

Length:

488

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01566

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00375

outside

1  -  488

 

 

Pi

190.495258

Theta

179.77271

Tajima's D

0.187659

CLR

0.219374

CSRT

0.425778711064447

Interpretation

Uncertain