Gene

KWMTBOMO16230

Pre Gene Modal

BGIBMGA013981

Annotation

PREDICTED:_protein_Wnt-2-like_[Bombyx_mori]

Location

Bomo_Chr28(+):2579864-2603049      View in EpiBrowser

Full name

Protein Wnt       + More
Protein Wnt-7b      

Location in the cell

Extracellular   Reliability : 4.256

CDS

ATGTGTCGGTCTTCTCCATCGGCTATAGCCGCAATCGGTGATGGACTTAAGATGGCATATGAAGAATGCCGGGCTCAATTGAGCGGCCACAGGTGGAACTGCTCAGGAGTGGGAGACGGAAATCACTTCGGGCACGTTATGCCGTTAGCAACGCGTGAGGCGGCTTTTACGTACGCCATCACATCGGCGGGGGTCACCCATGCTTTGAGCATGGCCTGCGCTCGTGGGGAGCTGCCTGGTTGTGGATGTACAGGAAATAAGAGGCGTACGATAAACACAATCGAGCAGTTCCAATGGGGCGGATGCGGTTCCAGTGCGTACGGCGCTAGGTTAGCCCGGCGGTTTTTGGACGCGAGAGAATTGGAACGAGACGGCAGAACCCTCATGAACCTCCACAACAACCGGGTCGGAAGGAAGGTGAGCGAGGTGGTAAAGGACCTAGTTCATCGCGAGTGCAAATGCCACGGCGTCTCGGGCTCCTGCGCTATGAGGACTTGCTGGCGGGCGCTACCGCAGTTCAGGGCTGCGGCTGCCACCCTGCGGGACAAGTATAAGCGAGCGAAGCTAGTTATGCCGCACCCAGCAACGAATCCACAGGACATTAACGTTCGAACACACCTCGTAATAAAACGACAAAAGCACCCAGGTCTCGGTCGACAGCCCAGGAAATCGGAGCTGGTGTTTCTCGAACAGTCACCTTCCTACTGCGAGCCTGATACTGCAGCAGGATCGTTTGGAACTCACGGAAGGATATGCAATAGGACGTCAAGAGGTGAGGACGGCTGCGAGACCCTATGCTGCGGACGCGGGTACAGCACGACCCGCAGCGTTGAGGAGACAAAGTGCCGCTGCCAGTTCCACTGGTGCTGCAACGTCACGTGCAGCAAATGCGTGACGACAGTGGAAACGCACCTTTGTAATTAG

Protein

MCRSSPSAIAAIGDGLKMAYEECRAQLSGHRWNCSGVGDGNHFGHVMPLATREAAFTYAITSAGVTHALSMACARGELPGCGCTGNKRRTINTIEQFQWGGCGSSAYGARLARRFLDARELERDGRTLMNLHNNRVGRKVSEVVKDLVHRECKCHGVSGSCAMRTCWRALPQFRAAAATLRDKYKRAKLVMPHPATNPQDINVRTHLVIKRQKHPGLGRQPRKSELVFLEQSPSYCEPDTAAGSFGTHGRICNRTSRGEDGCETLCCGRGYSTTRSVEETKCRCQFHWCCNVTCSKCVTTVETHLCN

Description

Ligand for members of the frizzled family of seven transmembrane receptors.
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619, PubMed:28803732). Required for normal fusion of the chorion and the allantois during placenta development (PubMed:11543617). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:28803732).
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:30026314). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314).

Subunit

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD1 and FZD10 (PubMed:15923619). Interacts with FZD4 (in vitro) (PubMed:15923619). Interacts with PORCN (PubMed:10866835). Interacts with glypican GPC3 (By similarity). Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (By similarity).
Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:16227623). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Interacts with FZD1 and FZD10. Interacts with FZD4 (in vitro). Interacts with PORCN (By similarity). Interacts with glypican GPC3 (PubMed:16227623). Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (PubMed:30026314).

Similarity

Belongs to the Wnt family.

Keywords

Complete proteome   Developmental protein   Disulfide bond   Extracellular matrix   Glycoprotein   Lipoprotein   Reference proteome   Secreted   Signal   Wnt signaling pathway  

Feature

chain  Protein Wnt

Uniprot

H9JWR7   A0A0N1I6U7   A0A212FE41   A0A0N0P9S5   A0A2H1V4K0   A0A1Y1MUT8   + More
A0A1Y1MRN2   A0A1Y1MWA3   A0A1Y1MV11   D6WT32   A0A1B6CTV4   K7IUK3   A0A1Q3FR18   A0A1Q3FQZ0   B0XE42   A0A3S1B792   A0A210PIC4   A0A1S4FJ50   Q16Z87   A0A1W4WQL4   A0A1W7R6K2   A0A182J8Y0   Q75PH8   A0A2K5SA58   Q75PH6   A0A2K5SA60   A0A0K8VCL5   A0A2K5SA53   A0A2K5SA56   A0A2R8NBC2   A0A2U3TVB0   U3BHR4   A0A2K6BRD2   A0A2K6MDG1   A0A2K5VJG3   A0A2K6RQ32   A0A2K5HJB1   A0A0P6J925   G5BVA8   A0A2I3GKQ7   A0A2R9BAW7   A0A2K6BRK5   A0A2K6MD94   A0A2I2YNF6   A0A2R9BAW6   A0A2I3LY45   A0A2K5P8L3   A0A2J8TW64   A0A2K5HJ68   G1RTL0   A0A2J8LMI4   A8K0G1   A0A2I2ZE89   V3Z3G3   I3NCV6   A0A286Y3S2   B8A595   A0A2J8TW35   H0VRH8   A0A1U7U421   F7HJM7   A0A2I2Y7P3   A0A0G2K3B7   Q6NZR1   A0A2K6BRC8   A0A2K6MDF6   A0A2K5VJ85   A0A2I3MYX8   A0A2K6RQ28   A0A2K5P8M7   A0A2K5HJ48   A0A1D5R7Q0   A0A2I3HGF4   H0VZV3   Q5NSW6   P28047   E9PU66   A0A2K6BRE8   A0A2K5VJD2   A0A2I3HZL1   A0A2K5ZBV8   A0A0D9QZ47   A0A096NKR7   A0A2K5P8S6   H2P4S1   A0A2I3TH72   P56706   I3N7Q1   A0A2K6RQ41   A0A2K6MDF5   A0A2K6RQ24   A0A2K5HJD1   A0A2R9BEM4   A0A1D5R803   A0A2K5P8M5   A0A1B0GBR3   G3ICH8   A0A2K5ZBW6   A0A1U7Q3Z5   D2HKK9  

Pubmed

19121390    26354079    22118469    28004739    18362917    19820115    + More
20075255    28812685    17510324    25243066    25362486    21993625    22722832    22398555    15164055    16136131    10591208    23254933    21993624    17431167    15057822    15489334    19468303    12147135    2279700    10866835    11543617    15923619    28803732    11562755    8168088    16227623    26902720    30026314    21804562    29704459    20010809   

EMBL

BABH01018551    KQ460689    KPJ12754.1    AGBW02008980    OWR51990.1    KQ459166    + More
KPJ03538.1    ODYU01000645    SOQ35763.1    GEZM01023608    JAV88280.1    GEZM01023607    JAV88281.1    GEZM01023611    JAV88276.1    GEZM01023612    JAV88275.1    KQ971354    EFA07553.2    GEDC01020533    JAS16765.1    AAZX01004215    AAZX01005813    GFDL01005051    JAV29994.1    GFDL01005004    JAV30041.1    DS232802    EDS45875.1    RQTK01000562    RUS77655.1    NEDP02076657    OWF36235.1    CH477495    EAT39973.1    GEHC01000851    JAV46794.1    AB167809    BAD12587.1    AB167811    BAD12589.1    GDHF01032883    GDHF01015620    JAI19431.1    JAI36694.1    GAMT01006051    GAMT01006050    GAMT01006049    GAMT01006048    GAMT01006047    GAMT01006046    JAB05812.1    AQIA01006583    AQIA01006584    AQIA01006585    AQIA01006586    GEBF01003593    JAO00040.1    JH172084    EHB13222.1    ADFV01129020    ADFV01129021    ADFV01129022    ADFV01129023    ADFV01129024    ADFV01129025    ADFV01129026    ADFV01129027    ADFV01129028    ADFV01129029    AJFE02039433    AJFE02039434    AJFE02039435    CABD030121578    CABD030121579    CABD030121580    AHZZ02001400    NDHI03003480    PNJ37239.1    AACZ04043605    NBAG03000283    PNI48474.1    BX511035    CR536603    AK289526    BAF82215.1    KB203301    ESO85168.1    AGTP01080758    AGTP01080759    AGTP01080760    AGTP01080761    AGTP01080762    AGTP01080763    AGTP01080764    AGTP01080765    AGTP01080766    AGTP01080767    AAKN02054985    AAKN02054986    PNJ37237.1    JSUE03005760    JSUE03005761    JSUE03005762    AABR07058588    AABR07073335    AC112534    AC115763    BC066003    AAH66003.1    AB197137    BAD83363.1    M89802    BC052018    AQIB01150601    AQIB01150602    ABGA01134833    ABGA01134834    ABGA01220113    ABGA01220114    ABGA01220115    ABGA01220116    ABGA01220117    ABGA01220118    ABGA01220119    ABGA01220120    PNJ37235.1    PNI48470.1    AB062766    AF416743    BC034923    CCAG010005876    CCAG010005877    CCAG010005878    CCAG010005879    CCAG010005880    JH001927    RAZU01000074    EGV98910.1    RLQ75186.1    GL192962    EFB24521.1   

Proteomes

UP000005204    UP000053240    UP000007151    UP000053268    UP000007266    UP000002358    + More
UP000002320    UP000271974    UP000242188    UP000008820    UP000192223    UP000075880    UP000233040    UP000008225    UP000233120    UP000233180    UP000233100    UP000233200    UP000233080    UP000006813    UP000001073    UP000240080    UP000001519    UP000028761    UP000233060    UP000002277    UP000005640    UP000030746    UP000005215    UP000005447    UP000189704    UP000006718    UP000002494    UP000000589    UP000233140    UP000029965    UP000001595    UP000092444    UP000001075    UP000273346    UP000189706   

PRIDE

H9JWR7    A8K0G1    B8A595    P28047    E9PU66    P56706    + More
G3ICH8   

Pfam

PF00110   wnt

Interpro

IPR018161   Wnt_CS        + More
IPR005817   Wnt       
IPR013300   Wnt7       

ProteinModelPortal

H9JWR7   A0A0N1I6U7   A0A212FE41   A0A0N0P9S5   A0A2H1V4K0   A0A1Y1MUT8   + More
A0A1Y1MRN2   A0A1Y1MWA3   A0A1Y1MV11   D6WT32   A0A1B6CTV4   K7IUK3   A0A1Q3FR18   A0A1Q3FQZ0   B0XE42   A0A3S1B792   A0A210PIC4   A0A1S4FJ50   Q16Z87   A0A1W4WQL4   A0A1W7R6K2   A0A182J8Y0   Q75PH8   A0A2K5SA58   Q75PH6   A0A2K5SA60   A0A0K8VCL5   A0A2K5SA53   A0A2K5SA56   A0A2R8NBC2   A0A2U3TVB0   U3BHR4   A0A2K6BRD2   A0A2K6MDG1   A0A2K5VJG3   A0A2K6RQ32   A0A2K5HJB1   A0A0P6J925   G5BVA8   A0A2I3GKQ7   A0A2R9BAW7   A0A2K6BRK5   A0A2K6MD94   A0A2I2YNF6   A0A2R9BAW6   A0A2I3LY45   A0A2K5P8L3   A0A2J8TW64   A0A2K5HJ68   G1RTL0   A0A2J8LMI4   A8K0G1   A0A2I2ZE89   V3Z3G3   I3NCV6   A0A286Y3S2   B8A595   A0A2J8TW35   H0VRH8   A0A1U7U421   F7HJM7   A0A2I2Y7P3   A0A0G2K3B7   Q6NZR1   A0A2K6BRC8   A0A2K6MDF6   A0A2K5VJ85   A0A2I3MYX8   A0A2K6RQ28   A0A2K5P8M7   A0A2K5HJ48   A0A1D5R7Q0   A0A2I3HGF4   H0VZV3   Q5NSW6   P28047   E9PU66   A0A2K6BRE8   A0A2K5VJD2   A0A2I3HZL1   A0A2K5ZBV8   A0A0D9QZ47   A0A096NKR7   A0A2K5P8S6   H2P4S1   A0A2I3TH72   P56706   I3N7Q1   A0A2K6RQ41   A0A2K6MDF5   A0A2K6RQ24   A0A2K5HJD1   A0A2R9BEM4   A0A1D5R803   A0A2K5P8M5   A0A1B0GBR3   G3ICH8   A0A2K5ZBW6   A0A1U7Q3Z5   D2HKK9  

PDB

6AHY     E-value=7.51534e-61,     Score=591

KEGG

101740841    K00572 wingless-type MMTV integration site family, member 7 | (RefSeq) protein Wnt-2-like

PATHWAY

04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0016055   GO:0007275   GO:0005576   GO:0005102   GO:0030182   GO:0005109   GO:0005615   GO:0045165   GO:0060070   GO:0071300   GO:0072089   GO:0048144   GO:0048018   GO:0061180   GO:0021871   GO:0032536   GO:0005886   GO:0007257   GO:0005737   GO:0048812   GO:0031175   GO:0051384   GO:0046330   GO:0072054   GO:0045879   GO:0032364   GO:0010628   GO:0060710   GO:0016332   GO:0048568   GO:0001701   GO:0022009   GO:0008284   GO:0003338   GO:0060482   GO:0072205   GO:0072236   GO:1902262   GO:0060033   GO:0072053   GO:0045669   GO:0060669   GO:0072207   GO:0060535   GO:0050768   GO:1902379   GO:0050808   GO:0001525   GO:0051145   GO:0042592   GO:0044237   GO:0060484   GO:0001944   GO:0072061   GO:0048864   GO:0036516   GO:1904938   GO:0005788   GO:0072060   GO:0060425   GO:0060428   GO:0030324   GO:0060560   GO:0021846   GO:0009986   GO:0042475   GO:0030666   GO:0070062   GO:0005796   GO:0070307   GO:0008233   GO:0001678   GO:0005536   GO:0046835   GO:0006281   GO:0006259  

PANTHER

PTHR12027  

Subcellular location

  
Secreted  
Extracellular space  
Extracellular matrix  

Length:

307

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0798199999999999

Exp number, first 60 AAs:

0.02929

Total prob of N-in:

0.02978

outside

1  -  307

 

 

Pi

212.551584

Theta

153.878494

Tajima's D

1.600066

CLR

0.180158

CSRT

0.809859507024649

Interpretation

Uncertain