Gene

KWMTBOMO16184

Pre Gene Modal

BGIBMGA013929

Annotation

juvenile_hormone_epoxide_hydrolase-like_protein_5_[Bombyx_mori]

Location

Bomo_Chr28(-):747968-754596      View in EpiBrowser

Full name

Epoxide hydrolase       + More
Juvenile hormone epoxide hydrolase      
Glutathione peroxidase      
Juvenile hormone epoxide hydrolase 1      
Juvenile hormone epoxide hydrolase 2      

Alternative Name

CfEH1
Juvenile hormone epoxide hydrolase I
Juvenile hormone-specific epoxide hydrolase I
CfEH2
Juvenile hormone epoxide hydrolase II
Juvenile hormone-specific epoxide hydrolase II

Location in the cell

Mitochondrial   Reliability : 0.979

CDS

ATGCGGTACGGTGTAATACAAAAGTTGAAACCGAAAGAATTCTATCCGATCCGAAATGACGTAATCGACGATTTGAAATATCGTCTCAAGAATCATCGACCCTTCGCCCCGCCACTAGAGGGTGTGACCTTCGAATACGGCTTCAACACGGCTGCCCTAGAACCCTGGCTGAAATACTGGGCCGAGGAGTATAAATTCGCTGACCGAGAAAAGTTCTTTAATCAGTTTCCACATTTCAAGACCAGCATCAAGGGCCTGGATATTCATTTCATCAGAGTTAAGCCGCAGGTATCTGCAGGAGTCCAGACTCTGCCCCTTCTTCTGTTACATGGCTGGCCAGGTTCCGTCAGAGAGTTCTATGAAGCCATCCCCCTGCTGACCAGTCAAAATTCTGGGTATGATTTTGCCTTTGAAGTCATAGTCCCGAGTCTACCCGGATATGGTTTTTCTGATGCTGCAGTGAGACCAGGCTTATCTTTGCCGTACGTAGCAGATATCTTCAGAATATTAATGAAAAGATTGGGTCATGATAAATTTTACATACAAGGGGGAGATTGGGGCGCAGCCATTGCCTCGGCCATGGTTACCCTATTCCCTGAAGATGTTCTTGGACATCACAGTAATTCAGCTGTTACACAGCATCCTCACGCCCTGCTCAGAACTCTGCTTGGTGCTTTAATACCGTCACTAATAGTGGAAGATCATCTAGCCGAAAGAATGTATCCACTTTCAAAACATCTGGCGTACTTGTTGGAAGAATTCGGATACTTTCACTTACAAGCCACAAAGCCTGATACAGTAGGTGTTTCCCTGACGGATTCTCCATCAGGTCTTCTAGCGTATATTTTAGAGAAATTCGCGGTTTGGACGCGCAAGGAGCACAAGTTTAAGAGTGACGGCGGTCTCGGCTTCAGGTTTAGCAAGGAAAAGCTGATAGATAATCTAATGGTCTACTGGATTACCAACTCTATTACAAGCTCAATGAGATTCTATTCCGAAAACATGAGTAACAAATTCAGGGAAATGAATTTGGAAGCTTTTACATCACCCGTTCCCACGTGGGCTCTCCAGGCCAGAGACGAGCTGGTCTATCAGCCGCCTGCAGTTTTACGTGCGAAGTACCTGAATCTCCTCAACGTGACGGTTTTAGACGACGGCGGACATTTCTTGGCTTTGGAACTTCCTGAGGTGTTCGCGGAAGACGTTTTCAAGGCGGTTCACGCGTTCAAGCAGTGGCGTTCTACTCATTCCAAGACTGATCATTAG

Protein

MRYGVIQKLKPKEFYPIRNDVIDDLKYRLKNHRPFAPPLEGVTFEYGFNTAALEPWLKYWAEEYKFADREKFFNQFPHFKTSIKGLDIHFIRVKPQVSAGVQTLPLLLLHGWPGSVREFYEAIPLLTSQNSGYDFAFEVIVPSLPGYGFSDAAVRPGLSLPYVADIFRILMKRLGHDKFYIQGGDWGAAIASAMVTLFPEDVLGHHSNSAVTQHPHALLRTLLGALIPSLIVEDHLAERMYPLSKHLAYLLEEFGYFHLQATKPDTVGVSLTDSPSGLLAYILEKFAVWTRKEHKFKSDGGLGFRFSKEKLIDNLMVYWITNSITSSMRFYSENMSNKFREMNLEAFTSPVPTWALQARDELVYQPPAVLRAKYLNLLNVTVLDDGGHFLALELPEVFAEDVFKAVHAFKQWRSTHSKTDH

Description

Catalyzes juvenile hormone hydrolysis.
Catalyzes juvenile hormone hydrolysis. Degrades juvenile hormone III (JH III) about 3 times and 5 times slower than juvenile hormone I (JH I) and II (JH II), respectively. Degrades cis-stilbene oxide and trans-stilbene oxide about 18 and 43 times slower than JH III, respectively.

Catalytic Activity

1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol
cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin

Biophysicochemical Properties

0.52 uM for juvenile hormone III

Subunit

Homodimer.

Similarity

Belongs to the peptidase S33 family.
Belongs to the glutathione peroxidase family.

Keywords

3D-structure   Aromatic hydrocarbons catabolism   Complete proteome   Endoplasmic reticulum   Hydrolase   Membrane   Microsome   Reference proteome   Transmembrane   Transmembrane helix   Direct protein sequencing  

Feature

chain  Epoxide hydrolase

Uniprot

D4Q9H4   H9JWL5   Q1W696   A0A2W1B2C5   A0A194Q5D4   A0A2A4K9D8   + More
L7R9X8   A0A194PZ48   A0A0N1IBG8   A0A3S2P9A9   A0A0R6CEE9   A0A2A4K8F5   A0A0N1IQA6   A0A2W1B6Y8   C0KH33   I4DKH4   A0A194PZ44   A0A212F9X4   A0A3S2LEJ8   A0A0N1ICQ7   H9JWL6   Q6U6J0   Q94806   O44124   A0A0N1IIM0   A0A194PZ55   A0A212F9Y7   A0A212F9W9   A0A194Q0T4   A0A0N0PEI4   A0A2A4JI09   A0A2W1B693   A0A0N0PCA1   C6KWM6   A0A1Y1K079   A0A1Y1K345   A0A2A4J6Z6   A0A0T6B3Y6   A0A088M9L0   A0A0T6BH94   D0W014   A0A0N0PD06   A0A2W1BCV7   A0A2A4JKY8   A0A194PZZ0   D6WGJ4   A0A2C9DK11   A0A2J7PHG7   H9JWT0   H9JI63   Q8MZR6   C6KWM7   A0A2H1VS44   V5G055   A0A067QLM6   D0W015   D6WGJ2   F4WV40   R4G4K1   A0A0P0ELB6   A0A154PRH0   A0A3S2NYE4   A0A226E0H1   D0W012   A0A1W4XE43   A0A0F6SIA8   J3JY41   A0A195EXA2   A0A1V0M8A5   A0A195DS73   Q8MZR5   D0W011   A0A0T6BDK1   B3U0E6   D6WGJ1   A0A0A9WSP4   V5G602   A0A3G6VF49   A0A0K8SHU3   A0A1S4EFE4   A0A151WUE8   A0A0N0PAA2   A0A3S2NQU9   N6UPP4   A0A146KNU3   A0A087ZVE8   A0A151I9X6   A0A195CR36   A0A1W6BRF0   A0A224XNL2   A0A2D3FB68   A0A0V0G516   A0A1W5KJY8   A0A0T6BDP9   A0A0L7QRY7   A0A195DZH4   A0A2A3E8M7   A0A069DUW8   A0A2P8YCD2   A0A158NNQ4  

EC Number

3.3.2.9

Pubmed

20622465    19121390    28756777    26354079    23276675    22651552    + More
22118469    15681225    25143157    9927177    28004739    26385554    18362917    19820115    28536442    12125060    24845553    21719571    26445454    22516182    28349297    18579785    20075255    25401762    23537049    26823975    28400585    26334808    29403074    21347285   

EMBL

AB299279    BAI94514.1    BABH01018381    BABH01018382    DQ431847    ABD85119.1    + More
KZ150418    PZC70942.1    KQ459583    KPI98605.1    NWSH01000031    PCG80508.1    JX681816    AGC00788.1    KPI98607.1    KQ459630    KPJ20526.1    RSAL01000177    RVE45007.1    KM926340    AJR27470.1    PCG80507.1    KPJ20527.1    PZC70941.1    FJ602793    ACM78602.2    AK401792    BAM18414.1    KPI98602.1    AGBW02009550    OWR50537.1    RVE45005.1    KQ459764    KPJ20092.1    BABH01018379    AY377854    AB362775    AAQ87024.1    BAF81491.1    U73680    AAB18243.1    AF035482    AAB88192.1    KPJ20091.1    KPI98601.1    OWR50538.1    OWR50536.1    KPI98604.1    KPJ20089.1    NWSH01001318    PCG71725.1    KZ150284    PZC70943.1    PZC71622.1    KQ460733    KPJ12641.1    AB293555    BAH97089.1    GEZM01096421    JAV54922.1    GEZM01096422    JAV54921.1    NWSH01002656    PCG67731.1    LJIG01009934    KRT82088.1    KJ579233    AIN34709.1    LJIG01000290    KRT86650.1    AB534188    BAI49689.1    KQ460417    KPJ14867.1    KZ150476    PZC70740.1    NWSH01001212    PCG72103.1    KPI98603.1    KQ971321    EFA00569.1    KX855995    ARE68677.1    NEVH01025136    PNF15772.1    BABH01018608    BABH01022402    AF503908    AAM22694.1    AB293556    BAH97090.1    ODYU01004100    SOQ43618.1    GALX01005126    JAB63340.1    KK853182    KDR10172.1    AB534189    BAI49690.1    EFA00568.1    GL888384    EGI61928.1    ACPB03008739    GAHY01001290    JAA76220.1    KT261710    ALJ30250.1    KQ435007    KZC13710.1    RSAL01000025    RVE52162.1    LNIX01000009    OXA50467.1    AB534186    BAI49687.1    KP271046    AKF11871.1    BT128165    AEE63126.1    KQ981953    KYN32509.1    KU755500    ARD71210.1    KQ980530    KYN15652.1    AF503909    AAM22695.1    AB534185    BAI49686.1    LJIG01001532    KRT85408.1    EU441215    ACC55233.1    EFA00567.1    GBHO01035734    JAG07870.1    GALX01002976    JAB65490.1    MH932586    AZB52850.1    GBRD01012965    JAG52861.1    KQ982745    KYQ51387.1    KQ459037    KPJ04294.1    RSAL01000008    RVE53920.1    APGK01022356    APGK01022357    KB740419    ENN80707.1    GDHC01020455    JAP98173.1    KQ978260    KYM95872.1    KQ977381    KYN03166.1    KY810195    ARJ54611.1    GFTR01006406    JAW10020.1    KY407548    ATU47254.1    GECL01002991    JAP03133.1    KU941586    AMR44689.1    LJIG01001533    KRT85407.1    KQ414766    KOC61382.1    KQ979999    KYN18300.1    KZ288345    PBC27632.1    GBGD01001402    JAC87487.1    PYGN01000706    PSN41919.1    ADTU01021716   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000283053    UP000007151    + More
UP000007266    UP000235965    UP000027135    UP000007755    UP000015103    UP000076502    UP000198287    UP000192223    UP000078541    UP000078492    UP000002358    UP000079169    UP000075809    UP000019118    UP000005203    UP000078542    UP000053825    UP000242457    UP000245037    UP000005205   

PRIDE

D4Q9H4    H9JWL5    H9JWL6    Q6U6J0    C6KWM6    H9JWT0    + More
H9JI63    C6KWM7    A0A087ZVE8   

Pfam

PF06441   EHN        + More
PF14529   Exo_endo_phos_2
PF00078   RVT_1
PF00255   GSHPx

Interpro

IPR029058   AB_hydrolase        + More
IPR016292   Epoxide_hydrolase       
IPR010497   Epoxide_hydro_N       
IPR000639   Epox_hydrolase-like       
IPR005135   Endo/exonuclease/phosphatase       
IPR036691   Endo/exonu/phosph_ase_sf       
IPR000477   RT_dom       
IPR029759   GPX_AS       
IPR036249   Thioredoxin-like_sf       
IPR029760   GPX_CS       
IPR000889   Glutathione_peroxidase       

SUPFAM

SSF53474   SSF53474        + More
SSF56219   SSF56219       
SSF52833   SSF52833       

Gene 3D

3.40.50.1820     3.60.10.10    

CDD

cd00340  GSH_Peroxidase

ProteinModelPortal

D4Q9H4   H9JWL5   Q1W696   A0A2W1B2C5   A0A194Q5D4   A0A2A4K9D8   + More
L7R9X8   A0A194PZ48   A0A0N1IBG8   A0A3S2P9A9   A0A0R6CEE9   A0A2A4K8F5   A0A0N1IQA6   A0A2W1B6Y8   C0KH33   I4DKH4   A0A194PZ44   A0A212F9X4   A0A3S2LEJ8   A0A0N1ICQ7   H9JWL6   Q6U6J0   Q94806   O44124   A0A0N1IIM0   A0A194PZ55   A0A212F9Y7   A0A212F9W9   A0A194Q0T4   A0A0N0PEI4   A0A2A4JI09   A0A2W1B693   A0A0N0PCA1   C6KWM6   A0A1Y1K079   A0A1Y1K345   A0A2A4J6Z6   A0A0T6B3Y6   A0A088M9L0   A0A0T6BH94   D0W014   A0A0N0PD06   A0A2W1BCV7   A0A2A4JKY8   A0A194PZZ0   D6WGJ4   A0A2C9DK11   A0A2J7PHG7   H9JWT0   H9JI63   Q8MZR6   C6KWM7   A0A2H1VS44   V5G055   A0A067QLM6   D0W015   D6WGJ2   F4WV40   R4G4K1   A0A0P0ELB6   A0A154PRH0   A0A3S2NYE4   A0A226E0H1   D0W012   A0A1W4XE43   A0A0F6SIA8   J3JY41   A0A195EXA2   A0A1V0M8A5   A0A195DS73   Q8MZR5   D0W011   A0A0T6BDK1   B3U0E6   D6WGJ1   A0A0A9WSP4   V5G602   A0A3G6VF49   A0A0K8SHU3   A0A1S4EFE4   A0A151WUE8   A0A0N0PAA2   A0A3S2NQU9   N6UPP4   A0A146KNU3   A0A087ZVE8   A0A151I9X6   A0A195CR36   A0A1W6BRF0   A0A224XNL2   A0A2D3FB68   A0A0V0G516   A0A1W5KJY8   A0A0T6BDP9   A0A0L7QRY7   A0A195DZH4   A0A2A3E8M7   A0A069DUW8   A0A2P8YCD2   A0A158NNQ4  

PDB

4QLA     E-value=8.42331e-145,     Score=1317

KEGG

100415790    K10719 juvenile hormone epoxide hydrolase | (RefSeq) jheh-lp5; juvenile hormone epoxide hydrolase-li

PATHWAY

00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0005789   GO:0019439   GO:0033961   GO:0016787   GO:0016021   GO:0004602   GO:0006979   GO:0016740   GO:0004601   GO:0003824   GO:0003676   GO:0016491   GO:0016311   GO:0016791   GO:0001678   GO:0005536   GO:0046835   GO:0006281   GO:0006259  

Subcellular location

Endoplasmic reticulum membrane  
Microsome membrane  

Length:

421

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.3126

Exp number, first 60 AAs:

0.00387

Total prob of N-in:

0.02405

outside

1  -  421

 

 

Pi

250.860637

Theta

178.996374

Tajima's D

1.982858

CLR

0

CSRT

0.87995600219989

Interpretation

Uncertain