Gene

KWMTBOMO16180  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013958

Annotation

serine_protease_inhibitor_14_precursor_[Bombyx_mori]

Location

Bomo_Chr28(+):669147-671102      View in EpiBrowser

Full name

Serine protease inhibitor 77Ba      

Location in the cell

PlasmaMembrane   Reliability : 2.647

CDS

ATGGCACTCAAACTGCTAATACTCCTCGCGTTCTGCCAAGCGATAACCGCCCTAAAGTACCCGTGCACAAACCACAAAACGATAGCGTTACTAAAACGACCAACTTACGACTTTTCGATCGGAATCCTCCAAAGAGTCGCCGAGGAGACGAATGACAATTTCGTGTTTTCGCCTCTCTCCAACTGGCTGCAGCTGATCGCGCTCTCCGAGGGCGCCAAAGGACGGACTCTGAAGGAACTATGGCGCGTCACCCGATTCCACATGAGGAACTGTTTCAAACGCGAACTAGGGAAGATCATGAGAAACATCGAGACAGATCTGAAATTCGAAACGAAAGAAACAAATGTCATCGTCATCGACAAGCTGATGAATGTGAAACGAAAATTCCTGCGCAACATAAAACAGTTGTACGGAGTTAAAGCTGCACTATTAGATTTCAACAGTCCAGAGAAGTCGGCGATCAAAGCCAACAAAATGATCGAGCAGGCCACGAACGGGAAGATATCCGAAGCCTTTTATTACGACGACTTCCTGAGCACAGTGCTGTTAATGAGTGACGCTAAATACTTCGATTCCTTCTGGAAGAGCCCGTTTAACGCGGCCTACACGAGAATGGAGCCCTTTTATTCAAAAAACGGCTTGAAGATCGGTGAAGTGGCCATGATGAATCAAATAGGCTACTTCAACATTACTTATTTCCCTCTGATCAAAGCTGACGTGCTCGAGCTTCCTCTGTCTGCGGGCCAGTACTCCATGCTGATATTCCTACCCGAAAAAAACACGTGGGTCAAGGAGATATTTTACTCACTGGAAGCGACAAGGTTGACGTCTCTGTTCAATGTTTACAAGAACGAAGGCCTCAAATTAGTCAATGTAAAGCTACCTAAGTTCAAAATTAGCACCGAAATTGAGAATCTACCTGAGTTGCTCGTTGATATGGGCATAGAGAGAATCTTTAGCCCGGATTCGGCTGAGTTTGGGGGCATCAGTGACTACAAAATCTATGCGTCCTTGATGACGCAAATCTGTGAGATTTCCGTGACCGAGAAAGGTGTTAAGGCTCATGGAACCGCCGAGTTCATCATCAGTGGAAATGAGACATTAATGTTTAATGCGAACCGGCCCTTCGCTTATATGATAGTGGAAAGGAAAACTGAATTCATTTTGTTTTCCGGCACGTACGCTGTGCCTTATTCATAA

Protein

MALKLLILLAFCQAITALKYPCTNHKTIALLKRPTYDFSIGILQRVAEETNDNFVFSPLSNWLQLIALSEGAKGRTLKELWRVTRFHMRNCFKRELGKIMRNIETDLKFETKETNVIVIDKLMNVKRKFLRNIKQLYGVKAALLDFNSPEKSAIKANKMIEQATNGKISEAFYYDDFLSTVLLMSDAKYFDSFWKSPFNAAYTRMEPFYSKNGLKIGEVAMMNQIGYFNITYFPLIKADVLELPLSAGQYSMLIFLPEKNTWVKEIFYSLEATRLTSLFNVYKNEGLKLVNVKLPKFKISTEIENLPELLVDMGIERIFSPDSAEFGGISDYKIYASLMTQICEISVTEKGVKAHGTAEFIISGNETLMFNANRPFAYMIVERKTEFILFSGTYAVPYS

Description

Serine protease inhibitor which plays an essential role in regulating the tracheal melanization immune response to bacterial and fungal infection (PubMed:18854145, PubMed:22227521). Acts by negatively regulating a protease cascade involving Mp1 and Sp7, that functions in the activation of the Hayan-phenoloxidase (PPO1) cascade (PubMed:18854145).

Similarity

Belongs to the serpin family.

Keywords

Complete proteome   Glycoprotein   Melanin biosynthesis   Protease inhibitor   Reference proteome   Secreted   Serine protease inhibitor   Signal  

Feature

chain  Serine protease inhibitor 77Ba

Uniprot

C0J8G3   A0A2H1W6I2   A0A2W1B1N1   A0A2A4K8F7   A0A2A4K9V2   A0A0N1PID3   + More
A0A0L7LTX4   A0A194PZ50   A0A212F553   A0A1E1WAH9   A0A2H1W4Y7   A0A2A4K8U7   C0J8F8   A0A290U612   A0A2W1BIT9   A0A3G1VCH4   I4DN94   A0A0N0PEL1   A0A0L7LTV5   A0A194PX66   A0A2W1B5Y5   A0A0M5KHD7   Q6Q2D5   A0A194R8R2   A0A0L7KUV3   A0A2A4K6S3   A0A0N1I9J2   I4DQD9   Q6Q2D3   A0A2H1VIL1   A0A290U611   A0A2A4K5E1   I4DN70   A0A1L5J018   A0A2W1BCV0   H9JWD5   A0A0L7LHE9   A0A2H1W4N9   A0A194PZY5   A0A0N1PFL7   A0A1L8DPF0   A0A1L8DP46   A0A1L8DPH6   A0A0N0P9C5   A0A1L8DPG3   R4TUT4   I4DMG6   A0A0L7LHI6   D2KQN9   Q6Q2D6   A0A182QX10   A0A182N513   A0A182YHI4   A0A182PT21   Q6Q2D7   A0A0M4JPK9   Q6Q2D8   A0A212EZK8   A0A034VN94   A0A182RC49   A0A0L7K494   A0A182LS71   A0A0N1ID49   A0A1E1WPC2   A0A182VWN0   B4PFB4   B4PFB0   A0A1E1WH84   A0A0K8U8K9   A0A182T0L0   A0A0K8UPF1   J7HF01   W8BHP8   A0A182K012   N6TYC6   A0A0N1PGT8   A0A182XE44   Q005M7   A0A182HJ80   F5HL11   Q7QBF4   A0A182U6B2   B4KY18   A0A182VGH0   A0A084VAK6   A0A067R1I1   Q0E8C8   I4DJ95   A0A1V1FQE8   B4IA79   B4QRW8   W5JE82   D6W777   B0X107   B4LGF4   A0A2J7QUH8   A0A1W4W744   A0A2J7QUH4   S4PH08  

Pubmed

19121390    19150649    28756777    26354079    26227816    22118469    + More
28953952    28987647    22651552    15695807    24837592    25244985    25348373    17994087    17550304    24495485    23537049    19394412    12364791    14747013    17210077    24438588    24845553    10731132    12537572    12537569    18854145    22227521    28410430    22936249    20920257    23761445    18362917    19820115    23622113   

EMBL

BABH01018373    EU935615    ACG61177.1    ODYU01006585    SOQ48556.1    KZ150452    + More
PZC70819.1    NWSH01000031    PCG80501.1    PCG80500.1    KQ459764    KPJ20095.1    JTDY01000095    KOB78902.1    KQ459583    KPI98596.1    AGBW02010243    OWR48867.1    GDQN01007183    JAT83871.1    ODYU01006359    SOQ48141.1    PCG80499.1    BABH01018369    EU935610    ACG61172.1    KY680239    ATD13320.1    KZ150289    PZC71593.1    MG732912    AYK02794.1    AK402782    BAM19384.1    KPJ20096.1    KOB78895.1    KQ459589    KPI97608.1    PZC71592.1    KR003728    ALD62506.1    AY566165    AAS68506.1    KQ460500    KPJ14228.1    JTDY01005636    KOB66799.1    NWSH01000108    PCG79463.1    KQ459547    KPJ00033.1    AK404064    BAM20129.1    AY566166    AY566167    AAS68507.1    AAS68508.1    ODYU01002563    SOQ40242.1    KY680238    ATD13319.1    PCG79465.1    AK402746    BAM19360.1    KX117918    APM86796.1    KZ150265    PZC71705.1    BABH01029200    JTDY01001104    KOB74872.1    ODYU01006002    SOQ47464.1    KPI98598.1    KPJ00034.1    GFDF01005830    JAV08254.1    GFDF01005831    JAV08253.1    GFDF01005829    JAV08255.1    KPJ00032.1    GFDF01005817    JAV08267.1    KC686693    AGM20455.1    AK402484    BAM19106.1    KOB74875.1    GU270470    ACZ81437.1    BABH01029205    AY566164    AAS68505.1    AXCN02000179    AY566163    AAS68504.1    KR003727    ALD62505.1    AY566162    AAS68503.1    AGBW02011249    OWR46936.1    GAKP01015919    JAC43033.1    JTDY01010789    KOB58011.1    AXCM01004089    KQ459680    KPJ20463.1    GDQN01002297    JAT88757.1    CM000159    EDW95200.2    EDW95196.1    GDQN01010706    GDQN01004833    JAT80348.1    JAT86221.1    GDHF01029312    JAI23002.1    GDHF01025876    GDHF01023735    GDHF01008477    JAI26438.1    JAI28579.1    JAI43837.1    JN400443    AFQ01142.1    GAMC01005750    JAC00806.1    APGK01047281    KB741077    KB632432    ENN74325.1    ERL95537.1    KPJ00031.1    DQ974167    ABJ52807.1    APCN01002129    AAAB01008879    EGK96972.1    EAA08472.4    CH933809    EDW18720.1    ATLV01004128    KE524190    KFB35000.1    KK852777    KDR16770.1    AE014296    AY060806    BT001829    BT150283    AAL28354.1    AAN71584.1    AGV77185.1    AK401363    BAM17985.1    FX985330    BAX07343.1    CH480826    EDW44192.1    CM000363    CM002912    EDX11214.1    KMZ00740.1    ADMH02001488    ETN62366.1    KQ971307    EFA11609.1    DS232250    EDS38399.1    CH940647    EDW70483.1    NEVH01010582    PNF32236.1    PNF32233.1    GAIX01003432    JAA89128.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000037510    UP000053268    UP000007151    + More
UP000075886    UP000075884    UP000076408    UP000075885    UP000075900    UP000075883    UP000075920    UP000002282    UP000075901    UP000075881    UP000019118    UP000030742    UP000076407    UP000075840    UP000007062    UP000075902    UP000009192    UP000075903    UP000030765    UP000027135    UP000000803    UP000001292    UP000000304    UP000000673    UP000007266    UP000002320    UP000008792    UP000235965    UP000192221   

PRIDE

C0J8G3    C0J8F8    Q6Q2D5    H9JWD5    D2KQN9    Q6Q2D6    + More
Q0E8C8   

Pfam

PF00079   Serpin        + More
PF03351   DOMON
PF03067   LPMO_10

Interpro

IPR036186   Serpin_sf        + More
IPR023796   Serpin_dom       
IPR042185   Serpin_sf_2       
IPR042178   Serpin_sf_1       
IPR000215   Serpin_fam       
IPR023795   Serpin_CS       
IPR000742   EGF-like_dom       
IPR013032   EGF-like_CS       
IPR004302   Cellulose/chitin-bd_N       
IPR005018   DOMON_domain       

SUPFAM

SSF56574   SSF56574       

Gene 3D

2.30.39.10     3.30.497.10    

ProteinModelPortal

C0J8G3   A0A2H1W6I2   A0A2W1B1N1   A0A2A4K8F7   A0A2A4K9V2   A0A0N1PID3   + More
A0A0L7LTX4   A0A194PZ50   A0A212F553   A0A1E1WAH9   A0A2H1W4Y7   A0A2A4K8U7   C0J8F8   A0A290U612   A0A2W1BIT9   A0A3G1VCH4   I4DN94   A0A0N0PEL1   A0A0L7LTV5   A0A194PX66   A0A2W1B5Y5   A0A0M5KHD7   Q6Q2D5   A0A194R8R2   A0A0L7KUV3   A0A2A4K6S3   A0A0N1I9J2   I4DQD9   Q6Q2D3   A0A2H1VIL1   A0A290U611   A0A2A4K5E1   I4DN70   A0A1L5J018   A0A2W1BCV0   H9JWD5   A0A0L7LHE9   A0A2H1W4N9   A0A194PZY5   A0A0N1PFL7   A0A1L8DPF0   A0A1L8DP46   A0A1L8DPH6   A0A0N0P9C5   A0A1L8DPG3   R4TUT4   I4DMG6   A0A0L7LHI6   D2KQN9   Q6Q2D6   A0A182QX10   A0A182N513   A0A182YHI4   A0A182PT21   Q6Q2D7   A0A0M4JPK9   Q6Q2D8   A0A212EZK8   A0A034VN94   A0A182RC49   A0A0L7K494   A0A182LS71   A0A0N1ID49   A0A1E1WPC2   A0A182VWN0   B4PFB4   B4PFB0   A0A1E1WH84   A0A0K8U8K9   A0A182T0L0   A0A0K8UPF1   J7HF01   W8BHP8   A0A182K012   N6TYC6   A0A0N1PGT8   A0A182XE44   Q005M7   A0A182HJ80   F5HL11   Q7QBF4   A0A182U6B2   B4KY18   A0A182VGH0   A0A084VAK6   A0A067R1I1   Q0E8C8   I4DJ95   A0A1V1FQE8   B4IA79   B4QRW8   W5JE82   D6W777   B0X107   B4LGF4   A0A2J7QUH8   A0A1W4W744   A0A2J7QUH4   S4PH08  

PDB

5CDZ     E-value=1.00588e-34,     Score=367

KEGG

100272178    no KO assigned | (RefSeq) serpin-14, BmSPN26, SPN26; serine protease inhibitor 14

GO

GO:0005615   GO:0008233   GO:0004867   GO:0010951   GO:0035009   GO:0045861   GO:0042438  

PANTHER

PTHR11461  

Subcellular location

   Detected in the extracellular space at the apical surface of tracheal cells.   With evidence from 3 publications.

SignalP

Position:   1 - 17,         Likelihood:  0.960733

 

 

Length:

399

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.10818

Exp number, first 60 AAs:

0.09138

Total prob of N-in:

0.00519

outside

1  -  399

 

 

Pi

188.743739

Theta

168.527742

Tajima's D

0.374209

CLR

0.642928

CSRT

0.485275736213189

Interpretation

Uncertain