Gene

KWMTBOMO16170

Pre Gene Modal

BGIBMGA013955

Annotation

PREDICTED:_protein_N-lysine_methyltransferase_METTL20-like_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr28(+):420447-463251      View in EpiBrowser

Full name

Electron transfer flavoprotein beta subunit lysine methyltransferase      

Alternative Name

ETFB lysine methyltransferase
Protein N-lysine methyltransferase METTL20

Location in the cell

Mitochondrial   Reliability : 2.031

CDS

ATGTTGAGAGACATTTCGGCTGCCATCATAAGGCACACGGCCTTATCGCGACGACACCTGACTCCCGAGCTGGTTCTGCGTCTCATCACACCGGAATGTCCGCTATGGAGAGCTAAAGAAGGCGAGTCGCCTTTCAGAGACCCGTTCTGGGCATTCTATTGGCCCGGAGGTCAGGCTACTGCGCGGTACATACTAGACAACCAAGACTTGGTAAAAGATCGTAATGTATTAGACATTGGATGTGGTTGCGGAGCGGGATCAATTGCGGCCGCTAAAATGAAGGCAAAATATGTTTTGGCCAACGACATTGACCACCATGCACTTGCAGCAACACATCTGAATGCAAATTTAAATGGAGTACTAATTGATACTAGTTCCAAGAATTTAATTGGTACAAAATGTGAAGAGTTCAATGTGATTTTGATCGGTGATATGTTTTACGATGAAGATTTTTCTCAGACACTATTCAAATGGCTAATTAAATTGCACGAAGCAGGAAAAACGATACTAATAGGAGATCCAGGTCGTCACGGCTTGACAGAGAAGCGTAGACGACATGTGCAGATGCTCGCCGAGTACAAGATGCCCAGGGAGAGCCAAGAGGAGAACAACGGTTTTACGAAGACTAAAGTTTGGAAGTTAAATAAATTGATTTGA

Protein

MLRDISAAIIRHTALSRRHLTPELVLRLITPECPLWRAKEGESPFRDPFWAFYWPGGQATARYILDNQDLVKDRNVLDIGCGCGAGSIAAAKMKAKYVLANDIDHHALAATHLNANLNGVLIDTSSKNLIGTKCEEFNVILIGDMFYDEDFSQTLFKWLIKLHEAGKTILIGDPGRHGLTEKRRRHVQMLAEYKMPRESQEENNGFTKTKVWKLNKLI

Description

Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain.

Subunit

Interacts with HSPD1; this protein may possibly be a methylation substrate.

Similarity

Belongs to the MT-A70-like family.
Belongs to the methyltransferase superfamily. ETFBKMT family.

Keywords

Complete proteome   Cytoplasm   Methyltransferase   Mitochondrion   Reference proteome   Transferase   Transit peptide  

Feature

chain  Electron transfer flavoprotein beta subunit lysine methyltransferase

Uniprot

A0A437B4I6   H9JWP1   A0A2W1BLC3   A0A1E1WAJ1   A0A0N1IJW4   A0A2P8Y016   + More
A0A194PZ45   R7VE04   A0A034VYL6   A0A210Q6L2   A0A0K8WIP6   A0A0L0CAM2   A0A1A9W128   A0A0A1XJP6   E0VWI7   A0A212EWR1   A0A1B0AAS2   A0A0A9W7Z3   A0A1B6BY50   W8CDF1   A0A1B0FP85   A0A1I8MQ77   J9K2C9   X1WI67   A0A1I8PSM1   A0A146LS71   V4A0W6   A0A0B6YS33   A0A2M4CWH8   A0A2M4AXI1   A0A0P4WHH7   A0A2A4K9D0   A0A0P5F1F7   A0A2M4CWI3   A0A444U4S1   A0A0P5Z2B4   A0A433TP12   E9HBZ1   A0A182IY09   Q174H9   K1R819   K7FXQ9   A0A0P5FUA0   Q4SM76   C3Z9A5   A0A3B3TF80   A0A1S3HVU2   A0A401REG6   A0A182P9W0   A0A182FIB1   A0A2M4CX05   H0ZMK5   A0A402EM00   A0A091GRC4   A0A094KVT4   K7IX40   A0A1S3PCL5   A0A091KBW8   A0A3Q1CUX6   A0A060WDU7   R4GLZ9   A0A091NGY5   H3AZ38   A0A091I1B0   A0A093CLW1   A0A093PAE8   A0A091UXQ8   A0A1J1ISQ6   A0A093IJ64   A0A091LPR0   Q6P7Q0   A0A0P6C3C0   A0A091VL41   A0A091QZM9   A0A0A0ADA5   A0A3Q0RKY2   A0A151NIS3   A0A091SCX9   A0A3P8SX37   A0A3B3YL61   A0A093FRM0   I3JWA6   A0A3B4VBZ3   A0A091KNQ8   I3JWA5   A0A2M4CWJ0   A0A091PBR0   A0A3B4XBU7   A0A1U7QRA2   A0A1B6FX26   A0A226MT24   A0A182TG15   A0A093QBZ2   A0A099ZNE8   A0A087RJF6   A0A182K3M4   A0A154PRG4   A0A087V914   A0A091SY32   A0A3Q3JHB1  

EC Number

2.1.1.-

Pubmed

19121390    28756777    26354079    29403074    23254933    25348373    + More
28812685    26108605    25830018    20566863    22118469    25401762    24495485    25315136    26823975    21292972    17510324    22992520    17381049    15496914    18563158    29240929    30297745    20360741    20075255    24755649    15592404    9215903    15489334    22293439    25186727   

EMBL

RSAL01000177    RVE45015.1    BABH01018358    KZ150184    PZC72473.1    GDQN01007089    + More
JAT83965.1    KQ459764    KPJ20103.1    PYGN01001100    PSN37598.1    KQ459583    KPI98591.1    AMQN01004815    KB294418    ELU14536.1    GAKP01011982    JAC46970.1    NEDP02004827    OWF44329.1    GDHF01001286    JAI51028.1    JRES01000678    KNC29301.1    GBXI01009301    GBXI01002703    JAD04991.1    JAD11589.1    DS235821    EEB17743.1    AGBW02011937    OWR45887.1    GBHO01039047    JAG04557.1    GEDC01031086    JAS06212.1    GAMC01002056    JAC04500.1    CCAG010011789    ABLF02024323    ABLF02024318    GDHC01007981    JAQ10648.1    KB201305    ESO97448.1    HACG01012148    HACG01012149    CEK59013.1    CEK59014.1    GGFL01005515    MBW69693.1    GGFK01012134    MBW45455.1    GDRN01052876    GDRN01052875    GDRN01052874    JAI66234.1    NWSH01000031    PCG80498.1    GDIQ01269004    JAJ82720.1    GGFL01005516    MBW69694.1    SCEB01215313    RXM30164.1    GDIP01051564    LRGB01000359    JAM52151.1    KZS19581.1    RQTK01000249    RUS83314.1    GL732618    EFX70673.1    CH477410    EAT41479.1    JH818716    EKC37350.1    AGCU01028385    AGCU01028386    GDIQ01249957    JAK01768.1    CAAE01014555    CAF98256.1    GG666599    EEN50834.1    BEZZ01003823    GCC16534.1    GGFL01005672    MBW69850.1    ABQF01016311    BDOT01000023    GCF45168.1    KL506511    KFO85027.1    KL345858    KFZ55720.1    AAZX01000615    AAZX01009233    KK553661    KFP34525.1    FR904508    CDQ65478.1    AADN05000523    KL383496    KFP89028.1    AFYH01126962    KL218095    KFP02309.1    KL244638    KFV13939.1    KL225530    KFW73401.1    KK466903    KFQ82383.1    CVRI01000059    CRL03231.1    KL215805    KFV66756.1    KL334465    KFP59148.1    BC061574    GDIP01009933    JAM93782.1    KK436010    KFQ90258.1    KK806044    KFQ32141.1    KL871447    KGL92131.1    AKHW03002956    KYO36559.1    KK948302    KFQ56173.1    KK401838    KFV60417.1    AERX01017318    AERX01017319    KK748133    KFP40920.1    GGFL01005518    MBW69696.1    KK655459    KFQ04628.1    GECZ01015045    JAS54724.1    MCFN01000467    OXB58447.1    KL671842    KFW83950.1    KL895188    KGL82443.1    KL226405    KFM13610.1    KQ435078    KZC14506.1    KL484389    KFO09106.1    KK491519    KFQ63642.1   

Proteomes

UP000283053    UP000005204    UP000053240    UP000245037    UP000053268    UP000014760    + More
UP000242188    UP000037069    UP000091820    UP000009046    UP000007151    UP000092445    UP000092444    UP000095301    UP000007819    UP000095300    UP000030746    UP000218220    UP000076858    UP000271974    UP000000305    UP000075880    UP000008820    UP000005408    UP000007267    UP000007303    UP000001554    UP000261540    UP000085678    UP000287033    UP000075885    UP000069272    UP000007754    UP000288954    UP000002358    UP000087266    UP000257160    UP000193380    UP000000539    UP000008672    UP000054308    UP000054081    UP000183832    UP000053875    UP000002494    UP000053858    UP000261340    UP000050525    UP000265080    UP000261480    UP000005207    UP000261420    UP000261360    UP000189706    UP000198323    UP000075902    UP000053258    UP000053641    UP000053286    UP000075881    UP000076502    UP000261600   

PRIDE

H9JWP1    Q6P7Q0   

Pfam

PF05485   THAP        + More
PF10294   Methyltransf_16
PF05063   MT-A70

Interpro

IPR006612   THAP_Znf        + More
IPR029063   SAM-dependent_MTases       
IPR038441   THAP_Znf_sf       
IPR019410   Methyltransf_16       
IPR007757   MT-A70-like       
IPR025848   MT-A70       

SUPFAM

SSF53335   SSF53335       

Gene 3D

3.30.40.180    

ProteinModelPortal

A0A437B4I6   H9JWP1   A0A2W1BLC3   A0A1E1WAJ1   A0A0N1IJW4   A0A2P8Y016   + More
A0A194PZ45   R7VE04   A0A034VYL6   A0A210Q6L2   A0A0K8WIP6   A0A0L0CAM2   A0A1A9W128   A0A0A1XJP6   E0VWI7   A0A212EWR1   A0A1B0AAS2   A0A0A9W7Z3   A0A1B6BY50   W8CDF1   A0A1B0FP85   A0A1I8MQ77   J9K2C9   X1WI67   A0A1I8PSM1   A0A146LS71   V4A0W6   A0A0B6YS33   A0A2M4CWH8   A0A2M4AXI1   A0A0P4WHH7   A0A2A4K9D0   A0A0P5F1F7   A0A2M4CWI3   A0A444U4S1   A0A0P5Z2B4   A0A433TP12   E9HBZ1   A0A182IY09   Q174H9   K1R819   K7FXQ9   A0A0P5FUA0   Q4SM76   C3Z9A5   A0A3B3TF80   A0A1S3HVU2   A0A401REG6   A0A182P9W0   A0A182FIB1   A0A2M4CX05   H0ZMK5   A0A402EM00   A0A091GRC4   A0A094KVT4   K7IX40   A0A1S3PCL5   A0A091KBW8   A0A3Q1CUX6   A0A060WDU7   R4GLZ9   A0A091NGY5   H3AZ38   A0A091I1B0   A0A093CLW1   A0A093PAE8   A0A091UXQ8   A0A1J1ISQ6   A0A093IJ64   A0A091LPR0   Q6P7Q0   A0A0P6C3C0   A0A091VL41   A0A091QZM9   A0A0A0ADA5   A0A3Q0RKY2   A0A151NIS3   A0A091SCX9   A0A3P8SX37   A0A3B3YL61   A0A093FRM0   I3JWA6   A0A3B4VBZ3   A0A091KNQ8   I3JWA5   A0A2M4CWJ0   A0A091PBR0   A0A3B4XBU7   A0A1U7QRA2   A0A1B6FX26   A0A226MT24   A0A182TG15   A0A093QBZ2   A0A099ZNE8   A0A087RJF6   A0A182K3M4   A0A154PRG4   A0A087V914   A0A091SY32   A0A3Q3JHB1  

KEGG

101744189    no KO assigned | (RefSeq) major facilitator superfamily domain-containing protein 9-like

GO

GO:0008168   GO:0005840   GO:0016422   GO:0005634   GO:1904736   GO:0016279   GO:0031072   GO:1904733   GO:0032991   GO:0005759   GO:0018023  

Subcellular location

Cytoplasm   Concentrated in cytoplasmic granular foci.   With evidence from 2 publications.
Mitochondrion matrix   Concentrated in cytoplasmic granular foci.   With evidence from 2 publications.

Length:

218

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00528

Exp number, first 60 AAs:

0.00141

Total prob of N-in:

0.06656

outside

1  -  218

 

 

Pi

28.085617

Theta

185.997012

Tajima's D

1.104203

CLR

0.360326

CSRT

0.690265486725664

Interpretation

Uncertain