Gene

KWMTBOMO16130  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004534

Annotation

PREDICTED:_plasma_membrane_calcium-transporting_ATPase_2_isoform_X7_[Bombyx_mori]

Location

Bomo_Chr27(-):9797627-9818335      View in EpiBrowser

Full name

Calcium-transporting ATPase      

Location in the cell

Cytoplasmic   Reliability : 2.101

CDS

ATGATTCACTGTCTTAGCGGTTCGAAGGCTGACCTGCAGCATCGGCGGGAAGTGTTCGGTTCAAACTTGATCCCGCCGAAGCCACCCAAGACTTTCCTGACGCTAGTATGGGAGGCTCTGCAGGATGTCACCCTTATTATCCTAGAAGTTGCTGCTGTTGTTTCATTAGGATTGAGTTTTTACAAGCCCGCAGATGACCCCAATGATGCGGCACATTTGGACGAAGAGGAGGGCCACTACCAGTGGATCGAGGGTCTGGCCATCTTAATATCGGTTATAGTCGTCGTCATAGTAACAGCGTTTAATGATTACACGAAAGAAAGGCAATTCAGAGGTCTGCAGTCTCGGATAGAAGGCGAGCACAAGTTCGCCGTGATCCGCGGCACGGAGGTCAAACAGGTGCCCATCAGCGAGATCGTCGTCGGCGACATATGTCAGATCAAGTACGGAGATCTGCTTCCGGCTGACGGTATCCTGCTGCAGAGCAACGATCTTAAGATTGACGAGTCATCCCTGACGGGAGAATCGGACCATGTCAAGAAGGGTGAAACATTTGATCCCATGGTGCTATCCGGTACACACGTTATGGAAGGTTCCGGCAAGATGTTAGTGACAGCCGTGGGGGTGAACTCCCAGGCCGGCATCATCTTCACGCTGCTCGGTGCCGCTGTCGACAAGCAGGAGAAGGAAATTAAACAGAAGAAGAAAGGTGAGGAGGAGGGAGTGGGGGGCGTGGGCGCCAACCACGCGCCGCCCGACGACAACCACGCGCCGCCCGCCGCCGACAAGCCGCCGCCAGAGCCGCAACACAAGAAGGAGAAGTCCGTGCTGCAGGCCAAACTTACCAAGCTCGCTATACAGATCGGTTACGCCGGCTCGACGATCGCCGTGCTCACGGTCATAATCCTGGTCATACAGTTCTGCGTCCGGACGTTCGCCATAGAGGGCAAGCCGTGGAAGGCGACCTACATTAACAACCTGGTGAAGCACCTCATCATCGGTGTGACGGTGCTGGTCGTCGCCGTGCCCGAGGGGCTGCCGCTCGCTGTCACACTCTCGCTTGCTTATTCCGTAAAGAAAATGATGAAAGACAACAATCTGGTGCGCCACCTGGACGCCTGCGAGACCATGGGCAACGCCACCGCCATCTGCTCGGACAAGACCGGCACGCTGACCACCAACCGCATGACGGTCGTGCAGTCGTACATCTGCGAGAAGCTGTGCAAGGTGACGCCCAACTACCGCGACATCCCGCCGCCCGTCGCCGACCTCATCGTGCAGGGCGTGGCGCTCAACTCCGCCTTCACCTCCAGGATCATGCCATCACAAGATCCAACGATGCCATCCATGCAAGTCGGTAACAAAACTGAATGCGCCCTCCTCGGATTCGTCCTGGCTCTAGGGCAGAGCTACGAAGCCGTCAGAGAAAGTCATCCCGAAGAGTCGTTCACCAGGGTGTACACCTTCAACTCGGTGCGGAAGAGCATGTCCACCGTCATACCGCACAACGGCGGCTACAGGCTCTACACTAAGGGAGCTTCGGAGATCGTGCTTAAAAAGTGCGCCTTCATCTACGGGCACGAGGGCCGCCTGGAGAAGTTCACGCGCGACATGCAGGAGCGGCTCGTGCGCCAGGTCATCGAGCCCATGGCCTGCGACGGGCTGCGGACCATCTCCGTGGCCTACCGGGACTTCGTGCCCGGGAAGGCGGACATCAACCAGGTGCACGTGGACCAGGAGCCGCACTGGGACGACGAGGACAACATCGTGAACAACCTGACCTGCCTCTGCGTTGTAGGGATCGAGGACCCCGTGAGGCCCGAGGTTCCAGAGGCCATCCGCAAGTGTCAGAAGGCCGGCATCACGGTGCGCATGGTGACGGGAGACAACGTGAACACCGCGCGCTCCATCGCCATGAAGTGCGGCATCCTCAGGCCCACGGACGACTTCCTGGTGCTCGAGGGGAAGGAGTTCAACCAACGCATACGGGACGCCAACGGAGAGGTGCAGCAGCAGCTGGTGGACAAGGTGTGGCCCAGCCTGCGCGTGCTGGCGCGCTCGTCGCCCACGGACAAGTACACGCTCGTCAAAGGCATGATCGAGTCCAAGGCATTCGACACGCGCGAGGTGGTGGCCGTCACCGGGGACGGGACCAACGACGGACCCGCGCTCAAGAAGGCCGACGTCGGATTCGCCATGGTGCGCCGCCACTACACGCACGCACACACGCACACACACACGCGCTGA

Protein

MIHCLSGSKADLQHRREVFGSNLIPPKPPKTFLTLVWEALQDVTLIILEVAAVVSLGLSFYKPADDPNDAAHLDEEEGHYQWIEGLAILISVIVVVIVTAFNDYTKERQFRGLQSRIEGEHKFAVIRGTEVKQVPISEIVVGDICQIKYGDLLPADGILLQSNDLKIDESSLTGESDHVKKGETFDPMVLSGTHVMEGSGKMLVTAVGVNSQAGIIFTLLGAAVDKQEKEIKQKKKGEEEGVGGVGANHAPPDDNHAPPAADKPPPEPQHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILVIQFCVRTFAIEGKPWKATYINNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVTPNYRDIPPPVADLIVQGVALNSAFTSRIMPSQDPTMPSMQVGNKTECALLGFVLALGQSYEAVRESHPEESFTRVYTFNSVRKSMSTVIPHNGGYRLYTKGASEIVLKKCAFIYGHEGRLEKFTRDMQERLVRQVIEPMACDGLRTISVAYRDFVPGKADINQVHVDQEPHWDDEDNIVNNLTCLCVVGIEDPVRPEVPEAIRKCQKAGITVRMVTGDNVNTARSIAMKCGILRPTDDFLVLEGKEFNQRIRDANGEVQQQLVDKVWPSLRVLARSSPTDKYTLVKGMIESKAFDTREVVAVTGDGTNDGPALKKADVGFAMVRRHYTHAHTHTHTR

Description

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.

Catalytic Activity

ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate

Similarity

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.

Uniprot

A0A232F311   V9I6Y1   A0A0K8W474   A0A0K8U0F8   A0A0K8UCZ8   A0A034W2K7   + More
A0A034W3M2   A0A034W478   A0A0K8V849   A0A034W033   A0A1W4VHY3   A0A0N8NZM1   A0A0P8XIK1   A0A1W4VIP7   A0A1I8P3E0   A0A1A9WYB0   T1P9V5   A0A1I8M346   A0A1I8PR34   A0A1I8MG26   A0A1S4ERF4   A0A3Q0IU77   B4PW03   A0A0R1ECC4   A0A0Q5SDQ7   E6EK15   A0A0Q5SQA8   A0A1B0F9W3   A0A1I8PK10   A0A0L7R0N1   A0A0M8ZY79   A0A310S5N1  

EC Number

7.2.2.10

Pubmed

28648823    25348373    17994087    25315136    17550304    10731132    + More
12537568    12537572    12537573    12537574    16110336    17569856    17569867   

EMBL

NNAY01001107    OXU25111.1    JR035946    JR035949    AEY56812.1    AEY56815.1    + More
GDHF01017233    GDHF01011200    GDHF01006296    JAI35081.1    JAI41114.1    JAI46018.1    GDHF01032117    GDHF01027167    JAI20197.1    JAI25147.1    GDHF01027762    GDHF01008159    GDHF01006384    JAI24552.1    JAI44155.1    JAI45930.1    GAKP01010025    GAKP01010023    JAC48929.1    GAKP01010032    GAKP01010030    JAC48922.1    GAKP01010026    GAKP01010022    JAC48930.1    GDHF01021214    GDHF01017197    JAI31100.1    JAI35117.1    GAKP01010031    GAKP01010029    JAC48921.1    CH902641    KPU74708.1    KPU74707.1    KA644945    AFP59574.1    CM000161    EDW99308.2    KRK04858.1    CH954184    KQS21513.1    AE014135    ADV37599.1    KQS21509.1    CCAG010020419    KQ414670    KOC64415.1    KQ435826    KOX72009.1    KQ769812    OAD52837.1   

Proteomes

UP000215335    UP000192221    UP000007801    UP000095300    UP000091820    UP000095301    + More
UP000079169    UP000002282    UP000008711    UP000000803    UP000092444    UP000053825    UP000053105   

PRIDE

E6EK15   

Pfam

PF12424   ATP_Ca_trans_C        + More
PF00690   Cation_ATPase_N
PF00689   Cation_ATPase_C

Interpro

IPR008250   ATPase_P-typ_transduc_dom_A_sf        + More
IPR006068   ATPase_P-typ_cation-transptr_C       
IPR023298   ATPase_P-typ_TM_dom_sf       
IPR001757   P_typ_ATPase       
IPR023299   ATPase_P-typ_cyto_dom_N       
IPR030320   ATP2B1       
IPR022141   ATP_Ca_trans_C       
IPR036412   HAD-like_sf       
IPR023214   HAD_sf       
IPR006408   P-type_ATPase_IIB       
IPR018303   ATPase_P-typ_P_site       
IPR004014   ATPase_P-typ_cation-transptr_N       
IPR034304   ATP2B4       
IPR030325   ATP2B3       

SUPFAM

SSF81665   SSF81665        + More
SSF81660   SSF81660       
SSF56784   SSF56784       
SSF81653   SSF81653       

Gene 3D

3.40.1110.10     3.40.50.1000    

ProteinModelPortal

A0A232F311   V9I6Y1   A0A0K8W474   A0A0K8U0F8   A0A0K8UCZ8   A0A034W2K7   + More
A0A034W3M2   A0A034W478   A0A0K8V849   A0A034W033   A0A1W4VHY3   A0A0N8NZM1   A0A0P8XIK1   A0A1W4VIP7   A0A1I8P3E0   A0A1A9WYB0   T1P9V5   A0A1I8M346   A0A1I8PR34   A0A1I8MG26   A0A1S4ERF4   A0A3Q0IU77   B4PW03   A0A0R1ECC4   A0A0Q5SDQ7   E6EK15   A0A0Q5SQA8   A0A1B0F9W3   A0A1I8PK10   A0A0L7R0N1   A0A0M8ZY79   A0A310S5N1  

PDB

6A69     E-value=9.11273e-162,     Score=1466

KEGG

101744319    K05850 P-type Ca2+ transporter type 2B [EC:7.2.2.10] | (RefSeq) plasma membrane calcium-transporting

GO

GO:0016021   GO:0005388   GO:0005524   GO:0006816   GO:0005886   GO:0006874   GO:0000166   GO:0046872   GO:0016311   GO:0016791   GO:0001678   GO:0005536   GO:0046835   GO:0006281   GO:0006259  

PANTHER

PTHR24093:SF245   PTHR24093:SF435   PTHR24093:SF284  

Subcellular location

Membrane  

Length:

748

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

103.89829

Exp number, first 60 AAs:

16.03522

Total prob of N-in:

0.74528

POSSIBLE N-term signal

sequence

inside

1  -  42

TMhelix

43  -  60

outside

61  -  79

TMhelix

80  -  102

inside

103  -  201

TMhelix

202  -  224

outside

225  -  286

TMhelix

287  -  309

inside

310  -  329

TMhelix

330  -  352

outside

353  -  748

 

 

Pi

234.508353

Theta

181.266469

Tajima's D

0.743714

CLR

0.351605

CSRT

0.590620468976551

Interpretation

Uncertain