Gene

KWMTBOMO16122

Pre Gene Modal

BGIBMGA004513

Annotation

PREDICTED:_tyrosine-protein_phosphatase_69D_[Bombyx_mori]

Location

Bomo_Chr27(+):9678946-9706413      View in EpiBrowser

Full name

Protein-tyrosine-phosphatase       + More
Tyrosine-protein phosphatase 69D      

Alternative Name

Protein-tyrosine-phosphate phosphohydrolase

Location in the cell

Nuclear   Reliability : 2.81

CDS

ATGTATCATAGACCTGACTTCAGTGGTACTTCCGCCATGACAATGGGTACTGTGGTCGGGAAGTGTTCCTTCGCGTTTTTAGTTTATTTGGCGTGTATTGAACTTTTGTATCCTGTTTTGGCTGAAGACAATGGAATTAGTTTAACAGCAAAAGGTGAAATCGGTAATGAATCAAATATTACTTGTGTTGTGCCCCTAGAAAATGCTACTGTTGAGTGGCAGTTTCAAGGAGAATCACTCAAAAAAGATAACAGACTACACATCACCGCATCTCAAGGTACACTGTCGAGGAAAGATCAAGATGGCTCATTGCAGAAGACTACAATTTCCACAATCATCATAACCAATACTACATCAGATTATGAAGGGAATTATACTTGTATAGCCAAGCAAGGAACCGAAGGACCCAGTATAAAGGAGTCTAGATTTCTGGACCTCAGTTTCCCAGGAAGGCTCATAAACACAACTAAAAGTCCTATCCGTGAAAATGCTACTAATCACAATAATGTCACTCTGGAATGCATATTTGAAGTTTATAAGCCTGGAACGGTCGTGTGGTCGAAGCGTGGCTCGGAAGACGACACCAGCAACCTGAACGATATAAAACAAGAGAATATAAACCTTAAACAAGTGAAGAGCTCCGTCGTGGTCCGCATCCGGAACGCGGACAACGACGACGGCTCGTACGTCTGCGAGGTGGACGACCACGTCACTAGCAGGCGGCTGTCCGGCGTCATCGACATCCACGTGTACGCGATGCCGGTCGTGGCCGTGGACAAGGCGGTCGCCGTCAACACCACCGAGGTCTTCCTCAACTGGACGGTCAAGTCCTACAGGCAGAAGATCGCGAACTACACCCTGATGTATCGCGTGAACTCGTCCAACGAAACGTTTCGGTTTTGCCGCGAACCGATAGACGTGAACAACACTTCGTTTGTGCTGAACGACCTGAACGCCTCCACGGAATACCAGCTGGTCCTGCAGGTCACCACCGCCTACGGCACGAGCAAGTCCAAAAACGTGATCGTGAGAACTTTGGACAAGGAACCGGTGTTTGTGCCGAACATTTCTATTAACGGTTTTTCCGCGACGTCAGTGACGATAGGCTGGCAACCCCCGCCCGAAGAAATATCGTCTCTGATCCACTACTACCTGTTAGAGGCGAGGAAGAAGGACGAGAACTCAACGAGGCGAGCCTACCACTCCGGAGGCATCATGAACCTGCCCTACATGTTCGACAACTTGGAGCCTCACAGCACTTACATATTTCGGGTGCGCGCGTGCTCGGAGATGACGCGGCGCTGCGGGCCCCGCTCGGCGGACATGCAGGCGGCCACGCTGGACGGCACGCCGGGCCGCCCCGCGCGTCTCCGCCTCCGCTGCGGCGCGCGCTCCCTGCGCGTGATGTGGGAGCCGCCCGAGCGACCCAACGCTGAGATCAAGGGCTACATGTTGGAATTGACAGGGAATGCTAATTACATAGATAAAACGGGCAAGGAGCAGAAGACCACCTGGGGGCCCTTGTCGAAGTTCACCTCCAACGATTCCAGGGAAGTCAGGTTCGAGGACCTGCAGCCCAACACGCAGTACACGGTGCGGCTGAGCGCCATGACGCGCACGCGGCGCCGCGGCGAGGAGGAGCTGCAGCGCTGCACCACGGCGCGGGCCGGCCCCGACCTGCCGCCCAGCCCGCGCTGGAGGAAGATATTAGACAACGATAATTATTATTTCAAAGTGTACATACCGCGTGTGTCGGAGAGAAACGGACCTATATGCTGCTACAGGGTGTACATGGTCCGCGTGGCGGGCGACGCGTCGCTGCGGGAACTGTCCCCGCTGCGCGCCGGACACTCCGCGCACCTCGACGCCTACGTCACCGACATCTTCTCCAACAAAAACTTCCCGCCGGATTCCGAGCTGGTGATGGGAGACGGGCGCTCGCACTACGACCCGGCGCGCGACCCCGCCCTCGCCGACGACAACTGCTCGCGCTGTCTCAAGGAACCCAAACGGTGA

Protein

MYHRPDFSGTSAMTMGTVVGKCSFAFLVYLACIELLYPVLAEDNGISLTAKGEIGNESNITCVVPLENATVEWQFQGESLKKDNRLHITASQGTLSRKDQDGSLQKTTISTIIITNTTSDYEGNYTCIAKQGTEGPSIKESRFLDLSFPGRLINTTKSPIRENATNHNNVTLECIFEVYKPGTVVWSKRGSEDDTSNLNDIKQENINLKQVKSSVVVRIRNADNDDGSYVCEVDDHVTSRRLSGVIDIHVYAMPVVAVDKAVAVNTTEVFLNWTVKSYRQKIANYTLMYRVNSSNETFRFCREPIDVNNTSFVLNDLNASTEYQLVLQVTTAYGTSKSKNVIVRTLDKEPVFVPNISINGFSATSVTIGWQPPPEEISSLIHYYLLEARKKDENSTRRAYHSGGIMNLPYMFDNLEPHSTYIFRVRACSEMTRRCGPRSADMQAATLDGTPGRPARLRLRCGARSLRVMWEPPERPNAEIKGYMLELTGNANYIDKTGKEQKTTWGPLSKFTSNDSREVRFEDLQPNTQYTVRLSAMTRTRRRGEEELQRCTTARAGPDLPPSPRWRKILDNDNYYFKVYIPRVSERNGPICCYRVYMVRVAGDASLRELSPLRAGHSAHLDAYVTDIFSNKNFPPDSELVMGDGRSHYDPARDPALADDNCSRCLKEPKR

Catalytic Activity

H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate

Similarity

Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily.

Keywords

Alternative splicing   Cell adhesion   Complete proteome   Disulfide bond   Glycoprotein   Hydrolase   Immunoglobulin domain   Membrane   Protein phosphatase   Receptor   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Tyrosine-protein phosphatase 69D
splice variant  In isoform B.

Uniprot

H9J4S3   A0A212FIL0   A0A3S2NU76   A0A194RGQ7   A0A2H1WF51   A0A194QBE4   + More
A0A2A4JGE0   K7IW60   A0A232F3N6   A0A067R8F5   A0A182YHJ0   A0A182LCE1   A0A336KPC3   A0A182XE51   A0A182HJ73   A0A182UQ71   B4L0P5   A0A1B0CK56   Q7QBG0   A0A182UBP6   A0A0L7QQQ1   A0A3B0JSF7   A0A182MFS8   A0A0J7KYF5   B0X101   A0A182RC55   A0A182PT15   B4LGG7   A0A182K464   A0A1Q3F8L9   Q2M0K8   A0A1Q3F8M0   C4IXZ1   A0A182QX88   A0A182JAQ7   W4VRM2   E2AHY3   W8BFL1   A0A1B6ISM3   A0A154P569   Q176N2   A0A1S4FD43   A0A182GNL7   A0A088A887   A0A182VWN8   B4HG53   A0A2J7Q3D3   A0A2J7Q3C3   A0A1B0BAB4   A0A1A9VMX8   A0A1B0G3J5   A0A1A9W4L0   A0A1B6KQ29   A0A0Q5UJ07   B3NCT8   A0A1A9YN25   A0A0J9RUH2   B4QRQ6   A0A1B6M0D4   A0A182N519   A0A1B0A2G4   A0A0M9A5X6   A0A034VDE1   B4IWZ0   P16620   P16620-2   A0A1W4XER9   A0A1W4X4E2   A0A0R1DXQ0   B4PGT9   A0A1W4XDU9   A0A1W4X4B1   A0A0T6AW03   A0A1W4UV77   A0A1W4UGK5   A0A1W4UG17   A0A310SHL4   A0A1I8MQR4   A0A084VAL3   A0A158NNE2   A0A1I8PYB7   A0A1I8PYC5   A0A151I388   A0A1Y1NLL3   A0A0L0BLG0   E2BAF9   A0A151J091   A0A151WUK2   A0A1Y1NGV2   A0A151JYX5   F4WXN1   A0A195CCJ6   B3M9P4   A0A2A3E8K9   A0A1Y1NGW3   E0VNQ0   A0A1J1IFK4   A0A2M4B973  

EC Number

3.1.3.48

Pubmed

19121390    22118469    26354079    20075255    28648823    24845553    + More
25244985    20966253    17994087    12364791    14747013    17210077    15632085    20798317    24495485    17510324    26483478    22936249    25348373    2554325    10731132    12537572    12537569    19349973    17550304    25315136    24438588    21347285    28004739    26108605    21719571    20566863   

EMBL

BABH01035520    AGBW02008361    OWR53575.1    RSAL01000078    RVE48717.1    KQ460207    + More
KPJ16772.1    ODYU01008270    SOQ51708.1    KQ459249    KPJ02310.1    NWSH01001588    PCG70778.1    NNAY01001046    OXU25361.1    KK852812    KDR15856.1    UFQS01000322    UFQT01000322    SSX02860.1    SSX23227.1    APCN01002128    CH933809    EDW18122.2    AJWK01015759    AJWK01015760    AJWK01015761    AAAB01008879    EAA08408.5    KQ414786    KOC60952.1    OUUW01000009    SPP85055.1    AXCM01008699    LBMM01002057    KMQ95329.1    DS232250    EDS38393.1    CH940647    EDW70496.2    GFDL01011130    JAV23915.1    CH379069    EAL30922.1    GFDL01011131    JAV23914.1    BT083422    ACQ91626.1    AXCN02000177    GANO01001405    JAB58466.1    GL439602    EFN66973.1    GAMC01006450    JAC00106.1    GECU01017777    JAS89929.1    KQ434820    KZC07001.1    CH477385    EAT42115.1    JXUM01014645    JXUM01014646    JXUM01014647    JXUM01014648    JXUM01014649    JXUM01014650    KQ560409    KXJ82559.1    CH480815    EDW41299.1    NEVH01019068    PNF23077.1    PNF23076.1    JXJN01010887    JXJN01010888    CCAG010011629    GEBQ01026421    JAT13556.1    CH954178    KQS43863.1    EDV51594.1    CM002912    KMY99272.1    CM000363    EDX10270.1    KMY99271.1    GEBQ01010578    JAT29399.1    KQ435747    KOX76519.1    GAKP01019172    JAC39780.1    CH916366    EDV97391.1    M27699    AE014296    BT001531    CM000159    KRK01765.1    EDW94328.1    LJIG01022682    KRT79270.1    KQ759883    OAD62167.1    ATLV01004129    KE524190    KFB35007.1    ADTU01021299    ADTU01021300    ADTU01021301    ADTU01021302    ADTU01021303    ADTU01021304    KQ976489    KYM83471.1    GEZM01002835    JAV97136.1    JRES01001699    KNC20876.1    GL446721    EFN87321.1    KQ980644    KYN14909.1    KQ982730    KYQ51508.1    GEZM01002836    JAV97134.1    KQ981453    KYN41587.1    GL888426    EGI61031.1    KQ977935    KYM98579.1    CH902618    EDV39050.1    KZ288325    PBC28040.1    GEZM01002837    JAV97132.1    DS235341    EEB15006.1    CVRI01000047    CRK98538.1    GGFJ01000463    MBW49604.1   

Proteomes

UP000005204    UP000007151    UP000283053    UP000053240    UP000053268    UP000218220    + More
UP000002358    UP000215335    UP000027135    UP000076408    UP000075882    UP000076407    UP000075840    UP000075903    UP000009192    UP000092461    UP000007062    UP000075902    UP000053825    UP000268350    UP000075883    UP000036403    UP000002320    UP000075900    UP000075885    UP000008792    UP000075881    UP000001819    UP000075886    UP000075880    UP000000311    UP000076502    UP000008820    UP000069940    UP000249989    UP000005203    UP000075920    UP000001292    UP000235965    UP000092460    UP000078200    UP000092444    UP000091820    UP000008711    UP000092443    UP000000304    UP000075884    UP000092445    UP000053105    UP000001070    UP000000803    UP000192223    UP000002282    UP000192221    UP000095301    UP000030765    UP000005205    UP000095300    UP000078540    UP000037069    UP000008237    UP000078492    UP000075809    UP000078541    UP000007755    UP000078542    UP000007801    UP000242457    UP000009046    UP000183832   

PRIDE

H9J4S3    C4IXZ1    P16620   

Pfam

PF00047   ig        + More
PF00041   fn3
PF07679   I-set
PF00102   Y_phosphatase
PF02348   CTP_transf_3

Interpro

IPR036179   Ig-like_dom_sf        + More
IPR036116   FN3_sf       
IPR013151   Immunoglobulin       
IPR013783   Ig-like_fold       
IPR003961   FN3_dom       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR013098   Ig_I-set       
IPR000242   PTPase_domain       
IPR000387   TYR_PHOSPHATASE_dom       
IPR016130   Tyr_Pase_AS       
IPR029021   Prot-tyrosine_phosphatase-like       
IPR003595   Tyr_Pase_cat       
IPR003598   Ig_sub2       
IPR003329   Cytidylyl_trans       
IPR029044   Nucleotide-diphossugar_trans       

SUPFAM

SSF48726   SSF48726        + More
SSF49265   SSF49265       
SSF52799   SSF52799       
SSF53448   SSF53448       

Gene 3D

2.60.40.10     3.90.190.10     3.90.550.10    

CDD

cd00063  FN3

ProteinModelPortal

H9J4S3   A0A212FIL0   A0A3S2NU76   A0A194RGQ7   A0A2H1WF51   A0A194QBE4   + More
A0A2A4JGE0   K7IW60   A0A232F3N6   A0A067R8F5   A0A182YHJ0   A0A182LCE1   A0A336KPC3   A0A182XE51   A0A182HJ73   A0A182UQ71   B4L0P5   A0A1B0CK56   Q7QBG0   A0A182UBP6   A0A0L7QQQ1   A0A3B0JSF7   A0A182MFS8   A0A0J7KYF5   B0X101   A0A182RC55   A0A182PT15   B4LGG7   A0A182K464   A0A1Q3F8L9   Q2M0K8   A0A1Q3F8M0   C4IXZ1   A0A182QX88   A0A182JAQ7   W4VRM2   E2AHY3   W8BFL1   A0A1B6ISM3   A0A154P569   Q176N2   A0A1S4FD43   A0A182GNL7   A0A088A887   A0A182VWN8   B4HG53   A0A2J7Q3D3   A0A2J7Q3C3   A0A1B0BAB4   A0A1A9VMX8   A0A1B0G3J5   A0A1A9W4L0   A0A1B6KQ29   A0A0Q5UJ07   B3NCT8   A0A1A9YN25   A0A0J9RUH2   B4QRQ6   A0A1B6M0D4   A0A182N519   A0A1B0A2G4   A0A0M9A5X6   A0A034VDE1   B4IWZ0   P16620   P16620-2   A0A1W4XER9   A0A1W4X4E2   A0A0R1DXQ0   B4PGT9   A0A1W4XDU9   A0A1W4X4B1   A0A0T6AW03   A0A1W4UV77   A0A1W4UGK5   A0A1W4UG17   A0A310SHL4   A0A1I8MQR4   A0A084VAL3   A0A158NNE2   A0A1I8PYB7   A0A1I8PYC5   A0A151I388   A0A1Y1NLL3   A0A0L0BLG0   E2BAF9   A0A151J091   A0A151WUK2   A0A1Y1NGV2   A0A151JYX5   F4WXN1   A0A195CCJ6   B3M9P4   A0A2A3E8K9   A0A1Y1NGW3   E0VNQ0   A0A1J1IFK4   A0A2M4B973  

PDB

4PBX     E-value=3.45231e-14,     Score=193

KEGG

101746939    no KO assigned | (RefSeq) tyrosine-protein phosphatase 69D

GO

GO:0004725   GO:0016021   GO:0035335   GO:0008045   GO:0006470   GO:0097155   GO:0005001   GO:0007415   GO:0048813   GO:0030424   GO:0016201   GO:0007155   GO:0007411   GO:0005886   GO:0050254   GO:0005515   GO:0016311   GO:0016791   GO:0001678   GO:0005536   GO:0046835   GO:0006281   GO:0006259  

Subcellular location

Membrane  

Length:

671

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

16.61885

Exp number, first 60 AAs:

16.60647

Total prob of N-in:

0.75419

POSSIBLE N-term signal

sequence

outside

1  -  671

 

 

Pi

219.35547

Theta

182.103278

Tajima's D

0.66046

CLR

0.386198

CSRT

0.560321983900805

Interpretation

Uncertain