Gene

KWMTBOMO16099

Pre Gene Modal

BGIBMGA004625

Annotation

PREDICTED:_chloride_channel_protein_2_[Bombyx_mori]

Location

Bomo_Chr27(-):9062882-9139455      View in EpiBrowser

Full name

Chloride channel protein       + More
Chloride channel protein 2      

Alternative Name

Chloride channel-a

Location in the cell

PlasmaMembrane   Reliability : 4.809

CDS

ATGTATGGTCGCTATCAACGCGACCTCAGCGAAGCGGCAAGAGAAGAAGCAAGGAGACTCCGTAGACTGCGCAAGAAGAGACGCAGAGACGACAAACTCCGACAAAAGGAGCTGGCGGCTACCGGGAAACCGCGACCCAGGGGGAAGTTCTTTAAAGTTTTAGGCTACATATGGAGACACACGTTCGCTCGTTTAGGCGAAGACTGGATCTTTCTCGCCGTTCTCGGTATAATCACGGCTATACTTAATTTCGCTATGGACAGAGGGATCGCTATCTGCAATAATGCTCGCATGTGGATGTACAATGACCTGGCAACGTCCACGTTCAGTCAGTATGTGGCTTGGGTGTCTCTGCCCGTATGCCTGATACTATTCGCTGCTGGCTTCGTGCATATTGTTGCTGCACAGAGCATAGGTTCAGGCATACCGGAAATGAAGACGATTCTCCGAGGTGTCCACCTAAAAGAATATTTGACCTTCAGAGCACTCATATCCAAGCTCATCGGTCTCACTGCCACATTAGGATCTGGTCTTCCACTAGGGAAAGAAGGACCGTCAGTTCACATAGCCTCAATGGTGGCCACACTGCTCTCCAAGCTGGTGACCACCTTCCAAGGGATCTACAGCAACGAGTCTCGGAACAGCGAGATGTTGGCCGCAGCTTGTGCTGTCGGCGTGGCCTCGTGCTTTGCCGCACCTGTTGGCGGCGTGCTCTTCTCCATAGAAGTCACGACGACGTACTTCGCTGTGAGGAACTATTGGAGGGGATTCTTTGCGGCTTGCTGCGGGGCTATCATGTTCAGGCTTCTGTCGGTTTGGTCTGGCGCTATGCCGACTATCAAACCTCTGTTCCCAACGAACCTACCGCAGGACTTTCCTTTCGACCCCCAGGAGTTTGCCGTCTTCGTTCTTCTTGGTGTGGTGTGCGGTCTCTTAGCCTCGTTATGGATCTGGTTGCATCGGCAGTACGTTTTGTTTATGCGGAACACAAAAACCTTAAGCAACTTCTTGCAGAAGAACCGTTTCATATATCCCGGCTTCATAACTCTGGCCGTGATGTCGATACTGTTCCCGCCAGGCATCGGGAAGTACATGGCAGCAGTTCTAGGGAATCAGGAACAGGTGCTGTCCCTTTTCGCGAACTTCACTTGGTCCGATGAGTTGACCGCGGAACAAGCCTCAATAGTGTCTCATTGGAGGACACCCGAAGTTGAATATTGGGGGTGCCTCATCATCTTCTTCTTTTCTATTTTCTTCCTGAGTATGGTCTCTTGCACTCTGCCAGTTCCGGCGGGCATTTTCGTGCCGGCTTTCAAAATGGGAGCTTCGTTGGGACGGTTCACGGGCGAAGTGATGCACTACTTCTGTCCGCTCGGCGTGGCTTATGGAGGACACATCCAGAAGATTCTACCAGGAGGGTACGCGGTCGTCGGAGCCGCGGCCTTCACCGGCGCCGTCACTCACACTGTCTCCACCATTGTCATAGTCAGCGAAATGACCGGGCAGGTAACTCATCTCCTTGGCATAATGGCGGCGGTTTTGGCGGCAAATGCAGTAGCGGCTCTGCTTGGACCTTCCTGCTTCGACAGTATCATCCTCATCAAGAAGCTACCCTACCTGCCCGATCTGCTTTCCTCTGCTAGTCGTATGTATGACATTTGCGTGGAGGACTTCATGGTGCGTGAGGTCAAGTACATATGGAACAGAATGACCTTCCAACAACTGAAGGATCTCTTGAAAGAGAACAAGGCCATAAAGAGTTTCCCGCTGGTGGACAGTCCGGCGTCGATGGTGCTGCTGGGGTCCATCCACCGCTGGGAGCTGGTGCGCGTCATCGAGCGGCAGGTGGGGCGCTCGCGGCGGCTGCAGGTGGCCGCGCAGTGGCACCGCCGCGCGCTGCAGGACGAGGCCCGCGCCCGCACCAGGAGACCCTCCAGATTCGAGGTGACTCCTGCTCCGGACATGCTACACGCGCCGGGGACCGGCATGACGCGAGGGTCCTCGCTCACCACCAAGGACCAAGGAGGACTACTGCCATCTCCGGGTCAGCTGTTCCGGCCGAAGTCCATCCTGAAGAAGACGAACTCGTTCACGTTGACGCGCGGACTGGCCTCCCCGCCCCCGCAGGCGACCACCCCCTCCCCCGCGTCCTCCCCGGCGCAAGTGTACAGCACCGTCACCGGAGCCGAGACCAGGATCCGCGCGGCCTTCGAAGCCATCTTCAGGCGGTCGACGCTGCTGCAGGACGTGGAGGGAGGCCTCTCCGACCAGCTCACCCCCGGACTGCCGAGGAGTCCCTCCATCAACAAGAAAGTTCAACTGCCCCGCGAGCGAGTCTGCGACATGTCCCCCGAGGACCAGAAAGCCTGGGAGCAACTAGAGATGGCTAAAGAAATTGACTTCGATCGGATGCTTGGCATCGCCAGGAAACGAGATCTGCTGCCCGAGGACTCGGAGTACGAGGACGAGACGCTGTACATCTGCCACATCGACCCGGCGCCCTTCCAGCTGGTGGAGAGGACTTCTCTACTCAAGGTCCACTCACTGTTCTCCACGCTGGGGGTGAGCCGCGCTTACGTCACGGCCATCGGCAGACTCATCGGGGTCGTCGCGCTCAAAGAGCTCCGAAAAGCGATCGAAGACGTGAACAGCGGCGTGCTGACGGTCGCCACCCGGCCCTCGCCTCCCACCACCCCGCTGCCCACCATCATTAAGGTGCCCTCCACGCAGCCCGCACCGCCCTCCGACAGCGAGACCGCCAAACTAACGACGTCGGAGAAGACATAA

Protein

MYGRYQRDLSEAAREEARRLRRLRKKRRRDDKLRQKELAATGKPRPRGKFFKVLGYIWRHTFARLGEDWIFLAVLGIITAILNFAMDRGIAICNNARMWMYNDLATSTFSQYVAWVSLPVCLILFAAGFVHIVAAQSIGSGIPEMKTILRGVHLKEYLTFRALISKLIGLTATLGSGLPLGKEGPSVHIASMVATLLSKLVTTFQGIYSNESRNSEMLAAACAVGVASCFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAACCGAIMFRLLSVWSGAMPTIKPLFPTNLPQDFPFDPQEFAVFVLLGVVCGLLASLWIWLHRQYVLFMRNTKTLSNFLQKNRFIYPGFITLAVMSILFPPGIGKYMAAVLGNQEQVLSLFANFTWSDELTAEQASIVSHWRTPEVEYWGCLIIFFFSIFFLSMVSCTLPVPAGIFVPAFKMGASLGRFTGEVMHYFCPLGVAYGGHIQKILPGGYAVVGAAAFTGAVTHTVSTIVIVSEMTGQVTHLLGIMAAVLAANAVAALLGPSCFDSIILIKKLPYLPDLLSSASRMYDICVEDFMVREVKYIWNRMTFQQLKDLLKENKAIKSFPLVDSPASMVLLGSIHRWELVRVIERQVGRSRRLQVAAQWHRRALQDEARARTRRPSRFEVTPAPDMLHAPGTGMTRGSSLTTKDQGGLLPSPGQLFRPKSILKKTNSFTLTRGLASPPPQATTPSPASSPAQVYSTVTGAETRIRAAFEAIFRRSTLLQDVEGGLSDQLTPGLPRSPSINKKVQLPRERVCDMSPEDQKAWEQLEMAKEIDFDRMLGIARKRDLLPEDSEYEDETLYICHIDPAPFQLVERTSLLKVHSLFSTLGVSRAYVTAIGRLIGVVALKELRKAIEDVNSGVLTVATRPSPPTTPLPTIIKVPSTQPAPPSDSETAKLTTSEKT

Description

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.

Miscellaneous

The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels.

Similarity

Belongs to the chloride channel (TC 2.A.49) family.

Keywords

Alternative splicing   CBS domain   Chloride   Chloride channel   Complete proteome   Ion channel   Ion transport   Membrane   Reference proteome   Repeat   RNA editing   Transmembrane   Transmembrane helix   Transport   Voltage-gated channel  

Feature

chain  Chloride channel protein 2
splice variant  In isoform G and isoform H.

Uniprot

A0A2W1BLB1   A0A194QKY5   A0A195BPF1   A0A158P2X7   A0A151WYL9   F4X527   + More
E2AUK8   A0A0M9AA48   A0A154P3M6   A0A146M938   A0A026VZT3   E9ICR2   A0A0A9XWK7   A0A0C9RR94   A0A195DNB4   K7J6E3   A0A195EZZ8   A0A146LJA2   A0A0A9XR97   A0A1Q3G3D8   A0A1Q3G3D7   A0A1Q3G372   A0A1W4XVD9   A0A1W4XW78   A0A2H1W2K5   A0A0L7RD51   A0A023F429   A0A088AM85   A0A139WGD7   A0A310SMZ5   E0VHT5   A0A1I8NIP0   A0A1J1J6W0   A0A1I8NIP9   A0A0A1WTS8   T1I221   A0A0L0CK26   A0A034VCU2   W8B894   A0A034VA27   A0A182F979   A0A1I8P531   W8BZY0   A0A0K8TRF6   A0A2M4AGQ6   A0A2M4CG84   W5JW39   A0A1B6CT71   A0A1I8NIQ3   A0A0A1WL81   A0A0A1XPJ5   A0A0A1X0R7   A0A182RP26   W8BNB8   A0A034V7U2   A0A182P7R8   A0A034VCT9   A0A1I8P555   A0A182M8A1   A0A182JKU1   A0A182VYP3   Q9VGH7-4   A0A182XW91   Q9VGH7-6   A0A1W4W1I1   Q9VGH7-3   H1UUP0   A0A0R1E6S0   A0A1W4WDH5   A0A0R1E490   A0A1W4WC70   A0A182N708   A0A084VT41   A0A0R1E468   A0A182K0S4   A0A182HA86   A0A3B0KT60   A0A1B6FC04   I5APM4   I5APM2   A0A0Q9X818   A0A0Q9X638   B4N837   I5APM5   A0A1S4FC75   Q178C9   Q178D0   A0A0Q9X4L6   Q178C8   A0A0Q9W1C3   A0A0P9ARS4   A0A0P9A033   A0A182XHJ4   A0A0P8YFI5   F5HKH6   A0A1B6K060   A0A0Q9WDW6   A0A0Q9W1P6   F5HKH4  

Pubmed

28756777    26354079    21347285    21719571    20798317    26823975    + More
24508170    30249741    21282665    25401762    20075255    25474469    18362917    19820115    20566863    25315136    25830018    26108605    25348373    24495485    26369729    20920257    23761445    10731132    12537572    12537569    15501232    17018572    17601953    25244985    17994087    17550304    24438588    26483478    15632085    17510324    12364791    14747013    17210077   

EMBL

KZ150011    PZC75071.1    KQ458671    KPJ05565.1    KQ976432    KYM87521.1    + More
ADTU01007642    ADTU01007643    KQ982649    KYQ52973.1    GL888680    EGI58484.1    GL442829    EFN62902.1    KQ435711    KOX79606.1    KQ434796    KZC05838.1    GDHC01003333    GDHC01002890    JAQ15296.1    JAQ15739.1    KK107538    QOIP01000005    EZA49145.1    RLU22975.1    GL762354    EFZ21619.1    GBHO01020341    JAG23263.1    GBYB01009821    JAG79588.1    KQ980713    KYN14395.1    KQ981905    KYN33449.1    GDHC01011244    JAQ07385.1    GBHO01020342    JAG23262.1    GFDL01000727    JAV34318.1    GFDL01000731    JAV34314.1    GFDL01000839    JAV34206.1    ODYU01005901    SOQ47267.1    KQ414615    KOC68686.1    GBBI01002501    JAC16211.1    KQ971345    KYB27012.1    KQ762882    OAD55366.1    DS235171    EEB12858.1    CVRI01000074    CRL08157.1    GBXI01011813    JAD02479.1    ACPB03006207    JRES01000301    KNC32600.1    GAKP01019584    JAC39368.1    GAMC01011693    JAB94862.1    GAKP01019588    JAC39364.1    GAMC01011691    JAB94864.1    GDAI01000882    JAI16721.1    GGFK01006652    MBW39973.1    GGFL01000067    MBW64245.1    ADMH02000272    ETN67164.1    GEDC01020875    JAS16423.1    GBXI01014670    JAC99621.1    GBXI01001799    JAD12493.1    GBXI01009957    JAD04335.1    GAMC01011694    JAB94861.1    GAKP01019586    JAC39366.1    GAKP01019589    JAC39363.1    AXCM01005921    AE014297    AY119539    BT009973    BT030454    AAF54702.3    AAM50193.1    AAQ22442.1    BT133125    AEY64293.1    CM000160    KRK03891.1    KRK03897.1    ATLV01016166    KE525060    KFB41135.1    KRK03893.1    JXUM01030864    KQ560899    KXJ80428.1    OUUW01000014    SPP88421.1    GECZ01022068    JAS47701.1    CM000070    EIM52909.1    EIM52907.1    CH933806    KRG00862.1    KRG00852.1    CH964232    EDW81288.2    EIM52910.2    CH477366    EAT42524.1    EAT42523.1    KRG00858.1    EAT42525.1    CH940652    KRF78876.1    CH902617    KPU80158.1    KPU80163.1    KPU80155.1    AAAB01008859    EGK96727.1    GECU01023788    GECU01002872    JAS83918.1    JAT04835.1    KRF78869.1    KRF78866.1    EGK96728.1   

Proteomes

UP000053268    UP000078540    UP000005205    UP000075809    UP000007755    UP000000311    + More
UP000053105    UP000076502    UP000053097    UP000279307    UP000078492    UP000002358    UP000078541    UP000192223    UP000053825    UP000005203    UP000007266    UP000009046    UP000095301    UP000183832    UP000015103    UP000037069    UP000069272    UP000095300    UP000000673    UP000075900    UP000075885    UP000075883    UP000075880    UP000075920    UP000000803    UP000076408    UP000192221    UP000002282    UP000075884    UP000030765    UP000075881    UP000069940    UP000249989    UP000268350    UP000001819    UP000009192    UP000007798    UP000008820    UP000008792    UP000007801    UP000076407    UP000007062   

PRIDE

Q9VGH7    H1UUP0   

Pfam

PF00654   Voltage_CLC        + More
PF00571   CBS

Interpro

IPR000644   CBS_dom        + More
IPR014743   Cl-channel_core       
IPR001807   Cl-channel_volt-gated       

SUPFAM

SSF81340   SSF81340       

Gene 3D

1.10.3080.10    

ProteinModelPortal

A0A2W1BLB1   A0A194QKY5   A0A195BPF1   A0A158P2X7   A0A151WYL9   F4X527   + More
E2AUK8   A0A0M9AA48   A0A154P3M6   A0A146M938   A0A026VZT3   E9ICR2   A0A0A9XWK7   A0A0C9RR94   A0A195DNB4   K7J6E3   A0A195EZZ8   A0A146LJA2   A0A0A9XR97   A0A1Q3G3D8   A0A1Q3G3D7   A0A1Q3G372   A0A1W4XVD9   A0A1W4XW78   A0A2H1W2K5   A0A0L7RD51   A0A023F429   A0A088AM85   A0A139WGD7   A0A310SMZ5   E0VHT5   A0A1I8NIP0   A0A1J1J6W0   A0A1I8NIP9   A0A0A1WTS8   T1I221   A0A0L0CK26   A0A034VCU2   W8B894   A0A034VA27   A0A182F979   A0A1I8P531   W8BZY0   A0A0K8TRF6   A0A2M4AGQ6   A0A2M4CG84   W5JW39   A0A1B6CT71   A0A1I8NIQ3   A0A0A1WL81   A0A0A1XPJ5   A0A0A1X0R7   A0A182RP26   W8BNB8   A0A034V7U2   A0A182P7R8   A0A034VCT9   A0A1I8P555   A0A182M8A1   A0A182JKU1   A0A182VYP3   Q9VGH7-4   A0A182XW91   Q9VGH7-6   A0A1W4W1I1   Q9VGH7-3   H1UUP0   A0A0R1E6S0   A0A1W4WDH5   A0A0R1E490   A0A1W4WC70   A0A182N708   A0A084VT41   A0A0R1E468   A0A182K0S4   A0A182HA86   A0A3B0KT60   A0A1B6FC04   I5APM4   I5APM2   A0A0Q9X818   A0A0Q9X638   B4N837   I5APM5   A0A1S4FC75   Q178C9   Q178D0   A0A0Q9X4L6   Q178C8   A0A0Q9W1C3   A0A0P9ARS4   A0A0P9A033   A0A182XHJ4   A0A0P8YFI5   F5HKH6   A0A1B6K060   A0A0Q9WDW6   A0A0Q9W1P6   F5HKH4  

PDB

6QVU     E-value=3.08658e-126,     Score=1160

KEGG

101747210    K05011 chloride channel 2 | (RefSeq) chloride channel protein 2

GO

GO:0005247   GO:0016021   GO:0005887   GO:0016324   GO:0034707   GO:0005254   GO:0034765   GO:1902476   GO:0006821   GO:0003091   GO:0003097   GO:0015629   GO:0009925   GO:0035377   GO:0030321   GO:0016020   GO:0005216   GO:0042626   GO:0001678   GO:0005536   GO:0046835   GO:0006281   GO:0006259   GO:0055085  

Subcellular location

Membrane  

Length:

928

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

257.955299999999

Exp number, first 60 AAs:

0.01911

Total prob of N-in:

0.16854

outside

1  -  69

TMhelix

70  -  92

inside

93  -  112

TMhelix

113  -  135

outside

136  -  157

TMhelix

158  -  180

inside

181  -  186

TMhelix

187  -  209

outside

210  -  218

TMhelix

219  -  241

inside

242  -  253

TMhelix

254  -  276

outside

277  -  299

TMhelix

300  -  319

inside

320  -  339

TMhelix

340  -  362

outside

363  -  412

TMhelix

413  -  435

inside

436  -  441

TMhelix

442  -  464

outside

465  -  473

TMhelix

474  -  496

inside

497  -  502

TMhelix

503  -  525

outside

526  -  928

 

 

Pi

280.72387

Theta

170.58651

Tajima's D

1.920429

CLR

0.21461

CSRT

0.873806309684516

Interpretation

Uncertain