Gene

KWMTBOMO16097  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004616

Annotation

PREDICTED:_ATP-binding_cassette_sub-family_D_member_2_[Amyelois_transitella]

Location

Bomo_Chr27(+):8986175-9002642      View in EpiBrowser

Full name

ATP-binding cassette sub-family D member      

Location in the cell

PlasmaMembrane   Reliability : 2.526

CDS

ATGCCGGCCATTTTGTCGAAAATTCGCGAACAAGCAACGCGGGTGCAACCCTCGCTCGCACTCGGCGTGGGCGTAGGGGTGGCGCTAGCCGCGTGCGCCGTTTATTCAACAAGAGACAAGAAACAAGCCCCACCATGCAACAATAACAATAATTATAAGATCTTGAAGAACGGTAATATTCACACGGAAGATAATGTCAAGACGAACGAAACTTGTGGGGGGAGGTGCGGGGCGGAGCAGTGCGCCCTCTGCAGGGGGGAAGTCGACACCGACAACAAACAGAATATCGAAGACGCCGACGAAACCCAATCAATCGAGGAGCACGTCCCGGGTCTCAACCTCGAATTCCTCAGGCAGCTGATCTCACTCGCGAGGATCATGGTCCCAGGGTTCAGGAGCCACGAAGTAGCTCTACTTACAGCTCATACTCTATGCTTATTTTCGAGGACCTTTCTATCGATCTACGTCGCTTCCTTGGAAGGGTCCATTGTGAAGCACATAGTCCAAAAAGACATGCGCAGTTTCTCGTCGTTGCTGATGCAGTGGTTCGGCATTGCCATACCGGCTACCTTCATCAACTCCATGATCAGATACCTCGAGAGTCGATTGGCCCTGGCCTTCAGAACCAGACTGGTCAATCACGCTTACGAGCTGTACTTTAAAAACCAGACCTACTATAGGGTCGCTAACTTGGACGCTAGGATCGAAAACGCTGATCACAGGTTGACGGAAGATGTCTCCGTGTTCACGCAGTCCGTGGCGCATCTCTACAGTTCGCTCACAAAACCTTGCTTCGACTTGCTGCTGATTGTCCTCACTCTGGCTTCGTACTCCAACAAGATGAAAGGAAACATATTCATTGGTCCCGGGATAGCAACGGTGGTGATATGCGCGACCGGACAAGTCCTTCGTATGCTCAGTCCGAGGTTCGGTGCTTTGGCCGGGGAGGAGGCGAGGATGCGCGCTAACCTGCGCCATGTCCACGCCAGTCTCATCGCGCACGCTGAAGAAGTCGCCTTCTACGGAGGGCATAAGGTGGAACTAGGACAGCTGCAGTCCGCGTACAAACAGCTGGTCGCGCAAATGACTTCGGTGTTCAACAAGAAACTGTGGTACGTGATGCTGGAGCAATTCTGCATGAAGTATCTGTGGTCCGGCACCGGAATGGTCATGCTGGCGCTGCCCATACTCACGGGGACTAAGGAAGGAGGTGAAAGCAACAGCATCAGCGCGAGAACAGAATACATGACCACGTCCAGGAACCTGCTGAATTCGGCTGCGGACGCCATCGAGAGGCTCATGTCCAGTTATAAGGAGGTGGTGACGCTGGCGGGGTACGCCACGCGCGTGTCCGACATGCTGCTGGTGTTCGGCGAGGTGGCGCGCGGCCGCTGCGTGCGCGCCGTGCACGTGGCGCCGCCGCACCAAGCCTTCCAGGTCACCTTCCGGGACAACCAGCCCGTGCCGCAAGGCAAAGTAATGTACACGGACGACTTGTCGATAAAGCTTCGCAACGTGCCGATAGTGACCCCGGCCTGCGACGTGGTGGCCGCCGGCGTGACCCTGGACATCGCGCCGGGGACGCACCTCCTCATCGTTGGACCCAACGGATGTGGGAAGTCCAGCTTATTCCGAATAATCTCCGGTCTGTGGCCGGTGTTCGGCGGCGAGCTGTCGGTGCCGCGGCCCTGCGCGTGCGGCCACTGCGCCGACGAGACCAACACCAGCGACGCCTGCGCCTCGCGCCCCATCATGTTCTACATACCGCAAAGACCGTACATGTCGGCGGGCTCGCTGCTGGACCAGGTGACGTACCCGTCGCGCGCGGCGCCGGACGACGCGGCGGCGGAGGAGCGCGCGCGGCGCATCCTGCGCGCGGTGCGGCTGCACGCGGCGGCGGCGCGGCTGGGCGGGCTGCGGGCCGTGCGCGACTGGCGCGCCACGCTCTCCGGCGGCGAGAAGCAGCGCCTCGCCATGGCCAGGATGTTCTACCACAGGCCGGTGTACGCTCTGCTGGACGAGTGCACGAGTGCCGTTTCCATGGAGACGGAGGTCGTCATGTATGAGGAGGCTGTCAAGGAGGGCATCACGCTACTCTCAATCACGCACCGACCGAGCGTGTGGAAGTACCACACGCACGTTTTGGAGTTCGACGGCGCCGGCAACTGGTCGTTCCGGAAGCTGGACAAGGAGAGCGCGGTCTCCAGCCCCGCCATCAACAGCGCCGCGACCAGCACGCCAGCGGAGCCCCCCGCCGAACACTAG

Protein

MPAILSKIREQATRVQPSLALGVGVGVALAACAVYSTRDKKQAPPCNNNNNYKILKNGNIHTEDNVKTNETCGGRCGAEQCALCRGEVDTDNKQNIEDADETQSIEEHVPGLNLEFLRQLISLARIMVPGFRSHEVALLTAHTLCLFSRTFLSIYVASLEGSIVKHIVQKDMRSFSSLLMQWFGIAIPATFINSMIRYLESRLALAFRTRLVNHAYELYFKNQTYYRVANLDARIENADHRLTEDVSVFTQSVAHLYSSLTKPCFDLLLIVLTLASYSNKMKGNIFIGPGIATVVICATGQVLRMLSPRFGALAGEEARMRANLRHVHASLIAHAEEVAFYGGHKVELGQLQSAYKQLVAQMTSVFNKKLWYVMLEQFCMKYLWSGTGMVMLALPILTGTKEGGESNSISARTEYMTTSRNLLNSAADAIERLMSSYKEVVTLAGYATRVSDMLLVFGEVARGRCVRAVHVAPPHQAFQVTFRDNQPVPQGKVMYTDDLSIKLRNVPIVTPACDVVAAGVTLDIAPGTHLLIVGPNGCGKSSLFRIISGLWPVFGGELSVPRPCACGHCADETNTSDACASRPIMFYIPQRPYMSAGSLLDQVTYPSRAAPDDAAAEERARRILRAVRLHAAAARLGGLRAVRDWRATLSGGEKQRLAMARMFYHRPVYALLDECTSAVSMETEVVMYEEAVKEGITLLSITHRPSVWKYHTHVLEFDGAGNWSFRKLDKESAVSSPAINSAATSTPAEPPAEH

Description

Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation.

Catalytic Activity

an acyl-CoA(out) + ATP + H2O = ADP + an acyl-CoA(in) + H(+) + phosphate

Similarity

Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

Keywords

ATP-binding   Complete proteome   Membrane   Nucleotide-binding   Peroxisome   Reference proteome   Translocase   Transmembrane   Transmembrane helix   Transport  

Feature

chain  ATP-binding cassette sub-family D member

Uniprot

H9J526   A0A2H4KAY7   A0A2A4JR80   A0A2W1BQ90   A0A3S2N9A1   A0A0F6PPS3   + More
B4MF35   D0Z7D6   A0A3B0KKF8   B4H855   B4NHJ8   A0A1W4VKR3   B0X1Z0   A0A1Q3FG40   A0A1S4FP38   Q16U17   U5ESG0   B3P9V3   A0A182JMF9   B4L791   A0A0M4EL68   Q7JUN3   B4PVY9   B4IL86   A0A2M4BEY5   A0A2M4BF29   B4R2D7   B3MZ72   B4JZT5   W5JCN6   A0A182F969   A0A084VG00   A0A2M4ACZ8   A0A182MEX3   A0A182V7P4   A0A182LR33   A0A182X0A9   Q7PYR2   A0A182HZZ9   A0A0K8TRC7   A0A182R667   A0A182YAP5   A0A182JWY4   A0A182P570   A0A182TMR9   A0A182Q2Q6   A0A0A1WRQ0   A0A0K8UZC5   T1PGC0   A0A182VZ73   A0A034WUZ5   A0A182N432   A0A1I8N2I5   A0A0C9R3B0   A0A1I8NST5   A0A1A9VII3   A0A1A9YI24   A0A1J1HX65   A0A2J7RSR6   A0A1B0ACJ2   A0A067R8U3   A0A1L8DE96   A0A1A9WYA2   A0A161ANQ7   A0A1B0GFD5   W8BK32   A0A1B6E0P3   A0A1B6DPX4   A0A3R5SPM1   X1WJH0   A0A1B6GNJ2   A0A2H8TNP3   A0A3R7PDN8   A0A0P4VSN3   A0A224X910   T1IBG3   A0A023F3W5   A0A0K8TE93   A0A0A9WL02   E0VFF5   A0A0P5HI86   A0A182GZL9   A0A0P5GEH9   A0A0P5LLE6   A0A0P6GBM8   A0A0N8C7Z0   A0A0P5HTC7   A0A0P5YQ79   A0A0P5NB15   A0A0P5RHB2   A0A0P6FSV7   A0A0N8B820   A0A0P5JKH3   A0A0A7AS24   A0A0N7ZUX1   A0A0P5J1J3  

EC Number

7.6.2.4

Pubmed

19121390    28756777    25662100    17994087    17510324    18057021    + More
10731132    12537572    12537569    29739804    17550304    22936249    20920257    23761445    24438588    20966253    12364791    14747013    17210077    26369729    25244985    25830018    25348373    29121518    25315136    24845553    24495485    27129103    25474469    25401762    26823975    20566863    26483478   

EMBL

BABH01038867    BABH01038868    BABH01038869    BABH01038870    KY484781    ASS36023.1    + More
NWSH01000731    PCG74537.1    KZ150011    PZC75066.1    RSAL01000181    RVE44929.1    KM244040    AKC42333.1    CH940665    EDW71136.1    CM000831    ACY70493.1    OUUW01000017    SPP89050.1    CH479221    EDW34855.1    CH964272    EDW83567.1    DS232275    EDS38920.1    GFDL01008540    JAV26505.1    CH477634    EAT38025.1    GANO01003262    JAB56609.1    CH954184    EDV45266.1    CH933813    EDW10885.1    KRG07224.1    CP012527    ALC48108.1    AE014135    AY122172    AAM52684.1    CM000161    EDW99294.1    KRK04798.1    KRK04799.1    CH480867    EDW53717.1    GGFJ01002463    MBW51604.1    GGFJ01002462    MBW51603.1    CM000365    CM002916    EDX15188.1    KMZ07159.1    CH902633    EDV33677.1    KPU74652.1    CH916380    EDV90951.1    ADMH02001893    ETN60589.1    ATLV01012589    KE524806    KFB36894.1    GGFK01005309    MBW38630.1    AXCM01003710    AAAB01008987    EAA01050.4    APCN01002026    GDAI01000917    JAI16686.1    AXCN02000023    GBXI01012553    GBXI01011005    JAD01739.1    JAD03287.1    GDHF01020363    JAI31951.1    KA647811    AFP62440.1    KY849632    GAKP01000929    GAKP01000928    GAKP01000927    ATY74513.1    JAC58025.1    GBYB01002455    JAG72222.1    CVRI01000020    CRK91118.1    NEVH01000250    PNF43877.1    KK852808    KDR16020.1    GFDF01009313    JAV04771.1    KF828789    AIN44106.1    CCAG010012309    CCAG010012310    CCAG010012311    CCAG010012312    CCAG010012313    GAMC01012949    JAB93606.1    GEDC01005851    JAS31447.1    GEDC01009587    JAS27711.1    MH172503    QAA95910.1    ABLF02040307    ABLF02040314    GECZ01005788    JAS63981.1    GFXV01003999    MBW15804.1    QCYY01003703    ROT62385.1    GDKW01001625    JAI54970.1    GFTR01007579    JAW08847.1    ACPB03000223    GBBI01002606    JAC16106.1    GBRD01001928    JAG63893.1    GBHO01036426    GBRD01001925    GDHC01011756    JAG07178.1    JAG63896.1    JAQ06873.1    DS235111    EEB12111.1    GDIQ01227695    JAK24030.1    JXUM01099895    JXUM01099896    JXUM01099897    JXUM01099898    KQ564527    KXJ72135.1    GDIQ01249337    JAK02388.1    GDIQ01171910    GDIQ01132388    JAK79815.1    GDIQ01046010    JAN48727.1    GDIQ01105939    JAL45787.1    GDIQ01223039    JAK28686.1    GDIP01056337    JAM47378.1    GDIQ01155565    JAK96160.1    GDIQ01105941    JAL45785.1    GDIQ01046011    JAN48726.1    GDIQ01203699    JAK48026.1    GDIQ01203700    JAK48025.1    KF906291    AHK05656.1    GDIP01210169    LRGB01002019    JAJ13233.1    KZS09636.1    GDIQ01254875    GDIQ01206844    GDIQ01036358    JAK44881.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000008792    UP000268350    UP000008744    + More
UP000007798    UP000192221    UP000002320    UP000008820    UP000008711    UP000075880    UP000009192    UP000092553    UP000000803    UP000002282    UP000001292    UP000000304    UP000007801    UP000001070    UP000000673    UP000069272    UP000030765    UP000075883    UP000075903    UP000075882    UP000076407    UP000007062    UP000075840    UP000075900    UP000076408    UP000075881    UP000075885    UP000075902    UP000075886    UP000075920    UP000075884    UP000095301    UP000095300    UP000078200    UP000092443    UP000183832    UP000235965    UP000092445    UP000027135    UP000091820    UP000092444    UP000007819    UP000283509    UP000015103    UP000009046    UP000069940    UP000249989    UP000076858   

PRIDE

H9J526    Q7JUN3   

Pfam

PF06472   ABC_membrane_2        + More
PF00005   ABC_tran

Interpro

IPR003593   AAA+_ATPase        + More
IPR017871   ABC_transporter_CS       
IPR003439   ABC_transporter-like       
IPR027417   P-loop_NTPase       
IPR011527   ABC1_TM_dom       
IPR036640   ABC1_TM_sf       
IPR031239   ABCD2       
IPR031237   ALDP       

SUPFAM

SSF52540   SSF52540        + More
SSF90123   SSF90123       

Gene 3D

1.20.1560.10    

ProteinModelPortal

H9J526   A0A2H4KAY7   A0A2A4JR80   A0A2W1BQ90   A0A3S2N9A1   A0A0F6PPS3   + More
B4MF35   D0Z7D6   A0A3B0KKF8   B4H855   B4NHJ8   A0A1W4VKR3   B0X1Z0   A0A1Q3FG40   A0A1S4FP38   Q16U17   U5ESG0   B3P9V3   A0A182JMF9   B4L791   A0A0M4EL68   Q7JUN3   B4PVY9   B4IL86   A0A2M4BEY5   A0A2M4BF29   B4R2D7   B3MZ72   B4JZT5   W5JCN6   A0A182F969   A0A084VG00   A0A2M4ACZ8   A0A182MEX3   A0A182V7P4   A0A182LR33   A0A182X0A9   Q7PYR2   A0A182HZZ9   A0A0K8TRC7   A0A182R667   A0A182YAP5   A0A182JWY4   A0A182P570   A0A182TMR9   A0A182Q2Q6   A0A0A1WRQ0   A0A0K8UZC5   T1PGC0   A0A182VZ73   A0A034WUZ5   A0A182N432   A0A1I8N2I5   A0A0C9R3B0   A0A1I8NST5   A0A1A9VII3   A0A1A9YI24   A0A1J1HX65   A0A2J7RSR6   A0A1B0ACJ2   A0A067R8U3   A0A1L8DE96   A0A1A9WYA2   A0A161ANQ7   A0A1B0GFD5   W8BK32   A0A1B6E0P3   A0A1B6DPX4   A0A3R5SPM1   X1WJH0   A0A1B6GNJ2   A0A2H8TNP3   A0A3R7PDN8   A0A0P4VSN3   A0A224X910   T1IBG3   A0A023F3W5   A0A0K8TE93   A0A0A9WL02   E0VFF5   A0A0P5HI86   A0A182GZL9   A0A0P5GEH9   A0A0P5LLE6   A0A0P6GBM8   A0A0N8C7Z0   A0A0P5HTC7   A0A0P5YQ79   A0A0P5NB15   A0A0P5RHB2   A0A0P6FSV7   A0A0N8B820   A0A0P5JKH3   A0A0A7AS24   A0A0N7ZUX1   A0A0P5J1J3  

PDB

4F4C     E-value=9.44636e-13,     Score=181

KEGG

101735553    K05676 ATP-binding cassette, subfamily D (ALD), member 2 | (RefSeq) ATP-binding cassette sub-family

PATHWAY

02010    ABC transporters - Bombyx mori (domestic silkworm)
04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0005524   GO:0042626   GO:0001676   GO:0005778   GO:0006635   GO:0016887   GO:0006810   GO:0001678   GO:0005536   GO:0046835   GO:0006281   GO:0006259   GO:0055085  

PANTHER

PTHR11384:SF24   PTHR11384:SF21  

Subcellular location

Peroxisome membrane  

Length:

754

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

83.0573400000001

Exp number, first 60 AAs:

20.29873

Total prob of N-in:

0.07945

POSSIBLE N-term signal

sequence

outside

1  -  14

TMhelix

15  -  37

inside

38  -  135

TMhelix

136  -  158

outside

159  -  177

TMhelix

178  -  200

inside

201  -  282

TMhelix

283  -  305

outside

306  -  754

 

 

Pi

187.90636

Theta

164.8188

Tajima's D

0.825238

CLR

0

CSRT

0.607819609019549

Interpretation

Uncertain