SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO16087  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA004612
Annotation
heat_shock_protein_83_[Bombyx_mori]
Location
Bomo_Chr27(+):8749005-8751393      View in EpiBrowser
Full name
Heat shock protein 83      
Location in the cell
Cytoplasmic   Reliability : 3.856
 

Sequence

CDS
ATGCCGGAAGAAATGGAGACACAGCCAGCGGAGGTTGAAACCTTCGCGTTCCAGGCTGAGATCGCTCAGCTTATGTCCCTGATCATCAACACCTTTTACTCCAACAAAGAAATTTTCCTTCGTGAGCTGATTTCCAATTCATCGGACGCTTTAGACAAAATCAGGTATGAATCTCTCACGGATCCGTCAAAACTCGATAGTGGCAAAGAGCTGTACATCAAGATCATTCCCAACAAGAACGAGGGCACTCTTACGATCATCGATACCGGTATTGGTATGACCAAGGCCGATTTGGTGAACAATTTGGGAACCATCGCGAAATCTGGTACTAAAGCTTTCATGGAGGCTCTTCAAGCAGGTGCCGACATCAGCATGATTGGACAGTTCGGTGTTGGCTTCTACTCCAGTTACTTGGTCGCTGACCGCGTGACTGTTCACTCTAAACACAATGACGACGAGCAATACGTGTGGGAATCTTCTGCAGGAGGCTCGTTCACAGTCCGCCCAGACAGCGGTGAGCCCCTTGGTCGAGGTACAAAGATCGTCCTTCACGTCAAAGAGGACTTGGCAGAATTCATGGAAGAACACAAAATCAAAGAGATCGTAAAGAAACATTCCCAGTTCATCGGCTACCCAATCAAGCTGATGGTTGAAAAAGAACGCGAAAAAGAACTGTCTGATGATGAAGCCGAAGAAGAAAAGAAGGAAGAGGAAGATGAGAAGCCTAAGATTGAAGATGTAGGTGAGGATGAAGACGAGGACAAAAAAGATACGAAGAAGAAGAAGAAAACAATTAAAGAAAAATACACAGAGGATGAAGAACTCAACAAGACAAAGCCTATCTGGACCAGAAACGCTGATGACATTACCCAAGATGAGTATGGAGACTTCTACAAATCCCTTACCAATGATTGGGAGGACCATCTTGCAGTCAAACACTTCTCCGTTGAAGGTCAGTTAGAGTTCCGTGCACTACTTTTTGTGCCACGTCGTGCACCTTTTGACTTGTTTGAAAACAAGAAGCGCAAGAACAATATCAAGCTGTATGTACGAAGAGTTTTCATCATGGACAACTGTGAGGATCTCATCCCAGAGTACCTTAACTTCATTAGAGGTGTTGTCGACAGTGAGGACCTTCCTCTAAACATTTCACGTGAGATGCTTCAACAGAATAAAATTCTGAAAGTAATTAGGAAGAATTTAGTTAAAAAATGCCTAGAACTATTTGAAGAATTGGCAGAGGACAAAGAAAACTACAAGAAGTATTATGAACAATTCAGCAAGAACTTAAAATTGGGTATCCATGAAGACTCTCAAAACAGGGCTAAGCTCTCTGAGCTTCTGCGGTACCACACTTCGGCATCGGGTGATGAAGCCTGCTCTCTGAAAGAGTATGTATCCAGGATGAAGGAGAATCAGAAACATATCTACTACATCACTGGAGAAAACAGAGACCAGGTGGCGAACTCCTCATTTGTGGAGAGAGTGAAGAAACGTGGCTATGAAGTAGTCTACATGACTGAGCCCATTGATGAATATGTAGTACAACAGATGAGGGAGTATGATGGCAAGACCCTTGTATCGGTCACAAAGGAAGGATTAGAACTTCCTGAAGATGAGGAAGAAAAGAAGAAACGTGAGGAAGATAAGGTGAAGTTCGAAGGGCTGTGCAAGGTGATGAAGAACATCCTGGACAACAAAGTTGAGAAAGTTGTTGTCTCTAACAGACTTGTGGAGTCTCCTTGCTGTATTGTTACTGCTCAATATGGATGGTCTGCCAACATGGAACGTATCATGAAGGCTCAGGCTCTACGTGACACATCCACAATGGGATACATGGCTGCGAAGAAGCATTTGGAAATCAATCCTGATCACTCGATTGTGGAAACATTAAGGCAGAAAGCGGAAGCCGACAAGAATGACAAAGCTGTTAAGGATCTTGTTATCTTATTGTATGAAACTGCCCTGCTGTCTTCTGGCTTCACGCTTGATGAGCCCCAAGTCCATGCTTCCCGTATCTATAGAATGATCAAACTGGGTCTTGGTATTGATGAAGATGAGCCGATTCAGGTTGAAGAGCCTGCTTCTGGAGATGTGCCGCCATTGGAGGGTGATGCCGATGATGCATCTCGCATGGAGGAGGTTGATTAA
Protein
MPEEMETQPAEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELYIKIIPNKNEGTLTIIDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADRVTVHSKHNDDEQYVWESSAGGSFTVRPDSGEPLGRGTKIVLHVKEDLAEFMEEHKIKEIVKKHSQFIGYPIKLMVEKEREKELSDDEAEEEKKEEEDEKPKIEDVGEDEDEDKKDTKKKKKTIKEKYTEDEELNKTKPIWTRNADDITQDEYGDFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENKKRKNNIKLYVRRVFIMDNCEDLIPEYLNFIRGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEELAEDKENYKKYYEQFSKNLKLGIHEDSQNRAKLSELLRYHTSASGDEACSLKEYVSRMKENQKHIYYITGENRDQVANSSFVERVKKRGYEVVYMTEPIDEYVVQQMREYDGKTLVSVTKEGLELPEDEEEKKKREEDKVKFEGLCKVMKNILDNKVEKVVVSNRLVESPCCIVTAQYGWSANMERIMKAQALRDTSTMGYMAAKKHLEINPDHSIVETLRQKAEADKNDKAVKDLVILLYETALLSSGFTLDEPQVHASRIYRMIKLGLGIDEDEPIQVEEPASGDVPPLEGDADDASRMEEVD

Summary

Description
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins.
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins (By similarity).
Subunit
Homodimer.
Similarity
Belongs to the heat shock protein 90 family.
Keywords
ATP-binding   Chaperone   Complete proteome   Cytoplasm   Nucleotide-binding   Phosphoprotein   Reference proteome   Stress response  
Feature
chain  Heat shock protein 83
Uniprot
Q9BLC5   E0XJK6   A0A1P8PEX8   D5JAK9   A5A3D8   A0A0F6PBH3   + More
Q75NF6   A0A2Z4NA30   F5ANK0   A0A0B4L0J0   A0A1S4FUH2   Q16FA5   A0A2H4FFC0   Q16PB5   Q7PT10   A0A0P5SB17   A0A0N8B3F2   A0A182UE71  
Pubmed
11418243    19121390    22902560    23681506    18393570    17510324    + More
12364791   
EMBL
AB060275    GU324473    HQ437671    GU230736    ADM26739.1    KU522474    + More
APX61060.1    GU235994    ADD91573.1    EF523380    ABP93404.1    KJ679917    AJK31515.1    AB176669    BAD15163.1    MG520364    AWX67685.1    AEB39782.1    KC620427    AHE77376.1    CH478474    CH477789    EAT32919.1    EAT36187.1    KX358700    AOQ25849.1    EAT36186.1    AAAB01008807    GDIQ01096087    JAL55639.1    GDIQ01216643    JAK35082.1   
Proteomes
UP000005204    UP000008820    UP000007062    UP000075902   
PRIDE
Q9BLC5    F5ANK0    Q7PT10   
Pfam
PF00183   HSP90        + More
PF02518   HATPase_c
Interpro
IPR020575   Hsp90_N        + More
IPR037196   HSP90_C       
IPR003594   HATPase_C       
IPR020568   Ribosomal_S5_D2-typ_fold       
IPR019805   Heat_shock_protein_90_CS       
IPR001404   Hsp90_fam       
IPR036890   HATPase_C_sf       
SUPFAM
SSF54211   SSF54211        + More
SSF55874   SSF55874       
SSF110942   SSF110942       
Gene 3D
1.20.120.790     3.30.565.10    
CDD
cd00075  HATPase_c
ProteinModelPortal
Q9BLC5   E0XJK6   A0A1P8PEX8   D5JAK9   A5A3D8   A0A0F6PBH3   + More
Q75NF6   A0A2Z4NA30   F5ANK0   A0A0B4L0J0   A0A1S4FUH2   Q16FA5   A0A2H4FFC0   Q16PB5   Q7PT10   A0A0P5SB17   A0A0N8B3F2   A0A182UE71  
PDB
2CG9     E-value=0,     Score=1817

Ontologies

KEGG
692420    K04079 molecular chaperone HtpG | (RefSeq) Hsp90, BmHSP90, Hsp83; 90-kDa heat shock protein
PATHWAY
04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)
GO
GO:0005737   GO:0005524   GO:0006457   GO:0051082   GO:0005829   GO:0032991   GO:0097718   GO:0009986   GO:0005886   GO:0050821   GO:0048471   GO:0034605   GO:0006950   GO:0022857   GO:0001678   GO:0005536   GO:0046835   GO:0006281   GO:0006259  
PANTHER
PTHR11528  

Topology

Subcellular location
Cytoplasm  
Length:
716
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0873800000000001
Exp number, first 60 AAs:
0.05878
Total prob of N-in:
0.00316
outside
1  -  716
 
 

Population Genetic Test Statistics

Pi
228.777162
Theta
182.790112
Tajima's D
0.21404
CLR
0.345597
CSRT
0.429678516074196
Interpretation
Uncertain
Peptides ×
Source Sequence Identity Evalue
28556443 HLEINPDHSIVETLR 100.00 8e-16
28556443 HLEINPDHSIVETLR 100.00 8e-16
26822097 GYEVVYMTEPIDEYVVQQMR 96.55 2e-15
25044914 HMYIFPDYK 96.55 2e-15
27102218 RGYEVVYMTEPIDEYVVQQMR 96.55 2e-15
28556443 KHLEINPDHSIVETLR 100.00 4e-10
28556443 KHLEINPDHSIVETLR 100.00 4e-10
26822097 YESITDPSK 95.24 8e-10
26280517 IVAGFENESIITSGGVTIAGTR 95.24 8e-10
25044914 IVESIQQDYSQADQDQFMHVAIPR 95.24 8e-10
28467696 IVESIQQDYSQADQDQFMHVAIPR 95.24 8e-10
25044914 RGYDTPVIDYIIFR 100.00 4e-08
27102218 APFDIFENK 100.00 4e-08
26822097 IDSGKEIYIK 100.00 5e-08
26280517 HIYHSIYMK 100.00 5e-08
27102218 VVVSNR 100.00 5e-08
28467696 HIYYITGENR 100.00 5e-08
26822097 EKYTEDEEINK 95.24 7e-08
26280517 IGTIYEGTSNMQIQTIAK 95.24 7e-08
25044914 IIPMNTGVEGGESACK 95.24 7e-08
24402669 IIPMPASIPGIR 95.24 7e-08
27102218 CIEIFEEIAEDKENYKK 95.24 7e-08
28467696 IIPNEDGTIITMR 95.24 7e-08
26822097 EGIEIPEDEEEKK 100.00 3e-07
26280517 GSPPQWSPVYTVK 100.00 3e-07
25044914 GYEVIYITEAVDEYCISSIPEYDGHK 100.00 3e-07
27102218 YTEDEEINKTKPIWTR 100.00 3e-07
28467696 GYEPEDISIAPAATPDKR 100.00 3e-07
28556443 GYEVVYMTEPIDEYVVQQMR 100.00 3e-07
28556443 GVVDSEDLPLNISR 100.00 3e-07
28556443 GVVDSEDLPLNISR 100.00 3e-07
28556443 ALLFVPR 100.00 5e-06
28556443 TVRPDSGEPLGR 100.00 5e-06
28556443 APFDLFENKK 100.00 1e-04
28556443 APFDLFENK 100.00 1e-04
28556443 NEGTLTIIDTGIGMTK 100.00 2e-04
28556443 NEGTLTIIDTGIGMTK 100.00 2e-04
28556443 NEGTLTIIDTGIGMTK 100.00 2e-04
28556443 NEGTLTIIDTGIGMTK 100.00 2e-04
28556443 NADDITQDEYGDFYK 100.00 2e-04
28556443 IEDVGEDEDEDKKDTK 100.00 2e-04
28556443 NADDITQDEYGDFYK 100.00 2e-04
28556443 IEDVGEDEDEDKKDTK 100.00 2e-04
28556443 EGLELPEDEEEKK 100.00 5e-04
28556443 HLEINPDHSIVETLR 100.00 7e-04
28556443 HLEINPDHSIVETLR 100.00 7e-04
28556443 HIYYITGENR 100.00 7e-04
28556443 HFSVEGQLEFR 100.00 7e-04
28556443 YHTSASGDEACSLK 100.00 0.001
28556443 YESLTDPSK 100.00 0.001
28556443 SLTNDWEDHLAVK 100.00 0.001
26822097 ISSDGVITVVAPR 100.00 0.001
26280517 IVNVIYYGSDSVK 100.00 0.001
25044914 NACGQIGFGDTVTR 100.00 0.001
24402669 NACEVQTFKK 100.00 0.001
27102218 RAPFDIFENKK 100.00 0.001
28467696 NADCVIEAVFEDINIK 100.00 0.001
28556443 NADDITQDEYGDFYK 100.00 0.001
28556443 NADDITQDEYGDFYK 100.00 0.001
28556443 LVESPCCIVTAQYGWSANMER 100.00 0.001
28556443 MTEPIDEYVVQQMR 100.00 0.001
28556443 LVESPCCIVTAQYGWSANMER 100.00 0.004
20518026 LIPNKTAGTLTIIDTGIGMTK 100.00 0.005
20518026 HFSVEGQLEFR 100.00 0.010
28556443 SLTNDWEDHLAVK 100.00 0.010
28556443 SLTNDWEDHLAVK 100.00 0.010
28556443 SLTNDWEDHLAVK 100.00 0.010
28556443 SLIINTFYSNK 100.00 0.010
28556443 SLIINTFYSNK 100.00 0.010
28556443 GVVDSEDLPLNISR 100.00 0.014
28556443 GVVDSEDLPLNISR 100.00 0.014
28556443 ELISNSSDALDK 100.00 0.014
28556443 ELISNSSDALDK 100.00 0.014
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