Gene

KWMTBOMO16065

Pre Gene Modal

BGIBMGA004579

Annotation

PREDICTED:_calcium-dependent_secretion_activator_isoform_X9_[Bombyx_mori]

Location

Bomo_Chr27(-):7968342-7994834      View in EpiBrowser

Full name

Calcium-dependent secretion activator      

Alternative Name

Calcium-activated protein for secretion

Location in the cell

Cytoplasmic   Reliability : 3.144

CDS

ATGCCGAAGTTTGTGCTTAAAGAAATGGAATCCCTGTACATTGAGGAGCTGAAGTCATCCATCAACCTCCTCATGGCGAATCTGGAGTCCCTGCCCGTGTCGAAGGGAGGGGCGGACTCCAAATACGGACTCCACAAAATCAAGCGGTATAACCACAGATCCCAAGGCTCTTTAGCCAACAAACTGACGGGAGAAACGGACGGCGAAGTTGACACGCAGCTCACCAAAATGGACGTTGTGCTAACATTCCAAATCGAGGTAGTCGTCATGGAGGTTAAGGGTCTGAAGTCATTGGCACCAAATAGAATAGTTTACTGCACTATGGAAGTGGAGGGTGGTGATAAACTGCAGACTGATCAAGCTGAGGCGTCCAAGCCTATGTGGGACACGCAAGGTGATTTTAGTACAACGCAGCCTCTTCCAGCCGTGAAAGTGAAACTTTACACAGAGAACCCCGGAGTTTTGGCTTTGGAAGACAAAGAACTGGGGAAAGTGGTCTTAAGACCTACACCGTTGTCTAGTAAGGCGCCGGAGTGGCACAGGATGACGGTTCCGAAGAATCTACCTGACCAGGACTTGAGGATCAAGATCGCGTGTCGGATGGACAAGCCTTTGAATATGAAGCATTGCGGCTACTTGCACGTAATAGGGAAGAACGTGTGGCGGAAATGGAAACGCCGGTACATGGTGCTCGTGCAGGTCAGCCAGTACACCTTCGCGCTTTGCTCCTATAAAGACAAGAAGTCAGAGCCGGCCGAGATGATGCAGCTCGACGGCTTCACTGTCGACTACATAGAGCTCGCAAGCGCCCAACTCATCGTTGGACAAGGTAAGAAAGAAAATTTCAACACTAAACTGGAAGGCGCGAAGTACTTCATGAACGCGGTCCGCGACGGAGAGTCGGTGCTGATGGGAACCACAGACGAGAACGAGTGCCATCTGTGGGTGATGGCGTTGTACAGAGCGACGGGACAAAGTCACAAACCCACTCCCCCCACCACGTCCGATACGCATCACAAGATAATGGGAGACGCAGACAAAGCTCGTAAGCACGGAATGGAGGACTACATCCAGGCGGACCCGTGCCAGTTCGACCACCACCAACTGTTCTGCACGCTGCAGTCGCTGACCTTGAAATATCGACTACAAGACCCTTATTGCTCGCTGGGTTGGTTCTCCCCCGGCCAAGTGTTCGTCCTGGACGAGTACTGCGCCCGGTACGGAGTGCGAGGCTGCTATCGACACCTCTGCTACCTCTCCGACCTTTTGGACGTGGCGGAGAGCGGGCAGCAGACCGTGGACCCGACCCTCATGCACTACTCCTTCGCGTTCTGCGCCAGCCACGTGCACGGGAACAGTACCGCGACGTTGCCTGGCAGGCCAGACGGCGTTGGCAGCATCACCGTCCAGGAGAAGGAGAAGTTCGCCGAGATCAAAGAGCGGCTGAAGACGTTACTGCAACACCAAATAACTAACTTTAGATACGCATTCCCGTTCGGAAGACCGGAGGGAGCTCTGAAGGCTACGCTGTCGCTCTTGGAGAGAGTGCTGATGAAAGACGTGGTGACACCGGTGGCGCCGGAGGAGGTGCGGACAATGATACAGACGAGCTTGGAGAACGCGGCGCTTCTGAACTACACGCAGCTCAGTCAGAAAGCCAACATCGAAGATCTCAGAGGCGATACCATGGTAACGCCAGCTAAAAAATTAGAAGATCTCATACATCTGGCAGAACTCTGCGTTGACCTACTACAGCAAAACGAAGAACATTACGCGGAGGTTTATAACACAAAACCGGATTCTAGCGGTCAACAAAATGCATTTGCATGGTTCTCTGAACTTCTGGTGGAACACGCTGAGATCTTCTGGGCACTGTTCGCCGTGGACATGGACCGCGTTCTGTCCGAGCAGCCACCGGACACATGGGATTCGTTCCCACTCTTCCAAATATTAAACGACTATTTAAGAACAGATACTGATACCGAAGGAACATACCCAATGGATAATTTAAAAGGTGGCAGATTCCACGAACATCTCCGAGATACGTTTGCGCCATTGGTTGTACGTTACGTGGACCTGATGGAGAGTTCTATAGCTCAATCACTTCATAAAGGTTTCGAAAAGGAGCGATGGGAAATAAAGGGTAATGGCTGCGCGACTAGCGAAGAGTTGTTCTGGAAGCTGGACGCGTTGCAGTGCTTCATCAGAGACCTTCACTGGCCAGAGCCGGAGTTCCGTTCACACCTTGAACAGCGACTCAAACTCATGGCTAGTGACATGATGGAAACTTTAATACAGAGGACCGAGGCTGCTTTTCAGTCGTGGTTGAAGAAGAGCGTCACTTTCATGTCCACGGACTACATACTGCCGGCCGAGACGTGCGCGATGGTCAACGTCGCGCTGGACGCGAAGAACCAGGCCCTCAAGCTCTGCGCAGTTGAAGGGGTGGATATTTATCAGTACCACGCCAAAATGGACGGTCAAATCGAGGCCTGTCTAGTGGCGATGGCAACTGGCATGACAACAAGACTGTCCGCTGTTCTCGAAGCGACCTTAGCTAAGATTGCAAGATTCGATGAGGGAAGCCTTATCGGCTCCATCCTTACAATTGCCAACGTGTCCGGCTCTGGCAAGGACATCGGTCAGGGCTACGTCAACTTCATGAGAAACTCCATGGACCAAATCAGATCAAAGGTAACCGACGAGCTCTGGATCCTGCAGCTCTTCGAGCAATGGTACGGGAACCAGGTGACGATGATCAACAATTGGTTGTCAGAACGACCGGCGTTACATCCTCACCAGGTCGCCTGCCTCTCCATCTTGTTAAAGAAAATGTACAGCGACTTCGAGCTACAGGGGGTCATTGATGACAAGTTAAACTCTAAGACGTACCAGGGAGTCGCGGCCCGGATGCACACTGAAGAAGCGACGTGCAGCCTGTTGCTGAGTCAGCAAGACGGCGGTGGCGGTGACGATGGTGGTTCCGAAGAAGGCTCAAGAGGTGGAAAGTCGAAACTAGAAGCCCTCACCGAGGAAGCTAAGCTAGGCAACGTTACGGCTGTAGTTGGAAAGGTTGGAAATATGTTTGGTCGCGGCATAGGAGAACTGTCAACGAAACTAGGAGGCGCTTCGTCATGGTTCTAG

Protein

MPKFVLKEMESLYIEELKSSINLLMANLESLPVSKGGADSKYGLHKIKRYNHRSQGSLANKLTGETDGEVDTQLTKMDVVLTFQIEVVVMEVKGLKSLAPNRIVYCTMEVEGGDKLQTDQAEASKPMWDTQGDFSTTQPLPAVKVKLYTENPGVLALEDKELGKVVLRPTPLSSKAPEWHRMTVPKNLPDQDLRIKIACRMDKPLNMKHCGYLHVIGKNVWRKWKRRYMVLVQVSQYTFALCSYKDKKSEPAEMMQLDGFTVDYIELASAQLIVGQGKKENFNTKLEGAKYFMNAVRDGESVLMGTTDENECHLWVMALYRATGQSHKPTPPTTSDTHHKIMGDADKARKHGMEDYIQADPCQFDHHQLFCTLQSLTLKYRLQDPYCSLGWFSPGQVFVLDEYCARYGVRGCYRHLCYLSDLLDVAESGQQTVDPTLMHYSFAFCASHVHGNSTATLPGRPDGVGSITVQEKEKFAEIKERLKTLLQHQITNFRYAFPFGRPEGALKATLSLLERVLMKDVVTPVAPEEVRTMIQTSLENAALLNYTQLSQKANIEDLRGDTMVTPAKKLEDLIHLAELCVDLLQQNEEHYAEVYNTKPDSSGQQNAFAWFSELLVEHAEIFWALFAVDMDRVLSEQPPDTWDSFPLFQILNDYLRTDTDTEGTYPMDNLKGGRFHEHLRDTFAPLVVRYVDLMESSIAQSLHKGFEKERWEIKGNGCATSEELFWKLDALQCFIRDLHWPEPEFRSHLEQRLKLMASDMMETLIQRTEAAFQSWLKKSVTFMSTDYILPAETCAMVNVALDAKNQALKLCAVEGVDIYQYHAKMDGQIEACLVAMATGMTTRLSAVLEATLAKIARFDEGSLIGSILTIANVSGSGKDIGQGYVNFMRNSMDQIRSKVTDELWILQLFEQWYGNQVTMINNWLSERPALHPHQVACLSILLKKMYSDFELQGVIDDKLNSKTYQGVAARMHTEEATCSLLLSQQDGGGGDDGGSEEGSRGGKSKLEALTEEAKLGNVTAVVGKVGNMFGRGIGELSTKLGGASSWF

Description

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. However, it probably also participates in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering.

Keywords

Alternative splicing   Calcium   Cell junction   Complete proteome   Cytoplasmic vesicle   Exocytosis   Lipid-binding   Membrane   Metal-binding   Protein transport   Reference proteome   Synapse   Transport  

Feature

chain  Calcium-dependent secretion activator
splice variant  In isoform 3.

Uniprot

H9J4Y9   A0A0N0PEE3   A0A2H1W8I2   A0A0N0PA63   A0A2A4JN00   A0A2A4JLM5   + More
A0A2A4JNH4   A0A2A4JMA7   A0A2A4JME3   A0A2A4JNE7   A0A2A4JML3   A0A2A4JNG7   A0A2A4JLV3   A0A2A4JLK0   A0A1Y1NFK5   A0A1W4WR25   A0A1W4WF75   A0A0T6BCC2   A0A1Y1NKE4   A0A2J7QJ63   A0A023EWW7   A0A069DY17   A0A067R127   E0VZ67   Q9NHE5-7   A0A1W4WBT6   A0A0Q9WWP0   A0A0Q5UX39   A0A0K8V7Z7   A0A0K8U112   A0A0P8XJH8   A0A0Q9XNT8   E2AI42   A0A151IMN5   A0A3L8D724   A0A2J7QJ73   A0A026W1K1   A0A0L0C5Q7   W8B7Q0   A0A158NPM9   A0A195EL55   A0A195ESH6   F4W7M3   A0A1A9WFC3   A0A151WJ46   A0A1B0BQD5   A0A1B0G6G9   A0A1A9ZSL9   A0A1A9V6J9   A0A195AT40   A0A1A9YP30   A0A1I8PC61   A0A1I8MUB9   A0A336M007   A0A0R1E7M4   A0A336KFR6   A0A1D2MT12   D6W738   E9J9W3   A0A154PMK3   A0A0L7QL63   E2C3B1   A0A0N0BG10   V9IDM1   A0A088AUU4   A0A310SMY2   A0A0A9Y0M3   A0A0A9Y4Q5   E9FY77   A0A0P5BZT2   A0A0P5BZX1   A0A0P5ARW3   N6T9E0   A0A0P5CC19   A0A0P6JE70   A0A0P5C007   A0A0J7KKK1   A0A0P4YEE4   A0A0N8A6J0   A0A0P5XHU0   A0A0P5C194   A0A0P4ZZC5   A0A0P4WRQ3   A0A0P5DMU3   A0A034W024   A0A0P5DEF1   K7IXW6   A0A087TFQ3   A0A2A3E199   A0A164QUF7   A0A0P5ZJ57   A0A0P5ZQ14   A0A0P6ACZ0   A0A0P5JPQ8   A0A0P5C1A3   A0A0P6FH06   A0A0P6D3D7   A0A0P4YKS6   A0A0N8A6J7   A0A0P5AT02  

Pubmed

19121390    26354079    28004739    25474469    26334808    24845553    + More
20566863    11516399    10731132    12537572    12537569    10731138    17994087    20798317    30249741    24508170    26108605    24495485    21347285    21719571    25315136    17550304    27289101    18362917    19820115    21282665    25401762    21292972    23537049    25348373    20075255   

EMBL

BABH01025689    KQ459890    KPJ19586.1    ODYU01007014    SOQ49378.1    KQ458842    + More
KPJ04906.1    NWSH01001042    PCG72964.1    PCG72957.1    PCG72960.1    PCG72959.1    PCG72956.1    PCG72963.1    PCG72958.1    PCG72962.1    PCG72961.1    PCG72955.1    GEZM01003808    JAV96549.1    LJIG01001968    KRT84972.1    GEZM01003803    JAV96556.1    NEVH01013560    PNF28627.1    GBBI01005090    JAC13622.1    GBGD01000109    JAC88780.1    KK852819    KDR15617.1    DS235849    EEB18673.1    AF223578    AE014135    AY118427    AF145637    CH940665    KRF85291.1    CH954250    KQS47970.1    GDHF01017318    JAI34996.1    GDHF01032299    JAI20015.1    CH902646    KPU74920.1    CH933813    KRG07338.1    GL439639    EFN66893.1    KQ977026    KYN06215.1    QOIP01000012    RLU16079.1    PNF28630.1    KK107488    EZA49950.1    JRES01000956    KNC26759.1    GAMC01009315    JAB97240.1    ADTU01022623    ADTU01022624    ADTU01022625    KQ978730    KYN28990.1    KQ981986    KYN31200.1    GL887844    EGI69896.1    KQ983049    KYQ47856.1    JXJN01018561    CCAG010007966    KQ976745    KYM75388.1    UFQS01000373    UFQT01000373    SSX03300.1    SSX23666.1    CM000161    KRK05017.1    SSX03301.1    SSX23667.1    LJIJ01000606    ODM95924.1    KQ971307    EFA11414.2    GL769474    EFZ10391.1    KQ434954    KZC12528.1    KQ414934    KOC59352.1    GL452318    EFN77557.1    KQ435794    KOX74118.1    JR039550    AEY58752.1    KQ759866    OAD62492.1    GBHO01017012    JAG26592.1    GBHO01017013    JAG26591.1    GL732527    EFX87826.1    GDIP01177616    JAJ45786.1    GDIP01177562    JAJ45840.1    GDIP01209358    JAJ14044.1    APGK01047302    APGK01047303    APGK01047304    KB741077    KB631602    ENN74348.1    ERL84569.1    GDIP01177564    JAJ45838.1    GDIQ01018773    JAN75964.1    GDIP01182263    GDIP01145668    JAJ41139.1    LBMM01006277    KMQ90746.1    GDIP01229607    GDIP01195411    GDIP01180558    JAI93794.1    GDIP01177617    JAJ45785.1    GDIP01071875    JAM31840.1    GDIP01177565    JAJ45837.1    GDIP01210408    JAJ12994.1    GDIP01252552    GDIP01238561    GDIP01230707    GDIP01196458    GDIP01180559    GDIP01152365    GDIP01145667    GDIP01132067    GDIP01132066    GDIP01132065    GDIP01130866    JAI70849.1    GDIP01155115    JAJ68287.1    GAKP01010041    JAC48911.1    GDIP01162661    JAJ60741.1    KK115013    KFM63942.1    KZ288455    PBC25523.1    LRGB01002371    KZS08069.1    GDIP01044334    JAM59381.1    GDIP01044332    JAM59383.1    GDIP01044333    JAM59382.1    GDIQ01196984    JAK54741.1    GDIP01177566    JAJ45836.1    GDIQ01050245    JAN44492.1    GDIQ01083379    JAN11358.1    GDIP01229608    GDIP01219906    GDIP01071876    JAI93793.1    GDIP01177561    JAJ45841.1    GDIP01198410    JAJ24992.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000192223    UP000235965    + More
UP000027135    UP000009046    UP000000803    UP000192221    UP000008792    UP000008711    UP000007801    UP000009192    UP000000311    UP000078542    UP000279307    UP000053097    UP000037069    UP000005205    UP000078492    UP000078541    UP000007755    UP000091820    UP000075809    UP000092460    UP000092444    UP000092445    UP000078200    UP000078540    UP000092443    UP000095300    UP000095301    UP000002282    UP000094527    UP000007266    UP000076502    UP000053825    UP000008237    UP000053105    UP000005203    UP000000305    UP000019118    UP000030742    UP000036403    UP000002358    UP000054359    UP000242457    UP000076858   

PRIDE

H9J4Y9    Q9NHE5   

Pfam

PF06292   DUF1041        + More
PF00169   PH
PF00388   PI-PLC-X
PF00387   PI-PLC-Y
PF00168   C2

Interpro

IPR001849   PH_domain        + More
IPR011993   PH-like_dom_sf       
IPR014770   Munc13_1       
IPR033227   CAPS       
IPR010439   CAPS_dom       
IPR000008   C2_dom       
IPR035892   C2_domain_sf       
IPR017946   PLC-like_Pdiesterase_TIM-brl       
IPR000909   PLipase_C_PInositol-sp_X_dom       
IPR011992   EF-hand-dom_pair       
IPR001192   PI-PLC_fam       
IPR001711   PLipase_C_Pinositol-sp_Y       

SUPFAM

SSF51695   SSF51695        + More
SSF47473   SSF47473       

Gene 3D

2.30.29.30     2.60.40.150     3.20.20.190    

ProteinModelPortal

H9J4Y9   A0A0N0PEE3   A0A2H1W8I2   A0A0N0PA63   A0A2A4JN00   A0A2A4JLM5   + More
A0A2A4JNH4   A0A2A4JMA7   A0A2A4JME3   A0A2A4JNE7   A0A2A4JML3   A0A2A4JNG7   A0A2A4JLV3   A0A2A4JLK0   A0A1Y1NFK5   A0A1W4WR25   A0A1W4WF75   A0A0T6BCC2   A0A1Y1NKE4   A0A2J7QJ63   A0A023EWW7   A0A069DY17   A0A067R127   E0VZ67   Q9NHE5-7   A0A1W4WBT6   A0A0Q9WWP0   A0A0Q5UX39   A0A0K8V7Z7   A0A0K8U112   A0A0P8XJH8   A0A0Q9XNT8   E2AI42   A0A151IMN5   A0A3L8D724   A0A2J7QJ73   A0A026W1K1   A0A0L0C5Q7   W8B7Q0   A0A158NPM9   A0A195EL55   A0A195ESH6   F4W7M3   A0A1A9WFC3   A0A151WJ46   A0A1B0BQD5   A0A1B0G6G9   A0A1A9ZSL9   A0A1A9V6J9   A0A195AT40   A0A1A9YP30   A0A1I8PC61   A0A1I8MUB9   A0A336M007   A0A0R1E7M4   A0A336KFR6   A0A1D2MT12   D6W738   E9J9W3   A0A154PMK3   A0A0L7QL63   E2C3B1   A0A0N0BG10   V9IDM1   A0A088AUU4   A0A310SMY2   A0A0A9Y0M3   A0A0A9Y4Q5   E9FY77   A0A0P5BZT2   A0A0P5BZX1   A0A0P5ARW3   N6T9E0   A0A0P5CC19   A0A0P6JE70   A0A0P5C007   A0A0J7KKK1   A0A0P4YEE4   A0A0N8A6J0   A0A0P5XHU0   A0A0P5C194   A0A0P4ZZC5   A0A0P4WRQ3   A0A0P5DMU3   A0A034W024   A0A0P5DEF1   K7IXW6   A0A087TFQ3   A0A2A3E199   A0A164QUF7   A0A0P5ZJ57   A0A0P5ZQ14   A0A0P6ACZ0   A0A0P5JPQ8   A0A0P5C1A3   A0A0P6FH06   A0A0P6D3D7   A0A0P4YKS6   A0A0N8A6J7   A0A0P5AT02  

PDB

6A68     E-value=3.04298e-71,     Score=687

KEGG

101742581    K19933 calcium-dependent secretion activator | (RefSeq) calcium-dependent secretion activator

GO

GO:0098793   GO:0016079   GO:1990504   GO:0016192   GO:0007269   GO:0030659   GO:0045956   GO:0005509   GO:0015031   GO:0045202   GO:0030054   GO:0008289   GO:0008021   GO:0035249   GO:0006887   GO:0035556   GO:0006629   GO:0004435  

PANTHER

PTHR12166  

Subcellular location

Cytoplasmic vesicle membrane  
Cell junction  
Synapse  

Length:

1047

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00742999999999999

Exp number, first 60 AAs:

0.00015

Total prob of N-in:

0.00005

outside

1  -  1047

 

 

Pi

283.936666

Theta

193.845282

Tajima's D

1.358901

CLR

0.108099

CSRT

0.756562171891405

Interpretation

Uncertain