Gene

KWMTBOMO16010  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004603

Annotation

PREDICTED:_tubulin_beta_chain_isoform_X1_[Plutella_xylostella]

Location

Bomo_Chr27(+):5915186-5917160      View in EpiBrowser

Full name

Tubulin beta chain       + More
Tubulin beta-4 chain      

Alternative Name

Beta-tubulin

Location in the cell

Cytoplasmic   Reliability : 3.636

CDS

ATGAGGGAAATAGTTCATATCCAAGGAGGTCAATGCGGAAACCAGATTGGGGCTAAGTTCTGGGAAGTTATATCCGATGAGCATGGCATCGATCCGACCGGAACGTATCACGGAGACTCCGACCTCCAGCTGGAGCGCATCAACGTGTACTATAACGAGGCGACTGGAGGAAAGTACGTGCCTCGGGCTATCCTTGTGGACCTAGAGCCCGGGACAATGGACTCTGTACGCTCCGGACCATTCGGTCAGATCTTCCGTCCGGACAACTTTGTCTTTGGGCAATCGGGTGCTGGCAACAACTGGGCTAAGGGTCACTACACCGAAGGCGCAGAGCTGGTAGATTCTGTGCTCGATGTAGTCAGAAAAGAAGCTGAAGGTTGCGACTGTCTGCAAGGATTCCAGTTGACTCACTCACTTGGCGGAGGAACTGGAGCTGGTCTTGGAACGTTACTCATTTCCAAAATTCGTGAGGAATACCCCGATAGGATCATGAACACCTTTAGCGTGGTTCCATCACCTAAGGTATCAGATACTGTGGTCGAACCGTACAATGCCACCCTTTCAGTACATCAGTTGGTAGAAAATACAGATGAATCGTACTGCATTGACAACGAGGCTCTGTATGATATCTGCTTCCGCACGCTGAAGCTAACAACCCCGACTTATGGCGACTTGAACCATCTTGTTTCGGCGACAATGTCAGGCGTGACGACTTGTCTACGGTTCCCTGGTCAGTTGAATGCAGATCTGCGCAAGCTAGCAGTGAACATGGTGCCGTTCCCACGGTTGCACTTTTTCATACCGGGTTTCGCGCCTCTGACGTCACGCGGGAGTCAGCAGTACCGTGCGCTAACGGTGCCGGAGTTGACGCAGCAGATGTTTGACGCGAAGAACATGATGGCGGCTTGTGATCCGCGCCACGGTCGCTACCTGACTGTGGCCGCTGTCTTCCGAGGTCGCATGTCTATGAAGGAGGTGGACGAACAAATGATGAACATTCAGAACAAGAACTCATCGTACTTTGTTGAGTGGATTCCAAACAACGTTAAAACAGCGGTGTGTGATATTCCGCCTCGAGGACTAAAAATGTCTGCTACATTCATAGGCAACTCAACAGCAATACAGGAGCTGTTTAAGCGTGTCTCGGAACAGTTCACGGCGATGTTCAGGCGCAAAGCGTTCTTACACTGGTATACGGGTGAGGGTATGGACGAGATGGAGTTCACTGAGGCAGAGTCAAACATGAACGACCTGGTATCGGAGTACCAACAGTACCAAGATGCTACTGCTGAAGAAGAAGGCGAGTTTGACGAGGAGGAAGAAGGGGGAGACGAGGGCGACTAG

Protein

MREIVHIQGGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCLQGFQLTHSLGGGTGAGLGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDESYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFIPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMMNIQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFDEEEEGGDEGD

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Subunit

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Similarity

Belongs to the tubulin family.

Keywords

Cytoplasm   Cytoskeleton   GTP-binding   Microtubule   Nucleotide-binding   Isopeptide bond  

Feature

chain  Tubulin beta chain

Uniprot

A0A2W1BD95   A0A2A4JTH9   A0A0N0PBJ8   A0A3S2TRY0   A0A2H1VRL4   A0A212ETB0   + More
H9J513   A0A194Q559   A0A1I8FZR8   A0A2G8KRV2   T1JL27   A0A267E855   T1FNQ3   Q0IIR4   G5BFZ1   A0A091CSX5   K9J100   K7RW51   W4X9L8   P11833   A0A1S3MQY2   A0A2C9JVG7   W4XHC0   A0A1S3M440   A0A2B4SNI6   A0A3M7PQY2   A0A1E1XN09   A0A1I8G0E9   A0A2I0TEB5   A0A3L8SEN6   A0A218UDV0   A0A3M0IW58   A0A1V4J794   F1NYB1   B5G4G7   A0A369S2L5   H2YR68   A0A1S3JH24   A0A2L1TH01   V3ZVA4   V4APA2   A0A1S3K232   A0A1W2WKR4   A0A1L8F5P2   A0A3B3R037   A0A3N0XHU7   Q6IQJ2   A0A1S3PR98   A0A2B4RJH1   V4B3V6   P30883   A0A2D0QG95   A0A2R8Q8X0   A0A0P6K1V8   A7S8I3   A0A0L8GJ55   A0A2T7NK64   A0A1S3JFN2   A0A1E1XAB0   A0A2D0Q4T1   A0A1W4YKF2   A0A3Q3BDZ6   A0A210R050   B3RQ31   A0A1S3JGZ3   B0RZ78   A0A3B4YS84   A0A0F8CDM5   A0A3Q1IB31   A0A3B4V1S7   F7J912   A0A224YUG0   A0A131YRB1   A0A1S3JG93   L7M875   A0A131XJZ2   V3ZL11   B7PA92   A0A3B3QEJ0   W5M3A6   A0A3P8Z2M3   A0A2U9CQ62   A0A3B1JNB6   A0A1S8WTZ6   A0A0K8RJ59   C6FDX2   A0A3R7CN35   A0A1S3JFJ6   Q70SJ8   V4A9P5   A0A183AP50   R7V9M3   A0A3B3Q9X6   A0A2D0RHR1   Q6TGT0   A0A3B4DBV8   Q6P5M9   Q7ZY50   G4VHK8   A0A094ZQ17  

Pubmed

28756777    26354079    22118469    19121390    26392545    29023486    + More
23254933    20431018    21993625    23110442    2762163    15562597    30375419    29209593    30282656    15592404    17018643    30042472    12481130    15114417    27762356    29240929    23594743    1379202    17615350    28503490    28812685    18719581    19175291    18372053    25835551    22193391    28797301    26830274    25576852    28049606    25069045    25329095    19513750    15520368    22253936    22246508   

EMBL

KZ150419    PZC70936.1    NWSH01000668    PCG74924.1    KQ460891    KPJ10834.1    + More
RSAL01000012    RVE53489.1    ODYU01004017    SOQ43460.1    AGBW02012621    OWR44709.1    BABH01025836    KQ459460    KPJ00673.1    MRZV01000406    PIK50736.1    JH431796    NIVC01002550    PAA56989.1    AMQM01007627    KB097642    ESN92436.1    AAMC01107528    AAMC01107529    BC121707    BC135706    KV460631    AAI21708.1    AAI35707.1    OCA16315.1    JH170063    EHB08202.1    KN124375    KFO21452.1    GABZ01006096    JAA47429.1    JQ959543    AFV81455.1    AAGJ04132828    X15389    AAGJ04065213    LSMT01000025    PFX32244.1    REGN01009284    RNA01532.1    GFAA01002831    JAU00604.1    NIVC01001153    NIVC01000679    PAA71604.1    PAA78557.1    KZ511739    PKU32141.1    QUSF01000027    RLW00442.1    MUZQ01000386    OWK51899.1    QRBI01000209    RMB93521.1    LSYS01008925    OPJ67924.1    AADN05000150    DQ217194    ACH46178.1    NOWV01000092    RDD40762.1    KY707330    AVF19947.1    KB203049    ESO86515.1    KB201441    ESO96620.1    CM004480    OCT66897.1    RJVU01073043    ROI27855.1    AL929549    CR855258    BC071414    AAH71414.1    LSMT01000405    PFX18544.1    KB203796    ESO83079.1    L06232    BC054297    GEBF01006200    JAN97432.1    DS469598    EDO39945.1    KQ421603    KOF77031.1    PZQS01000011    PVD21551.1    GFAC01003041    JAT96147.1    NEDP02001056    OWF54380.1    FJ387017    DS985242    ACJ72071.1    EDV28284.1    AM933587    KZ430015    KZ428772    CAP72051.1    PIS84897.1    PIS89312.1    KQ042255    KKF16960.1    AB642157    BAK41866.1    GFPF01006316    MAA17462.1    GEDV01006763    JAP81794.1    GACK01004799    JAA60235.1    GEFH01001172    JAP67409.1    ESO83090.1    ABJB010532527    ABJB010977054    DS670557    EEC03514.1    AHAT01021582    CP026259    AWP16822.1    KV894628    OON18002.1    GADI01002870    JAA70938.1    EU878031    ACJ65327.1    NIRI01000312    RJW71828.1    AJ550806    CAD79598.1    KB202518    ESO90011.1    UZAN01046394    VDP84105.1    AMQN01005238    KB295515    ELU13056.1    AY398426    AAQ97859.1    FP085432    BC056533    BC062827    AAH56533.1    AAH62827.1    BC043974    CM004481    AAH43974.1    OCT65195.1    HE601627    CCD79871.1    KL250660    KGB35139.1   

Proteomes

UP000218220    UP000053240    UP000283053    UP000007151    UP000005204    UP000053268    + More
UP000095280    UP000230750    UP000215902    UP000015101    UP000008143    UP000006813    UP000028990    UP000007110    UP000087266    UP000076420    UP000225706    UP000276133    UP000276834    UP000197619    UP000269221    UP000190648    UP000000539    UP000253843    UP000007875    UP000085678    UP000030746    UP000008144    UP000186698    UP000261540    UP000000437    UP000221080    UP000001593    UP000053454    UP000245119    UP000192224    UP000264800    UP000242188    UP000009022    UP000261360    UP000265040    UP000261420    UP000001555    UP000018468    UP000265140    UP000246464    UP000018467    UP000050740    UP000014760    UP000261440    UP000008854   

PRIDE

H9J513    P11833    P30883    L7M875   

Pfam

PF00091   Tubulin        + More
PF03953   Tubulin_C

Interpro

IPR037103   Tubulin/FtsZ_C_sf        + More
IPR002453   Beta_tubulin       
IPR013838   Beta-tubulin_BS       
IPR008280   Tub_FtsZ_C       
IPR003008   Tubulin_FtsZ_GTPase       
IPR017975   Tubulin_CS       
IPR036525   Tubulin/FtsZ_GTPase_sf       
IPR018316   Tubulin/FtsZ_2-layer-sand-dom       
IPR000217   Tubulin       
IPR023123   Tubulin_C       

SUPFAM

SSF52490   SSF52490        + More
SSF55307   SSF55307       

Gene 3D

1.10.287.600     3.30.1330.20     3.40.50.1440    

ProteinModelPortal

A0A2W1BD95   A0A2A4JTH9   A0A0N0PBJ8   A0A3S2TRY0   A0A2H1VRL4   A0A212ETB0   + More
H9J513   A0A194Q559   A0A1I8FZR8   A0A2G8KRV2   T1JL27   A0A267E855   T1FNQ3   Q0IIR4   G5BFZ1   A0A091CSX5   K9J100   K7RW51   W4X9L8   P11833   A0A1S3MQY2   A0A2C9JVG7   W4XHC0   A0A1S3M440   A0A2B4SNI6   A0A3M7PQY2   A0A1E1XN09   A0A1I8G0E9   A0A2I0TEB5   A0A3L8SEN6   A0A218UDV0   A0A3M0IW58   A0A1V4J794   F1NYB1   B5G4G7   A0A369S2L5   H2YR68   A0A1S3JH24   A0A2L1TH01   V3ZVA4   V4APA2   A0A1S3K232   A0A1W2WKR4   A0A1L8F5P2   A0A3B3R037   A0A3N0XHU7   Q6IQJ2   A0A1S3PR98   A0A2B4RJH1   V4B3V6   P30883   A0A2D0QG95   A0A2R8Q8X0   A0A0P6K1V8   A7S8I3   A0A0L8GJ55   A0A2T7NK64   A0A1S3JFN2   A0A1E1XAB0   A0A2D0Q4T1   A0A1W4YKF2   A0A3Q3BDZ6   A0A210R050   B3RQ31   A0A1S3JGZ3   B0RZ78   A0A3B4YS84   A0A0F8CDM5   A0A3Q1IB31   A0A3B4V1S7   F7J912   A0A224YUG0   A0A131YRB1   A0A1S3JG93   L7M875   A0A131XJZ2   V3ZL11   B7PA92   A0A3B3QEJ0   W5M3A6   A0A3P8Z2M3   A0A2U9CQ62   A0A3B1JNB6   A0A1S8WTZ6   A0A0K8RJ59   C6FDX2   A0A3R7CN35   A0A1S3JFJ6   Q70SJ8   V4A9P5   A0A183AP50   R7V9M3   A0A3B3Q9X6   A0A2D0RHR1   Q6TGT0   A0A3B4DBV8   Q6P5M9   Q7ZY50   G4VHK8   A0A094ZQ17  

PDB

5Z4U     E-value=0,     Score=2210

KEGG

101744975    K07375 tubulin beta | (RefSeq) tubulin beta chain

PATHWAY

04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0005874   GO:0007017   GO:0005525   GO:0005737   GO:0003924   GO:0005200   GO:0000226   GO:0000278   GO:0003725   GO:0005623   GO:0060271   GO:0007166   GO:0016020   GO:0000287   GO:0006281   GO:0006259  

PANTHER

PTHR11588  

Subcellular location

  

Length:

447

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01642

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00418

outside

1  -  447

 

 

Pi

270.076995

Theta

183.274466

Tajima's D

1.526189

CLR

0

CSRT

0.792810359482026

Interpretation

Uncertain